胰管结石的诊断与外科治疗：附43例报告

目的:探讨胰管结石的诊断及手术治疗方式。方法:回顾性分析6年间进行外科手术的43例胰管结石患者的临床资料。结果:患者男女比例约为2:1,主要症状为上腹痛,部分伴腰背痛。全组均采用影像学检查方法确诊。行胰管切开取石、胰管空肠侧侧Roux-en-Y吻合术34例(其中同时切除胰体尾2例),保留十二指肠的胰头切除术5例,保留幽门的胰十二指肠切除1例,胰十二指肠切除术1例,胰体尾、脾切除1例,探查发现恶变无法切除1例。随访5个月至6年;43例患者中23例腹痛症状完全缓解,18例有不同程度的缓解。结论:影像学检查是确诊胰管结石的主要方法。对胰管结石的手术应制定个体化方案。胰管切开取石,胰管-空肠Roux-en-Y吻合术为胰管结石的主要术式,其他可根据情况采用保留十二指肠的胰头切除术或胰体尾切除等术式。     

慢性胰腺炎伴胰管结石外科治疗体会

目的 探讨慢性胰腺炎伴胰管结石外科治疗的术式选择.方法 对1991年6月至2006年6月收治的17例慢性胰腺炎伴胰管结石手术治疗的患者进行回顾性分析,总结不同类型的胰管结石的手术方式及结果.结果 本组17例中胰头部胰管结石13例,胰体尾部胰管结石4例,合并胆石症6例,其中6例行胰管切开取石胰管空肠吻合术(Partington法);4例行胰管胃吻合术(Warren法);3例行保留十二指肠胰头次全切除术(Beger法);3例行胰尾切除胰腺空肠吻合术(Duval法);1例行胰尾、脾切除胰腺空肠吻合术.17例临床治愈,其中上腹部顽固性疼痛完全缓解15例,血糖控制2例,胰漏2例,1例术后11个月死于胰腺癌.结论 针对慢性胰腺炎合并胰管结石患者的不同状况采取的手术方式应高度个体化,有主胰管扩张者采取引流术,无胰管扩张及局部胰腺病变者采取胰腺部分切除联合内引流术,同时注意尽量保存胰腺组织功能,可明显改善患者生活质量.     

胰管结石的临床特点及外科处理

目的探讨胰管结石的临床特点及外科处理策略。方法回顾性分析2002年1月至2007年12月间收治的14例胰管结石病人临床资料。结果14例病人均有上腹痛症状,11例合并慢性胰腺炎,14例病人中,13例病人行手术治疗,1例放弃手术。其中10例行胰管空肠Roux—en-Y吻合术;1例行保留十二指肠的胰头切除术;1例行胰体尾加脾切除术,1例胰管切开取石,胰管内置T型管引流,术后症状均有不同程度缓解。结论上腹痛及合并慢性胰腺炎是胰管结石的主要临床特点,B超、CT及MRCP是诊断胰管结石最主要的手段,手术治疗是胰管结石的最佳方法。手术方式应该根据病人情况进行选择。     

胰管结石合并胰腺癌的诊治分析(附9例报道)

目的总结胰管结石合并胰腺癌的诊治经验。方法回顾性分析2005年1月至2015年12月期间中山大学孙逸仙纪念医院收治的9例胰管结石合并胰腺癌患者的临床资料,总结其临床特征、影像学诊断方法和手术方式。结果 9例胰管结石合并胰腺癌患者中,4例行B超联合CT血管造影(CTA),均诊断为胰管结石合并胰腺癌;4例行磁共振胰胆管造影/磁共振血管显像(MRCP/MRA),3例考虑胰管结石合并胰腺癌;3例行经内镜逆行性胰胆管造影(ERCP),均诊断为胰腺癌。所有患者均行手术治疗,包括胰十二指肠切除术4例,胰体尾及脾切除术3例,胰管切开取石、远端胰管空肠吻合术1例,腹腔镜探查、活检术1例。术后无死亡病例,发生应激性溃疡出血1例,B级胰瘘1例。所有患者均获访,随访时间5~36个月,中位数为13个月。随访期间死亡7例,5例生存时间超过1年,2例生存时间超过3年。结论对于反复发作的胰管结石患者应该警惕合并胰腺癌的可能,CT和MRCP均可作为该病的进一步检查方法;影像学检查发现胰腺肿物、无手术禁忌证时,均应积极行手术治疗,推荐行标准的胰十二指肠切除或胰体尾切除术。     

胰管结石的分型及手术治疗

目的：探讨胰管结石的分型及手术方法。方法对8例行手术治疗的胰管结石合并慢性胰腺炎或胰腺癌患者病历资料进行分析。8例患者术前均行腹部B超、上腹部CT平扫＋增强或磁共振胆胰管水成像（MRCP）检查以明确诊断。其中Ⅰ型2例,采用胰头十二指肠切除术;Ⅱ型1例,采用胰尾切除＋脾切除＋胰管空肠吻合术;Ⅲ型5例,采用胰管切开取石并胰管空肠吻合术。结果8例均成功手术,1例术后并发胰漏,经非手术治疗后好转;5例糖尿病患者术后3例血糖恢复正常。结论胰管结石发病率虽然不高,但常合并胰腺炎、糖尿病甚至胰腺癌,后果严重,依胰管结石部位分型并选择合理的手术方法极为重要。     

胰头肿块型慢性胰腺炎手术治疗体会

目的探讨胰头肿块型慢性胰腺炎的手术治疗效果。方法回顾性分析1999年1月至2013年12月间经手术治疗的18例胰头肿块型慢性胰腺炎患者的临床资料。其中4例合并胰管结石,5例合并胰腺囊肿。10例行胰十二指肠切除术,5例行胰管空肠Roux-Y吻合术,2例行胰腺囊肿空肠Roux-Y吻合术,1例行胆总管空肠Roux-Y吻合术,其中1例同时行胰肠吻合和胃空肠吻合术。比较不同术式对腹部疼痛的缓解率。结果 17例完成手术,1例损伤肠系膜上静脉大出血术中死亡。术后出现胸腔积液2例,切口裂开1例。获随访13例,其中行胰十二指肠切除术8例(61.5%),疼痛完全消失;胰肠或胆肠吻合4例(30.8%),疼痛部分缓解;胰肠吻合和胃肠吻合1例(7.7%),疼痛无缓解,反复住院治疗未痊愈。结论外科手术是胰头肿块型慢性胰腺炎的有效治疗方式,胰十二指肠切除术效果显著。     

胰管结石的诊治探讨

目的：探讨胰管结石的诊治方法。方法：对15例胰管结石患者,11例行胰管切开取石,或胰管内巨大结石用体内微爆破碎石仪碎石,T型管引流加大网膜黏合于引流管周围。3例胰管取石或胰尾切除后行胰管空肠Roux-en-Y吻合术。1例行胰十二指肠切除术。结果：14例术后随访1～5年,1例术后11个月发现结石复发伴胰头部占位,再手术行胰十二指肠切除术,1例胰管内乳头状黏液性癌患者术后27个月死于癌症复发。6例伴有糖尿病者术后2例恢复正常,4例症状有不同程度改善。2例慢性脂肪泻患者症状改善。1例发生胰瘘,经治疗痊愈。结论：胰管结石切开取石、T型管引流术为治疗胰管结石的理想术式。     

胰头结石的手术方式选择(附12例报告)

目的:探讨治疗胰头结石的手术方式选择。方法:回顾分析2002年至2011年我院收治的12例胰头结石病人的临床资料,并结合复习有关文献。结果:12例病人均伴有慢性胰腺炎,1例伴有胰头癌,3例伴有糖尿病。12例病人均行手术,其中行胰管切开取石、胰管空肠吻合术7例,胰十二指肠切除术3例,保留十二指肠的胰头切除术2例。结论:胰头结石手术治疗方法应根据具体情况采取不同的手术方式,对胰头部胰管结石的年轻病人可考虑行保留十二指肠的胰头切除术。     

胰管结石的外科治疗

目的:探讨胰管结石外科治疗的术式选择。方法:回顾性分析11例胰管结石患者的临床资料。11例中采用胰管切开取石胰管空肠Roux en Y吻合术3例，胰管切开取石、胰管空肠Roux en Y吻合术＋胆管探查＋T管外引流术2例，胰管切开取石＋气压弹道碎石＋胰管空肠Roux en Y吻合术3例，胰体尾切除、胰断端空肠Roux en Y吻合术1例，合并胰腺癌采用胰十二指肠切除术2例。结果:11例均痊愈;2例合并胰腺癌者于术后1～1.5年后死亡。结论:引流术和胰腺切除术仍是胰管结石的主要治疗方法，有主胰管扩张者采用引流术，无胰管扩张和胰腺病变局限化者采用胰腺部分切除加引流术；对结石位于胰头钩突、胰管扩张而无法取净的胰管结石需采用气压弹道碎石＋引流术。     

胰头肿块型慢性胰腺炎18例外科治疗体会

【摘要】〓目的〓探讨胰头肿块型慢性胰腺炎的外科治疗效果。方法〓回顾性分析1999年1月~2013年12月15年间经手术治疗的18例胰头肿块型慢性胰腺炎患者的临床资料。18例中4例合并胰管结石,5例合并胰腺囊肿;10例行胰十二指肠切除术,4例行胰管空肠Roux-y吻合术,2例行胰腺囊肿空肠Roux-y吻合术,1例行胆总管空肠Roux-y吻合术,1例同时行胰肠吻合和胃空肠吻合术。结果〓17例完成手术,1例损伤肠系膜上静脉大出血术中死亡。术后出现胸腔积液2例,切口裂开1例。获随访13例,行胰十二指肠切除术8例疼痛完全消失;胰肠或胆肠吻合4例疼痛部分缓解;1例顽固性疼痛,反复住院治疗。结论〓外科手术是胰头肿块型慢性胰腺炎的有效治疗方式,胰十二指肠切除术效果显著。     

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??Surgical treatment for pancreatic duct calculi: a report of 18 cases WANG Kai, WANG Gang, ZOU Shu-bing??et al. Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University??Nanchang 330006??China Corresponding author??SHAO Jiang-hua??E-mail: shao5022@163.com Abstract Objective To explore the method of surgical treatment for pancreatic duct calculi. Methods The clinical data of 18 cases of pancreatic duct calculi performed surgery from 2002 to 2007 in the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Nanchang University were analyzed retrospectively. Results Eleven cases were performed with lateral pancreaticojejunostomy. Five cases were performed pancreaticoduodenectomy. One case was performed with duodenum-preserving pancreatic head resection. One case was performed with distal pancreatectomy and splenectomy. All the cases were cured successfully. No pancreatic or bile fistula was occurred. Improvement of clinical symptoms after surgery was achieved in all cases. All the cases were followed up from 1 month to 5 years. Except one case died of pancreatic carcinoma twenty-eight months after the operation, all other cases were survived. Conclusion Surgical intervention is recommended for pancreatic duct calculi cases. The principle of individualized therapy should be followed.     

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??Near the second porta hepatic parenchyma lithotomy in the treatment of complicated bile duct stones??A analysis of 13 cases LI En-liang??WU Lin-quan??YIN Xiang-bao??et al. Department of Hepatobiliary Surgery??the Second Affiliated Hospital of Nanchang University, Nanchang330006??China
Corresponding author??WU Lin-quan, E-mail??Wulqnc@163.com
Abstract Objective To investigate the clinical significance of near the second porta hepatic parenchyma lithotomy in the treatment of complicated bile duct stones. Methods The clinical data of 13 cases of complex hepatolithiasis admitted from January 2009 to December 2013 in the Second Affiliated Hospital of Nanchang University were analyzed retrospectively. Surgical methods were hepatic parenchyma incision lithotomy near the second hepatic portal, or combined partial hepatectomy. Thirteen cases include 6 males and 7 females. Stones are mainly located in section ??, ??, ?? section. Results One case died during hospitalization and the other cases were recovered and discharged. A total of 11 cases were followed up to now, during which residual calculi happened in 1 case, recurrent hepatolithiasis in 2 cases, and other cases showed no signs of recurrent calculus and cholangitis through using ultrasound or CT examination. Conclusion Hepatic parenchyma incision lithotomy near the second hepatic portal used to treat those cases whose stones mainly located in??, ?? and ?? segments accompanied by partial liver compensatory hypertrophy around the lesions and those cases who cannot tolerate multiple hepatic segment resection has a better effect.     

第二肝门附近肝实质切开取石术治疗复杂性肝胆管结石13例疗效分析

目的 探讨第二肝门附近肝实质切开取石术治疗复杂性肝胆管结石的临床意义。方法 回顾性分析南昌大学第二附属医院2009年1月至2013年12月收治的13例复杂性肝胆管结石病人的病例资料。手术方法为第二肝门附近肝实质切开取石术,部分病人联合肝部分切除术。结石主要位于肝脏Ⅱ、Ⅳ、Ⅷ段。结果 住院期间病人死亡1例,其他病人均康复出院。11例病人随访至今,1例结石残留,2例复发,其他病例应用B超或CT检查未见胆管炎及结石复发迹象。结论 对于结石主要位于肝脏Ⅱ、Ⅳ、Ⅷ段,伴有病变周边部位肝脏代偿性肥大,无法耐受多肝段切除的病人,第二肝门附近肝实质切开取石术具有较好的疗效。     

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??Left and right sides plastic duct and choledochojejunostomy of hilar cholangiocarcinoma: A study of 11 cases LI Ke-hao??WU Lin-quan??YIN Xiang-bao??et al. Department of Hepatobiliary Surgery??the Second Affiliated Hospital of Nanchang University??Nanchang 330006, China
Corresponding author??WU Lin-quan??E-mail??Wulqnc@163.com
Abstract Objective To investigate safety and practicality of left and right sides dults anaplasty respectively with duct jejunum anastomosis after radical resection of Bismuth ?? hilar cholangiocarcinoma. Methods The clinical data and follow-up of 11 cases of Bismuth II hilar cholangiocarcinoma under double bile ducts jejunum anastomosis admitted between January 2010 and January 2015 in Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Nanchang University were analyzed retrospectively. Results The average operation time was about 5 hours; the intraoperative bleeding was 400 mL averagely; all the cases began to eat in postoperative 3 to 6 days; the hospitalization days was about 11 to 20 days. There was no hospital death. There were 3 cases of postoperative bile leakage??2 cases of abdominal infection??3 cases of pleural effusion. The symptoms had been alleviated by anti-infection treatment and drainage. There was no case of anastomotic bleeding. The follow-up period was 3 to 60 months. Ten cases were followed up with outpatient services and letters. The total follow-up rate was 90.9%. Review methods were T angiography??CT??MRI examination. There were 1 case of anastomotic stricture considered recurrence of cholangiocarcinoma, 1 case of accidental biliary tract infection symptoms which can be improved by antibiotic therapy. All the 10 cases were with a median survival of 29 months and overall survival rate of 70.0% (7/10). Conclusion Type II hilar cholangiocarcinoma after resection of the tumor with large number and distance of left and right sides bile ducts should plastic alone and concide with jejunum respectively.     

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??Hepatic segment resection in the treatment of cholangetic calculus in the left lateral liver: A clinical analysis of 21 cases CHEN Nan??WU Lin-quan??YUAN Rong-fa??et al. Department of Hepatobiliary Surgery??the Second Affiliated Hospital of Nanchang University??Nanchang 330006??China
Corresponding author??WU Lin-quan??E-mail??Wulqnc@163.com
Abstract Objective To investigate the clinical effect of hepatic ??segment or ?? segment resection in the treatment of cholangetic calculus in the left lateral liver. Methods The clinical data of 21 cases of cholangetic calculus in the left lateral liver admitted from June 2013 to February 2016 in the Second Affiliated Hospital of Nanchang University were analyzed retrospectively. The hepatolithiasis were limited to section ?? or section III of the liver. The surgical methods were anatomical hepatic ??segmentectomy or ?? segmentectomy. Results All the cases recovered and were discharged. A total of 21 cases were followed up in 18(2-32)months??during which residual calculi of left liver happened in 1 case??and other cases showed no sign of recurrent calculus and cholangitis through ultrasound, CT or MRI examination. Conclusion For hepatic calculus limited to bile ducts of hepatic ?? segment or hepatic ?? segment??while other hepatic bile ducts have no primary stones and stenosis??anatomical hepatic ??segmentectomy or ?? segmentectomy should be performed rather than left lateral liver resection blindly.     

Glisson蒂横断式肝段切除术治疗肝癌15例分析

目的 报告Glisson蒂横断式肝段切除术在肝癌手术切除中的应用体会。 方法 对2010年2~8月南昌大学第二附属医院肝胆外科手术治疗15例不同肝段肝癌的临床资料进行分析。结果 15例均按Glisson蒂横断式肝段切除法行解剖性肝段切除术,顺利完成解剖性肝段切除,平均手术时间130（100～180）min,术中平均出血量180（80～320）mL,术中均未输血,无术后并发症。结论 Glisson蒂横断式肝段切除法技术简便、快速安全,是一种理想的解剖性肝切除的手术方式。     

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??Application of Glissonean pedicle transection method for hepatic segmentectomy in the treatment of hepatocellular carcinoma: an analysis of 15 cases LUO Zhi-qiang, SHAO Jiang-hua, WU Lin-quan, et al. Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
Corresponding author: SHAO Jiang-hua, E-mail: shao5022@163.com
Abstract Objective To report the clinical application experience of Glissonean pedicle transection method for hepatic segmentectomy in hepatocellular carcinoma. Methods The clinical data of 15 cases of hepatocellular carcinoma in different segments performed Glissonean pedicle transection method for hepatic segmentectomy from February 2010 to August 2010 in the Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University were analyzed. Results Anatomical hepatic segmentectomy was completed in all 15 cases successfully. The average operation time was 130 (100-180) min and the average blood loss was 180 (80-320) mL. There was not blood transfusion during operations and any complications after operations in all cases. Conclusion Glissonean pedicle transection method for hepatic segmentectomy is a kind of the perfect operation method of anatomical hepatic segmentectomy, which is convenient, fast and safe to perform.     

肝门胆管癌术中左右胆管成形后分别与空肠吻合11例临床研究

目的 探讨左右胆管成形后分别与空肠吻合术在BismuthⅡ型肝门胆管癌手术治疗中的安全性和实用性。方法回顾性分析南昌大学第二附属医院肝胆外科2010年1月至2015年1月收治的11例BismuthⅡ型肝门胆管癌病例的临床资料和随访情况,均行胆管癌根治性切除及左右胆管成形后分别与空肠端侧吻合。结果 手术时间平均5 h,术中出血平均400 mL,术后3～6 d进食,住院时间11～20 d,无住院死亡病例,术后发生胆漏3例,腹腔感染2例,胸腔积液3例,经抗感染及穿刺引流治疗后症状缓解,未出现吻合口出血病例。随访时间3～60个月,有10例病人经过门诊复查和信访获得随访。复查方法为T管造影、CT、MRI检查。1例出现吻合口狭窄,考虑胆管癌复发,1例偶发胆道感染症状,抗生素治疗后情况改善,10例病人中位生存期29个月。结论 BismuthⅡ型肝门部胆管癌切除肿瘤后,左右侧创面胆管残端数目较多且距离较远,可行左右胆管单独整形之后分别与空肠行端侧吻合术。     

肝段切除术治疗左肝外叶结石21例临床分析

目的 探讨肝Ⅱ段或Ⅲ段切除术治疗左肝外叶结石的临床效果。方法 回顾性分析南昌大学第二附属医院2013年6月至2016年2月收治的21例左肝外叶结石病人的临床资料,肝内胆管结石均局限于肝Ⅱ段或Ⅲ段。手术方法为解剖性肝Ⅱ段或Ⅲ段切除。结果 病人均康复出院。21例病人随访18（2~32）个月,1例左肝结石残余,其余病例通过B超、CT或MRI检查未发现胆管炎及结石复发迹象。结论 对于肝内结石局限于肝Ⅱ段或Ⅲ段胆管,而其他肝段胆管未见原发性结石及狭窄,应行解剖性肝Ⅱ段或Ⅲ段切除,不应该盲目切除左肝外叶。     

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??Epigenetic inheritance of cancer and molecular targeted therapy SHAO Jiang-hua, WANG Kai. Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University??Nanchang 330006??China
Corresponding author??SHAO Jiang-hua??E-mail: shao5022@163.com
Abstract There are two epigenetic modification mechanisms??including DNA methylation and histone modification. Epigenetic modification abnormalities can cause tumors. Studies of the mechanisms of epigenetic regulation and its reversibility have resulted in the identification of novel targets that may be useful in developing new strategieed for the molecular targets treatment of cancer.