体检人群动脉硬化早期检测的临床分析

目的了解在暨南大学附属第二医院体检的672例人群的血管病变状态。方法通过体检将人群分为健康组507例,疾病组（心脑血管疾病）165例。并对体检人群采用科林动脉硬化诊断装置进行踝臂指数（ABl）和踝臂脉搏波传导速度（baPWV）的测定,同时收集临床资料和生化检测指标,对资料进行统计学处理。结果受检人群中baPWV结果偏低的占1.2%（8/672）,结果正常的占67.7%（455/672）,结果升高的占31.1%（209/672）。ABI改变不明显,只有4.6%（31/672）表现异常。健康组的baPWV的异常率（25.6%）低于疾病组（47.9%）,差异有统计学意义（χ2=28.7,P=0.000）,健康组ABI的异常率（4.9%）与疾病组（3.6%）的差异无统计学意义（χ2=0.47,P=0.49）。结论疾病组血管损伤明显,且健康检查人群中也存在血管硬度和弹性改变的情况,建议通过对高危人群早期进行动脉硬化的检测,可对心脑血管疾病的预防发挥重要作用。     

健康体检人群脉搏波传导速度特征及其与心血管疾病危险因素关系的分析

目的　分析健康体检人群脉搏波传导速度特征,及其与心血管疾病危险因素的相关性。方法　选择四川省人民医院13841名健康体检人员,询问疾病史,测量身高、体重、BMI、血压等,检测FPG、血脂、UA等生化指标,应用动脉硬化仪检测踝臂脉搏波传导速度(baPWV)。结果　健康体检男女性人群baPWV值均随年龄增长而逐渐升高,<60岁男性baPWV值明显高于女性。多元线性回归分析显示年龄、SBP、BMI、FPG、UA和TG水平均为baPWV的影响因素,其中年龄、SBP对baPWV的影响最大,标准化回归系数>0．42。结论　健康体检人群的baPWV值随性别、年龄呈不同的分布特征。应加强对老年人群,尤其是老年女性的baPWV监测,早期预防高危人群心血管事件的发生。     

体检人员3577例动脉硬化检测结果

动脉硬化是随着人年龄增长而出现的血管疾病,通常在青少年时期发生,至中老年时期加重、发病。近年来该病在我国逐渐增多,成为老年人死亡的主要原因之一^[1]。2007年6月-2010年12月,我院对3 577例体检者进行了踝臂指数(ABI)和踝肱脉搏波传导速度(baPWV)的检测,以早期发现动脉硬化,现将结果报告如下。     

臂踝脉搏波速度和踝臂指数在高血压人群中评估动脉硬化和动脉粥样硬化的价值

目的研究臂踝脉搏波速度（ba PWV）和踝臂指数（ABI）评估高血压人群动脉硬化和动脉粥样硬化的价值。方法应用日本科林公司生产的VP-2000/1000型动脉硬化检测仪,对高血压（伴或不伴其相关疾病）患者组（5 112例）和无高血压对照组（606例）进行检测。患者组分为5组,即单纯高血压组（3 748例）、高血压合并血脂异常组（518例）、高血压合并2型糖尿病组（474例）、高血压合并冠心病组（34例）和高血压合并慢性肾功能不全血液透析组（338例）。结果 606例无高血压对照组成员中505例的ba PWV存在不同程度的异常改变,其中轻度异常203例（34%）,中度异常165例（28%）,重度异常137例（23%）;3例（0.5%）ABI〈0.90。5 112例高血压伴或不伴其相关疾病患者中,ba PWV轻度异常994例（20%）,中度异常1 300例（26%）,重度异常2 214例（44%）;89例（1.7%）ABI〈0.90。ba PWV中、重度异常在高血压患者人群中检出率为68.7%,明显高于无高血压对照组（49.8%）,差异有统计学意义（P〈0.05）。ABI〈0.90在高血压合并慢性肾功能不全血液透析组中最高（10.9%）,在无高血压对照组中为0.5%。结论 ba PWV检测可以早期发现高血压人群的动脉血管病变,并评价动脉硬化程度,ABI测量是筛查周围血管疾病的有效手段,有利于早期采取干预措施。     

华东地区成人高血压人群中血尿酸水平与臂踝脉搏波传导速度的关联性分析

  目的  了解华东农村地区高血压人群中血尿酸水平与臂踝脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)的相关性,并进一步探索可能影响两者关系的危险因素。  方法  本研究是于2013年7~9月在连云港市赣榆县和东海县、安庆枞阳和望江县进行的一项横断面研究。检测研究人群的血尿酸水平,并进行baPWV测定,采用多元线性回归分析来评估两者间关系。  结果  4278名成年高血压患者最终纳入本研究,平均年龄为(65.2±7.4)岁,baPWV水平为(1 835.1±383.4) cm/s。多元线性回归分析结果显示,调整年龄、性别等危险因素后,血尿酸水平与baPWV呈现正相关关系(每标准差(standard deviation,SD)增加(β=20.5 cm/s,95% CI:8.5~32.5,P=0.001)。按照血尿酸水平进行三等分组时,相较于第一等分组患者(< 277 μmol/L),第三等分组患者(≥ 349 μmol/L)的baPWV水平增加(β=51.2 cm/s,95% CI:23.8~78.6,P=0.001)。分层分析结果发现,在收缩压(systolic blood pressure,SBP) ≥ 140 mm Hg人群中,血尿酸水平与baPWV具有更强的关联(交互P值=0.001)。  结论  华东农村地区高血压人群的血尿酸水平与baPWV呈现正相关关系,血压控制不佳(SBP ≥ 140 mm Hg)人群具有更强的关联。     

健康体检人群脉搏波传导速度现状调查

目的 探讨动脉硬化早期无创检测技术及其主要指标在健康体检中的流行现状.方法 通过统一设计收集全国不同区域的27家体检中心的46824名健康体检者（男性24879名、女性21945名）动脉硬化无创检测数据资料及受试者相关基础信息,通过分析得到国人不同年龄段脉搏波传导速度（PWV）的常值范围、异常检出率,并分析PWV的主要影响因素.结果 不同性别体检人群PWV平均值及异常检出率随着年龄增长而增加,在60岁之前,男性PWV异常检出率明显高于女性（P〈0.05）,在60岁之后女性高于男性.PWV异常检出率风险分层结果,PWV〉1400 cm/s（轻度异常）、PWV〉1700 cm/s（中度异常）、PWV〉2000 cm/s（明显异常）的检出率分别为34.5%、7.5%和1.9%.相关结果分析,年龄和平均收缩压是影响PWV和ABI的主要因素（P〈0.05）.结论 动脉硬化早期无创检测技术及其主要指标PWV在健康体检与心血管病早期风险筛查中具有较好的应用价值.     

脉搏波信号分析用于动脉硬化诊断仪器的研究

由于以动脉硬化为代表的心血管疾病的发病率和死亡率越来越高,所以如何防治这类疾病,已成为世界各国迫切需要解决的一项重大课题。动脉硬化诊断仪,通过一种无创检测方法,对动脉脉搏波进行分析,得到一些有临床意义的病理指标,用脉搏信号来诊断动脉硬化。分析了脉搏波产生的生理机制,脉搏信号的特点及脉搏与动脉硬化的关系。论述了仪器主要检测参数与动脉硬化的诊断及临床应用。     

健康体检人群性别和血尿酸与肱-踝脉搏波速度的关系

目的探讨不同性别健康体检人群血尿酸与肱一踝脉搏波速度（baPWV）的关系。方法采用横断面研究的方法对1418例常规健康体检者收集生化指标,并测量baPWV。BaPWV≥1400cm／s定义为baPWV异常。分别根据男女性血尿酸水平的四分位数,将人群分为4组（Q1、Q2、Q3和Q4组）。Spearman相关分析不同性别血尿酸水平与baPWV的关系。在女性logistic回归分析血尿酸水平与baPWV异常的关系。结果男性和女性均有舒张压、空腹血糖、三酰甘油和体质指数随血尿酸水平增高而增高;高密度脂蛋白一胆固醇随血尿酸水平增高而降低。女性收缩压、总胆固醇和低密度脂蛋白-胆固醇水平和baPWV水平亦随血尿酸增高而升高,差异有统计学意义。相关分析显示女性血尿酸与baPWV显著正相关（r=0．18,P〈0．05）,男性血尿酸与baPWV未见相关（r=-0．05,P=0．16）。对女性人群单因素logistic分析结果表明,与血尿酸最低4分位组相比,最高4分位组baPWV异常的发病相对风险OR=2．69（95％CI1．68～4．29）。在校正肌酐和估算肾小球滤过率后,血尿酸第4分位组相对第1分位组baPWV异常的相对风险OR=2．45（95％CI1．48～4．06）。进一步用年龄和MS各组分校正后血尿酸与baPWV相关性消失OR=1．15（95％CI0．56～2．37）。结论女性血尿酸水平与baPWV异常的相关依赖于年龄和MS的组分。     

健康人群3859例人体成分与动脉功能关系及其影响因素的研究

目的探讨健康人群人体成分与动脉功能指标之间的关系,研究年龄、性别等因素对于其关系的影响。方法通过健康体检的方法入选3859例研究对象,应用生物电阻抗技术测定人体成分组成情况,并测定桡动脉增强指数（AI）及脉搏波传导速度（PWV）作为评价动脉功能的指标。采用多因素相关分析的方法探讨人体成分的相关指标与AI之间的关系,并进一步引入年龄、性别等因素后进行直线回归分析。结果PwV水平与体质指数（BMI）（r=0．072,P〈0．01）及体脂肪率水平之间均具有良好的相关性（r=0．114,P〈0．01）,但是BMI水平的变化并不能反应其变化（r=0．022,P〉0．05）,人体成分分析中的体脂肪率等指标的水平变化则能够有效的反应AI水平的变化（r=0．263,P〈0．01）。女性BMI（r=0．219,P〈0．01）及体脂肪率（r=0．316,P〈0．01）与AI之间均具有良好的相关性,但在男性中这种相关性则消失（r=0．033,r=0．046,P〉0．05）。引入年龄因素后发现在50岁以下人群中,这种关系则要更为密切（卢=0．479,IB=0．321,P〈0．叭）。结论体脂肪率对于动脉功能变化的预测性要优于目前临床常用的BMI,可以通过对于人体成分变化的监测来追踪动脉功能的变化。年龄、性别会对两者之间的关系产生影响,对于50岁以下的女性患者两者之间的相关性最佳。     

老年糖尿病患者动脉硬化与左室收缩功能相关性研究

目的通过回顾性分析糖尿病和非糖尿病人群中代表外周动脉硬化及僵硬度程度的肱踝脉搏波传导速度(ba PWV)、踝臂指数(ABI))与心脏收缩功能之间的相关性,探讨糖尿病对大血管及心脏收缩功能的影响。方法入组糖尿病患者48例,非糖尿病人群90例,均接受ba PWV、ABI及超声心动图检查,并留取血脂、糖化血红蛋白(Hb A1c)等相关临床资料。应用spearman相关分析各观察指标之间的相关性。结果基线资料比较显示,两组性别比例、血脂、尿酸水平差异均无统计学意义(P>0.05),Hb A1c、年龄差异有统计学意义(P<0.05);ABI、ba PWV差异有统计学意义(P<0.05)。心功能方面,左室射血分数(LVEF)、缩短分数(FS)差异无统计学意义(P>0.05)。组内分析显示,糖尿病组ABI与年龄、LVEF、Hb A1c之间存在相关性(相关系数r分别为0.67、0.42、0.47);ba PWV与年龄、BMI、Hb A1c及LVEF呈正相关(r分别为0.69、0.51、0.56、0.44)。非糖尿病组ABI同样与年龄、LVEF具有相关性(r分别为0.64、0.45);ba PWV与年龄、BMI、LVEF具有相关性(r分别为0.64、0.55、0.45)。结论无论在糖尿病还是非糖尿病人群中,ABI、ba PWV均与左室收缩功能的指标LVEF呈正相关性,即左室收缩功能受到外周动脉硬化及僵硬度的影响。     

高血压病患者血脂综合指标与大动脉僵硬度异常的相关性

目的  通过引入血脂综合指标探讨高血压病患者血脂异常与大动脉僵硬度异常的相关性。 方法  本研究共纳入高血压病随诊或疑诊动脉粥样硬化相关疾病患者431例。对所有入组患者依据有无高血压病及血脂异常病史分为无高血压病和血脂异常病史组（A组）、有血脂异常病史但无高血压病史组（B组）、有高血压病史但无血脂异常病史组（C组）、有高血压病及血脂异常病史组（D组）。依据总胆固醇（total cholesterol,TC）、甘油三酯（triglyceride,TG）、高密度脂蛋白胆固醇（high density lipoprotein-cholesterol,HDL-C）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol,LDL-C）等血脂指标分别计算血浆致动脉粥样硬化指数（atherogenic index of plasma,AIP）、非高密度脂蛋白胆固醇（non-high density lipoprotein-cholesterol,non-HDL-C）、TC/HDL-C、动脉硬化指数（atherogenic index,AI）等血脂综合指标,比较各指标组间差异。采用多元线性偏相关分析探讨各血脂指标与肱踝动脉脉搏波传导速度（brachial-ankle pulse wave velocity,baPWV）的相关性。 结果  TC、TG、HDL-C、AIP、AI、non-HDL-C及TC/HDL-C在各组间总体比较差异均存在统计学意义（均有P < 0.05）。针对高血压病患者（C组、D组）进行多元线性偏相关分析,结果显示,TG、HDL-C、AIP、AI、TC/HDL-C与baPWV均呈正相关关系（均有P < 0.05）,TC、LDL-C、non-HDL-C与baPWV均无明显相关性（均有P>0.05）。 结论  高血压患者血脂水平与大动脉僵硬度可能存在相关性,AI、AIP及TC/HDL-C等血脂综合指标可能更好反映高血压病患者血脂异常与大动脉僵硬度异常的相关趋势。     

血管硬化指数的测量方法与临床应用研究

本文从血管壁的构造和血管壁体积?压力关系解释了血管硬化指数(ASI)的测量原理,在测量时得到上臂袖带放气过程中袖带压结合脉搏波形的信息,取最大峰值前后最近似80%最大峰值的两个脉搏波峰所对应的袖带压差值作为基准参数值。据此方法制作的测量仪器通过临床测试,证明了测量方法的实用性和可靠性。     

Relation between alcohol consumption and arterial stiffness: A cross-sectional study of middle-aged Japanese women and men

Epidemiological data indicate the existence of a J–shaped association between alcohol consumption and cardiovascular mobility and mortality. However, studies assessing the relationship between alcohol consumption and pulse wave velocity (PWV) as a marker of arterial stiffness have provided inconsistent results. In addition, data regarding the effect of alcohol on arterial stiffness in women has been limited. This study aimed to clarify the relationship between alcohol consumption and PWV among female and male workers in Japan. Study participants were local government employees in Hokkaido, Japan, who underwent annual health check-ups. All data were collected using self-administered questionnaires. The average daily alcohol consumption of the previous month, based on the alcohol concentration of each beverage type (g/day, ethanol equivalent), was estimated according to the frequency and amount of consumption. Data from 3893 participants (812 women and 3081 men) were analyzed. In women, non-drinkers had significantly higher PWV than women who consumed <10 g/day of alcohol. In men, compared with those who reportedly drank 20–39 g/day, non-drinkers and those who drank <20 g/day and ≥60 g/day had significantly higher PWV. Alcohol consumption showed a J–shaped association with PWV in men (p for quadratic term < 0.036) and marginally in women (p < 0.056). The results of stratified analyses by age groups showed a significant J–shaped association, which was most notable for men ≥45 years (p < 0.005). In middle-aged Japanese women and men, light-to-moderate alcohol consumption is associated with lower PWV, which in turn correlates with a reduction in vascular stiffness.     

正常高值血压中青年男性合并糖尿病对动脉僵硬度的影响

目的探讨合并2型糖尿病(T2DM)对正常高值血压者臂踝脉搏波传导速度(baPWV)及颈动脉内膜中层厚度(CIMT)的影响。方法从2010年5月～2011年5月在杭州疗养院疗养或健康体检的中青年男性中,选取正常高值血压且合并T2DM患者64例,单纯正常高值血压者70例及理想血压66例。所有对象均检测颈动脉CIMT、baPWV以及血液生化指标。结果与理想血压组比较,单纯正常高值血压组CIMT及baPWV均增高,分别为(0.78±0.10)mm vs(0.73±0.08)mm及(1318.4±132.5)cm/s vs(1232.5±121.2)cm/s;与单纯正常高值血压组比较,正常高值血压合并T2DM组CIMT及baPWV也显著增高(0.84±0.13)mm vs(0.78±0.10)mm,(1406.7±139.8)cm/s vs(1318.4±132.5)cm/s,差异均有显著统计学意义(P<0.01)。Logistic回归分析,T2DM及空腹血糖增高是正常高值血压男性颈动脉CIMT和baPWV增高的独立危险因素,其中baPWV增高的OR及95%CI分别为3.49(1.67～7.34)及2.32(1.24～4.34)。结论正常高值血压合并T2DM者动脉僵硬度进一步增加,提示对该人群可能需调整正常高值血压的定义并强化干预措施。     

Relationship between two alternative occupational stress models and arterial stiffness: a cross-sectional study among Japanese workers

Objective  Numerous studies have reported the relationships between job characteristics and coronary heart diseases. However, there are only a few reports on the association between occupational stresses and arterial stiffness as a marker of early stage arthrosclerosis. The aim of this study was to clarify the relationship between occupational stress models—Siegrist’s effort reward imbalance and Karasek’s demand control model (DCM)—and arterial stiffness using brachial-ankle pulse-wave velocity (baPWV). Methods  The participants were local government employees (3,412 men and 854 women) aged 35 and over who had their annual health checkups. The associations between occupational stress questionnaires of the two theoretical models and a risk of increased arterial stiffness using baPWV were examined. Results  On performing multiple linear regression analysis after fully adjusting the model, high strain, which was defined as a combination of both low job control and high job demands in the DCM, was found to be significantly associated with a high risk of arterial stiffness (P = 0.027) in women. However, in men, although low job control was positively significant with a high value of baPWV adjusted for each step, modest but not significant association was found after adjustment for all covariates. Conclusion  In conclusion, the present study indicates that high strain indicated by high demands and low control is associated with increased arterial stiffness in women. The types of job stress associated with a high risk of arterial stiffness may differ by gender.     

不同类型降压药物对老年高血压患者动脉僵硬度的影响

目的评价不同类型降压药物对老年原发性高血压患者动脉僵硬度的影响。方法60例老年男性原发性高血压患者,随机分为缬沙坦组（80mg,l/d）、贝那普利组（10mg,l/d）、硝苯地平缓释片组（20mg,2／d）各20例,疗程共3个月。分析治疗前后肱一踝脉搏波速度（baPWV）及血压。结果治疗3个月后各组血压均有显著降低,硝苯地平缓释片组舒张压的下降幅度（△DBP）、脉压下降幅度（△PP）与另两组差异显著（分别为-40．1±11．3 vs-16．6±5．5、-14．6±4．2mmHg和-10．0±19．3vs -28．8±6．6、-25．7±6．5mmHg,P〈0．01）。缬沙坦组及贝那普利组治疗前后baPWV均显著下降,其下降幅度（AbaPWV）分别为-401±90、-280±97cm／s,显著大于硝苯地平缓释片组的-11±127cm／s（P〈0．01）。baPWV与APP在总体患者中呈显著正相关（r=0．64．P〈0．001）,贝那普利组或硝苯地平缓释片组ΔbaPWV至少与一项血压参数（APP,ASBP,ADBP）相关,而在缬沙坦组均不相关。结论与贝那普利或硝苯地平缓释片相比,缬沙坦对老年原发性高血压患者具有独立于降压功效外的减低动脉僵硬度的作用。     

The interleukin-6 –174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study

Arterial stiffness normally increases with age and has been established as a precursor of cardiovascular disease. Interleukin-6 is a pleiotropic inflammatory cytokine with an important role in the inflammatory cascade, such as up-regulation of C-reactive protein (CRP). The interleukin-6 –174-G/C promoter polymorphism appears to influence levels of inflammatory markers, which have been shown to be associated with arterial stiffness. We studied the association of this polymorphism with levels of interleukin-6 and CRP and with arterial stiffness. The study (n = 3849) was embedded in the Rotterdam Study, a prospective, population-based study. Analyses on the association between the –174-G/C polymorphism and pulse wave velocity, distensibility coefficient, and pulse pressure were performed using analyses of variance. Analyses on the levels of inflammatory markers and arterial stiffness were performed using linear regression analyses. Analyses were adjusted for age, sex, mean arterial pressure, heart rate, known cardiovascular risk factors, and atherosclerosis. We found pulse wave velocity to be 0.35 m/s higher for CC-homozygotes vs. wildtype GG-homozygotes (p = 0.018) with evidence for an allele-dose effect (p trend = 0.013), and a similar pattern for pulse pressure (p trend = 0.041). No apparent consistent association with the distensibility coefficient was found. CRP levels were associated with pulse wave velocity (p = 0.007). In conclusion, the interleukin-6 –174 G/C polymorphism is associated with increased arterial stiffness and pulse pressure.     

Is physical activity a modifier of the association between air pollution and arterial stiffness in older adults: The SAPALDIA cohort study

Introduction and objectives

Air pollution and insufficient physical activity have been associated with inflammation and oxidative stress, molecular mechanisms linked to arterial stiffness and cardiovascular disease. There are no studies on how physical activity modifies the association between air pollution and arterial stiffness. We examined whether the adverse cardiovascular effects of air pollution were modified by individual physical activity levels in 2823 adults aged 50–81 years from the well-characterized Swiss Cohort Study on Air Pollution and Lung and Heart Diseases (SAPALDIA).

Arterial stiffness and pharmacological interventions--the TRanscend arterial stiffNess Substudy (TRANS study)

The degree of arterial stiffness is correlated with the risk of cardiovascular diseases and it is a powerful predictor for morbidity and mortality. Studies have shown that arterial stiffness reduction is associated with an improvement in survival. Reduction of arterial stiffness by pharmacological drugs varies according to the drugs and doses used and duration of treatment. This effect on the arteries differs among the various classes of drugs and among individual drugs in the same class. Quantification of the stiffness and other properties of the arterial wall can be used to monitor the responses to therapy in individuals with hypertension and other cardiovascular diseases. These measures can then be used as surrogate markers for the risk of clinical events. Inhibition of the renin-angiotensin system (RAS) is associated with an important decrease in cardiovascular risk. Findings from clinical trials support the hypothesis that the protective effects of RAS inhibition are partly independent from blood pressure reduction and related to several mechanisms including vascular protective effects. The aim of the TRanscend Arterial stiffNess Substudy (TRANS) is to assess the effect of an angiotensin II receptor blocker (ARB), telmisartan, on the arterial stiffness in a subgroup of patients from the Telmisartan Randomized Assessment Study in aCE iNtolerant subjects with cardiovascular Disease (TRANSCEND) trial. The TRANSCEND trial is an international, multicenter, randomized double blind placebo controlled trial oftelmisartan that enrolled patients at high risk for cardiovascular events. Some clinical baseline data of the TRANS substudy are reported. When completed, the results of the TRANS substudy will show whether the beneficial effects of treatment with telmisartan on cardiovascular outcome may be related to an improvement in arterial stiffness.     

不同肥胖测量指标对北京市社区人群动脉僵硬度的评价

目的 探讨社区人群肥胖及其不同测量指标与动脉僵硬度的相关性.方法 北京市4个社区参加体检的2664名经知情同意的研究对象(男性1379名,女性1285名),平均年龄(53.19±15.73)岁,测量身高、体重、腰围(WC)、臀围,并计算其体重指数(BMI)、腰围臀围比(WHR),应用自动PWV分析仪测定颈-股动脉脉搏波传导速度(cfPWV),分析不同肥胖指标(BMI、WC、WHR)与cfPWV的关系.结果 2664名受试者中,BMI(r=0.0829,P＜0.01)、WC(r=0.2659,P＜0.01)、WHR(r=0.2749,P＜0.01)与cfPWV均呈正相关.单因素分析结果显示:将研究对象分为A组(cfPWV≤12 m/s)、B组(cfPWN＞12 m/s),与A组相比,B组的WC、WHR高于A组,差异有统计学意义(P＜0.05).BMI在A组与B组之间差异无统计学意义(P≥0.05).逐步回归分析显示:WC是cfPWV的危险因素,独立于性别、年龄、收缩压、高密度脂蛋白胆固醇、餐后2h血糖因素存在.结论 该社区人群中肥胖是动脉僵硬度的独立危险因素,其中不同的肥胖测量指标与动脉僵硬度的相关性不同.

Abstract：

Objective The aim of this study was to investigate the relationship between obesity [measured by body mass index(BMI), waist circumference(WC), waist-to-hip ratio(WHR)]and arterial stiffness on community populations in Beijing area. Methods In a cross-sectional study of 2664 subjects(1379 men and 1285 women)aged(53.19 ± 15.73 years, mean±standard deviation), BMI, WC, WHR and other cardiovascular risk factors, were measured and carotidfemoral pulse wave velocity(cfPWV)was measured to assess the arterial stiffness. All the data were analyzed with linear correlation analysis, univariate analysis and stepwise regression method to explore the relationship between obese indexes and arterial stiffness. Results We noticed that a showed the existence of positive correlations between BMI(r=0.0829,P＜0.01)and cfPWV, WC(r=0.2659, P＜0.01)and cfPWV, WHR(r=0.2749, P＜0.01)and cfPWV, in univariate analysis,cfPWV was associated with WC≥85 cm(male)or ≥80 cm(famale)(P＜0.01), WHR≥0.90(male)or≥ 0.85(famale)(P＜ 0.01). Stepwise regression analysis revealed that WC was an independent risk factor of cfPWV, other than age, gender, systolic blood pressure, HDL-C, OGTT2h etc. Conclusion Our findings indicated that obesity was an independent risk factor of cfPWV, which was an early marker of cardiovascular and renal diseases, among community population in Beijing area. There were different relationships between obesity measurement parameters(BMI, WC, WHR)and cfPWV.