共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
Jan S. Bauer MD Roberto Monetti PhD Roland Krug PhD Maiko Matsuura MS Dirk Mueller MD Felix Eckstein MD Ernst J. Rummeny MD Eva‐Maria Lochmueller MD Christoph W. Raeth PhD Thomas M. Link MD 《Journal of magnetic resonance imaging : JMRI》2009,29(1):132-140
Purpose
To investigate differences in magnetic resonance imaging (MRI) of trabecular bone at 1.5T and 3.0T and to specifically study noise effects on the visualization and quantification of trabecular architecture using conventional histomorphometric and nonlinear measures of bone structure.Materials and Methods
Sagittal MR images of 43 calcaneus specimens (donor age: 81 ± 10 years) were acquired at 1.5T and 3.0T using gradient echo sequences. Noise was added to obtain six sets of images with decreasing signal‐to‐noise ratios (SNRs). Micro‐CT images were obtained from biopsies taken from 37 calcaneus samples and bone strength was determined. Morphometric and nonlinear structure parameters were calculated in all datasets.Results
Originally, SNR was 1.5 times higher at 3.0T. In the simulated image sets, SNR was similar at both fields. Trabecular dimensions measured by μCT were adequately estimated by MRI, with residual errors (er), ranging from 16% to 2.7% at 3.0T. Comparing er at similar SNR, 3.0T consistently displayed lower errors than 1.5T (eg, bone fraction at SNR ≈4: er[3.0T] = 15%; er[1.5T] = 21%, P < 0.05).Conclusion
The advances of 3.0T compared to 1.5T in visualizing trabecular bone structure are partially SNR‐independent. The better performance at 3.0T may be explained by pronounced susceptibility, enhancing the visualization of thin trabecular structures. J. Magn. Reson. Imaging 2009;29:132–140. © 2008 Wiley‐Liss, Inc. 相似文献4.
Orbach DB Wu C Law M Babb JS Lee R Padua A Knopp EA 《Journal of magnetic resonance imaging : JMRI》2006,24(1):16-24
PURPOSE: To evaluate signal-to-noise ratio (SNR) and neuroradiologists' subjective assessments of image quality in 3-Tesla (3-T) or phased-array MR systems that are now available for clinical neuroimaging. MATERIALS AND METHODS: Brain MR images of six normal volunteers were obtained on each of three scanners: a 1.5-T single-channel system, a 12-channel, phased-array system, and a 3-T single-channel system. Additionally, clinically optimized images acquired from 28 patients who underwent imaging in more than one of these systems were analyzed. SNRs were measured and image quality and artifact conspicuity were graded by two blinded readers. RESULTS: The phased-array system produced higher SNR than either the 1.5-T or the 3-T single-channel systems, and in no instance was it outperformed. Both blinded readers judged the phased-array images to be of higher quality than those produced by the single-channel systems, with significantly less artifact. The 3-T magnet produced images with high SNR, but with increased artifact conspicuity. The phased-array system markedly decreased acquisition times without introduction of artifacts. CONCLUSION: Both quantitatively and qualitatively, the phased-array system provided image quality superior to that of the 1.5-T and 3-T single-channel systems. 相似文献
5.
6.
Noise limitation on the detected spatial resolution, described by the Rose Model, is well known in X-ray imaging and routinely used in designing X-ray imaging protocols. The purpose of this article is to revisit the Rose Model in the context of MRI where image data are acquired in the spatial frequency domain. A k-space signal-to-noise ratio (kSNR) is introduced to measure the relative signal and noise powers in a circular annulus in k-space. It is found that the kSNR diminishes rapidly with k-space radius. The Rose criterion that the voxel SNR approximately 4 is translated to kSNR cutoff values was tested using theoretical derivation and experimental histogram analysis. Experiments demonstrate that data acquisition beyond this cutoff k-space radius adds little or no information to the image. In order to reduce the noise limit on spatial resolution, the signal strength must be improved through means such as increasing the coil sensitivity, contrast enhancement, and signal averaging. This finding implies that the optimal k-space volume to be sampled or the optimal scan time in MRI should be matched to the relative SNR level. 相似文献
7.
An MRI detector is formed from a conducting strip separated by a dielectric substrate from a ground plane, and tuned to a quarter-wavelength. By distributing discrete tuning elements along the strip, the geometric design may be adjusted to optimize the signal-to-noise ratio (SNR) for a given application. Here a numerical electromagnetic (EM) method of moments (MoM) is applied to determine the length, width, substrate thickness, dielectric constant, and number of tuning elements that yield the best intrinsic SNR (ISNR) of the strip detector at 1.5 Tesla. The central question of how strip performance compares with that of a conventional optimized loop coil is also addressed. The numerical method is validated against the known ISNR performance of loop coils, and its ability to predict the tuning capacitances and performance of seven experimental strip detectors of varying length, width, substrate thickness, and dielectric constant. We find that strip detectors with low-dielectric constant, moderately thin-substrate, and length about 1.3 (+/-0.2) times the depth of interest perform best. The ISNR of strips is comparable to that of loops (i.e., higher close to the detector but lower at depth). The SNR improves with two inherently-decoupled strips, whose sensitivity profile is well-suited to parallel MRI. The findings are summarized as design "rules of thumb." 相似文献
8.
9.
T2 and T1rho MRI in articular cartilage systems. 总被引:3,自引:0,他引:3
Nina M Menezes Martha L Gray James R Hartke Deborah Burstein 《Magnetic resonance in medicine》2004,51(3):503-509
T2 and T1rho have potential to nondestructively detect cartilage degeneration. However, reports in the literature regarding their diagnostic interpretation are conflicting. In this study, T2 and T1rho were measured at 8.5 T in several systems: 1) Molecular suspensions of collagen and GAG (pure concentration effects): T2 and T1rho demonstrated an exponential decrease with increasing [collagen] and [GAG], with [collagen] dominating. T2 varied from 90 to 35 ms and T1rho from 125 to 55 ms in the range of 15-20% [collagen], indicating that hydration may be a more important contributor to these parameters than previously appreciated. 2) Macromolecules in an unoriented matrix (young bovine cartilage): In collagen matrices (trypsinized cartilage) T2 and T1rho values were consistent with the expected [collagen], suggesting that the matrix per se does not dominate relaxation effects. Collagen/GAG matrices (native cartilage) had 13% lower T2 and 17% lower T1rho than collagen matrices, consistent with their higher macromolecular concentration. Complex matrix degradation (interleukin-1 treatment) showed lower T2 and unchanged T1rho relative to native tissue, consistent with competing effects of concentration and molecular-level changes. In addition, the heterogeneous GAG profile in these samples was not reflected in T2 or T1rho. 3) Macromolecules in an oriented matrix (mature human tissue): An oriented collagen matrix (GAG-depleted human cartilage) showed T2 and T(1rho) variation with depth consistent with 16-21% [collagen] and/or fibril orientation (magic angle effects) seen on polarized light microscopy, suggesting that both hydration and structure comprise important factors. In other human cartilage regions, T2 and T1rho abnormalities were observed unrelated to GAG or collagen orientation differences, demonstrating that hydration and/or molecular-level changes are important. Overall, these studies illustrate that T2 and T1rho are sensitive to biologically meaningful changes in cartilage. However, contrary to some previous reports, they are not specific to any one inherent tissue parameter. 相似文献
10.
The loopless antenna magnetic resonance imaging detector is comprised of a tuned coaxial cable with an extended central conductor that can be fabricated at submillimeter diameters for interventional use in guidewires, catheters, or needles. Prior work up to 4.7 T suggests a near-quadratic gain in signal-to-noise ratio with field strength and safe operation at 3 T. Here, for the first time, the signal-to-noise ratio performance and radiofrequency safety of the loopless antenna are investigated both theoretically, using the electromagnetic method-of-moments, and experimentally in a standard 7 T human scanner. The results are compared with equivalent 3 T devices. An absolute signal-to-noise ratio gain of 5.7 ± 1.5-fold was realized at 7 T vs. 3 T: more than 20-fold higher than at 1.5 T. The effective field-of-view area also increased approximately 10-fold compared with 3 T. Testing in a saline gel phantom suggested that safe operation is possible with maximum local 1-g average specific absorption rates of <12 W kg(-1) and temperature increases of <1.9°C, normalized to a 4 W kg(-1) radiofrequency field exposure at 7 T. The antenna did not affect the power applied to the scanner's transmit coil. The signal-to-noise ratio gain enabled magnetic resonance imaging microscopy at 40-50 μm resolution in diseased human arterial specimens, offering the potential of high-resolution large-field-of-view or endoscopic magnetic resonance imaging for targeted intervention in focal disease. 相似文献
11.
An imaging method called "quantification of relaxation times and proton density by twin-echo saturation-recovery turbo-field echo" (QRAPTEST) is presented as a means of quickly determining the longitudinal T(1) and transverse T(2) (*) relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B(1) field inhomogeneity. High-resolution images covering large volumes can be achieved within clinically acceptable times of 5-10 min. The range of accuracy for determining T(1), T(2) (*), and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm(3) voxels was achieved in less than 8 min. 相似文献
12.
Cheng HL 《Journal of magnetic resonance imaging : JMRI》2007,25(5):1073-1078
PURPOSE: To propose a simple, accurate method for measuring T(1) in flowing blood and the arterial input function (AIF), and to evaluate the impact on dynamic contrast-enhanced MRI (DCE-MRI) quantification of pharmacokinetic parameters. MATERIALS AND METHODS: A total of 10 rabbits were scanned at 1.5 Tesla and administered a bolus of Gadomer. Preinjection T(1) and AIF measurements were acquired in the iliac arteries using a rapid three-dimensional (3D) spoiled gradient recalled echo (SPGR) approach. Correction was made for imperfect B(1) fields, in-flow, and partial volume effects. DCE-MRI parameters blood volume (v(b)) and endothelial transfer constant (K(trans)) in resting skeletal muscle were estimated from pharmacokinetic analysis using individually measured AIFs. Literature comparisons were made to assess accuracy. RESULTS: Blood T(1) was more accurate and precise after correction for B(1) and partial volume errors (1267 +/- 72 msec). Measured AIFs followed reported biexponential decay characteristics for Gadomer clearance in rabbits. Parameters v(b) (2.47 +/- 0.65%) and K(trans) (3.6 +/- 1.0 x 10(-3) minute(-1)) derived from AIFs based on corrected blood T(1)s were more reproducible and in better agreement with literature values. CONCLUSION: The proposed method enables accurate in vivo blood T(1) and AIF measurements and can be easily implemented in a range of DCE-MRI applications to improve both the accuracy and reproducibility of pharmacokinetic parameters. 相似文献
13.
14.
Deanna L. Langer MSc Theodorus H. van der Kwast PhD MD Andrew J. Evans PhD MD John Trachtenberg MD CM Brian C. Wilson PhD Masoom A. Haider MD 《Journal of magnetic resonance imaging : JMRI》2009,30(2):327-334
Purpose
To develop a multi‐parametric model suitable for prospectively identifying prostate cancer in peripheral zone (PZ) using magnetic resonance imaging (MRI).Materials and Methods
Twenty‐five radical prostatectomy patients (median age, 63 years; range, 44–72 years) had T2‐weighted, diffusion‐weighted imaging (DWI), T2‐mapping, and dynamic contrast‐enhanced (DCE) MRI at 1.5 Tesla (T) with endorectal coil to yield parameters apparent diffusion coefficient (ADC), T2, volume transfer constant (Ktrans) and extravascular extracellular volume fraction (ve). Whole‐mount histology was generated from surgical specimens and PZ tumors delineated. Thirty‐eight tumor outlines, one per tumor, and pathologically normal PZ regions were transferred to MR images. Receiver operating characteristic (ROC) curves were generated using all identified normal and tumor voxels. Step‐wise logistic‐regression modeling was performed, testing changes in deviance for significance. Areas under the ROC curves (Az) were used to evaluate and compare performance.Results
The best‐performing single‐parameter was ADC (mean Az [95% confidence interval]: Az,ADC: 0.689 [0.675, 0.702]; Az,T2: 0.673 [0.659, 0.687]; Az,Ktrans: 0.592 [0.578, 0.606]; Az,ve: 0.543 [0.528, 0.557]). The optimal multi‐parametric model, LR‐3p, consisted of combining ADC, T2 and Ktrans. Mean Az,LR‐3p was 0.706 [0.692, 0.719], which was significantly higher than Az,T2, Az,Ktrans, and Az,ve (P < 0.002). Az,LR‐3p tended to be greater than Az,ADC, however, this result was not statistically significant (P = 0.090).Conclusion
Using logistic regression, an objective model capable of mapping PZ tumor with reasonable performance can be constructed. J. Magn. Reson. Imaging 2009;30:327–334. © 2009 Wiley‐Liss, Inc. 相似文献15.
Xiaojun Xu Graham Norquay Steven R. Parnell Martin H. Deppe Salma Ajraoui Ralph Hashoian Helen Marshall Paul D. Griffiths Juan Parra‐Robles Jim M. Wild 《Magnetic resonance in medicine》2012,68(6):1900-1904
In this study, the signal‐to‐noise ratio of hyperpolarized 129Xe human lung magnetic resonance imaging was compared at 1.5 T and 3 T. Experiments were performed at both B0 fields with quadrature double Helmholtz transmit–receive chest coils of the same geometry with the same subject loads. Differences in sensitivity between the two field strengths were assessed from the signal‐to‐noise ratio of multi‐slice 2D 129Xe ventilation lung images obtained at the two field strengths with a spatial resolution of 15 mm × 4 mm × 4 mm. There was a systematically higher signal‐to‐noise ratio observed at 3 T than at 1.5 T by a factor of 1.25. Mean image signal‐to‐noise ratio was in the range 27–44 at 1.5 T and 36–51 at 3 T. T of 129Xe gas in the partially inflated lungs was measured to be 25 ms and 18 ms at 1.5 T and 3 T, respectively. T of 129Xe gas in fully inflated lungs was measured to be 52 ms and 24 ms at 1.5 T and 3 T, respectively. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
16.
J T Vaughan M Garwood C M Collins W Liu L DelaBarre G Adriany P Andersen H Merkle R Goebel M B Smith K Ugurbil 《Magnetic resonance in medicine》2001,46(1):24-30
Signal-to-noise ratio (SNR), RF field (B(1)), and RF power requirement for human head imaging were examined at 7T and 4T magnetic field strengths. The variation in B(1) magnitude was nearly twofold higher at 7T than at 4T ( approximately 42% compared to approximately 23%). The power required for a 90 degrees pulse in the center of the head at 7T was approximately twice that at 4T. The SNR averaged over the brain was at least 1.6 times higher at 7T compared to 4T. These experimental results were consistent with calculations performed using a human head model and Maxwell's equations. Magn Reson Med 46:24-30, 2001. 相似文献
17.
18.
19.
Andrew J Wheaton Arijitt Borthakur Matthew T Corbo Gul Moonis Elias Melhem Ravinder Reddy 《Magnetic resonance in medicine》2004,52(6):1223-1227
In this work, the feasibility of using T2rho weighting as an MR contrast mechanism is evaluated. Axial images of a human brain were acquired using a single-slice spin-lock T2rho-weighted pulse sequence and compared to analogous T2-weighted images of the same slice. The contrast between white matter and gray matter in T2rho-weighted images was approximately 40% greater than that from T2-weighted data. These preliminary data suggest that the novel contrast mechanism of T2rho can be used to yield high-contrast T2-like images. 相似文献
20.
S. Newman V. M. Haughton Z. Yetkin R. Breger L. F. Czervionke A. L. Williams K. C. Ho R. A. Papke A. A. Rimm M. E. Fischer G. A. Meyer R. Asleson 《European radiology》1993,3(1):49-52
The possibility that cerebral tumours may be graded by measuring T1 or T2 with magnetic resonance (MR) imaging was studied. A consecutive series of patients with subsequently verified gliomas was enrolled, and studied with MR. Patients who had prior surgical, chemotherapeutic or steroid treatment were excluded. Single slice multiple saturation recovery and multiple spin echo techniques were used to measure T1, T2 and proton density in the tumour. In 33 patients with cerebral gliomas there were 5 grade I, 12 grade II, 7 grade III and 9 grade IV. T1 and T2 values tended to be smaller in grade I gliomas than in grades II, III and IV gliomas. Relaxation parameters overlapped considerably in tumours with different grades. Proton density values did not show much change between different grades of gliomas. Relaxation parameters cannot be used to determine tumour grade reliably.
Correspondence to: S. Newman 相似文献