冠状动脉搭桥术患者围术期血浆神经元特异性烯醇化酶浓度与术后认知功能

目的研究冠状动脉搭桥术患者围术期血浆神经元特异性烯醇化酶（NSE）浓度及术后认知功能。方法40例接受冠状动脉搭桥术的男性患者，分为体外循环组和非体外循环组，每组20例。在术前、术后6、12、18和24h采血，用放射免疫方法测定血浆NSE浓度。在术前1天和术后7～10天进行神经心理测试。结果体外循环组患者术后6h血浆NSE浓度比术前显著升高，同时高于非体外循环组；非体外循环组患者各时点无差别。非体外循环组患者在数字广度测验（逆向）、斯特鲁字色干扰测验改正反应和阻塞反应的结果显著优于体外循环组患者。体外循环组患者术后6hNSE水平与连线测验A型相关，术后12hNSE浓度与数字广度测验（顺向）、连线测验A型、斯特鲁字色干扰测验时间分项相关。结论心脏手术后血浆NSE浓度的升高可在某种程度上反映术后认知功能障碍，但在具体应用时应考虑NSE的组织多源性及体外循环因素的影响。     

常规与微创冠脉搭桥术围手术期血浆S100-B蛋白水平的相关研究

目的: 通过测定体外循环和非体外循环条件下冠脉搭桥术患者血浆S100-B蛋白水平的变化，比较2种手术方式对脑损伤程度有无不同，探讨术中影响血浆S100-B蛋白水平变化的相关因素。方法: 30例择期行冠脉搭桥术的患者，分为体外循环组（CPB group，A组）和微创非体外循环组（non-CPB group，B组）,每组均为15例。于术前、麻醉后、主动脉侧壁钳开放时、术毕时、术后2 h、6 h、12 h和24 h采血测血浆S100-B蛋白浓度。结果： （1） 两组患者血浆S100-B蛋白浓度均在升主动脉侧壁钳开放时显著高于术前，且A组患者血浆S100-B蛋白浓度峰值是B组的3倍多（2.32±0.26 μg/L和0.71±0.14 μg/L）,之后逐渐降低，到术后24 h基本接近正常。（2） 术中患者血浆S100-B蛋白升高水平与体外循环转机时间或心表手术操作时间呈正相关（A组：r＝0.659，P＜0.05;B组：r＝0.584, P＜0.05）。结论： 血浆S100-B蛋白水平可以用来评价2种冠脉搭桥术对脑的损伤程度，术后连续检测对于诊断脑损伤并及时采取相应预防措施具有重要价值;非体外循环微创冠脉搭桥术较常规体外循环下手术更能够有效降低对脑损伤的程度和术后出现神经功能障碍的风险。     

瑞芬太尼复合丙泊酚把空输注在非体外循环冠脉搭桥手术中的应用

目的探讨丙泊酚复合瑞芬太尼靶控输注在非体外循环冠脉搭桥手术中应用的临床意义。方法选择32例择期行非体外循环冠脉搭桥手术病人。采用瑞芬太尼复合丙泊酚靶控输注,瑞芬太尼丙泊酚靶控浓度分别为1.6ng/ml和1.5-4μg/ml辅以安氟醚吸入,间断推注维库溴铵。记录围麻醉期血流动力学,及麻醉后恢复情况。结果所有病人麻醉诱导后收缩压舒张压均明显降低（P〈0.05）,心率减慢（P〈0.05）气管插管、切皮后血压回升。术毕停用瑞芬太尼后心率加快、血压升高,需辅以长效镇痛药物。术毕病人均在5h内拔气管插管。结论瑞芬太尼复合丙泊酚靶控输注用于非体外循环冠脉搭桥手术,血流动力学稳定,对气管插管和锯胸骨等强刺激反应轻微;术后清理迅速,可安全用于非体外循环冠脉搭桥手术的麻醉。     

冠状动脉搭桥体外循环湿备的技术改良

对冠状动脉搭桥术备体外循环的湿备模式进行改良,以达到即满足临床需要,又节省医疗资源的预期。采用储血器、微栓滤器、接头和管道连接并预充排气的湿备模式,术中根据需要再连接氧合器。232例冠状动脉搭桥术的患者,术中因血压偏低转为体外循环辅助下冠脉搭桥共7例,平均用时约2~3 min。此种改良湿备模式能更好地满足冠状动脉搭桥术备体外循环的需要,并可节约大量医疗资源。     

体外循环冠状动脉搭桥术中不同停跳液灌注方法的心肌保护作用

背景:体外循环下冠状动脉搭桥的远期效果优于常温冠状动脉搭桥。对于严重冠脉狭窄患者,单纯经主动脉根部顺行灌注心肌保护效果欠佳,如何取得良好的心肌保护效果成为影响搭桥效果的关键因素之一。目的:比较体外循环下应用不同停跳液灌注方法对冠状动脉移植搭桥患者心肌的保护作用。方法:23例冠状动脉移植搭桥患者,根据停跳液灌注方法的不同分为主动脉根部灌注组;主动脉根部灌注+冠状动脉桥灌注组;主动脉根部灌注+经冠状静脉窦逆行灌注组。分别于搭桥前、体外循环30 min、升主动脉开放后5 min、2 h、6 h、24 h取血标本测量血清肌钙蛋白Ⅰ、磷酸肌酸激酶和磷酸肌酸激酶同工酶水平,记录体外循环时间、升主动脉阻断时间、升主动脉开放后心脏复跳情况、搭桥后正性肌力药物的应用情况、气管插管拔管时间及ICU停留时间等临床监测指标。结果与结论:肌钙蛋白Ⅰ复灌后2-24 h;CK复灌后5 min到24 h;磷酸肌酸激酶同工酶复灌后6,24 h,主动脉根部灌注+冠脉桥灌注组与主动脉根部灌注+经冠状静脉窦逆行灌注组明显低于主动脉根部灌注组(P0.05)。心脏自动复跳率及多巴胺应用等临床监测指标3组比较差异无显著性意义。结果表明,应用心脏停跳液进行冠状动脉顺行性灌注的同时结合冠状动脉桥灌注或经冠状静脉窦逆行灌注,对心脏体外循环冠状动脉移植搭桥可取得良好的心肌保护效果。     

食道超声和漂浮导管对不同冠脉搭桥术中心脏功能状况和肺动脉压的评价

目的使用食道超声和漂浮导管比较非体外循环不停跳冠状动脉搭桥术(off-pump-CABG)和体外循环下冠状动脉搭桥术(on-pump-CABG)患者的心脏功能状况和肺动脉压,以探知何种冠脉搭桥术式术中的心脏功能状况更优。方法采用完全随机方法将36例患者按照计算器随机数字法随机分为2组,A组为off-pump-CABG术组(n=18),B组为on-pump-CABG术组(n=18)。检测时间点设定为全部手术操作完成后、患者出手术室前,使用食道超声和漂浮导管测量肺动脉收缩压、右心室舒张末期容积、右心室射血分数和左室舒张末压。结果 2组超声心动图与漂浮导管的测量结果差异无统计学意义(P0.05);超声心动图与漂浮导管的测量结果均显示A组的肺动脉舒张压低于B组(P0.05),A组的冠脉搭桥术中心脏功能状况诸指标优于B组(P0.05)。结论 off-pump-CABG和on-pump-CABG术中施行超声心动图与漂浮导管的监测,其效果基本一致;off-pump-CABG术的冠脉搭桥术中心脏功能状况诸指标优于on-pump-CABG术,其原因可能与off-pump-CABG更少的血流动力学扰动和没有血液直接接触非生理管道诱发的细胞因子瀑布有关。     

异氟烷对全麻结、直肠癌手术患者白细胞介素、皮质醇、血糖变化的影响

分析异氟烷对全麻结、直肠癌手术患者术后白介素、皮质醇、血糖变化的影响。麻醉方法对照组采用乙醚,观察组采用异氟烷。术后24 h内,两组患者白介素含量上升,术后48 h时点下降;术后48 h内,观察组白介素含量更低。术后24 h内,两组患者皮质醇含量下降,术后48 h时点上升;术后48 h内,观察组皮质醇含量更高。术后48...     

非体外循环下冠状动脉搭桥术后护理体会

主动脉-冠状动脉旁路移植术又称搭桥术（CABG），是目前治疗冠心病的常用的方法之一，非体外循环下冠脉搭桥术（Off pump Coronary artery bypass grafting，Off pump CABG）现在已成为国内外冠心病搭桥术中的一种常用选择。我院2003年1月至2005年10月在非体外循环下行CABG手术25例，现将护理体会报告如下。     

松果体腺、褪黑素与抗应激作用

褪黑素呈典型的昼夜节律合成分泌 ,褪黑素激素水平的变化是 2 4h生物钟的探针。褪黑素合成分泌受光 /暗循环、视上核以及褪黑素合成过程中的底物血清素 (STN)、两个限速酶N 乙酰转移酶 (NAT)和羟吲哚 氧 甲基转移酶 (HIOMT)昼夜节律变化的调控 ;松果体腺内STN浓度戏剧性节律波动是由NAT浓度在昼夜间的较大波动所引起 (NAT夜间峰值是白昼低谷的 5 0 10 0倍 )。褪黑素的节律合成分泌与HPA轴所控制的激素 (ACTH和皮质醇 )所呈现昼夜节律性恰好相反 ,褪黑素可能与减少皮质激素分泌总量和增加糖皮质激素反馈调节敏感性有关 ;外源性褪黑素保护实验性糖尿病动物可能与抗氧化应激作用有关。     

体外与非体外循环下冠状动脉旁路移植术对照研究的Meta分析

背景:研究表明,非体外循环下冠状动脉旁路移植术和体外循环下冠状动脉旁路移植术后患者生活质量无明显差别。导致冠状动脉旁路移植术后患者生活质量下降的主要原因是桥血管病变和心律失常。目的:评价非体外循环下冠状动脉旁路移植术与常规体外循环下冠状动脉旁路移植术相比是否具有优越性。方法:检索2000/2009国内关于检索非体外循环下冠状动脉旁路移植术与体外循环下冠状动脉旁路移植术手术后疗效的临床对比研究,收集相关数据并用RevMan4.2统计软件进行Meta分析。结果与结论:检索并纳入本次研究的文献共16篇,其中行非体外循环下冠状动脉旁路移植术组的病例1392例,行体外循环下冠状动脉旁路移植术组的病例1252例。Meta分析结果示:非体外循环下冠状动脉旁路移植组的手术效果优于体外循环下冠状动脉旁路移植组,非体外循环下冠状动脉旁路移植组在ICU时间、呼吸机辅助时间、住院时间、术后24h引流量、术后并发症上都明显低于体外循环下冠状动脉旁路移植组(P0.05),但在移植血管数上低于体外循环下冠状动脉旁路移植组(P0.05),而两组在年龄上差异无显著性意义(P0.05)。提示近期观察非体外循环下冠状动脉旁路移植术治疗冠状动脉病变比体外循环下冠状动脉旁路移植治疗效果更好,但远期效果如何,尚未形成定论。     

Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting

Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (n?=?20) or desflurane (n?=?20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.     

Coronary artery bypass grafting with concomitant resection for carcinoma of lung

A 69-year-old woman with angina had a lesion in the left lower lobe on chest film. Angiography revealed coronary artery disease in three vessels. Combined off pump coronary artery bypass grafting (CABG) and left lower lobectomy were performed through median sternotomy. This approach avoids complications due to staged operations and cardiopulmonary bypass (CPB). This report shows that simultaneous off pump CABG and pulmonary operations can be performed safely in patients with coronary artery disease (CAD) associated with lung cancer.     

Postoperative circadian disturbances

An increasing number of studies have shown that circadian variation in the excretion of hormones, the sleep wake circle, the core body temperature rhythm, the tone of the autonomic nervous system and the activity rhythm are important both in health and in disease processes. An increasing attention has also been directed towards the circadian variation in endogenous rhythms in relation to surgery. The attention has been directed to the question whether the circadian variation in endogenous rhythms can affect postoperative recovery, morbidity and mortality. Based on the lack of studies where these endogenous rhythms have been investigated in relation to surgery we performed a series of studies exploring different endogenous rhythms and factors affecting these rhythms. We also wanted to examine whether the disturbances in the postoperative circadian rhythms could be correlated to postoperative recovery parameters, and if pharmacological administration of chronobiotics could improve postoperative recovery. Circadian rhythm disturbances were found in all the examined endogenous rhythms. A delay was found in the endogenous rhythm of plasma melatonin and excretion of the metabolite of melatonin (AMT6s) in urine the first night after both minor and major surgery. This delay after major surgery was correlated to the duration of surgery. The amplitude in the melatonin rhythm was unchanged the first night but increased in the second night after major surgery. The amplitude in AMT6s was reduced the first night after minimally invasive surgery. The core body temperature rhythm was disturbed after both major and minor surgery. There was a change in the sleep wake cycle with a significantly increased duration of REM-sleep in the day and evening time after major surgery compared with preoperatively. There was also a shift in the autonomic nervous balance after major surgery with a significantly increased number of myocardial ischaemic episodes during the nighttime period. The circadian activity rhythm was also disturbed after both minor and major surgery. The daytime AMT6s excretion in urine after major surgery was increased on the fourth day after surgery and the total excretion of AMT6s in urine was correlated to sleep efficiency and wake time after sleep onset, but was not correlated to the occurrence of postoperative cognitive dysfunction. We could only prove an effect of melatonin substitution in patients with lower than median pain levels for a three days period after laparoscopic cholecystectomy. In the series of studies included in this thesis we have systematically shown that circadian disturbances are found in the secretion of hormones, the sleep-wake cycle, core body temperature rhythm, autonomic nervous system tone, myocardial ischaemia and activity rhythm after surgery. Correlation exists between circadian rhythm parameters and measures of postoperative sleep quality and recovery. However, oral melatonin treatment in the first three nights after surgery, cannot yet be generally recommended for improvement of sleep quality or other recovery parameters based on the available results. It may be indicated in subgroups or if other perioperative treatment algorithms were used, but this has to be investigated in future trials.     

Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass

Cardiopulmonary bypass (CPB) with extracorporeal circulation produces changes in the immune system accompanied by an increase in proinflammatory cytokines and a decrease in anti-inflammatory cytokines. We hypothesize that dexmedetomidine (DEX) as an anesthetic adjuvant modulates the inflammatory response after coronary artery bypass graft surgery with mini-CPB. In a prospective, randomized, blind study, 12 patients (4 females and 8 males, age range 42-72) were assigned to DEX group and compared with a conventional total intravenous anesthesia (TIVA) group of 11 patients (4 females and 7 males). The endpoints used to assess inflammatory and biochemical responses to mini-CPB were plasma interleukin (IL)-1, IL-6, IL-10, interferon (INF)-γ, tumor necrosis factor (TNF)-α, C-reactive protein, creatine phosphokinase, creatine phosphokinase-MB, cardiac troponin I, cortisol, and glucose levels. These variables were determined before anesthesia, 90 min after beginning CPB, 5 h after beginning CPB, and 24 h after the end of surgery. Endpoints of oxidative stress, including thiobarbituric acid reactive species and delta-aminolevulinate dehydratase activity in erythrocytes were also determined. DEX+TIVA use was associated with a significant reduction in IL-1, IL-6, TNF-α, and INF-γ (P<0.0001) levels compared with TIVA (two-way ANOVA). In contrast, the surgery-induced increase in thiobarbituric acid reactive species was higher in the DEX+TIVA group than in the TIVA group (P<0.01; two-way ANOVA). Delta-aminolevulinate dehydratase activity was decreased after CPB (P<0.001), but there was no difference between the two groups. DEX as an adjuvant in anesthesia reduced circulating IL-1, IL-6, TNF-α, and INF-γ levels after mini-CPB. These findings indicate an interesting anti-inflammatory effect of DEX, which should be studied in different types of surgical interventions.     

Troponine Ic et CK-MB après pontage coronarien avec ou sans CEC

The aim of this work was to investigate the release profile of cardiac troponin I and CK-MB after coronary artery bypass grafting with and without cardiopulmonary bypass. In patients without postoperative cardiac complications, cTnI peak was observed 24 h after coronary artery bypass grafting both with and without cardiopulmonary bypass. The CK-MB peak was observed 24 h after surgery without cardiopulmonary bypass but as soon as 3 h after surgery with cardiopulmonary bypass. Moreover, cTnI and CK-MB concentrations were 2–3-fold higher with cardiopulmonary bypass than without. In patients with postoperative myocardial infarction, the cTnI and CK-MB peaks were observed 24 h after coronary artery bypass grafting both with and without cardiopulmonary bypass. Diagnosis of preoperative myocardial infarction can be suggested at 24 h with cTnI cut-off values seven or three fold higher than the cut-off value in medical cardiology (ROC curve) with or without cardiopulmonary bypass, respectively.     

Perioperative blood pressure control in hypertensive and normotensive patients undergoing off-pump coronary artery bypass grafting: prospective study of current anesthesia practice

Aim

To analyze blood pressure changes during intra- and immediate postoperative period in patients undergoing off-pump coronary artery bypass grafting.

Methods

The study included 355 consecutive patients undergoing off-pump coronary artery bypass grafting between January 5, 2004 and December 30, 2005. Out of these patients, 325 were allocated into groups with preoperative history of hypertension (n = 115) and without preoperative history of hypertension (n = 210). Systolic, diastolic, and mean arterial blood pressure was measured at the following four time points: on the day before surgery, before anesthesia induction, after the last graft, and on entry to intensive care unit.

Results

Mean arterial pressure was significantly higher in patients with a history of hypertension on the day before surgery (97 vs 92 mm Hg, P = 0.003, Mann-Whitney test) and before anesthesia induction (107 vs 98 mm Hg; P = 0.003). It was higher at all measuring points (after the last graft, 79 vs 78 mm Hg; and on entry to intensive care unit, 88 vs 86 mm Hg), but this difference was neither statistically nor clinically significant. The study showed that mean arterial pressure followed similar dynamics over time in both patient groups (P<0.001 both), with no significant time-dependent between-group differences.

Conclusion

Current anesthesia techniques that include deep opioid analgesia in combination with vasodilators provide a satisfactory control of intraoperative hypertension. Management of blood pressure changes during intra- and immediate postoperative period in off-pump coronary artery bypass grafting patients with preoperative hypertension was no more difficult than in patients without preoperative hypertension.Monitoring of hemodynamic stability, especially blood pressure and heart rate during perioperative period, is an important consideration (1). During conventional open heart surgery, hypertension can occur at almost any time, ie before, during, or after surgery, and is most commonly mediated by an increase in sympathetic tone.Off-pump coronary artery bypass grafting is a procedure that may achieve better in-hospital outcome, including shorter length of stay (2,3). Hypertension associated with off-pump coronary artery bypass grafting is typically not a result of dramatic increase in systemic vascular resistance (4).The reported incidence of perioperative hypertension associated with conventional coronary artery bypass grafting (CABG) ranges from 30 to 80%, and this wide range may explain different definitions of the condition and preoperative comorbid states (5).To the best of our knowledge, there are no studies dealing with off-pump coronary artery bypass grafting. The aim of our study was to analyze perioperative hypertensive response in patients undergoing off-pump coronary artery bypass grafting. We hypothesized that it was more difficult to control perioperative hypertension in these patients who had been preoperatively hypertensive than in those who had not.     

Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass

Cardiac surgery with cardiopulmonary bypass (CPB) leads to a systemic inflammatory response with secretion of cytokines (e.g. IL-6, TNF-alpha, IL-1 beta and sIL-2R). The objective of the following study was to investigate in vitro and in vivo cytokine responses and white blood cell counts (WBC) of patients with high versus low cytokine secretion after a coronary artery bypass grafting (CABG) procedure. Twenty male patients undergoing elective CABG surgery with CPB under general anaesthesia were enrolled in the study. On the day of surgery (postoperatively), serum levels of TNF-alpha and IL-1 beta were significantly higher in patients of the high IL-6 level group compared to the respective values in the patient group with low IL-6 levels. The inter-individual differences in IL-6 release in patients undergoing CABG surgery with CPB were accompanied by differences in the release of other cytokines, such as TNF-alpha, IL-1 beta and sIL-2R. To understand whether genetic background plays a role in influencing cytokine plasma levels under surgical stress, we examined the distribution of polymorphic elements within the promoter regions of the TNF-alpha and IL-6 genes, and determined their genotype regarding the BAT2 gene and TNF-beta intron polymorphisms. Our preliminary data suggests that regulatory polymorphisms in or near the TNF locus, more precisely the allele set 140/150 of the BAT2 microsatellite marker combined with the G allele at -308 of the TNF-alpha gene, could be one of the genetic constructions providing for a less sensitive response to various stimuli. Our results suggest: (1) close relationships between cytokine release in the postoperative period, and (2) inter-individually varying patterns of cytokine release in patients undergoing CABG surgery with CPB.     

Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine

OBJECTIVE

The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery.

INTRODUCTION

Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension.

METHODS

Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg⁻¹ (Group K) or propofol 0.5 mg.kg⁻¹ (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy.

RESULTS

There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (p<0.01).

CONCLUSION

There were no differences between groups in the consumption of sevoflurane or in the use of additional fentanyl. The combination of ketamine, midazolam, and fentanyl for the induction of anesthesia provided better hemodynamic stability during induction and until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery.     

Leukocyte Depletion During CPB: Effects on Inflammation and Lung Function

Cardiopulmonary bypass (CPB) is related to inflammatory response and pulmonary dysfunction. The aim of this study was to evaluate the effects of CPB leukocyte filtration on inflammation and lung function after coronary artery bypass grafting (CABG). A prospective randomized study was performed to compare CABG patients undergoing CPB leukocyte filtration (n?=?9) or standard CPB (n?=?11). Computed tomography, oxygenation, leukocyte count, hemodynamic data, PaO₂/FiO₂, shunt fraction, interleukins, elastase, and myeloperoxidase were evaluated. Data were analyzed using two-factor ANOVA for repeated measurements. The filtered group showed lower neutrophil counts up to 50 min of CPB, lower shunt fraction up to 6 h after surgery, and lower levels of IL-10 at the end of surgery (p?<?0.05). There was no statistically significant difference between groups related to other parameters. Leukodepletion during CPB results in neutrophil sequestration by a short time, decreased IL-10 serum levels, and lower worsening of lung function only temporarily.