1049例妇科门诊病人HPV感染基因型分析

目的研究宝安区妇女感染HPV的优势亚型,为宫颈癌防治提供依据。方法利用HPV基因芯片检测技术检验我院妇科门诊样本HPV亚型。结果 1049例病人中,HPV感染264例,阳性率25.17%。其中高危型（HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、和MM4）162例,占感染者81.44%;低危型（HPV11、6、42、43）49例,占感染者18.56%。二组感染率比较差异有统计学意义;264例感染HPV优势亚型HPV52,其次依次为16、43、58、68、18、53型;〈30岁及≥30岁两年龄段HPV感染率比较差异无统计学意义;组间优势亚型分布比较HPV53在〈30岁年龄组明显增加,其他优势亚型分布比较差异无统计学意义;单一亚型感染239例,占90.52%。结论高危亚型、单一亚型为主要常见感染类型;HPV基因分型诊断在宫颈癌筛查和防治中具有重要意义。     

宁波地区1035例女性感染HPV基因类型分析

目的了解宁波地区各年龄段女性感染人乳头瘤病毒（human papilloma virus,HPV）基因类型分布及多重感染分布状况,为预防HPV感染和宫颈癌防治提供理论依据。方法利用反向杂交技术分男1对2007年1月～2008年12月来医院就诊的1035例可疑患者进行23种HPV基因亚型检测,其中包括18种与宫颈癌密切相关的高危亚型（HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、MM-4）及5种低危亚型（HPV6、11、42、43、44）。结果患者阳性检出率为37．68％（390／1035）,其中单一HPV亚型感染占68．72％（268／390）,2重HPV亚型感染为21．03％（82／390）,3重HPV亚型感染为6．67％（26／390）,4重HPV亚型感染为2．82％（11／390）,5重、6重、7重HPV亚型感染各占0．26％（1／390）;项目阳性检出率为2．35％（559／23805）,其中高、低危型检出率分别为1．58％（375／23805）与0．77％（184／23805）,高危型中主要为HPV16、58、33、18感染,低危型主要为HPV11、6感染。各年龄段感染的比率为≤20岁33．33％（2／6）,（21—30）岁47．62％（130／273）,（31—40）岁35．69％（111／311）例,（41—50）岁32．76％（96／293）例和〉50岁33．55％（51／152）例;各年龄段项目阳性的比率为3．62％,3．11％,2．21％,1．83％和2．23％。结论HPV16、11、6、58、33、18是宁波地区HPV感染的主要型别,各年龄段均为感染的高峰人群,对HPV阳性者进行定期的跟踪,是防治尖锐湿疣与宫颈癌的重点。     

金华地区女性感染人乳头瘤病毒基因类型分析

目的：了解金华地区各年龄段与不同生殖道疾病女性感染人乳头瘤病毒（humanpa pilloma virus,HPV）基因类型分布状况,为金华地区HPV分子流行病学研究提供依据。方法：利用反向杂交技术分别对2006年1月～2007年12月来医院就诊的236例可疑患者进行23种HPV基因亚型检测,其中包括18种高危亚型（HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、MM4）及5种低危亚型（HPV6、11、42、43、44）。结果：HPV阳性检出率为13.6%（32/236）,其中高、低危型检出率分别为13.1%（31/236）与3.4%（8/236）,高危型中主要为HPV16、18、58感染,低危型主要为HPV6、11感染。不同生殖道疾病[尖锐湿疣、宫颈上皮内瘤变（CIN）]与正常对照组比较差异有显著性意义（P〈0.05）。（20～30）岁,（31～40）岁,（41～50）岁和〉50岁各年龄组中HPV阳性的比率为33.3%,38.5%,2.31%和5.1%。结论：HPV6、11、16、18、58是金华地区HPV感染的主要型别,（20～50）岁为感染的高峰人群,对HPV阳性者进行定期的跟踪,是防治尖锐湿疣与宫颈癌的重点。     

厦门地区女性人乳头瘤病毒感染状况调查

目的 对厦门地区妇女宫颈人类乳头瘤病毒（human papilloma virus,HPV）亚型进行筛查,以探讨其分布规律.方法 采用凯普医用核酸分子快速杂交仪,对7683名2013年1月-2013年12月到厦门市174医院妇科门诊或病房就诊的女性进行生殖道21种HPV感染基因亚型筛查.结果 7683例样本中,HPV感染者1421例,阳性率18.50％.感染人群主要集中在30～39岁.其中高危型HPV阳性率为16.01％,低危型HPV阳性率为2.49％.单一基因型别者1148例,阳性率为14.94％;双重感染者220例阳性率为2.86％;三重以上感染者53例,阳性率为0.70％;HPV感染阳性率居前6位的基因型分别为HPV-52（3.64％）、HPV-16 （3.33％）、HPV-58（2.98％）、HPV-53（2.16％）、HPV-CP8304（1.91％）和HPV-18（1.09％）.结论 厦门地区妇女HPV感染率高,且以高危型单一基因亚型感染为主;感染基因型别主要以HPV-52、16、58、53、CP8304和18为主,具有一定的地域差异性;52及58型感染率高,对于疫苗的研制和开发有参考意义.     

1448例妇科患者HPV感染型别分布及临床分析

目的分析女性HPV感染的阳性率和各年龄段的关系及常见亚型的分布情况,探讨女性HPVDNA基因分型技术检测在宫颈癌防治方面的应用价值。方法采用HPV基因分型技术对1448例妇科门诊就诊者进行HPV分型检测。结果1448例样本中,检出HPV阳性者531例,总阳性率为36．7％,其中高危型HPV468例,占感染率88％,低危型HPV63例,占感染率12％,混合感染HPV122例,占感染率23％,HPV基因型单一感染为77．2％,二重感染为17．9％,三重感染为3．6％,四重感染为1．5％。高危型中未检出HPV35、73、83、MM4型,低危型中未检出HPV43、44型。患者其亚型感染率由高到低依次为HPV58、16、52、33、18、31、53、68、66、51、39、56和59型,低危型依次为HPV11、6、42型。不同年龄组中HPV感染高峰在50～59岁和60～69岁这两个年龄段,感染率分别为78．9％和73．7％。结论HPV感染型别普遍化,各年龄段感染的阳性率差异有统计学意义（P〈0．05）,25岁前后及〉50岁的妇女更应予以重视,对阳性患者要加强定期随访,HPV基因分型及多种亚型的检测有利于宫颈癌的早期预警和早期治疗。     

妇女宫颈病变筛查分析

目的 研究HPV与宫颈癌及癌前病变的相关性,提供防治宫颈癌的思路。方法 以2012年1月~2017 年12月送检到浙江迪安诊断技术股份有限公司的433447例宫颈病变标本为研究对象,同时检测人乳头瘤病毒（HPV）基因分型和薄层液基细胞学（TCT）,并分析HPV基因亚型分布及年龄分布。结果 HPV阳性率为12.51%,其中单一高危HPV阳性率为9.28%,单一低危HPV阳性率为1.22%。HPV亚型阳性率最高的是16型2.09%、58型1.82%、52型1.61%。TCT 阳性检出率是5.69%,其中 ASC-US3.91%、LSIL1.21%、ASC-H0.32%、HSIL及以上0.23%、AGC 0.02%。HPV发病率最高的年龄段是41~50岁,阳性率为5.54%,与其它年龄段比较,差异有统计学意义（P＜0.05）。结论 HPV亚型中16、52及58感染率最高,同时具有明显年龄特征。HPV感染可引起一系列的宫颈病变,防治重点应针对高危HPV感染的人群。     

许昌地区妇女宫颈人乳头瘤病毒感染型别分布特征分析

目的了解许昌地区妇女宫颈人乳头瘤病毒（HPV）感染的分布情况及高危因素,确定该地区的优势型别。方法采用PCR加导流杂交技术对3100例已婚妇女宫颈脱落细胞进行21种HPV基因检测,分析HPV感染高危因素及宫颈病变中HPV亚型感染分布特点。结论在检测的3100例妇女中感染总阳性率为18.8%,HPV感染阳性率排在前5位的亚型从高到低依次为HPV16、HPV58、HPV52、HPV11、HPV6,最低为亚型HPV43,占0.1%。HPV感染的高峰年龄为31～40岁,各年龄段HPV感染检出率差异在统计学上有显著意义（P〈0.05）。结论许昌地区HPV亚型感染分布以HPV16、HPV58、HPV52型为主,且存在明显的地域差异,HPV感染高发于中青年妇女。     

安岳地区女性高危型HPV基因分型结果分析

目的 分析安岳地区女性高危型人乳头瘤病毒的感染以及各亚型的分布情况,为本地区宫颈癌防治及流行病学研究提供依据。方法 收集2016年1月~2017年12月年安岳地区自愿进行15种高危型HPV检测的女性宫颈脱落细胞标本2078例,应用实时荧光定量PCR进行包括16、18、31、33、35、39、45、51、52、53、56、58、59、66、68在内的15种HR-HPV检测,分析HR-HPV在人群中的总体和不同年龄段感染情况以及各亚型的分布特点。结果 2078例女性宫颈脱落细胞标本总阳性检出率为22.81%,其中单一感染占17.37%,混合感染占5.44%;在各年龄组中＜20岁组与＞60岁年龄组HR-HPV感染率最高,差异具有统计学意义（P＜0.05）;15种高危型中检出前五位的依次为:52型、16型、31型、53型、58型。结论 本地区女性人群的高危型HPV检出率较高,对本地区相关人群进行高危型HPV筛查非常必要。     

宫颈癌患者人乳头瘤病毒基因分型的研究

目的研究宫颈癌患者人乳头瘤病毒（HPV）感染及基因分型情况,为临床早期诊断和治疗提供参考。方法应用实时荧光定量聚合酶链反应（FQ-PCR）对655名来我院就诊女性患者进行HPV分型检测,共检测2种低危型和13种高危型。结果 655例患者中,HPV阳性率为31.45%（206/655）,其中低危型占67%（138/206）,HPV6为高发型,人群40岁以下为主;高危型占33%（68/206）,HPV6、11、16、18、52为高发型,人群以40岁以上为主;混合型阳性率为2.9%（19/655）。HPV6＋11,6＋18为高发型。结论本地HPV感染基因型以6、11、16、18、52、6＋11、6＋18为主,应针对此采取措施,防治相关疾病。     

HIV合并HPV阳性标本中HPV的型别检测

目的探讨深圳地区人类免疫缺陷病毒（HIV）阳性人群中人乳头瘤病毒（HPV）感染分型情况,为HIV阳性人群中HPV感染的防治提供依据。方法运用荧光PCR方法和反向斑点杂交技术对HPV阳性患者进行HPV分型检测。结果在HIV感染者中。利用反向点杂交分型方法对40例HPV阳性标本进行HPV基因分型。其中单型感染有18例（45．0％）,混合感染有19例（47．5％）,共检出16种HPV型别,其中包括11种高危型（16、18、31、33、35、45、52、56、58、68、73型）和5种低危型（6、11、42、44、54型）。在16种型别中,感染率最高的为16型（25．0％）,其次为52型（17．5％）、58型（15．0％）。结论感染HIV人群中生殖器部位HPV的感染率较高,在HIV阳性人群中检出性病相关的高危HPV16／52／58亚型．对HIV阳性人群中HPV感染的防治有重要指导意义。     

Prevalence of human papillomavirus genotypes in women from three clinical settings

Prevalence of 27 human papillomavirus (HPV) genotypes was assessed in 1,331 women in three clinical settings: Family planning clinic (low-risk HIV-, n = 202, 21.3% HPV+), colposcopy clinic (high-risk HIV-, n = 854, 34.3% HPV+), and HIV outpatient clinic (HIV+, n = 275, 48.7% HPV+). Compared to women from both family planning and colposcopy clinics, HIV+ women revealed significantly higher prevalence of infection with oncogenic, non-oncogenic, and multiple HPV types. HPV types 52 and 51 were most prevalent in the low-risk HIV- women, whereas in the high-risk HIV- women, HPV types 16, 52, 58, and 35 were most prevalent. Interestingly, in the HIV+ women, less characterized types 83, 53, and 54 were most prevalent. The distinct profiles of genotype prevalence persisted after stratification by Pap smear status. After adjustment for concurrent infections with other types, HPV type 51 in the low-risk HIV- women, and types 16, 35, 39, 45, 52, and 58 in the high-risk HIV- women were significantly associated with cytologic abnormalities (exact P < 0.05). In HIV+ women across CD4 cell count strata, HPV types 42, 16, and 82 revealed significant decreasing trends with increasing CD4 counts (exact P for trend < 0.05). These data suggest distinct genotypic prevalence profiles in women at diverse risk for cervical cancer. The association of several genotypes with cytologic abnormalities underscores the need for vaccines targeting a wide range of HPV types.     

Prevalence of human papillomavirus infection in women in the Autonomous Region of Inner Mongolia: A population‐based study of a Chinese ethnic minority

Human papillomavirus (HPV) is one of the most common sexually transmitted infectious pathogens. Persistent infection has been linked to cancer development, in particular to cervical cancer. This study aims to investigate the epidemiology of HPV infection in women in Inner Mongolia of China and to dissect the disparities between the Han and Mongolian ethnic populations. Cervical cell samples from 5655 women (17‐68 years old) were collected during routine gynecologic examination. HPV infection was established using the HPV GenoArray kit detecting 21 HPV genotypes. The overall HPV prevalence was 14.5%. HPV16 (5.0%), HPV58 (2.2%), and HPV52 (1.5%) are the most common genotypes. Of the 21 genotypes investigated, high‐risk HPV genotypes dominate in all age groups. HPV16 and HPV58 are the most common genotypes in patients with cervical lesions. HPV prevalence among Han women is 11.5% and the most common genotypes are HPV16 (4%) and HPV58 (2.1%). HPV prevalence is significantly higher in Mongolian women (32.6%), with the most common genotypes being HPV16 (10.7%), HPV31 (7.1%), and HPV52 (4.3%). The multiple infection rate in Mongolian participants (14.9%) is also higher than that of Han participants (4.3%). Urbanization, the number of sex partners, and PAP history appear as risk factors for HPV infection in Han, but not in Mongolian participants. HPV infection is highly prevalent in women in Inner Mongolia, China. HPV16 remains the most common genotype in this area. However, there are clear ethnical disparities in respect to the HPV epidemiology between the Han and Mongolian population.     

High prevalence of human papillomavirus type 58 in patients with cervical pre‐malignant lesions in southern Brazil

Cervical cancer is the second most common type of cancer in women worldwide. Several human papillomavirus (HPV) genotypes, sexual behavior, and socioeconomic profile represent major risk factors for the development of this carcinoma. Cervical invasive cancer is preceded by cellular abnormalities that can be identified by cytological or histological exams. In order to determine the prevalence and genotypes of HPV in women with abnormal cytology or histopathology, cervical cell samples from 256 patients were evaluated for the presence of HPV/DNA by polymerase chain reaction (PCR), followed by virus genotyping by restriction fragment length polymorphism (RFLP). A total of 113 samples (51.2%) were HPV/DNA positive. Viral genotyping showed that the most prevalent genotypes were HPV 16 (34.7%) and 58 (13.8%), followed by HPV 33 (9.72%), 11 (8.33%), 18 (5.55%), 53 (5.55%), and 6 (4.2%). Four samples (5.55%) exhibited multiple infections due to the great similarity of socioeconomic characteristics and sexual behavior of HPV positive women, it was not possible to establish a risk profile for female HPV infection. J. Med. Virol. 81:1270–1275, 2009. © 2009 Wiley‐Liss, Inc.     

Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL

The contribution of human papillomavirus (HPV) types to the carcinogenesis of cervical cancer has been established for a long time. However, the role of phylogenetically related and rare variants remains uncertain, as well as the influence of concurrent multiple HPV genotypes infection. We aimed at studying the prevalence of several HPV genotypes infecting women with single versus concurrent multiple HPV genotypes infection with a HSIL diagnosis in a cervical cytology. We conducted a cross‐sectional study using Thin‐Prep^® liquid‐based cervical cytology specimens with the diagnosis of high‐grade squamous intraepithelial lesion (HSIL), in which HPV genotype was sequentially tested. Genotypes were determined with a PapilloCheck^® system, a DNA‐Chip for the type‐specific identification of 18 high‐risk and six low‐risk types of HPV. Of the total study population, 176 cases had a diagnosis of HSIL and positive HPV genotyping result, being HPV16 the most prevalent genotype (48.86%; 95%CI: 41.58–56.19) followed by HPV31 (14.20%; 95%CI: 9.75–20.18). Concurrent multiple HPV genotypes were detected in 36.93% (95%CI: 30.15–44.27) of the patients. The prevalence of the 10 most common HPV genotypes detected varied significantly according to the presence of single vs. concurrent multiple HPV genotypes (P = 0.022). Moreover, women with concurrent multiple HPV genotypes were on average 3.53 (95%CI: 0.43–6.64) years younger than women with single genotype infection. Our results suggest that women with multiple genotype HPV infection differ in terms of age and distribution of the most prevalent HPV genotypes. Additionally, we provide further evidence of the predominance of HPV16 in HSIL lesions of the uterine cervix. Diagn. Cytopathol. 2014;42:919–923. © 2014 Wiley Periodicals, Inc.     

Prevalence and type distribution of high‐risk human papillomavirus infection in women undergoing voluntary cervical cancer screening in Italy

The aim of this survey was to assess the prevalence and distribution of oncogenic human papillomavirus (HPV) genotypes in women who underwent screening for cervical cancer in Italy. The correlation of genotypes with the cytological results was also evaluated. Cervical samples were collected from 9,947 self‐referring women for cervical cancer screening. Participants were screened by liquid‐based cytology and high‐risk HPV testing using the Hybrid Capture 2 test. Positive samples were genotyped by PCR. Samples (1,474; 14.8%) were positive for high‐risk HPV. The prevalence was 29.4% in the 15–19 years‐group, decreasing progressively to 6.1% at 50–54 years of age and increasing to 12.2% in those aged over 65 years. HPV 16 was the genotype detected most frequently followed by HPV 31, HPV 18, HPV 56, and HPV 51. HPV 16 or 18 were present in 4% of women with normal cytology and both were detected contemporarily in only 14 women. Twenty‐two percent of atypical squamous cells, 26% of low‐grade and 56% of high‐grade squamous intraepithelial lesions at cytology were positive for HPV 16 and/or 18. The prevalence of HPV infection in Italy is in agreement with that reported worldwide. HPV 16 was the prevalent genotype. The concomitant infection with HPV 16 and HPV 18 (vaccine targets) was found rarely. Apart from HPV 16 and 18, there was a substantial presence of HPV genotypes against which the vaccines available currently have shown cross‐protection efficacy. The findings of this study may contribute to reliable predictions on the potential efficacy of an HPV vaccine in clinical practice. J. Med. Virol. 81:529–535, 2009. © 2009 Wiley‐Liss, Inc.     

人乳头瘤病毒基因型检测及其人群分布特征

目的 探讨河源地区女性感染人乳头瘤病毒（HPV）基因型分布,为预防HPV感染及临床诊治提供实验依据.方法 采用导流杂交技术对6745例宫颈脱落细胞标本行人乳头瘤病毒（HPV）分型检测.结果 检出HPV感染1 701例,总阳性率为25.20％,其中单一感染1 265例（74.40％）,多重感染436例（25.63％）,又以二重感染和单独高危型复合感染较为多见.六重感染和九重感染仅见于≤24岁年龄组,50岁以上年龄组均未见五重以上感染.HPV总阳性率、高危型HPV阳性率和低危型HPV阳性率均呈现“U”型特异性分布.受检21种亚型均被检出,常见的3种高危型为HPV52（25.69％）、HPV16（17.34％）和HPV58（15.52％）,2种低危型为HPV81 （8.23％）和HPV6 （6.94％）.各年龄组中最高感染率型别也有所差异.结论 河源地区受检女性HPV的感染率较高（25.20％）,多重感染者占25.63％.HPV总阳性率、高危型HPV阳性率和低危型HPV阳性率的年龄分布存在双峰现象,出现在≥60岁和≤24岁年龄组.最常见亚型是HPV52,不同年龄组HPV感染亚型分布略有不同.     

Epidemiology of human papillomavirus genotypes in pregnant Japanese women

To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in pregnant Japanese women, we performed Pap smear tests and HPV genotype testing in patients attending Nagasaki University Hospital and collaborating hospitals from August 2007 to July 2010. Serial uterine cervical specimens were obtained from 151 pregnant women. The HPV test was positive on the first visit in 54 women (35.8%; 54/151, average age 30). A total of 49 women (32.5%; 49/151) were infected by at least one high-risk HPV and 5 women were infected by only low-risk HPV. The three most prevalent high-risk HPV genotypes were HPV 52 (31.5%; 17/54), HPV 16 (29.6%; 16/51) and HPV 31 (13.0%; 7/51). The HPV infection pattern (negative, single infection and multiple infection) differed significantly according to the pregnancy trimester (χ(2)-test; P<0.01(Pearson)). Among HPV-infected pregnant Japanese women, HPV52 was the most common genotype. The second most common genotype was HPV16, and these two genotypes accounted for ～60% of HPV-positive pregnant women. Infection with multiple HPV genotypes was observed more frequently in the first trimester of pregnancy and the pattern of infection changed significantly depending on pregnancy stage.     

Detection of Chlamydia trachomatis and herpes simplex virus type 1 or 2 in cervical samples in human papilloma virus (HPV)-positive and HPV-negative women

This study investigated whether the prevalence of human papilloma virus (HPV) in association with Chlamydia trachomatis, herpes simplex virus (HSV)-1 and/or HSV-2 was greater in high-grade than in low-grade or control cervical biopsy specimens. HPV-positive (n = 86) and HPV-negative (n = 213) women were screened for HPV, HSV and C. trachomatis by PCR. The most common HPV genotypes were HPV-16, HPV-6 and HPV-33; mixed HPV infection (n = 12) was also seen. A higher prevalence of C. trachomatis, HSV-1 and HSV-2 was found in HPV-positive samples. High-risk HPV genotypes and combined HPV + C. trachomatis or HPV + HSV-1, but not HSV-2, infections were associated with a greater risk of developing cervical carcinoma.     

Associations of high-risk HPV types and viral load with cervical cancer in China.

BACKGROUND: Cervical cancer is the second most common cancer in women worldwide. Infection with some genotypes of human papillomavirus is the most important risk factor associated with cervical cancer. OBJECTIVE: The aim of this study was to determine the prevalence and genotypes of HPV in China, and to evaluate the correlation between viral load of high risk HPV and cervical cancer and its precursors. STUDY DESIGN: A cross-sectional study was carried out, wherein cervical samples were collected from 541 patients with cervical cancer, 262 with CIN, 139 with cervicitis and 68 age-matched healthy controls. Hybrid Capture 2 was employed to detect HPV DNA. Specimens from HPV DNA positive cervical cancer were tested for HPV types by using type specific PCR and general primer PCR with sequence-based typing (GP PCR-SBT). RESULTS: Overall high risk HPV prevalence was 68.8% in CIN1, 80.3% in CIN2, 90.2% in CIN3, 90.9% in cervical cancer in situ, 89.9% in invasive cervical cancer and 25% in healthy controls from China. The most common HPV DNA type found in patients with cervical cancer was HPV16 (79.6%), followed by HPV58 (5.92%), HPV33 (3.29%), HPV18 (1.97%), HPV6 (1.97%), HPV31 (1.31%), HPV39 (1.31%), HPV68 (1.31%) and other HPV types (3.3%). It was found that there was a significantly increased risk of increasing CIN stage with high viral load. Frequency of low viral load found in the controls was 13.2% and 22.9% of CIN1, obtaining an OR of 4.2 (1.5-12.0). Associations (OR) among low viral load and CIN2/3, CIS, and CC were 6.7 (2.9-15.6), 9.4 (2.7-32.3) and 8.3 (3.7-18.4), respectively. While high viral loads were found in 5.9% of controls, 27.1% of CIN1, 42.1% of CIN2/3 and 48.5% of CIS, demonstrating increasing odds ratios with severity of disease (OR for CIS=68.0, 95% CI=17.8-259.7). CONCLUSIONS: HPV16 was the most common genotype in central China. The developing cervical cancer precursors were associated with elevated high-risk HPV viral load.     

Human Papillomavirus types prevalence and their association with cervical dysplasia among HIV and non-HIV infected women attending reproductive health clinics in Eastern Kenya

BackgroundHuman Papillomavirus (HPV) causes over 99% of all cervical cancer globally. In 2019; it was responsible for 3,286 deaths in Kenya. Understanding the epidemiological distribution of HPV genotypes by cervical dysplasia and HIV infection is important in designing prevention strategy and management of cervical cancer.ObjectiveTo determine HPV genotypes prevalence and their distribution by cervical dysplasia, social-demographic and risk factors associated with cervical cancer among HIV-infected women aged 18–48 years seeking reproductive healthcare in Eastern Kenya.MethodsCervical specimens were obtained for cytology, HPV-genotyping, histology while social-demographic factors were collected using a questionnaire and analysed using Pearson chi-square test.Results317 womencases: 161(50.8%); control 156(49.2%), mean age: 34.3, range 18–46 years were recruited. Thirteen HPV genotypes associated with cervical dysplasia were: CIN1{cases: HPV81[12(3.8%), HPV11[2(0.6%); control: HPV53 and HPV66[1(0.3%)}, CIN2 {cases: HPV11, HPV16, HPV661(0.3%), HPV816(1.9%) and single case1(0.3%) of HPV9, HPV11, HPV16, HPV44, HPV66, HPV81 HPV88, HPV53 and HPV58; control: HPV81[2(0.6%)} and invasive cancer {cases: HPV16[1(0.3%) and HPV81[3(0.9%); control: HPV16 and HPV66[1(0.3%).ConclusionsCervical dysplasia was associated with more mixed-lr/hrHPV genotypes among HIV-infected than HIV-uninfected women. The finding adds to the pool of knowledge the epidemiological data required in determining the population at risk for cervical cancer.