Malignant fibrous histiocytoma of the bone]

Five cases of malignant bone fibrous histiocytoma diagnosed by bioptic material are presented. The authors state that the diagnosis of these rare bone malignant neoplasms do not present a larger diagnostical problem. However, some differential diagnostic problems are often met compared to other bone neoplasms, especially in osteosarcoma, so in these cases are recommended that together with routine histologic examinations in establishment of diagnosis should be also used enzymohistochemical methods, especially alkaline and acid phosphatase. Also, it is necessary to use immunohistochemical methods with corresponding markers which the authors have used in establishment of diagnosis of their cases. Based on the analysis of the presented cases the authors support the theory of J. Brooks on the histogenesis of these tumours within his theory of differentiation of the mesenchimal tissue which is easily recognized in recidives and metastases of soft tissue sarcomas by phenotypes organized at the lower level of differentiation.     

Malignant fibrous histiocytoma of the mandible

 We report a case of MFH of the mandible in a 16-year-old girl. The mandible is a rare location of MFH of bone, with only 21 cases described in the literature. Clinical, pathologic, and radiologic features are discussed, with special emphasis on the unusual pathologic and radiographic features.     

Malignant fibrous histiocytoma of the mandible

We report a case of malignant fibrous histiocytoma (MFH) primary within the mandible of a 32-year-old female. The mandible is a rare location of MFH, accounting for only 3% of all tumours of this type occurring within bone. The clinical, pathological and radiographic features are discussed with special emphasis on the radiographic features of this lesion.     

Malignant fibrous histiocytoma of the stomach

MFH is a kind of sarcoma, normally located in the soft tissues of the extremity and retroperitoneal space. The involvment of the gastroenteric tube and particularly of the stomach are rather rare. Our case shows some differences from the others described in literature: the sight of mass, the age of the patient, the extension at the moment of the diagnosis.     

Malignant fibrous histiocytoma of the liver

Malignant histiocytoma of the liver, a rare liver tumor, has not been reported in the radiological literature. The differential diagnosis of liver mass should be expanded to include primary malignant fibrous histiocytoma. Embolization of the mass was ineffective.     

Malignant fibrous histiocytoma associated with a bone infarct in a patient with hereditary bone dysplasia

Hereditary bone dysplasia (HBD) is an extremely rare clinicopathological entity manifested by diaphyseal medullary stenosis and cortical bone thickening associated with a propensity for fractures affecting the long tubular bone. Malignant transformation has been reported to occur at an alarming frequency. The hereditary pattern appears to be autosomal dominant. In this paper we present the case of a 19-year-old man with hereditary bone dysplasia who was unaware of his underlying condition until he presented with malignant transformation arising in an area of bone infarct of the left tibia.     

Malignant fibrous histiocytoma arising from the renal capsule.

Malignant fibrous histiocytoma (MFH) arising from the renal capsule is a rare tumor. We report a case of 55-year-old man with this tumor. Radiological imaging, including magnetic resonance (MR) imaging, was helpful in the differential diagnosis between MFH of the renal capsule and other renal tumors. In particular, a hypo-intense area identified on T(2)-weighted images reflecting the fibrous component was identified as an important characteristic of renal MFH.     

Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features

Objective. To evaluate the conventional X-ray and MR imaging features of malignant fibrous histiocytoma (MFH) of bone. Design. MRI examinations and conventional radiographs were reviewed in 39 patients with biopsy-proven MFH. Imaging characteristics were analyzed and the differential diagnoses assessed in a masked fashion by two experienced radiologists. Results. Typical X-ray features included aggressive, destructive tumor growth centrally located in the metaphysis of long bones. Periosteal reactions and expansive growth were rarely seen. On MR images extraosseous tumor spread was frequently noted. On T2-weighted images and contrast-enhanced T1-weighted images most of the tumors displayed an inhomogeneous, nodular signal pattern with peripheral Gd-DTPA enhancement. Conclusions. Although several MR imaging criteria were typical for MFH none of them was specific. X-ray diagnosis of MFH may also prove difficult, with the main differential diagnosis being metastasis in the older and osteosarcoma in the younger population.     

Malignant fibrous histiocytoma metastatic to the thyroid gland

Despite frequent cancer metastases to the thyroid gland demonstrated at autopsy, finding of thyroid metastasis in clinical practice is rare. Malignancies most commonly metastasizing to the thyroid are malignant melanoma and carcinoma of the breast, kidney, and lung. Very little is known about thyroid metastases caused by sarcomas. Of these, malignant fibrous histiocytoma (MFH) is one of the most common in adults, with a high rate of metastases. A case of clinically significant thyroid metastasis from primary MFH involving the thigh visualized on I-123 thyroid imaging is reported.     

Malignant fibrous histiocytoma of the spine causing spinal neural foramen widening.

A case with a clinical picture of a chronic low back pain radiating to both lumbar regions caused by malignant fibrous histiocytoma is reported. Radiological, surgical and histopathological findings and treatment of this rare case are discussed.     

Malignant fibrous histiocytoma of soft tissue. Apropos of 2 cases

Two cases of Malignant Fibrous Histiocytoma of soft tissue are presented. The value and limitations of computerized tomography, ultrasonography findings and percutaneous aspiration biopsy in these cases are discussed.     

肝恶性纤维组织细胞瘤1例

患者女,65岁。患者半月前无明显诱因出现右上腹痛,为间歇性隐痛,无放射痛,间歇时间数天至数十天不等．无发热、目黄、恶心、呕吐、腹泻、血便。查体：腹平坦,右上腹压痛,无反跳痛,未及包块,肝脾肋下未及。     

Malignant fibrous histiocytoma of soft tissue with metaplastic bone and cartilage formation: A new radiologic sign

The presence of bone and cartilage in some cases of malignant fibrous histiocytoma of the soft tissue as a microscopic finding has been reported previously but little note has been taken of the radiologic manifestations of these tumor elements. A series of five such cases with sufficient metaplastic osseous and cartilaginous elements to produce roentgenographic evidence of their presence is reported here. An additional two cases showed only histologic evidence of bone or cartilage formation.The reactive ossification tends to be peripheral in location, involving the pseudocapsule of the sarcoma or its fibrous septa. In three there was a zoning pattern with peripheral or polar orientation, strongly suggesting the diagnosis of myositis ossificans. The latter was the diagnosis considered radiologically in four of the five cases. Malignant fibrous histiocytoma with reactive bone and cartilage must be considered in the differential diagnosis of soft tissue masses with calcific densities, particularly when these occur in tumors of the extremities.     

Primary malignant fibrous histiocytoma (fibrous xanthoma) of bone

The probable histiocytic origin of a group of benign and malignant tumors known as histiocytomas or fibrous xanthomas appears to be well established and is based on a combination of conventional light microscopy, tissue culture and ultrastructural studies. Our experience with 23 cases of primary malignant fibrous histiocytoma of bone is presented, together with a review of additional cases documented in the literature. Particular emphasis has been placed on the radiologic aspects of primary malignant fibrous histiocytoma of bone, together with a brief review of its clinical and histologic features. The fact that the skeleton can be involved de novo rather than by direct extension from neighboring soft tissue tumors or by metastatic spread is a relatively new concept.