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1.
Some entomological observations on malaria transmission in a remote village in northwestern Thailand 总被引:2,自引:0,他引:2
R E Harbach J B Gingrich L W Pang 《Journal of the American Mosquito Control Association》1987,3(2):296-301
Anopheline mosquitoes and their relation to malaria transmission were studied during the months of March, May and July in the Karen village of Mae Tha Waw located in the northwestern mountains of Tak Province. Thirteen species were captured on human bait during 80 man-nights of collecting. Four additional species were collected during routine larval surveys. Anopheles minimus and An. maculatus comprised 92.5% of the specimens captured biting man. Anopheles minimus and An. nivipes were implicated as vectors based on the detection of sporozoite infections using enzyme-linked immunosorbent assays for Plasmodium falciparum and P. vivax. Anopheles dirus was rarely encountered and probably played little part in transmission in Mae Tha Waw during the period of study. Information is provided on nightly biting activity, incidence of disease, infectivity and larval bionomics. 相似文献
2.
C Boudin V Robert J P Verhave P Carnevale P Ambroise-Thomas 《Bulletin of the World Health Organization》1991,69(2):199-205
Transmission of Plasmodium falciparum and P. malariae was studied in a village in Burkina Faso. Consecutive captures of mosquitos were organized twice a month over a year and the species of the mosquitos identified. Also, the prevalences and densities of Plasmodium spp. were determined every 2 months in a sample of children who lived in the village. Anopheles gambiae, A. funestus, and A. nili were the local vectors, but only the first two played a predominant role in both P. falciparum and P. malariae transmission. The parasitological sporozoite index (SI) was 4.48% for A. gambiae and 4.22% for A. funestus. The immunological SIs were higher: 5.82% of A. gambiae were infected with P. falciparum and only 0.16% with P. malariae; the corresponding proportions for A. funestus were 6.45% and 0.41%. Transmission of Plasmodium spp. by A. gambiae was important during the rainy season (July-October) and by A. funestus at the beginning of the dry season (September-November). Each child in the study village could receive about 396 P. falciparum-infected bites per year but only 22 of P. malariae. The P. falciparum parasite indices were maximum during the middle of the rainy season (August), while those for P. malariae reached a peak during the dry season (February). 相似文献
3.
目的了解中缅边境上游疟疾疫源地的流行特征,为出入境流动人员疟疾防治提供参考依据。方法根据英国无国界卫生组织设在缅甸克钦邦第二特区的疟疾诊疗点上报的疟疾联防报表中的疟疾病例数计算发病率,并根据现场调查结果对不同疫点的疟疾流行情况、传染源种类、媒介蚊虫形态特征,村民的生产、生活、文化习俗以及卫生服务状况等进行分析。结果 2008年12月1日至2009年11月30日的疟疾发病率为513.01/万,流行病原以恶性疟为主,占疟疾病例总数的75.30%(1067/1417),间日疟占23.85%(338/1417),三日疟占0.14%(2/1417),混合感染占0.71%(10/1417);疟疾疫源地按流行程度分为高、中、低3类疫点村,高疫点村(克章村)距中缅边境线直线距离24.30km,中疫点村(卖沙坝村)距边境线10.20km,低疫点村(扎图广村)距边境线0.50km,其中高疫点村的疟疾带虫发病率高达14.14%(28/198),以恶性疟为主要病原,占67.86%(19/28),是重症疟疾的主要病原;在边境森林地带发现的大劣按蚊是野外作业者感染疟疾的高效媒介;从云南省元江县到缅甸克钦邦第二特区的21例务工者的疟疾患病率及恶性疟比例均为100%,是出境务工人员感染疟疾的典型案例;当地村民的防蚊意识和求医条件均处于较低水平。结论缅甸克钦邦第二特区为中缅边境务工人员感染疟疾的主要疫源地。 相似文献
4.
Vythilingam I Sidavong B Chan ST Phonemixay T Vanisaveth V Sisoulad P Phetsouvanh R Hakim SL Phompida S 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2005,99(11):833-839
Surveys were conducted in malaria-endemic villages in the southern province of Attapeu, Lao PDR during various seasons over a 3-year period. All-night mosquito landing collections, blood surveys and a case-control study were conducted. Plasmodium falciparum was the predominant species, and slide positivity rates were higher during the transition/dry season compared with the wet season. Anopheles dirus A was found to be the primary vector, and sporozoite rates were highest during the transition/dry season. Anopheles dirus was found to be endophagic and endophilic. Not using insecticide-treated bed nets, houses close to breeding sites and sleeping away from home were risk factors associated with malaria. 相似文献
5.
G T Strickland E Fox H Hadi 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1988,82(5):667-670
Splenomegaly and parasitaemia were correlated in 2891 children examined in outpatient clinics during 13 consecutive months in 4 Punjabi villages. The average monthly splenomegaly rate varied from 0.05-0.13 before the monsoon malaria transmission season to 0.18-0.27 during and after this season. Moderate splenic enlargement reached a peak during the malaria transmission season, while the highest proportion of very enlarged spleens occurred towards the end of, and after, the transmission season. Children with splenomegaly were 3 times more likely to have Plasmodium falciparum and 1.5 times more likely to have P. vivax parasitaemias than were children without palpable spleens. The larger the spleen the more likely a P. falciparum infection, whereas P. vivax was more commonly associated with minimal spleen enlargement. Although the probability of a child with splenomegaly having a malaria parasitaemia was highest (0.58-0.72) during and immediately following periods of malaria transmission, the odds ratio of malaria infections among those with splenomegaly to those without was at its lowest (1.41-2.11) during those months. Mean P. falciparum parasitaemias were significantly higher in infected children with moderately enlarged spleens than in infected children with nonpalpable spleens or in those with minimal or extensive splenomegaly. These results are compatible with splenomegaly being a result of both the malaria infection and the immune response. Early in infection many children had parasitaemia without splenomegaly; after the parasitaemia had cleared splenomegaly often persisted. 相似文献
6.
A stable, oligosymptomatic malaria focus in Thailand 总被引:1,自引:0,他引:1
R Rosenberg R G Andre S Ngampatom C Hatz R Burge 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1990,84(1):14-21
Blood from most of the 250 residents of a non-migratory farming village in south-eastern Thailand was visually examined for malaria parasites monthly for 2 years. Nearly 97% of the population had at least one (median = 5) patent Plasmodium falciparum infection per year; 72% had one due to P. vivax (median = 1). This contrasted with a slide positivity rate of 17% calculated from 12 months of passive case detection before the study began. Children 1-9 years old had the highest mean monthly prevalence (51%) and highest geometric mean density (10/500 white blood cells) of P. falciparum. Fewer than half the expected number of mixed infections were found but these were more common at high densities of P. falciparum. Individuals over 19 years old comprised 52% of the population but accounted for only 18% of P. vivax and 32% of P. falciparum gametocytaemias. Fever rates were marginally higher in those below 10 years old (8%) but occurred with equal frequency in those with patent infections or negative. The spleen rate (89% stage 1) was 24% in those under 15 years old and 7% in those older. No malaria mortality was seen P. falciparum cases treated for 10 d with quinine+tetracycline (QT) cleared the infection as often as those given one dose of mefloquine+sulfadoxine+pyrimethamine (MSP); both treatments reduced densities in cases not cured. Apparently unsupervised compliance was no better with MSP than with QT. The role played by hyperendemic, cryptic foci in Asian epidemics of malaria may have been underestimated. 相似文献
7.
G T Strickland A Zafar-Latif E Fox A A Khaliq M A Chowdhry 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1987,81(1):36-41
The prevalence of malaria in 4 villages 60 km south of Lahore, Punjab, where Anopheles culicifacies is the vector was estimated from blood films made during three mass malaria surveys (MS) and at 204 clinics (CS) held over 18 consecutive months. The highest parasite rate occurred during October 1984 when 43% of the CS population had parasitaemias. Plasmodium vivax predominated early in the major transmission season (23% and 15% vivax parasitaemias in August 1983 and 1984 respectively) whereas P. falciparum was the most common species later in the transmission season (an average falciparum prevalence of 37% in October and November 1984) and following the transmission season through March. Despite the proximity and habitat similarity of the 4 villages, both total and species malaria prevalence rates showed inter-village differences. Asexual stage and gametocyte parasite rates in children were 2 to 5 times higher than in adults. No increased mortality due to malaria was detected among the 4000 study population. Malaria was stable and endemic, albeit seasonally transmitted, in these 4 villages during 1983 and 1984. 相似文献
8.
T A Klein B A Harrison S V Dixon J R Burge 《Journal of the American Mosquito Control Association》1991,7(3):481-487
Seven Anopheles species/isolates were compared with Anopheles dirus (control) for susceptibility to Plasmodium cynomolgi B strain. The mean numbers of oocysts in paired replicates of An. dirus and An. takasagoensis were not significantly different. The remaining test species had significantly fewer mean numbers of oocysts than Anopheles dirus (P less than 0.01). Anopheles dirus had the highest percentage of mosquitoes infected with P. cynomolgi sporozoites (82%). Of the test groups, Anopheles dirus B and An. takasagoensis had the highest percentage of mosquitoes with sporozoites, 77 and 78%, respectively. Fewer than 50% of Anopheles maculatus E and An. maculatus B (NN isolate) had sporozoites in the salivary glands. Anopheles maculatus B (HK isolate) and Anopheles philippinensis were the least susceptible, with fewer than 30% having sporozoites in the salivary glands. 相似文献
9.
Zwetyenga J Rogier C Spiegel A Fontenille D Trape JF Mercereau-Puijalon O 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1999,93(4):375-380
Prolonged carriage of Plasmodium falciparum in humans during the dry season is critical for parasite survival, as the infected subjects constitute a major reservoir in the absence of transmission. Yet, very little is known about the host/parasite interactions contributing to parasite persistence. In order to study the characteristics of P. falciparum infections during the dry season, we have genotyped parasites collected from untreated, asymptomatic individuals during 3 cross-sectional surveys conducted during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Monthly entomological surveillance did not detect any transmission during that period. Parasite prevalence decreased markedly in the children aged < 7 years after 7 months of undetected transmission, but was stable in older children and adults throughout the dry season. In all chronically infected individuals, infection complexity remained stable, but there were substantial fluctuations of individual genotype(s), reflecting complex dynamics of multiple-clone infections during chronic asymptomatic parasite carriage. This fluctuation resulted in changes in the msp1 and msp2 allelic distribution within the cohort after 7 months of undetected transmission, contrasting with the stability observed during the preceding rainy season in that village. 相似文献
10.
Soe-Soe Khin-Saw-Aye Htay-Aung Nay-Win Tin-Aung Than-Swe Roussilhon C Pérignon JL Druilhe P 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2001,95(1):81-84
Premunition, naturally acquired protective immunity against Plasmodium falciparum, has been described in hyperendemic areas of Africa and Papua New Guinea. However, its occurrence in Asia is debatable. In order to elucidate this question, a longitudinal study was undertaken in Oo-Do, a malaria endemic village in Myanmar [Burma] in 1995-97. Only 2 species, Plasmodium falciparum and P. vivax, were detected, with the former predominating. Data from 116 subjects showed that all were infected at one time or another, over a period of 3 years, with a 38% reinfection rate after eradication of patent parasitaemia. The high rate of prevalence (90-100%) of parasite-specific antibodies in the indirect immunofluorescence antibody test and the presence of the primary vector (Anopheles minimus) and 15 other species of Anopheles throughout the year indicated a high level of transmission. The spleen rate was 70% in 5-9 years old children and was inversely related with age. The incidence of parasitaemia was maximal (49%) in children aged 2-4 years, and then declined marginally with age. There was a significant difference (P = 0.001) between the asymptomatic and febrile parasitaemia levels. Also, malarial episodes occurred more frequently in children than in adults (P = 0.001). Taken together, all these facts indicated that the inhabitants of Oo-Do had progressively developed non-sterile partial protective immunity against P. falciparum malaria, or premunition. To our knowledge, this is the first detailed clinico-epidemiological study to document the occurrence of premunition in Myanmar. 相似文献
11.
Associations of peak shifts in age--prevalence for human malarias with bednet coverage 总被引:2,自引:0,他引:2
Smith T Hii JL Genton B Müller I Booth M Gibson N Narara A Alpers MP 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2001,95(1):1-6
Effects of bednet coverage (C) on prevalence of malaria were analysed using data from 1990-92 from 9 Papua New Guinean villages. Effects of coverage varied by age, resulting in a shift in age of peak prevalence from 4.7 (C = 0%) to 11.6 (C = 100%) years for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with no bednets the age distribution of P. falciparum parasitaemia was like that of a holoendemic area. Where coverage was complete the pattern corresponded to mesoendemicity. Thus, protracted use of bednets can result in profound changes in the endemicity of malaria even when coverage is incomplete and without insecticide treatment. Average entomological inoculation rates (EIRs) estimated from indoor landing rates on individuals without bednets were 35, 12 and 10 infectious bites per person per annum for P. falciparum, P. vivax and P. malariae, respectively. Logistic regression analyses indicated that the EIR estimate for P. falciparum was related to prevalence of this species independently of effects of bednet coverage. However, the recent EIR still accounted for much less variation than did the bednets. A similar pattern was seen for P. malariae, while there were no significant relationships between the recent EIR and the parasite positivity for P. vivax. It is concluded that short-term variations in inoculation rate are not important determinants of parasite prevalence in this population. 相似文献
12.
Antonio-Nkondjio C Simard F Awono-Ambene P Ngassam P Toto JC Tchuinkam T Fontenille D 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2005,99(5):347-354
Entomological surveys were carried out in the town of Mbalmayo and in the nearby rural village of Olama, within the equatorial forest zone of Cameroon. Mosquitoes were captured when landing on human volunteers and by pyrethrum spray catches. Malaria vectors captured were Anopheles gambiae Giles (M and S forms) and A. moucheti Evans in both areas, together with A. funestus Giles in Mbalmayo. One A. marshallii (Theobald) specimen infected by Plasmodium falciparum was found in Olama. Anopheles moucheti was the most abundant anopheline species caught in Olama, while A. gambiae was the most abundant in Mbalmayo. All these vectors were highly anthropophilic as indicated by the fact that only 5 of 201 blood meals analysed had been taken from non-human hosts. Plasmodium falciparum was the only malaria parasite species found in Mbalmayo, while P. malariae was also found in Olama. The annual entomological inoculation rate was estimated at 129 infective bites/person/year in Mbalmayo and 322 in Olama. Comparison with data published in 1955 from Mbalmayo, before expansion of the town, showed the impact of urbanization on the composition of the vector system and malaria transmission dynamics. Such changes should be considered when implementing sustainable control measures. 相似文献
13.
von Seidlein L Clarke S Alexander N Manneh F Doherty T Pinder M Walraven G Greenwood B 《Bulletin of the World Health Organization》2002,80(10):790-796
OBJECTIVE: To find out what proportion of Plasmodium falciparum infections are treated in rural Gambia. METHODS: Subjects from four villages in the Gambia were followed over nine months through visits to village health workers. Monthly cross-sectional malaria surveys measured the prevalence of P. falciparum infection. Linked databases were searched for treatment requests. Treated cases were individuals with parasitaemia who requested treatment during narrow or extended periods (14 or 28 days, respectively) before or after a positive blood film was obtained. FINDINGS: Parasite prevalence peaked in November 1998, when 399/653 (61%) individuals had parasitaemia. Parasite prevalence was highest throughout the study in children aged 5-10 years. Although access to treatment was better than in most of sub-Saharan Africa, only 20% of infected individuals sought medical treatment up to 14 days before or after a positive blood film. Within two months of a positive blood film, 199/726 (27%) individuals with parasitaemia requested treatment. Despite easy access to health care, less than half (42%) of those with parasite densities consistent with malaria attacks (5000/ l) requested treatment. High parasite density and infection during October-November were associated with more frequent treatment requests. Self-treatment was infrequent in study villages: in 3/120 (2.5%) households antimalarial drugs had been used in the preceding malaria season. CONCLUSION: Many P. falciparum infections may be untreated because of their subclinical nature. Intermittent presumptive treatment may reduce morbidity and mortality. It is likely that not all untreated infections were asymptomatic. Qualitative research should explore barriers to treatment uptake, to allow educational interventions to be planned. 相似文献
14.
The efficiency of sporozoite transmission in the human malarias, Plasmodium falciparum and P. vivax 总被引:3,自引:0,他引:3
T R Burkot P M Graves J A Cattan R A Wirtz F D Gibson 《Bulletin of the World Health Organization》1987,65(3):375-380
Reported are malaria sporozoite and inoculation rates over a 1-year period in eight epidemiologically defined villages of different endemicity in Madang Province, Papua New Guinea. In the study, more than 41 000 wild-caught mosquitos were analysed for Plasmodium falciparum and P. vivax sporozoites by ELISA. In a given village the entomological inoculation rates correlated strongly with the prevalences of both these malarial parasites in children. However, the prevalence of P. falciparum infections in children was much higher than that of P. vivax, despite similar inoculation rates for the two species. These data suggest that in Papua New Guinea P. falciparum is more efficiently transmitted than P. vivax from mosquito to man. The increased efficiency of transmission of P. falciparum may be due to the heavier sporozoite densities in wild-caught mosquitos naturally infected with P. falciparum sporozoites that were tenfold greater than the sporozoite densities in mosquitos infected with P. vivax. 相似文献
15.
Absence of malaria mortality in villagers with chloroquine-resistant Plasmodium falciparum treated with chloroquine 总被引:1,自引:0,他引:1
S L Hoffman S Masbar P R Hussein A Soewarta S Harun H A Marwoto J R Campbell L Smrkovski I PurnomoWiady 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1984,78(2):175-178
We carried out a series of malaria studies in Robek , Flores, Indonesia, a coastal village of 900 farmers and fishermen where malaria is hyperendemic by parasite rate and holoendemic by spleen rate. The studies showed that: (i) 28 of 31 isolates (90%) of Plasmodium falciparum were resistant to chloroquine in vitro, (ii) 3 of 12 isolates (25%) were resistant at the R-11 level in vivo, (iii) 376 P. falciparum infections occurred in 301 individuals during one year, (iv) no villagers who were treated with chloroquine for P. falciparum infections during the year died, and (v) increasing the dosage of chloroquine base from 15 to 25 to 37.5 mg/kg led to improved clearing of parasitaemia. We conclude that chloroquine can still be used as the primary antimalarial in Robek , but the dosage may have to be increased to clear parasitaemia. 相似文献
16.
R Rosenberg R G Andre S Ketrangsee 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1990,84(1):29-33
Two numerically minor components of Plasmodium falciparum prevalence--gametocytaemia and trophozoite densities greater than 99/500 white blood cells--displayed an annual cycle that reflected the seasonal abundance of infective Anopheles dirus at a hyperendemic focus in Thailand, even though the gross monthly prevalence for combined ages remained stable. Gametocyte prevalence rose more than 300% within 30 d after the capture of the dry season's first infective mosquito, remained at about 8% until the beginning of the monsoon 7 months later, then fell within 60 d to about 2%. The number of cases with a high density of trophozoites behaved similarly. These periodic fluctuations represented changes in incidence, at least half of which appeared to be due to superinfection. Almost 49% of all gametocyte carriers were older than 14 years, but nearly all gametocyte densities greater than 20/500 white blood cells were in children. These observations, as well as the calculated efficiency of human infectivity, imply that superinfection of adults may contribute significantly to transmission in semi-immune populations. 相似文献
17.
A Bj?rkman M Willcox 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1986,80(4):572-574
The in vivo response of Plasmodium falciparum to standard treatment with sulphadoxine/pyrimethamine was studied in 19 hospital patients from Yekepa town with hypoendemic malaria and in 28 children, two to nine years old, living in a village with holoendemic malaria. In vitro tests were performed on eight isolates. In the hospital patients all parasites cleared with mean clearance time of 2.2 (range one to three) days and no recrudescence occurred during a 28-day follow-up period. In the village children, despite a high sporozoite inoculation rate, recurrent parasitaemias were only recorded after 28 days, suggesting a rather long-lasting prophylactic effect against reinfection by the drug combination. In vitro, inhibition of parasite multiplication was achieved by 3 X 10(-7) M sulphadoxine and 3.8 X 10(-9) M pyrimethamine. 相似文献
18.
Rowland M Mohammed N Rehman H Hewitt S Mendis C Ahmad M Kamal M Wirtz R 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2002,96(6):620-626
Anopheline vectors and malaria transmission were studied in 2 river-irrigated, rice-growing districts of eastern Afghanistan from May 1995 to December 1996. Clinical malaria was monitored in 12 rural villages (population 14,538) by passive case detection at local clinics. Adult mosquitoes were collected by space-spraying of living quarters and stables and by cattle bait catches. Mosquito head-thoraces (17,255 specimens) were tested for Plasmodium falciparum and P. vivax circumsporozoite protein (CSP) using enzyme-linked immunosorbent assay. The recorded incidence of P. vivax and P. falciparum was 199 and 41 episodes per 1000 person years, respectively. Twelve species of anopheline were recorded; Anopheles stephensi comprised 82% and A. culicifacies 5%. Eight species tested positive for CSP: A. stephensi, A. culicifacies, A. fluviatilus, A. annularis, A. pulcherrimus, A. maculatus, A. splendidus and A. superpictus. Among infected mosquitoes 46% were positive for P. falciparum, 45% for P. vivax VK-247, and 9% for P. vivax PV-210. Estimates of the feeding rates of infective vectors on humans indicated that A. stephensi would contribute 76% of infective bites, A. fluviatilis and A. pulcherrimus 7% each, and A. culicifacies and A. superpictus 3% each. The overall infective vector feeding rate correlated with the P. vivax incidence rate in the human population. The conventional view of A. culicifacies being the main rural vector and A. stephensi important only in urban settings needs to be reconsidered in western outreaches of the Indo-Pakistan subcontinent. 相似文献
19.
William K. Reisen Farida Mahmood Tauheeda Parveen 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1980,74(3):307-317
A mark-release-recapture experiment with the progeny of wild collected Anopheles culicifacies was performed during the monsoon season of 1978 at the village of Khano-Harni, a malarious area situated in Lahore District, Punjab Province, Pakistan. The recapture rates of males and females released at breeding and resting sites were statistically comparable and totalled 8·0% for females and 5·9% for males collected resting in houses and cattle sheds. Mating occurred mostly on the night following the evening of release when the females were about two days old. Insemination rates for females released at resting and breeding sites were statistically comparable. The initial gonotrophic cycle required four days; subsequent cycles occurred at two-day intervals with re-feeding on the same night as oviposition. Constant daily survivorship estimated from the decline in recaptures per day was 0·568 for females and 0·676 for males. Female survivorship estimated by vertical age grading methods ranged from 0·472 to 0·820. Horizontal life tables were calculated from the decline in recaptures and from vertical age-grading techniques and indicated that female or male life expectancy at emergence was less than 2·5 days. Population size was calculated using the Lincoln Index, Jackson's positive and negative methods and Ito's modification of Jackson's positive method and averaged from 1045·5 to 1049·6 females and from 449·1 to 1323·7 males. The relationship of these results to malaria transmission and genetical control is discussed. 相似文献
20.
Efficacy of chemoprophylaxis in preventing Plasmodium falciparum parasitaemia and placental infection in pregnant women in Malawi 总被引:1,自引:0,他引:1
J M McDermott D L Heymann J J Wirima A P Macheso R D Wahl R W Steketee C C Campbell 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1988,82(4):520-523
73 pregnant women in Malawi were given weekly antimalarial chemoprophylaxis under observation and were monitored for Plasmodium falciparum parasitaemia and placental infection. 3 of 19 women (16%) who were parasitaemic at the time they began chemoprophylaxis were infected with chloroquine-resistant P. falciparum. After clearance of initial infections, 25% of the 73 women became parasitaemic while taking prophylaxis and 56% had evidence of active or past placental infection at the time of delivery. None of the women who were parasitaemic at the time of enrollment, and only 11% of those who had breakthrough parasitaemias while taking prophylaxis, had a history of fever and signs or symptoms that they recognized as malaria. Although the density of P. falciparum infection and rates of placental infection appeared to be lower among women taking regular chloroquine prophylaxis, this drug did not prevent P. falciparum infection among pregnant women. 相似文献