Laparoscopic liver resection for hepatocellular carcinoma

Background Single, small hepatocarcinomas (HCC) are still an indication for partial liver resection in patients ineligible for transplantation. Anatomical resections are recommended for oncological reasons. The mini-invasive approach of laparoscopy should minimize hepatic and parietal injury, thereby decreasing the risk of liver failure and ascites. However, the oncological results of this approach and its presumed benefits remain undemonstrated. We evaluated the short- and midterm results of laparoscopic liver resections for HCC. Methods Between 1999 and 2006, we performed 32 laparoscopic liver resections for HCC. Mean tumor size was 3.8 ± 2 cm and the mean age of the patients was 65 ± 11 years. Twenty-two patients had cirrhosis (21 Child A and one Child C). Operative and postoperative results were analyzed, together with recurrence and survival rates. Results We carried out 13 unisegmentectomies, nine bisegmentectomies, one trisegmentectomy, two right hepatectomies, one left hepatectomy, and six atypical resections. The duration of the operation was 231 ± 101 minutes. Conversion to laparotomy was required in three patients (9%), none in emergency situations. Mean blood loss was 461 ml, with five patients (15.6%) requiring blood transfusion. The mean surgical margin was 10.4 mm. One cirrhotic patient (Child C) underwent surgery for a partially ruptured tumor and died of liver failure. Two patients had ascites and no transient liver failure occurred in the other 19 cirrhotic patients. Mean hospital stay was 7.1 days. During a mean follow-up of 26 months, 10 patients (31%) presented recurrence within the liver. None of the patients had peritoneal carcinomatosis or trocar site recurrence. Three-year overall and disease-free survival rates were 71.9% and 54.5%, respectively. Conclusions Laparoscopic liver resection for HCC is feasible and well tolerated. Midterm survival and recurrence rates are similar to those after laparotomy.     

腹腔镜切除78例肝肿瘤的临床研究

目的探讨腹腔镜肝切除（LH）的安全性、可行性和微创性。方法在2003年11月至2009年3月期间,选择78例患者行腹腔镜肝脏切除术。其中原发性肝癌39例、继发性肝癌10例、肝脏良性肿瘤29例。对其临床资料进行回顾性分析。结果78例肝切除手术在腔镜下全部顺利完成,无中转开腹手术。病灶分别位于Ⅱ（16例）、Ⅲ（24例）、Ⅳ（11例）、Ⅴ（11例）、Ⅵ（9例）、Ⅷ（4例）、Ⅰ（3例）等肝;病灶大小范围0.8～15cm;3个病灶4例、2个病灶8例、其余66例均为单病灶。术前肝功能Child‘A级者52例、Child’B级22例、Child’C级4例。术式包括：左半肝切除7例、左外叶切除14例、肝段切除11例、局部切除39例、腹腔镜直肠癌切除同时行肝转移灶切除7例。断肝方式为超声刀＋LigaSure联合分离法,结合内镜下切割缝合器,不阻断第1肝门。仅4例患者需要输血（400～800ml）。术后无创面出血及胆漏等并发症。术后肝功能多在1周左右恢复至手术前水平,无肝功能衰竭发生。结论（1）由于腹腔镜肝切除技术难度大,手术适应证应严格选择,病灶大小和位置是主要的参考指标;（2）腹腔镜肝切除手术对结直肠癌合并局部肝转移和肝功能Child’C级的病例具有较好的微创优势;（3）超声刀＋Ligasure联合断肝方法具有止血效果好、解剖结构清晰、术后创面渗出少、肝功能损害轻的优点;（4）手术者应具有丰富的开腹肝切除的经验和娴熟的腹腔镜操作技巧,同时应具备处理肝切除后各种并发症的能力。     

28例转移性肝癌腹腔镜肝切除术

目的 总结转移性肝癌的腹腔镜肝切除术经验.方法 对1999-2006年度布里斯班医院所实施的转移性肝癌腹腔镜肝切除术病人进行回顾性研究.结果 经病理证实的28例转移性肝癌病人进行了腹腔镜肝切除,13例进行左肝外侧叶切除,9例进行了右半肝切除,其余6例行肝段或不规则切除.追踪随访12例由直结肠转移的转移性肝癌病人2年存活率和无瘤生存率分别为75%和67%.结论 在严格选择过的恶性肿瘤病人中行腹腔镜肝切除术是安全可行的.对病人要有适当的分期,术者需具丰富的开腹肝切除术经验和腹腔镜操作技能.     

Laparoscopic liver resection: a systematic review

Background  Outcomes of laparoscopic liver resection (LLR) are not clarified. The objective of this article is to depict the state of the art of LLR by means of a systematic review of the literature. Methods  Studies about LLR published before September 2008 were identified and their results summarized. Results  Indications for laparoscopic hepatectomy do not differ from those for open surgery. Technical feasibility is the only limiting factor. Bleeding is the major intraoperative concern, but, if managed by an expert surgeon, do not worsen outcomes. Hand assistance can be useful in selected cases to avoid conversion. Patient selection must take both tumor location and size into consideration. Potentially good candidates are patients with peripheral lesions requiring limited hepatectomy or left lateral sectionectomy; their outcomes, including reduced blood loss, morbidity, and hospital stay, are better than those of their laparotomic counterparts. The same advantages have been observed in cirrhotics. Laparoscopic major hepatectomies and resections of postero-superior segments need further evaluation. The results of LLR in cancer patients seem to be similar to those obtained with the laparotomic approach, especially in cases of hepatocellular carcinoma, but further analysis is required. Conclusions  Laparoscopic liver resection is safe and feasible. The laparoscopic approach can be recommended for peripheral lesions requiring limited hepatectomy or left lateral sectionectomy. Preliminary oncological results suggest non-inferiority of laparoscopic to laparotomic procedures.     

Laparoscopic hepatic resection

Background Although laparoscopy in general surgery is increasingly being performed, only recently has liver surgery been performed with laparoscopy. We critically review our experience with laparoscopic liver resections. Methods From January 2000 to April 2004, we performed laparoscopic hepatic resection in 16 patients with 18 hepatic lesions. Nine lesions were benign in seven patients (five hydatid cysts, three hemangiomas, and one simple cyst), five were malignant in five patients (five hepatocarcinoma), and four patients had an uncertain preoperative diagnosis (one suspected hemangioma and three suspected adenomas). The mean lesion size was 5.2 cm (range, 1–12). Twelve lesions were located in the left lobe, three were in segment VI, one was in segment V, one was in segment IV, and one was in the subcapsular part of segment VIII. Results The conversion rate was 6.2%; intraoperative bleeding requiring blood transfusions occurred in two patients. Mean operative time was 120 min. Mean hospital stay was 4 days (range, 2–7). There were no major postoperative complications and no mortality. Conclusions Hepatic resection with laparoscopy is feasible in malignant and benign hepatic lesions located in the left lobe and anterior inferior right lobe segments (IV, V, and VI). Results are similar to those of the open surgical technique in carefully selected cases, although studies with large numbers of patients are necessary to drawn definite conclusions.     

腹腔镜肝切除术治疗肝血管瘤22例临床分析

目的 探讨腹腔镜肝切除术治疗肝血管瘤的技术要点和疗效.方法 回顾分析第三军医大学西南医院2007年3月1日至2008年2月29日22例肝血管瘤病人行腹腔镜肝切除术的临床资料.结果 22例中2例中转开腹,20例完成全腹腔镜肝切除术.规则性肝叶(段)切除14例,其中左半肝切除5例,左外叶切除5例(其中1例联合右肝血管瘤射频消融术),Ⅵ段切除4例;不规则肝切除8例.10例在区域性半肝血流阻断条件下手术,7例行间歇性第一肝门血流阻断,5例未行人肝血流阻断.平均手术时间209 min,平均术中出血量360 ml.全组无手术死亡及并发症发生.术后恢复顺利,平均术后住院时间6 d.随访2～14个月,无症状再发及肿瘤复发.结论 腹腔镜肝切除术治疗肝血管瘤具有手术安全、并发症少和术后恢复快等优点,其技术要点是选择恰当适应证和手术入路,有效控制入肝血流和妥善处理肝断面,肝实质离断沿瘤体周围0.5～1 cm正常肝实质内进行或直接行荷瘤肝叶(段)规则性切除.     

Laparoscopic liver resection: experience of 53 procedures at a single center

Background/Purpose The short-term outcome following laparoscopic liver resection at a single center is presented.Methods Fifty-three procedures were carried out in 47 patients, between August 1998 and April 2004 (6 patients were resected on two occasions). A previous laparotomy and/or hepatectomy had been done in 83% and 26% of the procedures, respectively. Colorectal metastasis was the main indication for treatment (42/53). A total laparoscopic approach was applied.Results Three of the 53 (6%) procedures were converted to laparotomy. In one additional procedure, radiofrequency ablation was done instead of resection. Sixty liver resections were done during the 49 procedures completed laparoscopically as planned (9 patients had concomitant resections performed). Nonanatomic (45/60) and anatomic (15/60; left lobectomies) resections were done. Tumor tissue was found in the resection margins of 6% of the specimens. The free margin was very short in 8% of the specimens. The morbidity was 16%. There was no mortality. Blood transfusions were given following 26% of the procedures. The median hospital stay was 3.5 days (range, 1–14 days) and the median number of days on which there was a need for opioids was 1 (range, 0–11 days).Conclusions Laparoscopic liver resection can be performed safely and seems to offer short-term benefits to the patients. Randomized studies are required to further evaluate the potential benefits of this treatment.     

Results of laparoscopic liver resection: retrospective study of 68 patients

Background  Although an increasing number of reports and publications have dealt with the laparoscopic approach to liver resection, this procedure remains uncommon, and its feasibility, safety and effectiveness are still not established. There are few reports of the advantages of this approach on postoperative recovery. Methods  From December 1997 to March 2007, laparoscopic hepatic resection were performed in 68 patients. Results  There were 52 malignant tumors (36 hepatocellular carcinomas, three intrahepatic cholangiocarcinomas, one cystadenocarcinoma, liver metastases from ten colorectal carcinomas and two other organs) and 16 benign lesions among our 68 patients. Fifteen patients with hepatocellular carcinoma had cirrhosis. The mean tumor size was 3.1 ± 1.8 cm (range 1.0–14.0 cm), and the tumors were located in every liver segment except segment I. Liver resection was anatomical in 17 patients and consisted of a lobectomy in four patients and a lateral segmentectomy in 13 patients. Non-anatomical resections were performed in 51 patients. The operative time was 214 ± 93 min. Mean blood loss was 393 ± 564 g. A hand-assisted laparoscopic method or mini-laparotomy method was required in 35 patients (51.4%). Operative complications occurred mainly in our early cases and included three patients (4.4%) with operative bleeding, 2 of whom (2.9%) requiring a conversion to open surgery. Postoperative complications occurred in seven patients (10.0%), and two of then eventually required a re-operation. The mean hospital stay was 17 days. There were no complications in the more recent cases. Conclusions  The laparoscopic approach for liver tumors is feasible, if the indication is carefully selected. The safety of this procedure depends on the surgical experience of the surgeon and team and the availability of the necessary technology.     

九例腹腔镜解剖性肝Ⅷ段切除的可行性与策略分析

目的:探讨完全腹腔镜解剖性肝Ⅷ段切除的策略、安全性及近期疗效。方法:回顾分析湖南省人民医院2015年1月至2019年12月行腹腔镜解剖性肝Ⅷ段切除9例患者资料,其中男性6例,女性3例,年龄范围29～67岁,平均年龄53.6岁。观察手术时间、术中失血量、术后住院时间、术后并发症等指标。出院后随访生存和复发情况。结果:9例...     

Laparoscopic liver resection assisted with radiofrequency

BACKGROUND: Radiofrequency-assisted laparoscopic liver resection is reported. METHODS: Patients suitable for liver resection were carefully assessed for laparoscopic resection. Patient and intraoperative and postoperative data were prospectively collected and analyzed. RESULTS: Eighteen patients underwent laparoscopic liver resection. All operations were performed without vascular clamping and consisting of tumorectomy (n = 9), multiple tumoretcomies (n = 2), segmentectomy (n = 2), and bisegmentectomies (n = 2). Mean blood loss was 121 +/- 68 mL, and mean resection was time 167 +/- 45 minutes. There was no need for perioperative or postoperative transfusion of blood or blood products. One patient developed pneumothorax during surgery as a result of direct puncture of pleura with the radiofrequency probe, and 1 patient had transient liver failure and required supportive care after surgery. The mean length of hospital stay was 6.0 +/-1.5 days. At follow-up, those with liver cancer had no recurrence. CONCLUSIONS: Radiofrequency-assist laparoscopic liver resection can decrease the risk of intraoperative bleeding and blood transfusion.     

Laparoscopic liver resections: A single center experience

Background Since the first report of laparoscopic liver resection, by Gagner et al. 1992, an increasing number of small prospective studies have been published. They have shown encouraging results for the feasibility and safety of the procedure. This paper prospectively evaluated the results of a single center’s experience with elective liver resections.Methods From January 1995 to January 2004 a prospective study of laparoscopic liver resections was undertaken in 31 patients with preoperative diagnosis of benign lesions (13 cases, 42.4%), hepatocellular carcinoma in absence of complicated cirrhosis (three cases, 9.1%), and liver metastases (15 cases, 45.5%). Mean tumor size was 34.9 mm (range 10–100 mm).Results The procedures included 11 (37.9%) major hepatectomies and 21 (62.1%) minor resections (one patient was submitted to repeat laparoscopic liver resection) . There were three conversions to open. Mean blood loss was 210 ml (range 0–700 ml). Mean operative time was 115 min (range 45–210 min). There were no deaths and no reoperations for complications. No port-site metastases occurred in patients with malignant lesions.Conclusions Laparoscopic liver resections, including major hepatectomies, are feasible and safe. Major and posterior resections are difficult, though, and conventional surgery remains an option.     

腹腔镜肝切除16例临床分析

目的　探讨腹腔镜肝切除手术的解剖基础与技术问题。　方法　选择病灶位于肝脏边缘、右肝表面或左半肝且肝功能Child分级B级以上 1 6例 ,其中原发性肝癌 8例 ,肝血管瘤 3例 ,左肝管胆管癌、肝细胞腺瘤、局灶性结节性增生、肝脓肿和肝囊肿伴感染各 1例。在上腹部放置 4～ 6个Trocar,应用电刀、超声刀和腔内直线形切割钉合器等多种断肝方法 ,采用钛夹夹闭、医用生物蛋白胶粘封等处理肝断面。　结果　对 1 6例在全气腹条件下完成 1 8个病灶的腹腔镜肝切除手术 ,包括左肝规则性切除 8例 ,肝局部切除 8例。手术时间 (2 0 6± 75 )min ,出血量 (35 4± 2 82 )ml,2例出血 1 0 0 0ml,术中输血 80 0ml。腹腔引流管放置时间 2天～ 4天 ,术后未发生胆漏和出血等并发症 ,术后住院 (5 8± 1 6 )天。　结论　腹腔镜肝切除手术的关键是恰当处理要切除肝的蒂部脉管 ,对次级肝门脉管的解剖分离是行肝段或左半肝切除时控制出血的关键     

Laparoscopic stapled left lateral segment liver resection—Technique and results

Because of the favorable anatomy of the left lateral segment of the liver, a totally laparoscopic approach to resection is feasible. Herein we describe a technique for laparoscopic stapled resection of the left lateral segment of the liver, including the necessary anatomic criteria for a safe operation and data on clinical outcome. Five patients at our center underwent laparoscopic exploration, ultrasound examination, and resection of segments II and III. After complete mobilization of the left lateral segment and minimal portal dissection, the totally laparoscopic resections were performed with two endoscopic staple loads (4.5 mm Χ 60 mm) applied sequentially across the portal pedicle and the left hepatic vein. The mean operative time was 182 minutes (range 130 to 240 minutes), blood loss was 41 ml (range 25 to 50 ml), and length of hospital stay was 2.2 days (range 1 to 3 days). All three patients with malignancy had negative surgical margins. All five patients returned to normal activity or work by 1 week postoperatively. There were no complications. Patients with isolated malignant and benign diseases of the left lateral segment of the liver are candidates for totally laparoscopic resection, if evaluation demonstrates a normal liver character and hepatic parenchymal thickness less than 3 cm overlying the ligamentum venosum groove. Such patients benefit from the minimally invasive approach, with no compromise in the surgical result as compared to the open approach. Presented at the Fourth Biennial Americas Hepato-Pancreato-Biliary Congress, Miami Beach, Florida, February 28, 2003. Supported in part by a Minnesota Medical Foundation Laparoscopy Training Grant (T.D.S.) and the Richard Lewis Varco Surgical Research Award (B.C.L.).     

Laparoscopic nonanatomic hepatic resection employing the LigaSure device.

BACKGROUND: Advancements in technology have allowed laparoscopic surgery to expand into advanced procedures such as liver resection; however, the value and safety of laparoscopic liver surgery is still a topic for debate. This study was designed to evaluate the feasibility and outcome of laparoscopic nonanatomic hepatectomy using the LigaSure device in a swine model. METHODS: Nonanatomic hepatic lobe resection was performed in 3 groups comparing the open finger-fracture method, the open method with the LigaSure device, and the laparoscopic method with the LigaSure device. The cut surfaces of the liver were evaluated for bleeding and biliary leakage at the time of the operation. The animals were inspected 48 hours later for hemorrhage and evaluated with cholescintigraphy (hepatobiliary iminodiacetic acid [HIDA] scan) for biliary leakage, in addition to histological evaluation of liver specimens. RESULTS: No hemorrhage or biliary leakage was noted in the groups where the LigaSure device was used, whereas 1 animal from the open finger-fracture method sustained a bile leak observed on HIDA scan. The operative blood loss was considerably less in the groups where the LigaSure device was used, and the shortest operative time was observed in the laparoscopic group. CONCLUSIONS: The LigaSure device can be safely and effectively used to perform a laparoscopic nonanatomic hepatectomy.     

Laparoscopic versus open liver resection of hepatic neoplasms: comparative analysis of short-term results

Background  Concerns have been raised regarding outcome after laparoscopic resection of hepatic neoplasms. This prospective study compared morbidity and adequacy of surgical margins in laparoscopic (LLR) versus open liver resection (OLR). Methods  Outcome in 359 consecutive patients [male/female ratio 187/172; median age 60 years (range 18–84 years)] who underwent partial hepatectomy was analysed. Cirrhosis was present in 32 patients and preoperative chemotherapy was administered in 141 patients. Comparative analyses were performed using propensity scores for all and for matched patients (n = 76 per group). Results  Complications occurred in 68/250 (27.2%) patients after OLR and in 6/109 (5.5%) after LLR [odds ratio (OR) 0.16; 95% confidence interval (CI) 0.07–0.37; p < 0.0001]. Median intraoperative blood loss was 500 ml (range 10–7,000 ml) in OLR and 100 ml (range 5–4,000 ml) in LLR (p < 0.0001). Postoperative hospital stay was 8 days (range 0–155 days) after OLR and 6 days (range 0–41 days) after LLR (p < 0.0001). In patients treated for liver malignancy, the surgical resection margin was positive on histopathological examination in 5/237 after OLR and in 1/77 after LLR. The magnitude of the resection margin was 7.5 mm (range 0–45 mm) in OLR and 10.0 mm (range 0–30 mm) in LLR (p = 0.087). Conclusions  LLR for hepatic neoplasms seems to be noninferior to OLR regarding adequacy of surgical margins, and superior to OLR regarding short-term postoperative outcome.     

Laparoscopic and robot-assisted one-stage resection of colorectal cancer with synchronous liver metastases: a pilot study

Background/purpose  One-stage resection of primary colon cancer and synchronous liver metastases is considered an effective strategy of cure. A laparoscopic approach may represent a safe and advantageous choice for selected patients with the aim of improving the early outcome. Methods  Between January 2008 and October 2008, 7 patients underwent one-stage laparoscopic resection for primary colorectal cancer combined with laparoscopic or robot-assisted liver resection. Results  A total of five laparoscopic left-colon, one right-colon, and one rectal resections were performed. Three patients underwent preoperative left-colon stenting and two received neoadjuvant chemotherapy. The patient with rectal cancer underwent neoadjuvant radiotherapy. Liver procedures included one bisegmentectomy (segments 2, 3), 3 segmentectomies, 6 metastasectomies, and four laparoscopic ultrasound-guided radiofrequency ablations (LUG-RFAs). One patient with multiple liver metastases was managed by a two-stage hepatectomy partially conducted by a totally laparoscopic approach. The overall postoperative morbidity was null. The median hospital stay was 10 days (range 7–10 days). Conclusions  This pilot study suggests that laparoscopic one-stage colon and liver resection is feasible and safe. Robot assistance may facilitate liver resection, increasing the number of patients who may benefit from a minimally invasive operation.     

Laparoscopic vs open hepatic resection: a comparative study

Background: Although the feasibility of minor laparoscopic liver resections (LLR) has been demonstrated, data comparing the open vs the laparoscopic approach to liver resection are lacking. Methods: We compared 30 LLR with 30 open liver resections (OLR) in a pair-matched analysis. The indications for resection were malignant disease in 47% of the LLR and 83% of the OLR. The average size of the lesions was 42 mm for LLR and 41 mm for OLR. Five wedge resections, 12 segmentectomies, and 13 bisegmentectomies were performed in each group. Results: The conversion rate for LLR was nil. The mean operative time was 148 min for LLR and 142 min for OLR. Mean blood loss was minimal in the LLR group (320 vs 479 ml; p < 0.05). Postoperative complications occurred in 6.6% of the patients in each group; there were no deaths. The mean postoperative hospital stay was shorter for LLR patients (6.4 vs 8.7 days; p < 0.05). In tumors, the resection margin was <1 cm in 43% of the LLR patients and 40% of the OLR patients (p = NS). Conclusions: Minor LLR of the anterior segments has the same rates of mortality and morbidity as OLR. However, the laparoscopic approach reduces blood loss and postoperative hospital stay.     

经脐单孔与多孔法腹腔镜肝切除术的对比研究

目的:回顾性分析经脐单孔法与多孔法腹腔镜肝切除患者的临床资料,探讨两种方法的疗效、安全性、可行性以及患者满意度。方法:收集2009年3月—2012年8月中国医科大学附属盛京医院胆道血管外科腹腔镜肝脏手术27例,其中单孔组13例,多孔组14例。对两组围手术期资料进行比较分析。结果:全部患者均顺利完成腹腔镜肝切除术。两组患者在平均手术时间(P=0.358)和术中出血量(P=0.595)方面的比较差异无统计学意义。单孔组患者术后肠道功能恢复早于多孔组(1.2±0.4dvs 1.5±0.5d,P=0.029)。所有患者均于术后8 d内出院。术后随访3个月~2年,两组患者并发症的发生率无统计学差异,术后患者满意度评分单孔组明显高于多孔组。结论:经脐单孔腹腔镜肝切除术可以达到与多孔腹腔镜手术相同的疗效,且美容效果好,具有可行性,其应用价值需进一步临床验证。     

机器人肝切除术与腹腔镜肝切除术的疗效比较

目的 配对比较机器人与传统腹腔镜肝切除的术中及术后结果,评价机器人肝切除术的安全性和优势。方法 对我院2010年3月至2017年8月实施的88例微创肝切除术病人的资料进行回顾性分析,按手术方式的不同分为机器人组(n=44)和腹腔镜组(n=44)。采用倾向匹配分析方法,按照1:1的比例,根据病人的性别、年龄、有无肝炎和肝硬化、体质量指数、美国麻醉师协会分级、肝脏切除范围在机器人组病人中进行配对。结果 两组病人的术中出血量、术中输血率、术后住院时间、术后并发症发生率和R0切除率无统计学差异。机器人组手术时间较腹腔镜组长[（183.36±64.40） min比（156.25±71.53） min, P=0.013]。但与腹腔镜组相比,机器人组中转开腹率较低（4.5%比22.7%,P=0.013）。结论 虽然机器人肝切除手术时间较长,但中转开腹率较低,与传统腹腔镜肝切除术具有相似的安全性。     

腹腔镜肝切除术治疗肝细胞癌37例临床分析

目的 探讨腹腔镜肝切除术治疗合并乙型肝炎后肝硬化的肝细胞癌的技术要点和近期疗效.方法 2007年3月1日至2008年9月30日西南医院对37例合并乙型肝炎后肝硬化的肝细胞癌患者施行腹腔镜肝切除术.结果 37例患者中32例完成全腹腔镜肝切除术,3例完成手助式腹腔镜肝切除术,2例中转开腹.解剖性肝切除23例,包括左半肝切除4例,左外叶切除8例,超左半肝切除1例,右半肝切除2例,单肝段切除8例;非解剖性肝切除术14例,其中10例在区域性半肝血流阻断条件下手术.本组患者平均手术时间212 min,平均术中出血量354 ml.全组无1例手术死亡,术后出现腹水和胸腔积液3例、肝断面包裹性积液2例、腹腔内出血1例.术后1～2 d下床活动,5～7 d肝功恢复正常,平均术后住院时间8 d.随访2～21个月,3例出现肝内非原位复发,其中1例术后8个月死亡,2例带瘤生存至今. 结论腹腔镜肝切除术治疗合并乙型肝炎后肝硬化的肝细胞癌安全可行.技术要点是根据病变大小、部位及肝硬化程度选择不同的肝切除方式及肝血流阻断方式,肝实质离断过程巾联合使用以超声刀为主的多种器材,妥善处理肝断面.