利培酮与氯氮平、舒必利治疗精神分裂症对照研究

目的：探讨利培酮治疗精神分裂症的疗效、副反应及作用机理。方法：利培酮与氯氮平、舒必利治疗精神分裂症20例,采用PANSS、ESRS量表评定疗效和副反应,用t检验,χ^2检验进行分析。结果：利培酮与氯氮平、舒必利治疗精神分裂症均有确切疗效,在改善阴性症状方面,利培酮优于氯氮平,在改善阳性症状方面,利培酮优于舒必利,利培酮副反应较少,安全性相对较高。     

氯氮平合并舒必利与利培酮治疗精神分裂症阴性症状的疗效对比

目的比较氯氮平合并舒必利与利培酮治疗精神分裂症阴性症状的疗效及安全性.方法对50例以阴性症状为主的精神分裂症患者随机分为两组:氯氮平合并舒必利为研究组(n=26)和利培酮对照组(n=24),于治疗前和治疗后12周末进行阳性和阴性症状量表(PANSS)及不良反应症状量表(TESS)评价疗效及副反应.结果 于治疗第12周末研究组总分、阳性及阴性症状,精神病性症状分比治疗前明显降低,而研究组总分、阴性症状分明显低于对照组.结论 氯氮平合并舒必利对精神分裂症具有起效快,疗效好,未出现严重副反应,能降低病人费用负担,增加长期服药依从性.     

氯氮平加舒必利与单用利培酮治疗精神分裂症疗效对照观察

比较采用氯氮平加舒必利与利培酮治疗精神分裂症疗效，结果，两组疗效相似，但利培酮组起效快，副反应轻。     

氯氮平加舒必利与单用利培酮治疗精神分裂症疗效对照观察

比较采用氯氮平加舒必利与利培酮治疗精神分裂症疗效，结果，两组疗效相似，但利培酮组起效快，副反应轻。     

利培酮(卓夫)、氯氮平治疗精神分裂症对照研究

目的 本文为探讨国产利培酮(卓夫)治疗精神分裂症的疗效与安全性.方法 将100例精神分裂症患者随机分成两组,利培酮组和氯氮平组各50例,于治疗前和治疗第2、4、6周末进行阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效及不良反应.结果两组PANSS减分率比较差异无显著性(P＞0.05)在认知因子及阴性症状方面利培酮组优于氯氮平组,差异有显著性(P＜0.05),氯氮平组不良反应广泛且较利培酮组严重.结论国产利培酮是一种有效的、安全性优于氯氮平的非典型抗精神病药物.     

舒必利与利培酮治疗精神分裂症对照分析

目的:比较舒必利与利培酮对精神分裂症的临床疗效、副作用和预后。方法:将符合入组标准的96例精神分裂症患者随机分为舒必利组和利培酮组(各48例),用阳性与阴性症状量表(PANSS)和副反应量表(TESS)评定其效疗和副反应,并追踪观察二年。结果:两组在疗效和副反应方面比较差异无显著性,二年追踪观察,从经济负担方面看,舒必利组依从性优于利培酮组。结论:舒必利疗效确切,对中、低收入家庭的患者仍是首选。     

氯氮平、舒必利与氯丙嗪治疗精神分裂症的疗效观察

目的 对比氯氮平、舒必利与氯丙嗪治疗精神分裂症的临床疗效和副作用。方法 随机对照研究。以简明精神病量表（BPRS）、阴性症状量表（SANS）、阳性症状量表（SAPS）评定疗效。以副反应量表（TESS）评定药不良反应。结果 对精神分裂症阳性症状两组疗效无显著性差异（P〉0．05）,阴性症状改善研究组优于对照组。有显著性差异（P〈0．01）,副反应．如流涎、白细胞增高有显著性差异（P〈0．05）。结论 提示氯氮平舒必利联合治疗精神分裂症阳性症状疗效近似,对阴性症状效果较好。     

氯氮平与利培酮副作用对比分析及护理对策

目的比较氯氮平和利培酮治疗精神分裂症的不良反应。方法将单用氯氮平和单用利培酮治疗的病人各50例分成两组,对在治疗过程中出现的副作用进行统计分析。结果氯氮平组出现副作用较多,主要有嗜睡、流涎、便秘、乏力、粒细胞减少或缺乏。利培酮组副反应较少,主要有锥体外系症状,发生率低。结论利培酮治疗精神分裂症不良反应较轻且少,病人治疗依从性好。氯氮平治疗精神分裂症不良反应较多且重,病人治疗依从性较差。在改善患者社会功能方面,利培酮优于氯氮平。     

利培酮与舒必利治疗首发精神分裂症的对照研究

目的　比较利培酮和舒必利治疗首发精神分裂症的疗效。方法　 70例首发精神分裂症随机分配到利培酮组和舒必利组 ,治疗 6周 ,评定PANSS和TESS。结果　利培酮治疗首发精神分裂症的疗效优于舒必利 ,副反应明显少于舒必利 ,尤其是对心电图的影响。结论　利培酮可作为一线抗精神病药。     

利培酮与氯氮平治疗首发精神分裂症的对照研究

目的：比较利培酮与氯氮平对首发精神分裂症的疗效和副作用。方法：对符合入组标准的首发精神分裂症随机分为利培酮组和氯氮平组，治疗前后用阳性和阴性症状量表(PANSS)、临床疗效总评量表(CGI)、锥体外系副反应量表(ESRS)、副反应量表(TESS)评定其疗效和副作用。结果：利培酮和氯氮平治疗首发精神分裂症的疗效相当，两组比较无显著差异，利培酮的副反应有锥体外系反应、焦虑不安、头痛等；氯氮平则为心动过速、便秘、流涎等。结论：利培酮治疗精神分裂症安全有效，疗效与氯氮平相似但副作用少。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.