深圳地区21 671例不同性别年龄体重指数与血脂、脂肪肝关系的探讨

目的探讨不同性别、年龄BMI与血脂、脂肪肝的关系.方法对2002年深圳地区企事业单位的21 671例健康体检者按体重指数(BMI)分为正常组、超重组、肥胖组(Ⅰ度肥胖组、Ⅱ度肥胖组)进行腹部B超及血脂测定,并对不同性别、年龄的结果进行统计分析.结果受检者中男性肥胖症的发病率41.82%,女性肥胖症的发病率20.60%,总体33.76%.肥胖组的高胆固醇(TC)、高甘油三脂(TG)及脂肪肝的检出明显高于超重组也高于正常体重组(P＜0.0001).肥胖组的高脂血症并发脂肪肝的检出率明显高于超重组也高于正常组(P＜0.0001).结论肥胖是导致高TC,高TG,脂肪肝的主要因素.肥胖伴发高脂血症又是引发脂肪肝的重要因素.其中肥胖伴高TG引发脂肪肝的发病率更高.     

高血压患者体重指数与脂肪肝相关性探讨

目的　探讨高血压患者体重指数与脂肪肝、血脂及血压之间的关系。方法　对 13 5例高血压患者按体重指数(BMI)分为 3组 :正常体重组 (BMI=2 0～ 2 3 ) ,超重组 (BMI=2 4～ 2 7) ,肥胖组 (BMI≥ 2 8) ,所有患者均测血脂、血压 ,并行腹部 B超检查。结果　肥胖组较正常组总胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白 (L DL )有明显差异(P<0 .0 5 ) ;肥胖组与超重组比较 ,仅 TC有差异 (P<0 .0 5 )。 BMI与脂肪肝的发生率呈正相关 (rs=0 .911,P<0 .0 1) ,且肥胖组中中、重度脂肪肝的发生率较正常组明显增多 (P<0 .0 1)。收缩压 (SBP)及舒张压 (DBP)均随着BMI的增加而明显增高 :肥胖组高于超重组 ,超重组高于正常组 ,差异有显著性 (P<0 .0 0 1及 P<0 .0 5 )。结论　合并超重的高血压患者应积极减重 ,并控制在正常范围 ,对降低血压、预防冠心病及脂肪肝均有重要意义     

糖尿病体重指数与脂肪肝相关性分析

目的探讨糖尿病患者体重指数与脂肪肝的相关性。方法选取2012年5月—2013年12月到该院进行健康体检的50例糖尿病患者作为研究对象,测算患者的体重指数,且检测患者并发脂肪肝的情况,计算患者的肥胖率和脂肪肝检出率。肥胖率=(偏胖患者例数+肥胖患者例数)/总例数×100%,脂肪肝检出率=脂肪肝例数/总例数×100%。比较糖尿病并脂肪肝患者和无脂肪肝糖尿病患者的体重指数等。结果肥胖率为76%,且糖尿病并肥胖的患者多见于2型糖尿病。脂肪肝患病率为42%。糖尿病并脂肪肝患者和无脂肪肝糖尿病患者在疾病分型、体重指数、腰围肥胖等方面的差异有统计学意义(P<0.05)。结论 2型糖尿病患者并发脂肪肝的概率高于1型糖尿病患者,而且糖尿病患者的体重指数和腰围越大,并发脂肪肝的可能性越大,即体重指数超标、腰围肥胖的糖尿病患者更易并发脂肪肝。     

152例高血压病病人体重指数与脂肪肝的关系分析

高血压病及肥胖是当今发病率较高的两种疾病,高血压病病人常伴有脂肪代谢紊乱和脂肪肝,现将152例高血压病病人的体重指数、血脂与脂肪肝的关系分析,以期探讨其间的相关性.     

广西机关干部脂肪肝患者血脂、血糖、血压及体重指数分析

目的了解广西机关干部脂肪肝患病情况及与血脂、血糖、血压、体重指数的关系,为控制和预防心脑血管疾病提供理论依据。方法对广西58家机关事业单位2337名（男1395人,女942人）23～89岁干部职工和离退休人员测量身高、体重、血压、心电图、B超、血尿酸、血脂、血糖。根据测量结果将研究对象分为脂肪肝组（957例）和非脂肪肝组（1380例）,分别进行统计比较。结果 （1）检出脂肪肝957例,占调查人数40.9%。脂肪肝组中男性（66.0%）多于女性（34.0%）;（2）脂肪肝组血尿酸、总胆固醇、甘油三酯、空腹血糖和体重指数高于非脂肪肝组（P〈0.05）;（3）脂肪肝合并高血压患病人数明显高于非脂肪肝组（P〈0.05）;（4）脂肪肝组体重指数（BMI）≥24kg/m2782人,占81.7%,明显高于非脂肪肝组（P〈0.05）。结论脂肪肝检出率较高,脂肪肝患者多伴有高血脂、高血压、高血糖和高尿酸。     

电针疗法对肥胖型非酒精性单纯性脂肪肝患者体重指数的影响

目的：观察电针疗法对非酒精性单纯性脂肪肝（NAFL）患者体重指数的影响。方法：将60例肥胖型NAFL患者随机分为电针治疗组和普通针刺对照组,两组患者均在调整饮食、适量运动的基础上治疗3个月。结果：两组患者的体重、体重指数、腰围、臀围均较治疗前下降（P﹤0.01）,治疗组患者体重指数、腰臀比值与对照组比较差异有显著性意义（P﹤0.05）。结论：电针和普通针刺均可降低肥胖型NAFL患者的体重、体重指数、腰围、臀围,电针效果明显优于普通针刺。     

体重指数与血液流变学关系的探讨

作者分析868名中老年人体重指数与血液流变学的相关系数,结果体重指数与全血粘度、红细胞压积、血清总胆固醇和β-脂蛋白含量成正相关关系,提示肥胖者血液粘度和血脂高于正常人,认为肥胖者的高血脂可引起血液粘度增高,而血液粘度增高是引起冠心病、高血压病、糖尿病等疾病的重要原因之一。     

血浆瘦素与体重指数和脂肪分布的关系

目的探讨血浆瘦素水平与体重指数和脂肪分布的关系。方法对100例肥胖者(男性52例,女性48例)和71非肥胖者(男性38例,女性33例)用免疫放射法测定血浆瘦素水平,测量身高、体重,计算体重指数(BMI)。对其中19例肥胖者(男12例,女7例),15例非肥胖者(男6例,女9例)经CT扫描测量腹部内脏和皮下脂肪面积,分析瘦素与肥胖程度和脂肪分布的关系。结果血浆瘦素水平性别差异显著(P<0.001),女性是男性的2～3倍;瘦素与体重指数呈正相关(男r=0.6772,P<0.01;女r=0.7191,P<0.01)。经CT扫描测量皮下和内脏脂肪面积,瘦素水平与皮下脂肪面积的正相关(r=0.8238,P<0.01),与腹部内脏脂肪面积无明显相关性(r=0.2118,P>0.05)。结论肥胖者血浆瘦素升高,瘦素水平不仅与肥胖程度有关,还与脂肪分布有关。     

中国成人体重指数和腰臀围比值分布特征的探讨

目的 探讨中国成人体重指数（ＢＭＩ）和腰臀围比值（ＷＨＲ）的分布特征。方法 从１９９４年全国糖尿病防治协作组资料库中选取１６３５４例具有完整糖耐量试验（ＯＧＴＴ）资料的中国成人（≥２５岁）,按不同性别、不同年龄段（２５～３４岁,３５～５４岁,５５～６４岁,≥６５岁）、不同血糖水平和不同纬度地区（北部、中部和南部）分组进行统计分分析。结果 总体人群男女两性的ＢＭＩ均为２４．３ｋｇ／ｍ＾２以不同年龄段     

650例男性体重指数与高脂血症的相关性分析

目的探讨25岁～60岁男性超重及肥胖与空腹血胆固醇(TC)、三酰甘油(TG)的关系.方法分别测量650名受检者的身高、体重和空腹血胆固醇、三酰甘油水平,计算体重指数(BMI),根据有无高血脂分组,并进行分析.结果体重指数与空腹血胆固醇、三酰甘油呈正相关,并与三酰甘油相关性相对密切.结论超重和肥胖是引起高脂血症的危险因素之一.     

Impact of body mass index in liver transplantation for nonalcoholic fatty liver disease and alcoholic liver disease

Background

This study evaluates long-term outcomes and body mass index (BMI) following liver transplantation (LT) for non-alcoholic fatty liver disease (NAFLD) in comparison with alcoholic liver disease (ALD).

Associations between body mass index and mortality in acute-on-chronic liver failure patients

Introduction and objectivesThe association between the level of body mass index (BMI) and the mortality of patients with critical liver disease remains unclear. This study aimed to examine the association between BMI and hospital mortality of patients with acute-on-chronic liver failure (ACLF).MethodsClinical data from 146 ACLF patients were collected and analyzed. BMI was categorized into three groups: lower BMI (<18.5 kg/m²), normal BMI (18.5–24.9 kg/m²), and overweight (25.0–32.0 kg/m²). BMI and laboratory parameters were measured one day before, or on the day of the start of the treatment. Values of BMI and laboratory parameters were compared between survivors and non-survivors, and then hospital mortality rates were compared among patients with different BMI levels.ResultsThe prognosis of ACLF patients was significantly correlated with international normalized ratio (INR), albumin and BMI. The ACLF patients with low albumin level and high INR values tend to have a high mortality rate. Also, survival time was significantly shorter in the ACLF patients with lower BMI, while patients with normal and overweight values had longer survival time.ConclusionsA graded association between BMI and hospital mortality with a strong significant trend was found in ACLF patients in China.     

Benefit of laparoscopic liver resection in high body mass index patients

AIM: To explore the impact of body mass index(BMI) on surgical outcomes in patients undergoing laparoscopic liver resection(LLR).METHODS: From January 2010 to February 2015, sixty-eight patients who underwent primary partial liver resection in our institute were retrospectively reviewed. Surgical outcomes of LLR were compared with those of open liver resection(OLR). In addition, we analyzed associations with BMI and surgical outcomes.RESULTS: Among 68 patients, thirty-nine patients underwent LLR and 29 were performed OLR. Significant difference in operation time, blood loss, and postoperative hospital stay was observed. There were no signi ficant di fferences in mortali ty and morbidity in two groups. Twenty-two patients(32.4%) were classified as obese(BMI ≥ 25). A statistically significant correlation was observed between BMI and operation time, between BMI and blood loss in OLR, but not in LLR. The operation time and blood loss of OLR were significantly higher than that of LLR in obese patients. Open liver resection and BMI were independent predictors for prolonged operation time and increased blood loss in multivariate analysis.CONCLUSION: The present study demonstrated that BMI had influenced to surgical outcomes of OLR. LLR was less influenced by BMI and had great benefit in obese patients.     

Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index

AIM:To investigate whether central obesity is associated with nonalcoholic fatty liver disease(NAFLD) formation after adjusting for general obesity.METHODS:The online databases Pub Med,EMBASE,and ISI Web of Science were searched for studies estimating the influence of central obesity on NAFLD occurrence published through April 2014.Studies that did not adjust for body mass index(BMI) were excluded.In addition,the independent effect of BMI was also assessed with the included studies.The pooled effect sizes and 95% confidence intervals(CIs) were calculated using random- or fixed-effects models based on the degree of heterogeneity.Furthermore,subgroup analyses,meta-regression,sensitivity analyses,and publication bias were performed.RESULTS:Twenty eligible studies were identified.The summary odds ratio(OR) values per-unit increase in waist circumference(WC) and BMI for NAFLD formation were 1.07(95%CI:1.03-1.10,I2 = 73.9%,n = 11 studies) and 1.25(95%CI:1.13-1.38,I2 = 88.7%,n = 11 studies),respectively.When the indices were expressed as binary variables(with the non-obesity group as reference),the pooled OR in WC,waist-tohip ratio,and BMI were 2.34(95%CI:1.83-3.00,I2 = 41.8%,n = 7 studies),4.06(95%CI:1.53-10.79,I2 = 65.7%,n = 3 studies),and 2.85(95%CI:1.60-5.08,I2 = 57.8%,n = 5 studies),respectively.Using the same studies as the latter(n = 5),pooled OR in WC was 3.14(95%CI:2.07-4.77),which is greater than that in BMI.CONCLUSION:Central obesity may pose a greater threat to national health than general obesity,although both are independently associated with increased risk of NAFLD.     

非酒精性脂肪性肝病严重程度与腹腔内脂肪面积、身体质量指数及腰围的相关性分析

目的研究非酒精性脂肪性肝病（NAFLD）严重程度与腹腔内脂肪面积（VAT）、身体质量指数（BMI）及腰围（WC）的相关性。方法 127例NAFLD病例,根据彩超脂肪变严重程度分为轻、中、重三组,其中轻度61例、中度45例、重度21例,选择21例同期就诊的非脂肪肝患者作为对照。所有研究对象均由专人测量身高、体重、WC,接受肝脏超声波检查及肝功能等检测,并接受腹部CT扫描,测量VAT、腹壁皮下脂肪面积（SAT）、腹部脂肪总面积（TA）。计量资料呈正态分布且方差齐性者以单因素方差分析比较组间差异,方差不齐者以ANOVA（Welch法）比较,否则改用非参数检验（Kruskal-Wallis H检验）。计数资料采用χ2检验进行组间比较。组间比较差异有统计学意义者再行两两比较。双变量正态分布资料采用Pearson相关分析,不服从双变量正态分布或等级变量资料相关性采用Spearman相关分析。结果各组年龄、性别差异无统计学意义（P均〉0.05）,各组WC、VAT、TA、SAT、BMI、AST、ALT、GGT差异有统计学意义（P均〈0.05）。NAFLD严重程度与BMI、WC、VAT、SAT、TA呈显著正相关,r分别为0.467（P=0.000）、0.503（P=0.000）、0.473（P=0.000）、0.280（P=0.001）、0.465（P=0.000）。结论控制体重,尤其是中心性肥胖者,是预防NAFLD的重要措施之一。     

Atherogenic index of plasma combined with waist circumference and body mass index to predict metabolic-associated fatty liver disease

BACKGROUNDEarly identification of metabolic-associated fatty liver disease (MAFLD) is urgent. Atherogenic index of plasma (AIP) is a reference predictor of obesity-related diseases, but its predictive value for MAFLD remains unclear. No studies have reported whether its combination with waist circumference (WC) and body mass index (BMI) can improve the predictive performance for MAFLD.AIMTo systematically explore the relationship between AIP and MAFLD and evaluate its predictive value for MAFLD and to pioneer a novel noninvasive predictive model combining AIP, WC, and BMI while validating its predictive performance for MAFLD.METHODSThis cross-sectional study consecutively enrolled 864 participants. Multivariate logistic regression analysis and receiver operating characteristic curve were used to evaluate the relationship between AIP and MAFLD and its predictive power for MAFLD. The novel prediction model A-W-B combining AIP, WC, and BMI to predict MAFLD was established, and internal verification was completed by magnetic resonance imaging diagnosis.RESULTSSubjects with higher AIP exhibited a significantly increased risk of MAFLD, with an odds ratio of 12.420 (6.008-25.675) for AIP after adjusting for various confounding factors. The area under receiver operating characteristic curve of the A-W-B model was 0.833 (0.807-0.858), which was significantly higher than that of AIP, WC, and BMI (all P < 0.05). Subgroup analysis illustrated that the A-W-B model had significantly higher area under receiver operating characteristic curves in female, young and nonobese subgroups (all P < 0.05). The best cutoff values for the A-W-B model to predict MAFLD in males and females were 0.5932 and 0.4105, respectively. Additionally, in the validation set, the area under receiver operating characteristic curve of the A-W-B model to predict MAFLD was 0.862 (0.791-0.916). The A-W-B level was strongly and positively associated with the liver proton density fat fraction (r = 0.630, P < 0.001) and significantly increased with the severity of MAFLD (P < 0.05).CONCLUSIONAIP was strongly and positively associated with the risk of MAFLD and can be a reference predictor for MAFLD. The novel prediction model A-W-B combining AIP, WC, and BMI can significantly improve the predictive ability of MAFLD and provide better services for clinical prediction and screening of MAFLD.