Acute vertebrobasilar occlusion: treatment with high-dose intraarterial urokinase

OBJECTIVE: The purpose of this study was to describe our successful experience with high-dose intraarterial urokinase therapy in treating acute, life-threatening vertebrobasilar occlusion. CONCLUSION: We successfully treated five patients with acute vertebrobasilar occlusion who presented up to 24 hr after the onset of symptoms. Higher doses of urokinase than are commonly reported in the literature were used in this series at a rapid infusion rate with a "pulse-spray" technique. The result was prompt thrombolysis and good clinical outcome.     

Superior mesenteric artery obstruction by intraaortic counterpulsation balloon simulating embolism: A case report

The use of intraaortic counterpulsation balloons has been lifesaving in patients with cardiogenic shock, and indications for its use have expanded in recent years. Several complications of catheter placement and use have been reported. We report what we believe is the first instance of simulated embolization of the superior mesenteric artery by a balloon that was intermittently occluding the vessel's origin.     

Acute renal vein thrombosis: successful treatment with intraarterial urokinase

When acute renal vein thrombosis is associated with renal failure, aggressive therapy to eliminate the venous obstruction is indicated. There are reports of successful treatment of this condition with thrombolytic agents administered systemically or directly into the renal vein. Renal arterial administration of urokinase was used successfully to treat acute renal vein thrombosis associated with renal failure in a 9 1/2-year-old child.     

Superior mesenteric artery angioplasty with the TEGwire: usefulness and technical difficulties.

The TEGwire percutaneous transluminal angioplasty balloon on a guide wire was used successfully for dilation of a proximal superior mesenteric arterial stenosis that was not well suited to dilation by conventional angioplasty catheters. After the stenosis was dilated, however, the balloon deflated only partially due to a kink in the TEGwire as it coursed over the acute angle between the aorta and the superior mesenteric artery. Several unsuccessful attempts to correct this problem were made; finally, the partially deflated balloon and the guide catheter had to be withdrawn. Although the TEGwire was used within the guidelines and recommendations of the product, this experience supports the manufacturer's recommendation that the TEGwire system should not be used with narrow-radius vascular curves such as that formed between the superior mesenteric artery and the aorta.     

肠系膜上动脉夹层一例

患者男,60岁.因右上腹部持续性疼痛,阵发性加剧3 d入院.实验室检查:白细胞12.8 × 109/L,血、尿淀粉酶正常,肝、肾功能正常.心电图未见异常.血压:135/80 mm Hg(1 nun Hg=0.133 kPa).体检无明显异常.     

Superior mesenteric artery stenting for mesenteric ischaemia in Sneddon's syndrome

Mesenteric ischaemia is a rare but serious cause of abdominal pain. We present the case of a man with Sneddon's syndrome, who had symptomatic mesenteric ischaemia secondary to a superior mesenteric artery stenosis in conjunction with a hepatic artery stenosis. As far as the authors are aware, this has not previously been described in Sneddon's syndrome, which is a vascular systemic disease characterized by an association between cerebrovascular accidents and a livedo reticularis skin rash. He was treated with balloon angioplasty and stent insertion, with good symptomatic improvement. This has implications for other stenoses in this condition should they become symptomatic.     

Intra-arterial fibrinolysis of superior mesenteric artery embolism

Intra arterial fibrinolysis for acute mesenteric embolism. Acute mesenteric ischemia has a poor prognosis because the diagnosis is often too late (greater than 12 h), leading to a difficult surgery in old patients. The lesions of the bowel don't always allow a single operative embolectomy but often need a resection when there is a long time interval between onset of symptoms and therapy. We report a case of acute embolism in the superior mesenteric artery with the clot located in its terminal part. A rapid diagnosis was made by arteriography and intra-arterial fibrinolysis was attempted with success permitting the complete cure of the affection, without sequellae. This treatment is only likely to be successful if it is carried out within 10-12 hours of the onset of clinical signs and symptoms.     

尿激酶动静脉溶栓治疗犬急性肺动脉栓塞的对照研究

目的 评价动脉内尿激酶(UK)溶栓治疗犬急性肺动脉栓塞的安全性和有效性.方法 用犬自体血栓建立选择性急性肺动脉栓塞模型,24只犬随机分为动脉溶栓组(30 min内经导管注入UK10 000 u/kg)、静脉溶栓组(2 h内经静脉滴入UK 20 000 u/kg)及对照组(2 h内经静脉滴入生理盐水100ml),每组8只.监测其平均肺动脉压(PAMP)、血气分析(PaO2、PaCO2)、凝血指标(PT、APTT)和D-二聚体(D-D)以及肺动脉造影复查.结果 溶栓后2 h三组PAMP、PaO2及D-D值比较差异有统计学意义(P＜0.05),溶栓后4 h动脉组与静脉组的PAMP、PaO2及D-D值比较无差异(P＞0.05).造影复查显示:动脉组比静脉组能更快溶解血栓,恢复肺组织血供.结论 动脉溶栓较静脉溶栓所需的UK剂量小,并能更快降低肺动脉压、提高动脉血氧分压,恢复肺组织血流.     

介入取栓术治疗急性肠系膜上动脉栓塞临床研究

目的评价经皮肠系膜上动脉吸栓和(或)溶栓治疗急性肠系膜上动脉栓塞的疗效。方法34例急性肠系膜上动脉栓塞的患者(房颤14例;左房黏液瘤2例;血栓形成15例;慢性缺血性肠病急性发作3例),行经皮动脉长鞘吸栓术和(或)溶栓术。结果34例患者均成功的去除栓子,动脉开通。31例痊愈;2例行开腹探查;1例24h后死亡。结论经皮介入取栓术对于治疗急性肠系膜上动脉栓塞,是一种简便有效的方法。准确地判断病因是提高疗效,避免合并症的关键。