Phenacetin-induced hemolytic anemia

The hematological features of phenacetin-induced hemolytic anemia are presented in order to make the physician aware of the abnormalities which suggest the use of an oxidant drug. The presence of “bitten out” red cells is the commonest initial clue to the existence of drug-induced hemolytic anemia. The diagnosis is confirmed by the demonstration of Heinz bodies and sulfhemoglobinemia. Early recognition of this form of drug-abuse may avert the development or progression of analgesic nephropathy.     

Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency

Congenital hemolytic anemia in the Basenji dog resembles pyruvate kinase (PK) deficiency in man as it is characterized by an abbreviated erythrocyte life span, an intense reticulocytosis, type II autohemolysis and splenomegaly. Glucose utilization and lactate production were inadequate with respect to the immature cell population. Analysis of enzymes involved in erythrocyte glycolysis revealed a deficiency of pyruvate kinase.     

Surgical treatment of hemolytic anemia

The therapeutic effect of splenectomy in 70 cases of hemolytic anemia are reported. The diagnosis and therapeutic effects were analysed. It was evident that the effects were related to different types of hemolytic anemia. The HS type had the best result. Gallstones were detected in 6 cases of this series. Splenectomy and cholecystectomy were performed together in 5 cases. The median incision of upper abdomen was selected. The authors believe that the causes of infection after splenectomy are complicated and they cannot be explained by Igs alone.     

部分脾栓塞治疗自身免疫性溶血性贫血

目的 :观察部分脾栓塞治疗自身免疫性溶血性贫血的效果。方法 :电视透视下经右股动脉插管至脾动脉分支 ,先注入造影剂观察脾脏大小 ,然后注入无菌明胶海绵 ,再注入造影剂观察栓塞面积。栓塞面积为脾脏的 5 0 %～80 %。结果 :5例病人均于术后 3d血红蛋白开始上升 ,一般在 1mon左右升至 10 0g/L以上。除 1例合并脾脓肿外 ,其余 4例仅伴轻微腹痛、发热。结论 :部分脾栓塞治疗自身免疫性溶血性贫血有比较满意的疗效 ,且可避免全脾切除或全脾栓塞带来的一系列副作用。     

自身免疫溶血性贫血红细胞抗体免疫分型

对 18例自身免疫溶血性贫血 ,行红细胞抗体免疫分型分析 ,并以血红蛋白量 ,网织红细胞绝对值及游离血红蛋白量作为贫血、溶血严重度的参数 ,结果得到如下类型 :lgG型、lgM型、C3型、lgG +C3型、lgG +lgM +C3型、lgG +lgM +lgA +C3型 ,其中以lgG +C3型为主。由于各型造成红细胞破坏的机理不尽相同 ,因而造成贫血、溶血的严重度也存在差异 ,lgG +lgM +C3和lgG +C3阳性的患者溶血及贫血最为严重 ,而单纯C3型及lgG型则较轻。认为型别及型变与本病的严重度及预后转归有关。