积雪苷霜软膏治疗慢性湿疹50例临床疗效观察

慢性湿疹是一种常见皮肤病,病因复杂,外用药一般以激素制剂为主,由于此病反复发作,经常或长期外用激素,易产生副作用。我们试用积雪苷霜软膏(上海现代制药股份有限公司生产),治疗慢性湿疹,取得较好的疗效,现报告如下。     

积雪苷霜联合胶原贴敷治疗黄褐斑疗效观察

目的观察积雪苷霜联合胶原贴敷治疗黄褐斑的疗效及安全性。方法治疗组45例用积雪苷霜均匀涂抹于患部,轻轻揉搓至完全吸收,3次/d,晚上涂抹30 min后,将胶原贴敷贴于面部15 min;对照组42例每晚将维A酸乳膏均匀涂抹于患部,轻轻揉搓至完全吸收。两组均4周为1疗程。结果 2疗程后,两组有效率比较差异有统计学意义(P0.05),且不良反应发生率治疗组低于对照组(P0.05)。结论积雪苷霜联合胶原贴敷治疗黄褐斑疗效好、安全性高、依从性好,可做为黄褐斑的一种治疗方案。     

低能量密度2 940 nm像素激光联合积雪苷治疗黄褐斑的疗效观察

目的 观察低能量密度2 940 nm像素激光联合积雪苷治疗黄褐斑的疗效及不良反应.方法 24例黄褐斑患者接受4次能量密度为400～500 J/cm2的2 940 nm像素激光治疗,并于术后外用积雪苷霜.于联合治疗12周时及治疗结束后6个月时由医生对治疗效果进行评估;由患者进行满意度评估.结果 24例患者中21例完成临床试验.联合治疗12周时及治疗结束后6个月时,总有效率分别为52.4％和47.6％;患者满意率分别为61.9％和57.1％.结论 低能量密度2 940 nm像素激光术后联合积雪苷霜治疗黄褐斑安全有效。     

高能超脉冲二氧化碳激光治疗睑黄瘤30例

睑黄瘤是发生于眼睑的最常见的扁平黄瘤 ,常对称发生于双侧内眦 ,不能自行消退 ,严重影响美容。过去用三氯醋酸、二氧化碳激光、冷冻、手术等传统方法治疗 ,不但难度大 ,深浅度难以掌握 ,而且效果不理想。我科于 2 0 0 0年 7月至今采用高能超脉冲二氧化碳激光治疗睑黄瘤 3 0例 ,取得满意的效果 ,现报告如下。1　临床资料　 3 0例患者均来自本院门诊 ,男 3例 ,女 2 7例 ,年龄 40～ 60岁 ,病灶从米粒到蚕豆大小不等。2　治疗方法　所有患者均采用ＸＨ ＣＯ2 2 0 0 0型高能超脉冲二氧化碳激光美容系统治疗 ,术前照相为评价资料。用 5 %碘伏常规…     

二氧化碳激光结合氦氖激光治疗尖锐湿疣创面愈合的疗效观察

1　临床资料　100例均为本科门诊患者,男 73例,女 27例,年龄 23~54岁。平素体健,初次发病,疣体单发于外生殖器、会阴及肛门周围,疣体大小为 4. 0cm×2. 5cm×3. 5cm~10. 0cm×8. 5cm×4. 5cm,无糜烂、渗出。临床均诊断为尖锐湿疣(CA)。2　治疗方法　100例患者先采用二氧化碳激光切除疣体,皮损数目多或面积大者,可分次手术,间隔时间为 1周。术后静滴抗生素 1周预防感染; 1∶5 000高锰酸钾溶液坐浴, 2次 /d,至创面愈合;同时肌注干扰素 300万u, 1次 /d,共 10次。随机对50例患者采用氦氖激光照射手术部位 10min,剂量 0. 5J/cm2, 1次 /d。观察…     

超脉冲CO2激光结合自体表皮移植治疗白癜风

目的 探讨CO2激光结合自体表皮移植治疗白癜风的临床疗效。方法 对1605例白癜风患者进行自体表皮移植治疗，共植皮30660片，其中局限型782例12151片，节段型319例8221片，泛发型226例7376片，散发型278例2912片。采用发疱取皮法，受皮区采用CO2激光汽化创面形成，治疗8周后判断疗效。结果 治愈率79．04％，有效率13．17％，总有效率92．21％。以局限型和散发型效果最好，泛发型效果较差，身体各部以面部效果最佳，胸背部次之，眉区及发际最差。结论 超脉冲CO2激光辅助自体表皮移植治疗白癜风具有操作简单、方便，手术时间短，出血少，皮片易存活，治愈率高的优点，值得临床推广。     

超脉冲CO_2激光配合红光治疗臭汗症120例疗效观察

目的观察超脉冲CO2激光配合红光治疗臭汗症的临床效果。方法对60例臭汗症患者采用超脉冲CO2激光配合红光治疗（治疗组）,并与同期60例单纯行超脉冲CO2激光治疗效果（对照组）进行比较。结果治疗组有效率（83.3%）明显高于对照组（53.3%）。结论超脉冲CO2激光配合红光治疗臭汗症简单易行,术后恢复快,愈合时间短,很少遗留瘢痕,患者容易接受,值得临床应用。     

Q开关532nm激光和超脉冲二氧化碳激光治疗脂溢性角化病临床观察

目的观察Q开关532nm激光及超脉冲二氧化碳激光治疗脂溢性角化病的疗效。方法采用Q升关532nm激光和超脉冲二氧化碳激光,根据皮损形态治疗135例患者,共计307处戍损。每次治疗4周后随访,回顾性分析治疗效果和不良反应。结果262处皮损痊愈,治愈率85.3％;38处皮损显效,有效率97．7％。暂时性色素沉着31例（10．1％）。结论根据皮损形态分别使用Q开关532nm激光及超脉冲二氧化碳激光治疗脂溢性角化病安全有效,可在临床推广应用。     

二氧化碳激光联合包皮环切治疗尖锐湿疣疗效观察

男性尖锐湿疣（CA）患者，尤其合并包皮过长者，单纯激光手术容易复发。为了寻找一种更有效的治疗方法，我科室从2006年5月-2007年5月对86例包皮过长合并尖锐湿疣患者，分别采用激光烧灼联合二氧化碳（CO2）激光包皮环切和仅行激光烧灼两种方法进行治疗，并进行疗效对比观察分析，报告如下。     

超脉冲CO_2点阵激光与微针治疗面部痤疮凹陷性瘢痕的疗效对比

目的探讨超脉冲CO_2点阵激光与微针对面部痤疮凹陷性瘢痕的临床疗效。方法选取120例痤疮凹陷性瘢痕患者,随机数字表法分为2组,观察组患者(60例)给予超脉冲CO_2点阵激光治疗,对照组患者(60例)给予微针治疗,观察并记录2组患者临床疗效,治疗前后的视觉模拟评分(VAS)评分及治疗期间不良反应情况,评价超脉冲CO_2点阵激光对面部痤疮凹陷性瘢痕的临床疗效。结果治疗前,2组患者VAS评分差异无统计学意义(P0.05);治疗后,2组温哥华瘢痕量表(VSS)评分均明显降低(P0.05)。与对照组相比,2组VAS评分差异无统计学意义(P0.05)。与对照组相比,观察组治疗有效率较高(P0.05),且观察组治疗总费用明显高于对照组(P0.05),治疗期间,观察组不良反应率发生率高于对照组(P0.05)。结论超脉冲CO_2点阵激光和微针治疗均对痤疮凹陷性瘢痕具有较好的治疗效果,超脉冲CO_2点阵激光疗效更佳,但治疗后不良反应较多,需提前预防,相比之下,微针治疗不良反应较低。     

Efficacy of Punch Elevation Combined with Fractional Carbon Dioxide Laser Resurfacing in Facial Atrophic Acne Scarring: A Randomized Split-face Clinical Study

Background:

A number of treatments for reducing the appearance of acne scars are available, but general guidelines for optimizing acne scar treatment do not exist. The aim of this study was to compare the clinical effectiveness and side effects of fractional carbon dioxide (CO₂) laser resurfacing combined with punch elevation with fractional CO₂ laser resurfacing alone in the treatment of atrophic acne scars.

Materials and Methods:

Forty-two Iranian subjects (age range 18–55) with Fitzpatrick skin types III to IV and moderate to severe atrophic acne scars on both cheeks received randomized split-face treatments: One side received fractional CO₂ laser treatment and the other received one session of punch elevation combined with two sessions of laser fractional CO₂ laser treatment, separated by an interval of 1 month. Two dermatologists independently evaluated improvement in acne scars 4 and 16 weeks after the last treatment. Side effects were also recorded after each treatment.

Results:

The mean ± SD age of patients was 23.4 ± 2.6 years. Clinical improvement of facial acne scarring was assessed by two dermatologists blinded to treatment conditions. No significant difference in evaluation was observed 1 month after treatment (P = 0.56). Their evaluation found that fractional CO₂ laser treatment combined with punch elevation had greater efficacy than that with fractional CO₂ laser treatment alone, assessed 4 months after treatment (P = 0.02). Among all side effects, coagulated crust formation and pruritus at day 3 after fractional CO₂ laser treatment was significant on both treatment sides (P < 0.05).

Conclusion:

Concurrent use of fractional laser skin resurfacing with punch elevation offers a safe and effective approach for the treatment of acne scarring.     

308nm准分子激光治疗面部局限型稳定期白癜风患者不同分区的疗效

目的 总结和分析面部局限型稳定期白癜风不同分区的疗效.方法 回顾性分析我科于2011年10月一2013年5月应用308 nm准分子激光治疗的112例面部局限型稳定期白癜风患者的临床资料,统计分析面部不同分区的疗效.结果 鼻区复色最好,依次为颊区、额区、口区、眼区（P=0.000）.75％的鼻区皮损,9.09％的颊区皮损完全复色,额区无皮损完全复色,6.98％的口区皮损,9.52％的眼区皮损完全复色.病程与疗效呈负相关（R=-0.070,P=-0.032）,病程短的面部稳定期局限型白癜风患者疗效更好.随着治疗次数（R=0.389,P=0.000）、红斑量（B=0.349,P=0.000）、累积剂量（R=0.065,P=0.033）的增加疗效增加,平台期的出现与三者有关.结论 308 nm准分子激光治疗面部局限型稳定期白癜风安全有效,面部不同分区的皮损疗效不同.     

激光碳膜术治疗面部痤疮的临床疗效观察

目的观察低能量Nd:YAG激光的两种不同参数设置及碳霜辅助治疗技术(激光碳膜术)治疗面部痤疮的临床疗效及安全性。方法入选面部痤疮患者65例,术前清洁皮肤,涂抹复方利多卡因乳膏30min后洗去,涂抹碳霜10min,采用Spectra模式(波长1064nm,长脉宽300μs,能量密度2.03J/cm2)照射第1遍;随后Q开关模式(波长1064nm,短脉宽5ns,能量密度2.59J/cm2)下照射3遍,频率均为10Hz,7mm平行手柄,每2～3周治疗1次,连续治疗3～5次。结果65例经3次治疗后的有效率为73.8%,其中49例经5次治疗后的有效率为91.8%,停止治疗2个月后随访39例的有效率为94.9%。接受治疗的患者自我评价的满意度3次治疗后为73.8%,5次治疗后为89.9%,停止治疗2个月后为92.3%。不良反应少。结论激光碳膜术对面部痤疮提供一种安全有效的新疗法。     

Porokeratosis of Mibelli: Rapid Recurrence of a Large Lesion After Carbon Dioxide Laser Treatment

Abstract: Porokeratosis of Mibelli was diagnosed in a 9-year-old Afro-American girl. The lesion was rather large (4.1 x 2.0 cm) and had developed rapidly over the course of six months. Considering the potential for malignant transformation without neglecting the importance of cosmesis, carbon dioxide laser vaporization with curettage was chosen to ablate the lesion. Within two months the entire treated area revealed recurrent porokeratosis. Due to the aggressive nature of this lesion, complete excision was performed.     

燃煤污染型砷中毒皮肤病变调查

目的探讨燃煤污染型砷中毒皮肤病变临床特征。方法选择国家认定的燃煤污染型砷中毒地区紫阳县蒿坪镇、平利县八仙镇,按《地方性砷中毒病区划分和临床诊断暂行规定》进行流行病学调查,对阳性病例皮肤体征进行统计分析。结果241例砷中毒患者中有不同程度手脚皲裂139例(57.68%),皮肤过度角化94例(39.00%),色素脱失84例(34.85%),色素沉着14例(5.80%)。结论燃煤污染型砷中毒患者皮肤病变以皲裂、角化人数最多,脱色次之,色沉最少;皮肤损害从皲裂角化开始,随后出现脱色和色沉。     

加替沙星治疗支原体性非淋菌性尿道炎(宫颈炎)的疗效观察

目的　探寻治疗支原体性非淋菌性尿道炎(宫颈炎) [NGU(NGC) ]的理想抗菌药。方法　观察加替沙星治疗支原体性NGU(NGC)的疗效,并与阿奇霉素进行比较。结果　加替沙星的有效率为75%,与阿奇霉素的疗效比较差异无统计学意义(P>0. 05),且无明显不良反应。结论　加替沙星是治疗支原体性NGU(NGC)的一种安全、有效的抗菌药。     

咪唑斯汀联合他克莫司软膏治疗颜面再发性皮炎疗效观察

目的观察他克莫司软膏治疗颜面再发性皮炎的疗效。方法将90例患者分两组,治疗组60例,口服咪唑斯汀10mg,1次/d,外用0.1%他克莫司软膏,2次/d,连用2周;对照组30例,口服咪唑斯汀10mg,1次/d,连用2周。结果治疗组有效率88.3%,对照组为63.3%,两组比较差异有显著性意义(P<0.01)。结论咪唑斯汀联合他克莫司软膏治疗颜面再发性皮炎疗效较好。     

Linear Nevus Sebaceus of Jadassohn Treated with the Carbon Dioxide Laser

Abstract: A 10-year-old boy from Guiana was born with a linear nevus sebaceus covering his entire nose from the glabella area to the tip. Cosmetic appearance, which was the major concern of the patient and his family, was greatly Improved by the use of the carbon dioxide (C0₂) laser. The CO₂? laser has not been reported previously as a treatment modality for nevus sebaceus.     

Successful Treatment of Pearly Penile Papules with Carbon Dioxide Laser Resurfacing After Local Anesthesia in an Adolescent Patient

Pearly penile papules (PPP) can cause significant psychological morbidity. Herein we report the successful use of a macrofractionated carbon dioxide laser at full‐field ablative density settings for the treatment of PPP in a 17‐year‐old boy using local anesthetic alone. Our experience leads us to believe that PPP can be successfully treated in the pediatric and adolescent populations using this novel and relatively noninvasive technique.