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1.
Synthesis and properties of the immunotoxin CD5-ricin 总被引:1,自引:0,他引:1
G. V. Vikha L. D. Uzhinova A. Zh. Kashaeva V. V. Goshev A. V. Krylov A. Yu. Baryshnikov R. G. Vasilov 《Bulletin of experimental biology and medicine》1995,119(1):70-73
Synthesis and properties of an immunotoxin produced by conjugating ricin with a novel monoclonal antibody (IgG3 of the ICO-104
class) are described. Cytolytic activity of the synthesized immunotoxin, determined by two independent methods and expressed
in LD50, is 0.3–0.6×10−7 M. Its specificity for target cells containing the CD5 antigen is shown.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
1, pp. 76–79, January, 1995
(Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences) 相似文献
2.
It is shown that the serotonin receptors 5-HT1c, 5-HT3, and 5-HT4 and α2-adrenergic receptors are involved in the regulation of audiogenic seizures in DBA/2 mice, and that the effects of these serotonin
receptors on the duration and magnitude of convulsive activity are the opoosite of those produced by α2-adrenergic receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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4, pp. 381–383, April, 1995 相似文献
3.
N. V. Sanotskaya Ya. K. Kurambaev D. D. Matsievskii V. A. Safonov 《Bulletin of experimental biology and medicine》1995,119(3):266-269
Experiments on cats demonstrate the capacity of alert animals to compensate for disorders in pulmonary and systemic hemodynamics
caused by organophosphorus compounds. Heart rate, systemic arterial pressure, and total peripheral resistance completely normalize
on day 3 after exposure. Pulmonary vascular resistance and pulmonary blood pressure remain negligibly increased.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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3, pp. 276–279, March, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences 相似文献
4.
E. O. Fedorovskaya N. G. Tsyshkova A. M. Poverennyi A. F. Tsyb 《Bulletin of experimental biology and medicine》1994,118(1):764-766
Arbidol, a new antiviral drug, is found to suppress metastases of Lewis' pulmonary carcinoma for various methods of transplantation.
The effects of arbidol are compatible with those of the standard interferon inductor poly-I-poly-C.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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7, pp. 80–81, July, 1994 相似文献
5.
N. V. Sanotskaya Ya. K. Kurambaev D. D. Matsievskii A. A. Khusinov V. A. Safonov 《Bulletin of experimental biology and medicine》1994,117(1):14-19
Shortly (30–90 min) after an intragastric administration of the organophosphorus pesticide Anthio to cats, their cardiac output
begins to decrease and the right ventricular output decreased to a greater extent than the left. Blood is redistributed to
the greater circulation with a diminution of blood flow in the pulmonary lobar vessels.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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1, pp. 18–21, January, 1994 相似文献
6.
T. A. Gremyakova V. A. Amel'chenko G. A. Anisimov 《Bulletin of experimental biology and medicine》1995,119(1):48-51
The protective properties of recombinantSalmonella minnesota R595/pFS1 strain soon after immunization (1–3 days) are studied in a model of experimental mouse plague. Unlike the commercial
EV strainYersinia pestis vaccine produced at the Saratov Anti-Plague Institute (Mikrob Research-Manufacturing Conglomerate), the experimental recombinant
p preparation affords a high level of protection from the 1st day postvaccination, and surpasses the commercial preparation
in such parameters as LD50, mean survival time, and percentage of survivors. By the 21st day the protective indexes of both preparations are comparable.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 119, N
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1, pp. 54–57, January, 1995
Presented by A. A. Vorob'ev, Member of the Russian Academy of Medical Sciences 相似文献
7.
Wei Huang T. G. Vishnyakova A. V. Bocharov E. V. Zaitseva E. G. Frolova D. D. Sviridov V. S. Repin J. -L. Nano P. Rompal 《Bulletin of experimental biology and medicine》1994,117(1):52-55
It is shown that glucocorticoids play a key regulatory role directed toward the maintenance of an optimal level of binding
and internalization of HDL3 in hepatocytes. Their stimulatory effect on the expression of HDL receptors proves to be independent of changes in the CH
content in parenchymal cells.
Translated fromByulleten' Eksperimentalnoi Biologii i Meditsiny, Vol. 117, N
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1, pp. 50–53, January, 1994 相似文献
8.
G. V. Burlakov 《Bulletin of experimental biology and medicine》1994,118(3):949-952
The effect of lectins (phytohemagglutinin — PHA, concanavalin A — ConA,Pisum sativum lectin — PSL,Ricinus communis lectin — RCL, and pokeweed mitogen — PWM) on the cardiac cholinoceptors is studied in experiments on isolated hearts of maleRana temporaria frogs. The test lectins in concentrations from 10−23 to 10−3 are shown to exhibit cholinomimetic properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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9, pp. 252–255, September, 1994
Presented by A. D. Ado, Member of the Russian Academy of Medical Sciences 相似文献
9.
B. I. Mazhbich L. M. Nepomnyashchikh E. L. Lushnikova 《Bulletin of experimental biology and medicine》1996,121(3):296-299
Morphofunctional examinations of the lungs of rats exposed to high-altitude conditions for 3 to 300 days revealed that systolic
pulmonary hypertension observed during the entire period of study is caused by a total increase of the elastic resistance
of pulmonary arteries. Adequate bloodflow in such a case is provided by intensive work of the right-ventricular myocardium
against this resistance.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 324–327, March, 1996
Presented by V. A. Trufakin, Member of the Russian Academy of Medical Sciences 相似文献
10.
Chorionic gonadotropin is shown to alter lactate dehydrogenase and alcohol dehydrogenase activity in the pathologically altered
liver and to exert a regulatory effect on the catalytic properties of these enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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6, pp. 590–591, June, 1994
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
11.
R. F. Menzeleev A. I. Bozhkov E. N. Zvonkova Yu. M. Krasnopol'skyii V. I. Shvets 《Bulletin of experimental biology and medicine》1995,119(4):414-417
In experiments on rats subjected to partial hepatectomy and experimentally induced hepatitis it is shown that GM3 ganglioside of equine erythrocytes can enhance liver cell proliferation. The effect was also observed in experiments on a
primary hepatocyte culturein vitro; moreover, enhancement of cell proliferation did not depend on the type of sialic acid residues.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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4, pp 427–430, April, 1995 相似文献
12.
V. A. Myshkin Z. G. Khaibullina S. A. Bashkatov V. P. Krivonogov D. A. Enikeev 《Bulletin of experimental biology and medicine》1995,120(2):785-788
Three pyrimidine derivatives — methyluracil, hydroxymethacil (a new compound), and its lithium salt — were tested in model
systems of differing complexity for antioxidant properties in comparison with the well-known antioxidant ionol. Tests for
antiradical activity and for effects on spontaneous and Fe2+-ascorbate- or NADPH-dependent lipid peroxidation revealed high antioxidant activity (comparable to that of ionol) of the
hydroxymethacil lithium salt.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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8, pp. 142–144, August, 1995
Presented by G.N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
13.
O. I. Skotnikova N. S. Sergeeva E. V. L'vova V. I. Chissov I. I. Pelevina 《Bulletin of experimental biology and medicine》1994,118(5):1202-1204
Effects of γ-irradiation in a dose of 6 Gy and platidiam in a total dose of 16 mg/kg on the growth rate of transplants of
20 human pulmonary carcinomas under the renal capsules of immunodepressed mice were studied. Ten out of 11 tumors resistant
to radiation were found to be resistant to platidiam as well. On the other hand, only 10 out of 15 carcinomas resistant to
platidiam were resistant to radiation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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11, pp. 505–507, November, 1994 相似文献
14.
V. V. Yasnetsov A. N. Gromov N. M. Kiseleva D. Yu. Rusakov S. G. Batrakov A. V. Evstratov V. S. Shashkov 《Bulletin of experimental biology and medicine》1994,117(4):443-444
Cat and rat experiments show that the protein fraction isolated from blood serum of the Greenland seal has a protective activity
against motion sickness. This activity is comparable to that of the classical vestibuloprotector scopolamine and is greater
than that of diprazine. Radioligand assay of the receptor binding showed that the serum protein fraction has the highest affinity
for α2-adrenoceptors, μ-opioid, and benzodiazepine receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol 117, N
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4, pp. 444–445, April, 1994 相似文献
15.
G. I. Nepomnyashchikh E. M. Malkova L. M. Nepomnyashchikh 《Bulletin of experimental biology and medicine》1994,118(3):1014-1018
In premature neonates with the respiratory distress syndrome the vessels of the pulmonary arterial system show stereotypical
changes: dystonia with the predominance of vasoconstriction, a thickened muscular layer, and a narrowed lumen. A morphometric
index is proposed: the coefficient of nonuniformity of the medial thickness of the vascular wall, which reflects a structural
reorganization of the pulmonary vessels in different pathological processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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9, pp. 311–314, September, 1994
Presented by Yu. I. Borodin, Member of the Russian Academy of Medical Sciences 相似文献
16.
Polyanskii N. B. Binyukov V. I. Mil' E. 《Bulletin of experimental biology and medicine》1994,118(2):831-834
The effect of catalin on cross-linking in the DNA-protein system is studied after illumination with visible and UV light.
Catalin is shown to stimulate this process. The use of a hydroxylamine trap reveals that catalin (10–100 μM) induces the accumulation
of free radicals in aqueous solutions as soon as 10 minutes after irradiation. A considerable amount of O
2
-
is fixed in the medium during illumination of catalin aqueous solution. Superoxide dismutase added to the incubation medium
considerably reduced the number of recorded radicals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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8, pp. 142–144, August, 1994
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
17.
Effects of thymogen on the behavior of mice were studied, and the results obtained suggest that this immunomodulator possesses
psychostimulatory, antidepressive, and stress-protecting properties which open up new prospects for the use of thymic peptides
in psychiatry.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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2. pp. 199–200, February, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
18.
P. V. Sergeev P. A. Galenko-Yaroshevskii S. M. Lemkina Ya. V. Kostin 《Bulletin of experimental biology and medicine》1995,119(5):484-487
Pharmacological effects of strophanthin combined with the action of some antiadrenergic agents were studied on isolated frog
atria and on models of acute and subacute cardiac insufficiency in rats. The studies demonstrated appreciable differences
in the effects of anapriline, cordarone and tropaphen on strophanthin toxicity and on its chronoinotropic properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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5 pp. 502–505, May, 1995 相似文献
19.
V. B. Turovetskii N. B. Porodina A. N. Erin E. M. Molnar G. T. Sukhikh 《Bulletin of experimental biology and medicine》1995,120(6):1239-1243
The intracellular pH (pHi) of mouse peritoneal neutrophils, initially 0.2 U, drops after a 15-min incubation of these cells with a peptide extract
of fetal brain tissue. Treatment with the preparation leads to appreciable changes in the distribution of neutrophils by the
examined parameter. For macrophages, the acidifying effect of the agent and its effect on the pattern of cell distribution
in terms of pH values are far less expressed. The effects of the agent in dilutions 1∶102 and 1∶104 on the mean pHi are virtually the same.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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12, pp. 626–630, December, 1995
Presented by V. I. Kulakov, Member of the Russian Academy of Medical Sciences 相似文献
20.
M. V. Bilenko V. G. Ladygina I. A. Tarakanova 《Bulletin of experimental biology and medicine》1996,121(1):67-71
The toxic effects of H2O2, paraquat, and oxidized low density lipoproteins are more expressed on superoxide dismutase-deficientE. coli strains than on its wild-type strains, and the effect of tert-butyl-hydroperoxide is less dependent on the presence or absence
of this enzyme in the bacterium, whereas that of bleomycin does not depend on it at all. The toxicity of the agents increases
in the following series: H2O2<oxidized low density lipoproteins<tert-butyl-hydroperoxide <paraquat≪bleomycin. A culture ofE. coli strains AB 1157 and JI 132 may be used for assessing the toxic effect of prooxidants, and anE. coli JI 132 culture with oxidative stress induced by prooxidants as a test system for detecting the potential antioxidants and
assessing the mechanism of the action.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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, pp. 74–79, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献