Bacterial Flora in Semen before and after Doxycycline Treatment of Infertile Couples

A group of men under investigation for infertility have been studied with regard to findings of aerobic and anaerobic bacteria in their ejaculates before and after medication. The group consisted of 27 men who received doxycycline concomitantly with their partners according to a fixed treatment schedule. Prior to medication 23 men delivered ejaculates which demonstrated bacterial growth. A total of 53 isolates were obtained. Following doxycycline treatment a significant number of men had a reduction in the number of isolates. The reduction was mainly confined to peptococci and propionibacteria.
Of the 9 men whose partners subsequently conceived, 6 harboured peptococci and/or propionibacteria in their semen before but not after treatment. It is concluded that these results warrant more extensive studies of the possible part played by peptococci and propionibacteria in genital-tract infections in the male partners of infertile unions.     

Treatment of Asthenozoospermia with HCG

30 patients with isolated asthenozoospermia received a treatment with 5000 I.U. Human-Chorionic-Gonadotropin (HCG) a week intramuscularly for twelve weeks. Pretreatment basal levels of FSH, LH and testosterone were in normal or low normal range. 16 males responded to therapy, the total motility of spermatozoa increased significantly from 34% to 40%. In spite of a decreased sperm density and morphologic quality 6 pregnancies occurred. This result strengthens the interpretation, that sperm motility is the most important factor for fertilization. HCG therapy must be considered as an additional approach for treating motility disturbances, especially in cases with high sperm densities.     

Minocycline Extended-Release Comparison with Doxycycline for the Treatment of Rosacea: A Randomized,Head-to-Head,Clinical Trial

ObjectiveMinocycline efficacy for the treatment of papulopustular rosacea (PPR) has not been evaluated in clinical trials at levels demonstrated to stay below the antimicrobial threshold. We assessed the efficacy, safety, and dose response of DFD-29, a minocycline extended-release oral capsule. Two studies are reported ({"type":"clinical-trial","attrs":{"text":"NCT03340961","term_id":"NCT03340961"}}NCT03340961).MethodsA single-center open-label, three-arm, Phase I pharmacokinetic study randomized 24 healthy subjects aged 18 to 45 years to receive 21 days of once-daily dosing with DFD-29 40 or 20mg, or doxycycline 40mg. Blood samples were collected over 24 hours on Days 1 and 21 to plot mean plasma concentration levels. A multicenter Phase II clinical trial randomized 205 subjects with mild-to-severe PPR 1:1:1:1 to receive once-daily DFD-29 40 or 20mg, doxycycline 40mg, or placebo for 16 weeks. Co-primary endpoints were the proportion of subjects achieving treatment success (IGA grade 0 or 1 and ≥2-grade improvement) at Week 16, and a reduction in total inflammatory lesion count at Week 16.ResultsPharmacokinetic analysis demonstrated that minocycline plasma levels of DFD-29 40mg were approximately half those of doxycycline 40mg after 21 days, with DFD-29 20mg even lower, demonstrating a dose response. In the Phase II trial, DFD-29 40mg met both co-primary endpoints, achieving IGA treatment success in 66.0 percent subjects versus 11.5 percent placebo (p<0.0001), 31.9 percent DFD-29 20mg (p=0.007), and 33.3 percent doxycycline 40mg (p<0.0010), and a mean reduction in lesion counts of −19.2 versus −7.3 placebo (p<0.0001), −12.6 DFD-29 20mg (p=0.0070), and −10.5 doxycycline 40mg (p=0.0004).LimitationsMIC values and plasma concentrations shown for antibacterial threshold data are mean values; fast absorbers/slow metabolizers could exceed the threshold, causing resistance selection pressure.ConclusionDFD-29 40mg demonstrated significantly greater efficacy than placebo, DFD-29 20mg, and doxycycline 40mg at plasma concentrations predicted to be below the antimicrobial threshold for the treatment of PPR.     

Pentoxifylline (BL 191) by Oral Administration in the Treatment of Asthenozoospermia

Pentoxyphyllin (BL 191) in der Behandlung der Asthenozoospermie bei oraler Applikation
In Verfolg einer experimentellen Studie über den Einfluß des Phosphodiesterase-Inhibitors Pentoxyphyllin auf die Motilität menschlicher Spermatozoen wird jetzt eine klinische Studie bei 15 Männern mit einer Asthenozoospermie vorgelegt. Die Tagesdosis betrug 1.200 mg peroral über wenigstens 4 Monate. Während und 3 Monate nach Beendigung der Therapie wurden Spermiogramme angefertigt. Es ergab sich eine signifikante Besserung des Prozentsatzes progressiv beweglicher Spermatozoen. In fünf Fällen zeigte sich sogar eine Normalisierung des Spermas, in 7 Fällen eine signifikante Besserung gegenüber den Vor-Werten. Zweimal kam es zu einer Schwangerschaft. Es wird betont, daß Pentoxyphyllin eine brauchbare Alternative zur Behandlung der normogonadotropen Asthenozoospermie ist.     

177例少弱精子症患者解脲支原体感染的研究分析

目的：探讨少、弱精子症患者中解脲支原体（UU）感染及与UU感染有统计学关联的一些因素,为UU感染的预防提供资料。方法：调查177例少、弱精子症患者和40例正常就诊者,采用计算机辅助分析系统行精液常规分析,用UU分离鉴定培养液检测精液UU,采用混合抗球蛋白反应试验检测精液AsAb,登记表记录UU感染者相关统计学因素。结果：在177例少、弱精子症患者中,UU感染率为35％,明显高于正常对照组UU感染率10％（P〈0．05）．并且UU感染和年龄、性生活频率、受教育程度、居住环境有关,与包皮过长关系密切。结论：UU感染可以导致精子质量下降,包皮过长是UU感染的易患因素,建议生育年龄人群进行包皮环切。     

Abnormal Germinal Exfoliation in Semen of Hypogonadotrophic Patients During a hCG Treatment

Abnormale Keimzellenabschilferung im Samen hypogonadotroper Patienten während HCG-Therapie
Bei sechs hypogonadotropen Patienten wurden unter HCG-Therapie wegen sexuellem Infantilismus große Mengen von Spermatiden im Samen gefunden. Und zwar wurden sowohl mononucleäre als auch polynucleäre Spermatiden nachgewiesen. Bei allen Patienten war der Prozentsatz der Spermatiden deutlich höher, als er normalerweise bei gesunden Männern nachzuweisen ist. Die Spermatozoendichte stieg in allen Fällen an und bewegte sich in dem Bereich von 3,0 - 29,0 Mill. Sp./ml, wobei zu berücksichtigen ist, daß vor Beginn der Therapie eine Azoospermie bestanden hatte. Der Prozentsatz an Spermatiden betrug 34 bis 89%. Ein derartig starker Anteil an Keimzellabschilferung ist nach Ansicht der Autoren auf das HCG zurückzuführen, welches hier eine Störung der Keimzellproduktion verursachte. Es wird daher die Ansicht vertreten, grundsätzlich eine Kombination von HCG und HMG zur Behandlung derartiger Zustände zu verwenden.     

Effective Treatment of Inflammatory Lesions of Rosacea with Subantibiotic Dose Doxycycline Irrespective of Patient Weight or Baseline Lesion Count Severity

ObjectiveSubantibiotic dose doxycycline (SDD40), formulated as a modified-release 40mg capsule administered once daily, is used to treat inflammatory lesions of rosacea. In order to investigate whether the patient’s weight or lesion severity impacts clinical outcomes with using SDD40, the efficacy and safety of SDD40 in treating rosacea were evaluated in randomized controlled studies (RCTs).MethodsPhase II, III, and IV RCTs, and a subsequent meta-analysis were described. For all studies, the primary efficacy endpoint was the change in total inflammatory lesion count (papules, pustules, and nodules) from baseline to Week 16. For one of the studies, body weights were categorized by BMI (body mass index). Secondary efficacy endpoints included the change in Investigator’s Global Assessment (IGA). Safety was assessed by monitoring adverse events (AEs). ResultsThe efficacy of SDD40 was consistent across the studies (two trials including n=72 and n=91 subjects) and meta-analysis (n=127 and n=142). SDD40 remained effective regardless of baseline disease severity and weight (with a weak correlation coefficient below 0.75); overweight or obese subjects with severe rosacea cleared at least as well if not better than those with a normal BMI and mild disease. The treatment was well tolerated with no to minimal gastrointestinal-related AEs.LimitationsRetrospective analyses have methodological limitations.ConclusionConsistency between study results including the meta-analysis supports the effectiveness and safety of SDD40, irrespective of the weight of the patient or rosacea severity based on inflammatory lesion count at baseline.     

正畸治疗联合基础性牙周治疗在侵袭性牙周炎患者中的效果

探讨对侵袭性牙周炎患者应用正畸治疗联合基础性牙周治疗的效果。方法 选取2020年1月- 2022年10月我院收治的侵袭性牙周炎患者100例为研究对象,采用随机数字表法分为对照组和观察组,各 50例。对照组采取基础性牙周治疗,观察组采取基础性牙周治疗联合正畸治疗,比较两组牙周指标和咀嚼 功能。结果 观察组治疗后菌斑指数、附着丧失、牙周探诊深度、龈沟出血指数低于对照组,牙龈退缩指 数高于对照组（P ＜0.05）;观察组对食物的要求、咀嚼时的稳定度、消化情况、咀嚼食物的情况、进食情 况、牙齿固定情况评分低于对照组（P ＜0.05）。结论 针对侵袭性牙周炎患者,正畸治疗联合基础性牙周 治疗的效果确切,能提高患者的牙周健康水平,且有利于恢复牙齿的咀嚼功能。     

隐形矫治配合牙周基础治疗对牙周炎患者炎症细胞因子的影响

目的 观察隐形矫治配合牙周基础治疗对牙周炎患者的炎症细胞因子、牙周健康指数的影响。 方法 选取2021年1月-2022年3月于南宁微笑天使口腔医院接受口腔正畸治疗的60例牙周炎患者为研究对 象,随机分为对照组和观察组,每组30例。对照组给予隐形矫治器治疗,观察组在隐形矫治器治疗前先 进行1次牙周基础治疗,佩戴隐形矫治器1年后再进行1次牙周基础治疗,比较两组血清炎症因子水平、 牙周健康指数及满意度。结果 观察组TNF-α、IL-8、IL-6水平均低于对照组（P＜0.05）;观察组菌斑 指数、牙龈出血指数、牙周袋深度均优于对照组（P＜0.05）;观察组满意度为100.00%,高于对照组的 80.00%（P＜0.05）。结论 隐形矫治配合牙周基础治疗可有效降低牙周炎患者的炎性因子水平,有利于改 善患者的牙周状况,且患者满意度较高。     

Impact of Pegylated Interferon and Ribavirin Treatment on Graft Survival in Liver Transplant Patients with Recurrent Hepatitis C Infection

Recurrent hepatitis C virus (HCV) infection is a major cause of morbidity and mortality after liver transplantation for HCV‐related end stage liver disease. Although previous studies have shown a short‐term effect of interferon‐based treatment on fibrosis progression, it is unclear whether this translates to improved graft survival. We evaluated whether treatment of recurrent HCV leads to an improved graft survival. Cohort study included consecutive HCV patients who underwent liver transplantation between 1 January 1995 and 1 January 2005 in the Mayo Clinic, Rochester, MN. Two hundred and fifteen patients were included in the study. During a median follow‐up of 4.4 years (interquartile range 2.2–6.6), 165 patients (77%) had biopsy‐proven recurrent HCV infection confirmed by serum HCV RNA testing. Seventy‐eight patients were treated. There were no differences in MELD‐score, fibrosis stage or time towards HCV recurrence between treated and untreated patients at time of recurrence. There was a trend for greater frequency of acute cellular rejection among untreated patients. The incidence of graft failure was lower for patients treated within 6 months of recurrence compared to patients not treated within this time‐period (log rank p = 0.002). Time‐dependent multivariate Cox regression analysis showed that treatment of recurrent HCV infection was statistically significantly associated with a decreased risk of overall graft failure (hazard ratio 0.34; CI 0.15–0.77, p = 0.009) and a decreased risk of graft failure due to recurrent HCV (hazard ratio 0.24; CI 0.08–0.69, p = 0.008). In conclusion, although a cause and effect relationship cannot be established, treatment of recurrent HCV infection after liver transplantation is associated with a reduced risk of graft failure.     

群组看病及中医养生教育对痤疮瘢痕患者激光疗效及遵医行为的影响

目的:探讨群组看病及中医养生教育对痤疮瘢痕患者激光治疗效果及遵医行为的影响。方法:选择2017年1月-2018年12月在笔者医院接受痤疮瘢痕激光治疗的320例患者为研究对象,根据随机数字表将患者分为观察组(n=160)及对照组(n=160),对照组行皮肤科常规护理,观察组实施群组看病及中医养生教育,比较两组患者遵医行为、治疗效果、预后情况、治疗满意率。结果:观察组患者总有效率、治疗满意率高于对照组,而观察组中显效及有效患者复发率低于对照组,差异均有统计学意义(P<0.05)。观察组干预后ECCA权重评分低于对照组,且痂皮自然脱落时间短于对照组,差异有统计学意义(P<0.05)。观察组干预后用药依从性、就医依从性、生活管理、皮肤管理、饮食管理及遵医行为总评分均高于对照组,差异有统计学意义(P<0.05)。结论:群组看病及中医养生教育能有效提高痤疮瘢痕激光治疗患者的遵医行为,有利于面部痤疮瘢痕恢复,从而提高患者治疗效果及满意率。     

Effect of Indomethacin on Semen of Infertile Men

The effects of long term administration of the prostaglandin inhibitor, Indomethacin, on semen, in 22 infertile men with severe oligozoospermia and/or asthenozoospermia have been studied. Quantitative assessment of semen in the whole group showed improved sperm motility ( P < 0.05), normal morphology ( P < 0.05) and concentration ( P < 0.002) after treatment. Individual qualitative evaluation of semen parameters showed improvement in sperm count in one third and improved motility and morphology in 18 per cent of the patients. It would seem that Indomethacin has a beneficial effect on semen in some men with idiopathic oligoasthenozoospermia. It remains to be elucidated whether these effects are related to changes in prostaglandin levels.     

心理护理在牙周病患者正畸治疗中的应用效果

目的 探讨心理护理在牙周病患者正畸治疗中的应用效果。方法 选取我院2022年1月-12月收治的 87例牙周病患者为研究对象,采用随机数字表法分为对照组（n =43）与观察组（n =44）。两组均接受正 畸治疗,对照组采取常规护理,观察组在对照组基础上增加心理护理,比较两组心理状态和生活质量。 结果 两组护理后健康关心、生活乐趣、积极的心态、精力、松弛与紧张、自我情绪调节、总体幸福感评 分均高于护理前,且观察组高于对照组,差异有统计学意义（P ＜0.05）;两组护理后精力状态、睡眠情 况、躯体活动、疼痛程度、情感反应和社会活动评分低于护理前,且观察组低于对照组,差异有统计学意 义（P ＜0.05）。结论 在牙周病患者正畸治疗中应用心理护理具有积极意义,能够改善患者的心理状态和 生活质量。     

中药熏洗坐浴治疗急性白血病化疗后肛周感染

目的探讨中药熏洗坐浴治疗急性白血病患者化疗后肛周感染的疗效。方法以住院时间为顺序将住院化疗后发生肛周感染的患者分为对照组（19例）和观察组（21例）,对照组实施常规护理及对症治疗,每日晨、晚用1：5000高锰酸钾溶液坐浴20min。观察组在对症治疗基础上每日晨、晚采用中药熏洗坐浴。结果治疗第7天,观察组治疗效果显著优于对照组（P〈0．05）。结论中药熏洗坐浴治疗急性白血病化疗后肛周感染的效果优于1：5000高锰酸钾溶液坐浴。     

中药熏洗坐浴治疗急性白血病化疗后肛周感染

目的 探讨中药熏洗坐浴治疗急性白血病患者化疗后肛周感染的疗效.方法 以住院时间为顺序将住院化疗后发生肛周感染的患者分为对照组(19例)和观察组(21例),对照组实施常规护理及对症治疗,每日晨、晚用1:5 000高锰酸钾溶液坐浴20min.观察组在对症治疗基础上每日晨、晚采用中药熏洗坐浴.结果 治疗第7天,观察组治疗效果显著优于对照组(P<0.05).结论 中药熏洗坐浴治疗急性白血病化疗后肛周感染的效果优于1:5 000高锰酸钾溶液坐浴.     

牙列缺损伴错牙合畸形患者修复前正畸治疗美容效果研究

目的 分析正畸治疗联合常规修复在错牙合畸形伴牙列缺损患者中的效果。方法 选取2021年 1月-2022年1月高唐县人民医院接诊的86例错牙合畸形伴牙列缺损患者,按照随机数字表法分为参照组 （n =60）和研究组（n =26）。参照组采用常规修复治疗,研究组先行正畸治疗,而后予以常规修复治疗, 比较两组临床效果、语言功能、咀嚼功能和美容效果。结果 研究组治疗总有效率为100.00%,高于参照组 的85.00%（P＜0.05）;研究组治疗后语言功能和咀嚼功能评分高于参照组（P＜0.05）;研究组排列整齐、 覆盖完整和咬合正常评分高于参照组（P ＜0.05）。结论 在行常规修复前,予以正畸治疗可改善错牙合畸形 伴牙列缺损患者牙齿形态,提升咀嚼功能及语言功能,且美观度较高。     

Adrenal Androgens and their Effect on Human Semen Quality

The purpose of this study was to elucidate the relationship between the sperm quality (concentration, motility, vitality and morphology) and elevated 17-ketosteroids (17KS) and their metabolites; Androsterone (A). Etiocholanolone (E), Dehydroepiandrosterone (D) and Pregnanediol (P₂). 162 men with normally fractionated urinary 17KS but with different degrees of sperm quality were evaluated. Statistical analysis did not reveal any correlation between sperm quality and levels of the metabolites. The same evaluation was performed on 36 men with elevated abnormal fractionated urinary 17KS metabolites. Here too, no correlation could be indicated. Eight men with pathological fractionated metabolites underwent adrenal gland stimulation by the ACTH test and suppression by dexamethasone concomitant with stimulation by hCG. All the 8 men responded normally. 4 men with abnormal urinary metabolites were treated with dexamethasone (0.5 mg/day) for 3 months. Sperm quality and urinary metabolites were checked during every month of treatment. No improvement in sperm quality was observed, although adrenal function was suppressed. However, 2 wives of the treated men conceived during treatment.
No correlation could be established between the metabolites of androgens in the urine, sperm quality and male fertility.     

多功能激光光电平台联合多西环素对玫瑰痤疮患者皮损情况及生活质量的影响

探讨强脉冲光联合多西环素对玫瑰痤疮患者皮损情况及生活质量的影响。方法 选取2022年 7月-2023年6月于我科就诊的60例玫瑰痤疮患者为研究对象,随机分为对照组和研究组,各30例。对照组 应用多西环素治疗,研究组应用强脉冲光联合多西环素治疗,比较两组皮损情况和生活质量。结果 研究 组治疗后3个月皮损评分低于对照组（P ＜0.05）;研究组治疗后3个月自我感知、情感功能、痤疮症状、社 会功能高于对照组（P＜0.05）。结论 对玫瑰痤疮患者应用强脉冲光联合多西环素治疗可促进患者皮损恢 复,并提高其生活质量。