颌骨中心性粘液表皮样癌的临床表现及治疗

目的 :探讨颌骨中心性粘液表皮样癌 (centralmucoepidermoidcarcinomaofthejaws ,CMCJ)的临床特点及诊治原则。方法 :回顾 5例CMCJ临床资料并进行随访。结果 :CMCJ常见临床表现为局部肿胀和疼痛 ,X线表现为单房或多房透光阴影 ,光镜下所见同涎腺粘液表皮样癌。所有病例均行根治术 ,1例术后 6个月死于并发症 ,4例经 0 .5 -14年随访 ,未见复发及转移。结论 :CMCJ的确诊有赖于详尽的临床检查 ,治疗应首选根治术     

下颌骨中心性黏液表皮样癌1例

黏液表皮样癌多发生于涎腺组织，发生于颌骨内者极少见。本文报告1例下颌骨中心性黏液表皮样癌，并复习相关文献，对该病的病因﹑临床表现﹑影像学及组织病理学特点﹑诊断和治疗进行讨论。     

颌骨中心性黏液表皮样癌的诊断与治疗--附3例报道

目的:通过分析颌骨中心性黏液表皮样癌的临床特点,为进一步提高其诊治水平提供参考。方法:对1995-2005年原发于颌骨的3例黏液表皮样癌的临床表现、治疗及预后进行回顾性分析。结果:3例颌骨中心性黏液表皮样癌临床主要表现为颌骨内渐进性增大的肿块,有感觉异常、疼痛和反复出血。2例术后局部复发,最长者在术后3a。肿瘤复发可能与切缘有关,1/2例复发患者行半侧下颌骨切除术后,未再发生局部复发和转移。结论:术前明确诊断以及定期复查,有利于颌骨中心性黏液表皮样癌的及早发现和及时治疗。而局部切除的范围依然是影响预后的主要因素之一。     

上颌前牙区原发性黏液表皮样癌1例

黏液表皮样癌多发生于唾液腺组织，如腮腺、舌下腺及颌下腺，小唾液腺多发生在腭腺和磨牙腺区，而原发于颌骨的黏液表皮样癌较少见。我院于2005-03-07收治1例，经病理切片证实为原发于右侧上颌骨黏液表皮样癌，现报告如下。     

原发性颌骨内癌:1例报告及文献复习

原发性颌骨内癌由于早期缺少特征性临床表现,诊断较为困难。本文报告1例上颌骨中心性黏液表皮样癌,并复习相关文献,就该病的病因、临床表现、影像学及组织病理学特点、诊断及治疗进行了讨论。     

RKIP及NPRL2在涎腺黏液表皮样癌中的表达及其临床意义

目的:研究口腔黏液表皮样癌组织中RKIP和抑癌基因NPRL2的表达,探讨其表达与口腔黏液表皮样癌各临床病理因素之间的关系.方法:应用免疫组织化学染色方法检测48例口腔黏液表皮样癌组织和13例正常组织中RKIP和NPRL2的表达,并对其与临床病理特征的关系进行统计学分析.结果:RKIP和NPRL2均表达于黏液表皮样癌细胞...     

下颌骨颏部原发性黏液表皮样癌1例报告

黏液表皮样癌多发生于唾液腺组织,发生于颌骨内者较少见,我院2003年6月收治1例经病理证实的下颌骨颏部原发性黏液表皮样癌,现报告如下。1病例报告患者男性,66岁,农民,主诉下颌骨颏部肿物,缓慢生长半年,于2003年6月19日入院。半年前无明显原因发现颏部肿胀,继而隆起形成肿物,偶有疼痛。肿物呈渐进性缓慢生长,抗感染治疗无效,因局部隆起畸形明显而求治于我院。检查两侧颜面部对称,下颌骨颏部隆起肿胀、前突,皮肤正常,可触及一6cm×4cm×3cm肿物,质硬、边界清、固定、轻度压痛,无口唇麻木,张口度及张口型正常,咬合关系正常,34与44间唇龈沟饱满…     

颌骨黏液瘤临床与病理研究

目的:总结颌骨黏液瘤临床、病理特点。方法:对29例颌骨黏液瘤的临床表现、X线影象及病理特征等进行回顾性分析。结果:29例中男9例,女20例,平均年龄31.8岁;病变位于下颌骨17例,上颌骨12例;临床多以颜面部肿胀而就诊。X线常表现为边界不清的多房性泡沫状透光影,其中间杂有不透光区。该瘤的组织病理学特征,主要是在黏液样基质中散在分布一些星芒状、梭形、三角形的瘤细胞。镜下依据胶原纤维的含量分为(纤维)黏液瘤(15例)和黏液纤维瘤(14例)2种类型。结论:临床上颌骨黏液瘤与其他一些颌骨病变很难鉴别,最后确诊仍需病理检验。通过分析表明,该瘤预后相对较好,但由于其具有局部浸润性,黏液纤维瘤型及保守性手术如刮治术不彻底可复发。     

8例颌骨尤文肉瘤的临床及影像学特征分析

目的 探讨颌骨尤文肉瘤的临床表现及CT影像学特征。方法 回顾性分析2010年1月—2022年6月经病理证实的8例颌骨尤文肉瘤的临床表现及CT影像学特征。结果 8例颌骨尤文肉瘤病例的发病平均年龄为29.4岁，男女比例为7∶1，发病部位下颌骨后部多见（75%），早期多数有下唇麻木及淋巴结肿大表现。下颌骨尤文肉瘤影像学表现为颌骨内混杂低密度骨质破坏伴软组织肿块形成，纤维索条状及毛刷状瘤骨为其特征型影像学表现。上颌骨尤文肉瘤主要变现为溶蚀状骨质破坏，伴软组织肿块形成。骨膜成骨少见。结论 颌骨尤文肉瘤具有一定的临床及影像学特征，这有助于其影像诊断。     

良性成牙骨质细胞瘤12例临床病理分析

目的分析12例良性成牙骨质细胞瘤的临床病理特征。方法对12例良性成牙骨质细胞瘤分别从患者发病年龄、性别、发病部位、临床表现、X线特征,组织病理学表现及治疗方式等方面进行回顾性分析。结果12例良性成牙骨质细胞瘤患者,发病年龄13~58岁,平均33.8岁;好发于下颌骨(66.7%),后牙区较多见(91.7%);最常见的症状是颌骨膨胀(75%)和疼痛(25%)。X线片特征是:肿瘤与牙根关系密切;肿瘤中央区为高密度阻射影,周围为环状低密度透射影。组织学上表现为不规则排列牙骨质样物体附着于牙根,有明显的嗜碱性反折线形成。采用摘除肿瘤并拔除受累牙的治疗方式可治愈。结论良性成牙骨质细胞瘤好发于中青年,颌骨后牙区最常见,多表现为疼痛或颌骨膨胀,X线片特征与组织病理学表现结合有助于该肿瘤与骨母细胞瘤、化牙骨质纤维瘤和非典型骨肉瘤鉴别。     

颌骨中心性粘液表皮样癌临床、Ｘ线、病理学研究

目的：对１１例罕见的颌骨中心性粘液表皮癌（ＣＭＣＪ）的临床资料，Ｘ线表现和病理特征进行分析研究，在国内首次提出ＣＭＣＪ的Ｘ线特征分型，以期为临床提供帮助，方法：对１９７５年－１９９９年间１１例经平理确诊的ＣＭＣＪ的临床表现，影像学特征，组织病理改9变分析研究，结果：１１例ＣＭＣＪＸ线分五型，（１）多囊型；（２）单囊形；（３）骨破坏型，（４）“火焰”状型，（５）发生在上凳骨ＣＭＣＪ由于上颌窦的存在，表现复杂，结论：ＣＭＣＪ的Ｘ线表现非常复杂，Ｘ线分型有助于对ＣＭＣＪ治疗，预后提供依据，Ｘ线分型与肿瘤恶性程度有一定关系。     

CT findings of cervical lymph node metastasis from intraoral mucoepidermoid carcinoma: Histopathological correlation

Objectives To evaluate CT findings of metastatic cervical nodes from intraoral mucoepidermoid carcinoma and to correlate them with histopathological findings. Methods Five metastatic cervical lymph nodes in four patients with intraoral mucoepidermoid carcinoma were included in this study. The primary sites of the tumors were the palate (n=2), the lower gingiva (n=1) and the tongue (n=1). The findings for these nodes on contrast-enhanced CT images were retrospectively evaluated and compared with the histopathological findings. Results Among the five metastatic nodes, the minimal axial diameter ranged from 12 mm to 19 mm. They all contained low-density areas on CT, suspicious for nodal necrosis, and showed heterogeneous or rim enhancement. Histopathologically, they all had intranodal cysts, which were consistent with the low-density areas detected on CT. Conclusion The CT findings of cervical metastases from intraoral mucoepidermoid carcinoma were characterized by the presence of low-density areas within the nodes. Although these findings suggested nodal necrosis typically seen in squamous cell carcinoma, they were histopathologically confirmed to reflect intranodal cyst formation.     

影响涎腺粘液表皮样癌术后复发的临床病理因素分析

目的 探讨影响涎腺粘液表皮样癌病人术后复发的临床病理因素。方法 回顾经本院手术并获得五年以上随访或不足五年而出现复发的涎腺粘波表皮样癌77例，对各项临床病理指标进行单因素似然比检验及多因素Logistic回归分析，资料的统计学处理全部通过SPSS软件完成。结果 本组涎腺粘液表皮样癌术后复发有其自身的特点。在单因素分析中，性别、分化程度、原发灶的处理方式、小涎腺粘液表皮样癌侵犯骨的处理等因素均与术后复发相关。性别、分化程度、原发灶的处理方式做为影响术后复发的主要因素进入Logistic回归方程，所得回归方程对术后复发的分类能力可达84．4％。结论 性别、分化程度、原发灶的处理方式是影响涎腺粘液表皮样癌术后复发的主要因素。     

Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases

Objective:  Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
Methods:  A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files. Information about demographic, clinical, histopathologic characteristics, and follow-up status were analyzed.
Results:  Sixty tumors (75.9%) were benign and 19 (24.1%) malignant. The most common tumor overall was pleomorphic adenoma (PA). The parotid was the most frequently involved site (43.0%). PA was the most common type of benign tumor. The most common malignant tumor was mucoepidermoid carcinoma. Five patients with parotid PA and two cases with palate myoepithelioma showed local recurrences. One patient with mucoepidermoid carcinoma showed local recurrences and died from the tumor 3 years after the initial treatment. One patient with adenocarcinoma presented local and neck recurrences, and died 4 years after initial treatment.
Conclusions:  Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands. Mucoepidermoid carcinoma was the most common malignant tumor, with majority of low grade. Initial treatment should be planned to excise the tumor completely with satisfactory margins. The neck dissections or postoperative radiotherapy were performed in patients with low differentiation malignancies, or patients who present nodal metastasis or with clinically suspicious regional metastasis.     

Necrotizing sialometaplasia

Necrotizing sialometaplasia is a non-neoplastic self-limiting inflammatory-ulcerous condition of the minor salivary glands. It is reported to appear in the oral cavity at every area where minor salivary glands exist, particularly those of the palate. Necrotizing sialometaplasia is a very rare disease that spontaneously develops with fearsome features. It is thought to be due to infarction of minor salivary glands, and heals in a few weeks, without any treatment. The clinical and histopathological features of necrotizing sialometaplasia often simulate those of such malignancies as squamosus cell carcinoma or mucoepidermoid carcinoma. Familiarity with necrotizing sialometaplasia and correct differential diagnosis are paramount in avoiding misdiagnosis and inappropriate treatment.     

Central mucoepidermoid carcinoma of the mandible: report of four cases with long-term follow-up

Central mucoepidermoid carcinomas are uncommon tumours, representing about 2 to 4% of all mucoepidermoid carcinomas. They are histologically low-grade cancers, usually affecting the mandible as uni- or multilocular radiographic lesions. The authors report four cases of central mucoepidermoid carcinomas affecting the mandible and discuss their clinical, radiographic and histological findings. Four females were affected, with a mean age of 42 years and all cases involved the posterior mandible. Treatment included surgery in three cases and surgery associated to neck dissection and radiotherapy in one case. Two patients showed no recurrence and were alive without signs of the disease after a mean follow-up of 78 months. The other two patients showed local recurrence and one was alive with disease after a follow-up of 384 months, and the other was followed-up for 324 months dying by other causes without signs of the tumour. Central mucoepidermoid carcinomas of the mandible are low-grade tumours, and effective surgical treatment involving wide local excision or en bloc resection allows patients to have a favourable prognosis after long-term follow-up.     

Oncocytic mucoepidermoid carcinoma of parotid gland origin

This article reports 3 cases of oncocytic mucoepidermoid carcinoma of the parotid gland and compares them with 9 cases from the literature with emphasis on clinical behavior, treatment, and recurrence rate. The tumor occurs most often in the middle-aged to elderly, with a decided predilection for the parotid gland. All three oncocytic mucoepidermoid carcinomas from the Armed Forces Institute of Pathology series were low grade with extensive oncocytic change. Treatment modalities consisted of superficial parotidectomy, total parotidectomy, or total parotidectomy. The mean follow-up interval was 5.5 years. Only one case from the literature, a high-grade mucoepidermoid carcinoma, recurred. Results of this study indicate that the parotid gland oncocytic mucoepidermoid carcinoma behaves in a fashion similar to typical mucoepidermoid carcinoma, with prognosis dependent on clinical stage, histopathologic grade, and adequacy of treatment. Recognizing the spectrum of oncocytic differentiation in salivary gland tumors will serve to establish appropriate diagnoses and treatment.