细胞膜脂质流动性和超氧化物歧化酶在肺结核和肺癌鉴别诊断中的应用

目的研究细胞膜脂质流动性和超氧化物歧化酶（ＳＯＤ）在肺结核和肺癌鉴别诊断中的价值。方法采用荧光标记（ＤＰＨ）技术测定膜脂质流动性；采用生物发光法测定ＳＯＤ。结果肺结核、肺癌患者淋巴细胞及肺腺癌和肺鳞癌癌细胞的膜脂质流动性分别为４．０２６±０．７２２、３８．２５４±０．１００、２２．５５７±３．７７１和３２．８７５±９．７０９。肺结核和肺癌患者淋巴细胞的ＳＯＤ含量分别为１７０．７和６５．１４ｍｇ／Ｌ。肺结核和肺癌患者比较，差异统计学上有显著意义（Ｐ＜０．０５）。其中轻、中、重度肺结核患者淋巴细胞的ＳＯＤ含量分别为２７０．８±４．１ｍｇ／Ｌ、１６０．２±１．９ｍｇ／Ｌ和９０．４±１．６ｍｇ／Ｌ，其变化随病情加重而降低。结论膜脂质流动性和ＳＯＤ测定对辅助临床鉴别诊断肺结核和肺癌是有用的手段。     

原发性高血压患者红细胞膜脂质组成及流动性变化的研究

本文报道了36例原发性高血压患者红细胞膜质含量及流动性的变化情况。胆固醇/磷脂克分子比率明显增大,P<0.001;过氧化脂质量明显增加,P<0.001;脂质流动性明显减低,P<0.01。结果提示,膜本身的上述变化与离子运输失常有直接关系,是高血压发病的重要基础。     

冠心病患者体内脂质过氧化损伤及其红细胞膜流动性变化的临床观察

目的 :观察冠心病 ( CHD)患者体内脂质过氧化损伤的程度以及红细胞膜流动性的变化。方法 :测定2 0例 CHD患者 ( CHD组 )及 2 0例健康者 (对照组 )体内血脂、脂质过氧化物 ( L po)、氧化修饰低密度脂蛋白 ( OX-L DL)、超氧化物歧化酶 ( SOD)、红细胞膜流动性 ( M- Flu)水平。结果 :CHD患者体内低密度脂蛋白胆固醇 ( L DL-C)、载脂蛋白 B( apo B)、L po、OX- L DL 水平明显增加 ( P <0 .0 5或 <0 .0 1) ,高密度脂蛋白胆固醇 ( HDL- C)、apo A1 、SOD、M- Flu水平明显降低 (均 P <0 .0 5 ) ;结论 :CHD患者体内不仅存在着脂质代谢紊乱 ,而且还存在着明显的脂质过氧化损伤以及红细胞膜功能异常     

氨氯地平对高脂血症家兔红细胞膜脂质过氧化物及膜流动性的效应

目的 :观察氨氯地平 (Aml)对高脂血症家兔红细胞膜脂质过氧化物及膜流动性的效应。方法 :2 4只家兔随机分为对照组、模型组、治疗组 ,分别给予普通饲料、高脂饲料以及高脂饲料加Aml连续喂 6 0d ,喂养前后分别采空腹耳中央动脉血 5ml测定红细胞膜脂质、脂质过氧化物 (LPO)、抗氧化酶以及膜流动性。结果 :高脂饲料喂养的家兔能诱导其红细胞膜低密度脂蛋白胆固醇 (M LDLC)、膜共轭双烯 (M CD)以及红细胞丙二醛 (E MDA)水平升高 ,红细胞膜流动性 (M Flu)以及红细胞超氧化物歧化酶 (E SOD)水平降低 ,而Aml可以防止高脂饲料所诱导的M LDLC、M CD、E MDA水平进一步升高 ,并能防止M Flu水平进一步降低。结论 :Aml具有抗红细胞膜脂质过氧化损伤 ,改善M Flu的作用。     

血清脂质结合唾液酸用于肺癌和肺结核的鉴别诊断

本文报道了52例肺癌和43例肺结核及结核性胸膜炎病人的血清脂质结合唾液酸(LSA)的检测结果。肺癌组LSA水平显著高于结核组(P<0.001),其诊断敏感性达78.8％,结核组诊断特异性达90.7％,诊断总符合率为84.2％,表明血清LSA对肺癌和肺结核的鉴別颇有价值。癌性胸水病人血清LSA水平和阳性率远高于结核性胸膜炎病人,提示缸清LSA可用于良、恶性胸水的鉴别诊断。     

肺结核合并肺癌105例对照分析

肺结核合并肺癌１０５例对照分析陈宗越，李继芬，杨淑玲，席家宁，周林，曹文辉肺结核诊断上一般多无困难，但在本病合并肺癌时，其发病机制、临床特征乃至如何妥善处理则有待进一步探讨。有鉴于此，我们就本院１９６２年１１月至１９９２年１２月住院病人确诊为肺结核合...     

56例肺结核球的鉴别分析

目的 提高对肺结核球的鉴别诊断水平。方法 调阅病历，回顾总结。结果 本组56例肺结核球中直径2－5cm者54例，占96．4％，发生于右35列，左肺21例，病灶呈分叶状3例，病灶内空洞12例，病灶周围卫星灶23例，胸膜皱缩征6例，合并肺不张2例；术前误诊为肺癌的18例，占32．1％，误诊为肺错构瘤的1例，占1．8％。结论 （1）本病的诊断在重视影像资料的基础上，应结合病史，症状和体征，尤其是PPD试验和痰抗酸杆菌检查；（2）应重视经皮肺穿刺活检术的应用。     

162例肺癌误诊肺结核鉴别诊断探讨

目的提高对肺癌的早期认识。方法回顾分析被误诊的肺癌病人的临床特点,X－线及CT影像分析,病理细胞学检查,纤支镜检查刷检和组织取材活检临床资料。结果162例肺癌患者被误诊为肺结核入院,经X-线、CT影像学、病理学等检查被确诊为肺癌,使病人延误诊断及治疗。结论误诊原因,绝大多数病人发病时,症状及X线、CT影像学检查等不典型,或细菌学及细胞学检查不及时,及当地医疗条件设施不足或认识欠缺等。     

肺癌与肺结核患者肠道菌群差异及其鉴别诊断意义

目的分析肺癌及肺结核患者肠道菌群差异及其在不同疾病中的鉴别诊断意义。 方法选择2019年5月至2020年4月我院收治的132例肺癌及肺结核患者,按病理结果分为肺癌组83例及肺结核组49例;检测患者肠道菌群水平,绘制ROC曲线分析肠道菌群鉴别肺癌及肺结核的诊断价值。 结果肺癌组患者肠球菌、肠杆菌水平均明显高于肺结核组,类杆菌、乳杆菌及双歧杆菌均明显低于肺结核组(P<0.05);以肠球菌、肠杆菌、类杆菌、乳杆菌及双歧杆菌对肺癌及肺结核诊断的敏感度、特异度均高于85%,且AUC高于0.85。 结论肺癌与肺结核患者肠道菌群存明显差异,检测肠道菌群可有效鉴别诊断肺癌及肺结核。     

X-ray differential diagnosis of focal tuberculosis and peripheral lung cancer

The paper deals with the differential diagnosis of focal tuberculosis and peripheral lung cancer. It presents data on 25 patients of whom 24 were misdiagnosed as having focal tuberculosis. The main reason for misdiagnoses was the similarity of early X-ray symptoms of the two diseases, namely, upper lobar site, increased and thickened lung pattern and focal shadows against this background. The most important differentially diagnostic criteria for the above diseases are varying optic densities of pulmonary structures at the site of involvement and different patterns of vascular changes in the lung portion with a pathological process.     

A clinical study of pulmonary tuberculosis in lung cancer patient]

We have reviewed 442 patients with lung cancer. There were 323 male patients with a mean age of 65.8 yr and 119 female patients with a mean age of 66.0 yr. Histological types of lung cancer were squamous cell carcinoma 177 patients (40.0%), adenocarcinoma 167 (37.8%), small cell carcinoma 75 (17.0%), large cell carcinoma 17 (3.8%) and undifferentiated carcinoma 6 (1.4%). When lung cancer was diagnosed, 55 patients (12.5%) showed tuberculous lesions on the initial chest X-ray film. The majority of these tuberculous lesions were old changes, but only one with cavitary lesion was confirmed to be active. Although there was no statistical significance, the incidence of squamous cell carcinoma was higher in the 55 patients with tuberculous lesions than in the remaining 387 patients without ones. In the present study, five patients developed active pulmonary tuberculosis while on a therapy of lung cancer. All of these five patients were male and they had advanced lung cancer on admission. The diagnosis of active tuberculosis was made by autopsy in two patients and by culture--positive after death in two. Only one patient was identified to have active tuberculosis by broncho-alveolar lavage. Three of 5 patients showed old tuberculous lesions on the initial chest X-ray film, but all of five patients showed caseoinfiltrative shadows when active tuberculosis occurred. In addition, the prevalence of active pulmonary tuberculosis was significantly higher in the patients with old tuberculous lesions (5.6%: 3 out of 54 patients) than in those without ones (0.52%: 2 out of 387 patients). Finally, all of the five patients died. The causes of death were lung cancer in three patients, both pulmonary tuberculosis and lung cancer in one and pulmonary tuberculosis in one.