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Semple RK Meirhaeghe A Vidal-Puig AJ Schwabe JW Wiggins D Gibbons GF Gurnell M Chatterjee VK O'Rahilly S 《Endocrinology》2005,146(4):1871-1882
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Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses
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Kim U Siegel R Ren X Gunther CS Gaasterland T Roeder RG 《Proceedings of the National Academy of Sciences of the United States of America》2003,100(15):8868-8873
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Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution. 总被引:7,自引:0,他引:7
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B Petryniak L M Staudt C E Postema W T McCormack C B Thompson 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(3):1099-1103
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Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand
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Willy PJ Murray IR Qian J Busch BB Stevens WC Martin R Mohan R Zhou S Ordentlich P Wei P Sapp DW Horlick RA Heyman RA Schulman IG 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(24):8912-8917
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Fong AM Premont RT Richardson RM Yu YR Lefkowitz RJ Patel DD 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(11):7478-7483
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting via G protein-coupled receptors. Because members of this receptor family are regulated ("desensitized") by G protein-coupled receptor kinase (GRK)-mediated receptor phosphorylation and beta-arrestin binding, we examined signaling and chemotactic responses in splenocytes derived from knockout mice deficient in various beta-arrestins and GRKs, with the expectation that these responses might be enhanced. Knockouts of beta-arrestin2, GRK5, and GRK6 were examined because all three proteins are expressed at high levels in purified mouse CD3+ T and B220+ B splenocytes. CXCL12 stimulation of membrane GTPase activity was unaffected in splenocytes derived from GRK5-deficient mice but was increased in splenocytes from the beta-arrestin2- and GRK6-deficient animals. Surprisingly, however, both T and B cells from beta-arrestin2-deficient animals and T cells from GRK6-deficient animals were strikingly impaired in their ability to respond to CXCL12 both in transwell migration assays and in transendothelial migration assays. Chemotactic responses of lymphocytes from GRK5-deficient mice were unaffected. Thus, these results indicate that beta-arrestin2 and GRK6 actually play positive regulatory roles in mediating the chemotactic responses of T and B lymphocytes to CXCL12. 相似文献
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Regulation of gene expression by the proto-oncogene BCL-6. 总被引:13,自引:0,他引:13
Alexander L Dent Farha H Vasanwala Lisa M Toney 《Critical reviews in oncology/hematology》2002,41(1):1-9
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