耳针治疗头痛的临床疗效与乙酰胆碱酯酶关系的观察

耳针疗法为祖国医学遗产之重要组成部分。早在黄帝《内经》中已有记载,并广泛应用于临床。我们曾经报道:耳针镇痛有效的头痛患者,其耳穴痛点的导电量降低。近年来,针刺镇痛过程中各种神经介质的作用,引起人     

电针治疗血管神经性头痛

血管性头痛是一种临床常见的神经系统疾病.表现为发作性、中或重度搏动性跳痛.位于一侧或双侧的头痛,常反复发作,有时伴恶心、呕吐等症状,严重影响患者的正常工作和生活,药物治疗效果欠佳.笔者以电针循经取穴治疗本病,取得了较满意的疗效,现报道如下.     

高频电针治疗神经性头痛

笔者从1987年9月至1989年2月用高频电针治疗神经性头痛46例,其中男31例,女15例,年龄最小者19岁,最大者62岁。病程最短为1年,最长为15年。现将中法、疗效及体会介绍如下。     

电针治疗头痛疗效观察

用电针治疗头痛,收到较好的疗效。结果：电针治疗头痛比不用电针针灸治疗头痛有明显差异。结论：电针治疗头痛方法疗效优于不用电针针灸治疗头痛。     

茶树油对乙酰胆碱酯酶的抑制作用

许多除虱制剂通过抑制乙酰胆碱酯酶(AChE)产生杀虱及其虫卵作用。茶树油是治疗头虱的外用制剂中的活性组分。作者研究了茶树油是否至少部分地通过抑制AChE而产生除虱作用的。以GC一MS分析所试4种茶树油样     

电针治疗紧张性头痛80例

紧张性头痛是指长期焦虑、紧张或疲劳等因素而致颈项部、头部肌肉的持久收缩和相应动脉的扩张而产生的头痛。笔者自１９９３年以来用电针治疗紧张性头痛８０例，现总结如下。１临床资料全部病例均为门诊患者，并作脑电图、脑血流图、副鼻窦Ｘ线摄片、头颅ＣＴ检查，排除颅...     

电针诱导对大白鼠不同脑分区乙酰胆碱含量及乙酰胆碱酯酶活性的影响

<正> 本文研究电针诱导对中枢胆硷能神经介质的影响。在大白鼠上模拟电针诱导,测定和比较针刺动物与对照动物的脑内不同部位乙酰胆硷(ACh)含量和乙酰胆硷酯酶(AChE)活力水平,以探讨中枢胆硷能神经介质与针麻作用的关系。     

治疗老年痴呆中药对乙酰胆碱酯酶的体外抑制作用研究

目的研究临床常用治疗老年性痴呆的中药复方及中成药对乙酰胆碱酯酶(AchE)的体外抑制作用。方法采用小鼠肝制备酶试液,对8种中药材的水和乙醚提取液活性初步筛选,再对初筛抑酶活性较强的益智仁、丹参和钩藤乙醚提取液经薄层层析(TLC)后作抑酶试验。结果8种中药的水和乙醚提取液均有不同程度的抑制乙酰胆碱酯酶活性,其中以益智仁、丹参和钩藤抑酶活性较强,其乙醚提取部位显示出多种抑酶活性成分。结论实验结果与动物实验一致,该实验采用小鼠肝制备酶试液筛选治疗老年性痴呆中药的抑制乙酰胆碱酯酶活性部位及成分,方法简便、可行。     

乙酰胆碱酯酶抑制剂对老年痴呆的治疗作用及其机制

伴随着世界上老龄人群持续的增加,老年痴呆患者的数量不断上升,研究与开发预防与治疗老年痴呆药己成为医药界的焦点问题.乙酰胆碱酯酶抑制剂作为目前首要治疗老年痴呆的药物仅仅是起到缓解该病症的作用,普遍用于轻、中度患者.本文通过对老年性痴呆症病理与乙酰胆碱酯酶（AChE）抑制剂的药理作用分析,详细论述乙酰胆碱酯酶抑制剂对老年痴呆的治疗作用及其机制.     

腹泻型肠易激综合征患者中医体质类型与相关影响因素的研究

目的:探讨腹泻型肠易激综合征患者中医体质类型与相关影响因素。方法:采用标准化的9种中医体质分类量表对50例肠易激综合征腹泻型(IBS-D)患者进行中医体质辨识,并就体质类型与性别、诱发因素、年龄、病程、文化水平以及职业分布的相关性进行分析。结果:体质类型最常见为阳虚质、气郁质,其次为痰湿质、湿热质;男性患者湿热质明显高于女性,女性气郁质明显高于男性,差异有统计学意义(P=0.05);诱发因素以饮食不节最常见,多数以进食生冷水果及饮品诱发;其次为受凉因素;阳虚质患者多因进食生冷、受凉而诱发,女性患者月经来潮亦为常见诱发因素;不同中医体质类型与年龄、病程、文化水平以及职业分布无明显相关性。结论:IBS-D与中医体质关系密切,主要分布在阳虚质、气郁质、痰湿质及湿热质4种体质类型中,余下5种体质类型分布较少;中医体质类型的相关因素是性别和诱发因素,而与年龄、病程、文化水平及职业分布无关。     

THE EFFECTIVENESS OF PRAGMATIC ACUPUNCTURE IN PATIENTS WITH PAINFUL DIABETIC NEUROPATHY:A PILOT STUDY

Background: Painful diabetic neuropathy(PDN) is a distressing and disabling complication of diabetes mellitus affecting about one-third of patients with type 2 diabetes.Objective: The aim of this study was to evaluate the effectiveness of pragmatic acupuncture treatment in patients with PDN.Methods: A single blind randomized control trial was conducted.Sixty patients(mean age(63.5±12.1) years) with PDN, recruited from two affiliated hospitals of Guiyang Traditional Chinese Medicine(TCM) College, Guizhou Province, China participated in the study.Individualized acupuncture treatment was administered by a qualified medical doctor(also a TCM acupuncturist).Fourteen sessions of pragmatic acupuncture over 2 weeks were given to two groups.Leeds Assessment of Neuropathic Symptoms and Signs(LANSS) scale was used to examine neuropathic symptoms, lower-limb pain intensity was assessed using the Visual Analogue Scale(VAS), sleep patterns was examined with the Sleep Problem Scale(SPS) and QoL was assessed with the SF36.Mann-Wihtney U tests were used for group comparisons.Results: There were significant differences(all P 0.001) in pain, LANSS and SF36 scores between the two groups.However, there was no significant difference(P0.05) in sleep disturbance between the two groups following the intervention.Conclusion: Traditional acupuncture was found to be an effective treatment strategy for pain and QoL in patients with PDN.It was also effective for alleviating the clinical symptoms associated with PDN as measured by LANSS.Therefore, traditional acupuncture may be an effective modality for managing patients with PDN.Clinicians and acupuncturists are to be aware of these findings as they may help to improve the management of patients with this condition.     

大鼠脑内甲硫氨酸脑啡肽(Met-Enk)和乙酰胆碱(ACh)的相互关系及其对电针镇痛作用的影响

<正> 脑啡肽和乙酰胆碱在针刺镇痛中的作用不少学者进行了研究,但是,它们在针刺镇痛作用中的相互关系尚不十分清楚。为了探讨大鼠脑内Met-Enk和ACh的相互关系及其对电针镇痛作用的影响,我们进行了本实验的研究。实验方法实验动物用成年健康的大白鼠,体重150～250克,雌雄兼用。第一部分:大鼠175只,随机分成二大     

EFFECT OF ELECTROACUPUNCTURE ON GASTRIC FUNCTIONAL ACTIVITY IN THE RAT

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STUDY ON SCALP ELECTROACUPUNCTURE TREATMENT OF APOPLEXY AND ITS INFLUENCE ON HEMORHEOLOGY IN ISCHEMIC APOPLEXY PATIENTS

Ｉｎｏｒｄｅｒｔｏｃｏｍｐａｒｅｔｈｅｔｈｅｒａｐｅｕｔｉｃｅｆｆｅｃｔｏｆｓｃａｌｐ ｅｌｅｃｔｒｏａｃｕｐｕｎｃｔｕｒｅｗｉｔｈｔｈａｔｏｆｃｏｎｖｅｎ ｔｉｏｎａｌｂｏｄｙａｃｕｐｕｎｃｔｕｒｅｆｏｒａｐｏｐｌｅｘｙａｎｄｔｈｅｉｒｉｎｆｌｕｅｎｃｅｏｎｈｅｍｏｒｈｅｏｌｏｇｙｏｆｉｓｃｈｅｍｉｃａｐｏｐｌｅｘｙｔｈｅａｕｔｈｏｒｓｈａｖｅｔｒｅａｔｅｄａｎｄｏｂｓｅｒｖｅｄ 1 83 ｐａ ｔｉｅｎｔｓ,ｆｏｌｌｏｗｉｎｇｉｓｔｈｅｒｅｐｏｒｔ:1　ＣＬＩＮＩＣＡＬＩＮＦＯＲＭＡＴＩＯＮＴｈｅａｐｏ…     

骨折早期血瘀证宏观指标与微观指标相关性研究

为探讨骨折早期血瘀证宏观指标与微观指标的相关性 ,将符合血瘀证的宏观标准的四肢骨折患者在外伤后 7天内与健康人作血细胞参数、血液流变学、甲皱微循环指标的对照检测。结果发现 ,血瘀组与对照组相比 ,血浆黏度 ,纤维蛋白原有显著性增高 (P <0 .0 0 1) ;甲皱微循环指标有显著性差异 (P <0 .0 5 )。表明微观指标血浆黏度、纤维蛋白原、甲皱微循环与骨折早期血瘀证宏观指标相关 ,但血液流变性障碍并不严重 ;纤维蛋白原在骨折早期血瘀证中具有重要的临床意义。     

骨伤油纱治疗骨折延迟愈合的疗效观察

为了研究活血化瘀的纯中药制剂骨伤油纱对骨折延迟连接的临床疗效,以三七片口服作对照对９８例骨折延迟愈合患者进行了１￣３个疗程的观察,结果显示治疗组有效率为８５．６％,对照组有效率为６０．３％,二者差异有显著性（Ｐ〈０．０１）,说明骨伤油纱外用对骨折延迟愈合的治疗有肯定的疗效。     

中缝核与针刺镇痛关系的研究概况

<正> 由延髓下端到中脑头端、脑干中缝两旁,有相对集中的中缝核。人、猫、兔和鼠的中缝核,由尾侧向头端均可分成下述八个核团:中缝隐核、中缝苍白核、中缝大核、中缝桥脑核、中央上核、中缝背核、线形中核和线形上核。在中枢神经内,5-羟色胺(5-HT)神经元主要分布在中缝核及其邻近的网状结构内。中缝核的联系相当广泛,共机能是多方面的。近来研究表明,它在针刺镇痛中起重要作用。 (一)损毁或电刺激中缝核对针刺镇痛的影响无论以电针刺激大鼠尾部引起嘶叫反应测痛,还是以刺激大鼠牙髓诱发的皮层     

COMPARISON RESEARCH ON THE EFFECTS OF ELECTROACUPUNCTURE AND MOXIBUSTION ON THE BRAIN-GUT FUNCTIONS OF PATIENTS WITH DIARRHEA-PREDOMINANT IRRITABLE BOWEL SYNDROME

Objective: Electroacupuncture(EA) and moxibustion are to some extent effective for diarrhea-predominant irritable bowel syndrome(D-IBS); however, it is not clear whether their regulations on brain-bowel axis of D-IBS patients are different.The research is expected to provide a suitable clinical treatment by comparing the regulation of EA and moxibustion on digestive tract, psychological symptoms, and brain functional areas of D-IBS patients.Methods: A total of 62 cases of D-IBS patients were randomly divided into EA group(n=32) and moxibustion group(n=30).ST-36 and ST-37 were selected in the two groups.Acupuncture followed by electric stimulation was given to the EA group while warm moxibustion was given to the moxibustion group, once a day.Results: Both the EA group and the moxibustion group reported significant improvement in abdominal pain and abdominal distension(P0.001, P0.001).The moxibustion group reported better improvement in defecation frequency, defecation emergency and stool features than the EA group(P=0.001, P0.001, P0.001, P0.001).The moxibustion group reported better improvement in anxiety(HAMA) and depression(HAMD)(P0.001, P0.001).Both the EA and moxibustion groups can significantly reduce colonic mucosa 5-HT, 5-HT3R and 5-HT4R expression after treatment(P0.001, P0.001, P0.001), with moxibustion better than EA in 5-HT(P=0.024).The moxibustion group reported decreased activated voxel values of brain left IC, right IC and PFC regions after given stimulation of 150 mL CRD after treatment(P=0.011, P=0.023, P=0.009).The EA group reported decreased activated voxel values of PFC region(P=0.025).Conclusion: EA and moxibustion are different in the regulation of brain-bowel axis in D-IBS patients.Moxibustion can significantly improve frequent defecation, defecation emergency, watery stool and other digestive symptoms, anxiety, depression and other psychological symptoms as well as abnormal excitation in brainrelative functional IC and PFC regions of D-IBS patients.It suggests that moxibustion is a more effective therapy than EA in the treatment of D-IBS.