Effect of sesame seed on lipid profile and redox status in hyperlipidemic patients

Pre-clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease. This study was designed to investigate the effects of sesame on reducing serum lipids and enhancing antioxidant capacity in 38 hyperlipidemic patients who were divided into two groups randomly. For all individuals along the 60 days of study period, the same drug treatments were considered. Intervention group patients were supposed to eat 40 g white sesame seeds daily, and instead of these calories, 240 kcal was removed from their diet. Anthropometric measurements including height, weight and body mass index (BMI) were measured. We assessed lipid profile and oxidative stress indicators such as glutathione peroxidase (GPX), superoxide dismutase (SOD) and thiobarbituric acid reactive substances (TBARS) before and after the intervention. Significant differences among and between the groups were determined by independent t-test and paired sample t-test using 13th version of statistical package for the social sciences. The results showed that the diet with sesame significantly decreased the levels of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and TC/HDL-C ratio. Lipid peroxidation (TBARS) decreased while the activities of GPX and SOD were increased. There were no significant changes in anthropometric indexes such as weight and BMI after consumption of sesame. The results suggested that sesame seed supplementation decreased serum TC, LDL-C and lipid peroxidation, and increased antioxidant status in hyperlipidemic patients.     

番茄红素对高脂血症大鼠血脂及抗氧化酶影响

目的观察番茄红素对实验性大鼠高脂血症的调节作用及抗氧化系统的影响。方法将40只纯种雄性健康Wistar按体重和血脂水平随机分成4组,分别接受正常饲料、高脂饲料、高脂饲料加番茄红素(低、高剂量分别为10,20mg/kg)灌胃处理。5周后取血测定血脂及抗氧化酶含量。结果与高脂模型组大鼠相比,给予番茄红素可降低大鼠血清总胆固醇和甘油三脂、低密度脂蛋白胆固醇的含量,升高高密度脂蛋白胆固醇,使血清和肝组织超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活力上升,丙二醛(MDA)含量降低(P<0.05)。结论番茄红素对高脂饲料饲喂的大鼠血脂水平有明显的调节作佣,可以降低高脂血症大鼠血脂水平,提高抗氧化能力,抑制脂质过氧化。     

鲢鱼寡肽对高血脂大鼠脂质代谢的调节与抗氧化作用研究

目的 研究了鲢鱼寡肽(SOP)对高血脂Wistar大鼠的杭氧化和降血脂能力的影响.方法 采用灌胃高脂乳剂方法建立实验性高胆固醉血症大鼠模型,检测血清和肝脏的甘油三酯(TG)和总胆固醉(TC)含量,分析血清和肝脏的抗氧化酶活性、丙二醛(MDA)含量和总杭氧化力.结果 SOP可以有效提高高血脂大鼠血清的TG水平(P<0.0...     

光合细菌对高脂家兔的血脂及抗氧化作用研究

目的:探讨光合细菌对高脂家兔的血脂与增强抗氧化能力的影响。方法:在采用高脂饲料建立高脂家兔模型的同时给予光合细菌。以螺旋藻为阳性对照,设立空白对照、高脂对照,观察光合细菌对家兔血清TC、TG、LDL-C含量、脂质参数H/L和AI的影响以及对家兔血中SOD活性、GSH、LPO含量和肝脏中GSH含量的作用。结果:光合细菌能显著降低高脂家兔血清TC、TG、LDL-C含量,改善H/L及AI两个脂质参数;并可显著增强高脂家兔血中SOD活性,对血及肝脏中GSH含量有明显的提高作用,同时显著降低血中LPO含量,且优于螺旋藻。结论:光合细菌对高脂家兔具有调脂及增强抗氧化能力的作用。     

番茄红素预防脂代谢紊乱的作用及机制探讨

目的探讨番茄红素预防高脂喂饲大鼠脂代谢紊乱的作用及机制。方法用高脂饲料喂养大鼠,同时,给予番茄红素灌胃,检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肝重、肝指数、脂蛋白脂酶(LPL)和肝脂酶(HL)活性;用蛋白印迹法测定低密度脂蛋白受体(LDL-R)的表达,探讨番茄红素预防高脂血症的可能机制。结果番茄红素各剂量组的血TC、TG、LDL-C肝重及肝指数显著减轻,有效地提高了LPL和HL活性,其中,高剂量组明显。同时,番茄红素可增加LDL-R的表达。结论番茄红素具有预防高脂喂饲大鼠肝组织脂代谢紊乱的作用。其机制可能是通过提高LRL和HL活性,增加LDL-R的表达,减少甘油三酯(TG)和低密度脂蛋白(LDL)在肝组织中的蓄积,从而预防肝组织脂代谢的紊乱。     

生活方式干预改善超重及肥胖青少年氧化应激状态

目的超重和肥胖已成为影响青少年健康的关键问题。本研究探讨饮食及运动干预对青少年体内氧化应激状态的影响。方法124名受试者中的93名超重及肥胖青少年年龄（13．6±0．7）岁,体重指数（BMI22．4～34．1kg／m。）随机分为四组：饮食干预组（D）、运动干预组（E）、饮食运动干预组（DE）、超重及肥胖对照组（O）。饮食方案根据研究对象的年龄及理想体重制定;运动干预为放学后1h中等强度运动,每周4次。干预周期为10周,干预前后分别进行人体测量、身体成分、代谢及氧化应激等指标检测。31名正常体重者为对照组。结果超重及肥胖组的空腹血糖、TC、LDL—C和MDA水平明显高于正常体重组（P〈0．05）,SOD水平低于正常体重组（P〈0．05）;MDA水平与体重、BMI、TC、LDL-C呈正相关（R=0．209,0．228,0．274,0．263,P〈0．05）,SOD与体重及BMI呈负相关（R=一0．334,一0．362,P〈0．05）;干预后D、E、DE组BMI、腰围、全身脂肪显著下降（P〈0．05）,D和E组的MDA水平下降（P〈0．05）;两个运动干预组的TC和LDL—C下降亦达统计学差异（P〈0．05）。结论超重青少年在糖脂代谢正常阶段体内即存在氧化应激失衡状态。为期10周的饮食和（或）运动的生活方式干预在改善青少年超重状态、调节血脂水平的同时,还可显著降低其体内的氧化应激水平。     

Hypolipidemic Effects and Safety of Lactobacillus Reuteri 263 in a Hamster Model of Hyperlipidemia

We aimed to verify the beneficial effects of probiotic strain Lactobacillus reuteri 263 (Lr263) on hypolipidemic action in hamsters with hyperlipidemia induced by a 0.2% cholesterol and 10% lard diet (i.e., high-cholesterol diet (HCD)). Male Golden Syrian hamsters were randomly divided into two groups: normal (n = 8), standard diet (control), and experimental (n = 32), a HCD. After a two-week induction followed by a six-week supplementation with Lr263, the 32 hyperlipidemic hamsters were divided into four groups (n = 8 per group) to receive vehicle or Lr263 by oral gavage at 2.1, 4.2, or 10.5 × 10⁹ cells/kg/day for 6 weeks, designated the HCD, 1X, 2X and 5X groups, respectively. The efficacy and safety of Lr263 supplementation were evaluated by lipid profiles of serum, liver and feces and by clinical biochemistry and histopathology. HCD significantly increased serum levels of total cholesterol (TC), triacylglycerol (TG) cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, hepatic and fetal TC and TG levels, and degree of fatty liver as compared with controls. Lr263 supplementation dose dependently increased serum HDL-C level and decreased serum TC, TG, LDL-C levels, LDL-C/HDL-C ratio, hepatic TC and TG levels, and fecal TG level. In addition, Lr263 supplementation had few subchronic toxic effects. Lr263 could be a potential agent with a hypolipidemic pharmacological effect.     

高脂饲料对肾病大鼠高脂血症和肾小球硬化的影响

以高脂饲料喂养阿霉素肾病大鼠观察高脂饲料对肾病大鼠内源性高脂血症和肾小球硬化的病理改变的影响。结果表明：高脂饲料能显著升高血清总胆固醇（ＴＣ）及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ），致使尿蛋白排泄量增加，肾小球内脂质沉积加重，“泡沫”细胞增多，局灶性节段性肾小球硬化（ＦＳＧＳ）范围扩大。提示高脂血症在肾小球损害发展过程中加剧对肾脏病理的恶化．     

A pilot study of open label sesame oil in hypertensive diabetics

The objective of this study was to investigate the effect of sesame oil in hypertensive diabetics medicated with atenolol (beta-blocker) and glibenclamide (sulfonylurea). This open label trial with two intervention periods comprised 22 male and 18 female patients, 45-65 years old, with mild to moderate hypertension and diabetes. Sesame oil (Idhayam Gingelly oil, V.V.V. & Sons, Virudhunagar, Tamilnadu, India) was supplied to the patients, who were instructed to use it in place of other cooking oils for 45 days. Blood pressure (BP), anthropometric measurements, plasma glucose, glycated hemoglobin (HbA1c), lipid profiles [total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol, and triglycerides (TG)], lipid peroxidation [thiobarbituric acid-reactive substances (TBARS)], electrolytes (sodium, potassium, and chloride), and enzymic (superoxide dismutase, glutathione peroxidase, and catalase) and nonenzymic (vitamin C, vitamin E, beta-carotene, and reduced glutathione) antioxidants were measured at baseline and after 45 days of sesame oil substitution. The same patients were then switched over to other oils like palm or groundnut oils as their regular oils at random for another 45 days, and the investigations were carried out again at the end. Systolic and diastolic BP decreased remarkably. When oil substitution was withdrawn, BP values rose again. Body weight, body mass index, girth of waist, girth of hip, and waist:hip ratio were reduced upon substitution of sesame oil. Plasma glucose, HbA1c, TC, LDL-C, and TG were decreased. TBARS level was reduced, while the activities of enzymic and the levels of nonenzymic antioxidants were increased. Plasma sodium levels were reduced, while potassium levels were elevated. These results indicate that substitution of sesame oil as the sole edible oil has an additive effect in further lowering BP and plasma glucose in hypertensive diabetics.     

富硒竹节人参提取物降血脂及抗氧化作用

目的观察富硒竹节人参提取物对实验性高脂血症大鼠血脂及抗氧化作用的影响。方法采用高脂饲料喂养大鼠建立高脂血症模型,富硒竹节人参提取物按2,4g/(kg·bw)给大鼠灌胃,1次/d,连续4周。4周后取血测定血脂及抗氧化酶含量。结果富硒竹节人参提取物高、低剂量组可降低大鼠血清总胆固醇(TC)和甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)的含量,升高高密度脂蛋白胆固醇(HDL-C),高剂量组作用尤其明显;可使血清总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力上升,丙二醛((MDA)含量降低,与高脂模型组比较差异有统计学意义(P<0.05或P<0.01)。结论富硒竹节人参提取物能降低高脂饲料喂养大鼠的血脂水平,提高抗氧化能力,抑制脂质过氧化。     

中老年人群血清胆固醇水平及其相关因素的研究

目的　探讨中老年“健康”人群血清总胆固醇 (TC)、高密度脂蛋白—胆固醇 (HDL- C)、低密度脂蛋白—胆固醇 (L DL- C)水平及与相关个体因素的关系。方法　随机抽取 340人 ,横断面调查方法进行问卷调查、体格检查和血脂水平测定。结果　 4 5岁以上的 340人 (男 183人、女 15 7人 )血清胆固醇水平均在正常范围内 ;女性 TC、HDL- C及 L DL- C水平均显著高于男性 (P<0 .0 5 ) ;70岁以上老人 HDL- C水平均显著高于其它年龄组。逐步回归分析显示 :显著影响 TC水平的个体因素为年龄、性别 ,影响 L DL- C的因素为年龄、性别和体重指数 (BMI) ,影响 HDL- C水平的因素为年龄、饮酒、BMI。结论　超重和肥胖、经常大量饮酒是升高血胆固醇的重要因素。健康教育和行为干预过程中应强调良好的生活方式和维持适当的体重。     

Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats

The underlying mechanisms for the detrimental consequences of a high-fructose diet in animal models are not clear. However, the possibility exists that fructose feeding facilitates oxidative damage. Thus, the aim of the present study was to assess, in weaning rats, the effect of a high-sucrose diet v. starch diet for 2 weeks on oxidative stress variables. Plasma lipid levels were measured and lipid peroxidation was evaluated by urine and plasma thiobarbituric acid-reactive substances (TBARS). The susceptibilities of several tissues to peroxidation were determined in tissue homogenates after in vitro lipid peroxidation. Antioxidant defence variables were evaluated by measuring plasma and heart vitamin E levels, and heart superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities. Higher plasma triacylglycerol (P<0.01) and TBARS (P<0.01) levels were found in rats fed the sucrose diet as compared with the starch-fed group, whereas plasma alpha-tocopherol levels were significantly decreased in the sucrose-fed group compared with the starch-fed group (P<0.01). Higher urine TBARS (P<0.01) were found in the sucrose-fed group compared with the starch-fed group, suggesting increased production of these substances from lipid peroxidation in vivo. Higher susceptibility to peroxidation in heart, thymus and pancreas was also found in the sucrose-fed group v. the starch-fed group. No statistical differences were observed for liver TBARS level between the two groups. Heart SOD activity was significantly decreased (P<0.001) in the sucrose-fed group compared with the starch-fed group, whereas heart vitamin E level and GPX activity were not different between the groups. However, the in vitro generation of superoxide radical in heart homogenate, measured by electron spin resonance detection and spin trapping, was not increased in the sucrose-fed group compared with starch-fed rats. Altogether, the results indicate that a short-term consumption of a high-sucrose diet negatively affects the balance of free radical production and antioxidant defence in rats, leading to increased lipid susceptibility to peroxidation.     

富铬酵母降低高血脂作用的研究

本文观察富铬酵母（合铬４０ｍｇ／ｋｇ）对高脂血症患者６３人，Ⅱ型糖尿病合并高脂血症患者８２人及血脂正常的Ⅱ型糖尿病人３５人血脂的作用。每日补充２．５ｇ富铬酵母（相当于１００μｇ酵母铬）３个月。以５０例健康成人的有关指标作为对照。结果表明：ａ．６３例高脂血症患者血请铬显著低于健康人（分别为３．５８和５．２７ｎｍｏｌ／Ｌ），服用富铬酵母后，血清铬升高（由３．５８升至６．１０ｎｍｏｌ／Ｌ）。高ＴＣ患者的ＴＣ和高ＴＧ患者的ＴＧ降低，分别为６．３５与５．３４ｍｍｏｌ／Ｌ和３．０５与２．２４ｍｍｏｌ／Ｌ，且ＬＤＬ－Ｃ降低，ＨＤＬ－Ｃ升高，与服药前比较均有显著性差异。降脂效果优于月见草油。合并Ⅱ型糖尿病的高脂血症患者服用富铬酵母后，血清Ｃｒ、ＴＣ、ＴＧ、ＬＤＬ－Ｃ和ＨＤＬ－Ｃ也有相似的变化，且有显著性差异。ｂ．富铬酵母（少数人加服２．５～５ｍｇ优降糖辅助）治疗Ⅱ型糖尿病合并高脂血症患者，其降脂降糖效果优于单纯使用口服降糖药，且过氧化脂质较治疗前显著降低（由６．９０降至５．５１μｍｏｌ／Ｌ）。血脂正常的Ⅱ型糖尿病人服用富铬酵母后除空腹血糖显著降低及ＨＤＬ－Ｃ显著升高外，ＴＣ、ＴＧ及ＬＤＬ－Ｃ均无明显变化。ｃ．富铬酵母对高脂?     

不同食用油和调合油对大鼠血脂影响的研究

观察６种食用油和４种调合油与高胆固醇同时摄入时大鼠血脂的变化。结果表明，饲以猪油，花生油，茶油可使大鼠血清ＴＣ，ＬＤＬ－Ｃ，ＴＣ／ＨＤＬ－Ｃ比值明显升高，ＨＤＬ－Ｃ下降；豆油次之，但有升ＴＧ作用油和牛油各项指标处于相对较低水平。４种调合油对大鼠ＴＣ，ＴＧ，ＴＣ／ＨＤＬ－Ｃ比值的升高和ＨＤＬ－Ｃ降低有明显抑制作用，能维持在实验前的正常水平，有利于维持大鼠脂质代谢。     

维生素E等药物抗动脉粥样硬化的作用

目的　探寻维生素E、氨氯地平、辛伐他汀抗动脉粥样硬化 (AS)的共同机制。方法　在高胆固醇饮食基础上建立兔AS模型 ,随机分组 ,检测各组兔主动脉AS面积、全血超氧化物歧化酶 (SOD)活力、血清丙二醛 (MDA)含量及血清脂质浓度。结果　与模型组相比 ,3组用药组主动脉AS面积均显著减少 (P <0 0 1) ,SOD活力明显升高 (P<0 0 1) ,MDA含量下降 (P <0 0 1) ,且以辛伐他汀组变化最显著。辛伐他汀组血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)、甘油三脂 (TG)较模型组显著降低 (P <0 0 1)。结论　脂质过氧化物减少和SOD活力增加可能是维生素E、氨氯地平、辛伐他汀抗AS作用的共同机制。     

菰米对高脂诱导脂代谢紊乱大鼠肝脏脂毒性的作用

目的观察由米面和菰米等不同构成饲料对高脂饲料大鼠血脂、游离脂肪酸(FFA)和瘦素(leptin)水平的作用,探讨菰米对高脂饲料诱导的脂代谢紊乱大鼠血脂及肝脏脂毒性的作用。方法 44只雄性SD大鼠随机分为阴性对照组、高脂模型组、米面组和菰米组;以相应饲料连续喂养8周,测定各组大鼠体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、FFA和leptin等指标,同时肝脏组织行病理切片检查。结果与阴性对照组相比,高脂模型组和米面组大鼠的血清TC、TG、FFA和leptin水平显著上升(P<0.05),HDL-C水平显著降低(P<0.05),肝脏发生脂肪变性;与高脂模型组和米面组相比,菰米组大鼠的血清TC、TG、FFA水平显著下降(P<0.05),HDL-C水平显著升高(P<0.05),leptin水平稍低于高脂模型组和米面组,但无显著性差异,肝脏脂肪变性程度显著减轻。结论菰米具有降低高脂饲料诱导的脂代谢紊乱大鼠血脂水平和肝脏脂毒性的作用。     

浒苔多糖降血脂及抗脂质过氧化作用

目的探讨浒苔多糖对大鼠的血脂影响及抗脂质过氧化作用。方法利用高脂饲料建立高脂血症模型,给予不同剂量的浒苔多糖进行干预,测定血脂水平、计算动脉粥样硬化指数(AI),同时测定超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)含量,并切片观察大鼠肝脏细胞。结果低、中、高剂量浒苔多糖均可显著降低高脂血症实验大鼠的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和丙二醛含量(P<0.01),其最大降幅分别为41.7%,79.3%,59.6%和55.0%;中、高剂量浒苔多糖可显著降低AI(P<0.01),其最大降幅为79.7%;低、中、高剂量浒苔多糖均可显著提高高密度脂蛋白胆固醇(HDL-C)含量和SOD、GSH-Px活性(P<0.01),其最大增幅分别为66.6%,63.8%和48.9%;同时,浒苔多糖还可降低高脂血症大鼠肝细胞的脂肪变性程度。结论浒苔多糖对实验性高血脂症模型大鼠具有降血脂、抗脂质过氧化及预防脂肪肝的作用。     

Effect of dietary cholesterol and fat levels on lipid peroxidation and the activities of antioxidant enzymes in rats

The aim of this study was to investigate the effect of dietary fat levels, with or without cholesterol, on lipid peroxidation and the activities of antioxidant enzymes in rats. Thirty-two Wistar rats aged 4 weeks were divided into 4 groups and fed high (20%; HF) or low (5%; LF) fat, with or without 1% cholesterol, for 6 weeks. Cholesterol feeding resulted in significantly higher concentrations of serum cholesterol, but lowered serum triacylglycerol levels. Cholesterol feeding also led to markedly decreased levels of hepatic thiobarbituric acid reactive substances (TBARS) and lower activities of hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase, and glucose-6-phosphate dehydrogenase (G6PDH) when compared with cholesterol-free counterparts in both HF and LF diets. On the other hand, rats fed high-fat diets showed increased serum and liver TBARS, but decreased hepatic GSH-Px, SOD, and G6PDH activities. Hepatic catalase activity was lower in rats fed cholesterol-containing diets, but higher in rats fed high-fat diets, and interaction existed between cholesterol and fat feeding. These results suggested that dietary cholesterol might delay lipid peroxidation and decrease the activities of the hepatic antioxidant enzymes. The degree of lipid peroxidation was also influenced by dietary fat levels.     

Effects of ��-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats

α-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks. Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC). Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and lipid peroxidation products, malondialdehyde (MDA) concentrations, were analyzed in serum, skin, and liver. Blood lipid profiles were measured, including triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05). Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups. Serum and skin MDA levels in the ALA and LC groups were lower than those in the CON group (P < 0.05). Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05). The HDL-C level in the LC group was higher than that in any other group (P < 0.05). LDL-C level was lower in the ALA + LC and LC groups than that in the CON group (P < 0.05). Thus, α-lipoic acid and L-carnosine supplementation increased antioxidant activity, decreased lipid peroxidation in the serum, liver, and skin of rats and positively modified blood lipid profiles.     

两种富硒植物对大鼠高脂血症和脂质过氧化作用的影响

目的比研究富硒绿羽和富硒蒜抑制高脂血症和脂质过氧化作用效果。方法取Wistar大鼠60只,经适应性喂养1w以后,按照体重队列随机分为6组,分别为基础饲料对照组、高脂饲料对照组、富硒蒜治疗组、富硒绿羽治疗组、富硒蒜预防组和富硒绿羽预防组。除基础饲料对照组外,其余5组均喂饲高脂饲料。富硒植物处理组以每日300μgSe/kgbw植物硒分别灌胃12w(预防组)和4w(治疗组),预防组从第2w、治疗组从第3个月开始植物硒灌胃,基础饲料对照组以同等体积蒸馏水灌胃。3个月后,处死大鼠,测定血浆、红细胞和肝脏丙二醛(MDA)、血清总胆固醇(TC)、甘油三酯TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量以及全血、肝脏谷胱甘肽过氧化物酶(GPX)活性。结果与高脂饲料对照(HFD)组比较,富硒植物处理组大鼠的血清TC、TG、LDL-C含量和动脉粥样硬化指数(AI)下降,HDL-C水平显著升高,预防组大鼠血脂的变化幅度显著大于治疗组。富硒植物处理组全血和肝脏GPX活性显著提高,血浆、红细胞和肝脏的MDA含量变化复杂,以富硒蒜治疗组MDA含量降低最明显。结论富硒绿羽和富硒蒜具有控制高血脂症发生发展能力,预防效果优于治疗效果。短期摄入富硒蒜清除组织MDA能力最高。