Clinical and experimental study of therapeutic effect of Weixibaonizhuan pills on gastric precancerous lesions

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CD44 V6和MMP-9在胃癌及癌前病变组织中表达

目的探讨CD44V6和基质金属蛋白酶9（MMP-9）在胃癌及癌前病变组织中表达。方法免疫组化SP法测定正常胃黏膜（NOR）、萎缩性胃炎伴中重度肠化（IM）、萎缩性胃炎伴中重度不典型增生（DYS）和早期胃癌（EGC）各40例，进展期胃癌（AGC）100例中CD44V6和MMP-9的表达。结果NOR、IM、DYS、EGC和AGC组中，分别有0、15．0％、25．0％、45．0％和72．0％CD44V6阳性，0、40．0％、50．0％、40．0％和68．0％MMP-9阳性。从IM、DYS至EGC和AGC组，CD44V6和MMP-9表达渐增（均P〈0．05）。结论CD44V6、MMP-9在胃痛的演变过程中不仅仅参与了浸润转移．其在胃癌早期发生、发展中也起着重要作用。     

Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions

AIM: To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions. METHODS: We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG,n = 32),chronic atrophic gastritis CAG,n = 43; 15 with and 28 without intestinal metaplasia (IM),gastric dysplasia (DYS,n = 11) and gastric cancer (GC,n = 48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy. METHODS: The positive rate of ODC expression was 34.4%,42.9%,73.3%,81.8% and 91.7% in cases with CSG,CAG without IM,CAG with IM,DYS and GC,respectively (P < 0.01),The positive rate of ODC expression increased in the order of CSG < CAG (without IM) < CAG (with IM) < DYS and finally,GC. In addition,ODC positive immunostaining rate was lower in well-differentiated GC than in poorly-differentiated GC (P < 0.05). CONCLUSION: The expression of ODC is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. This finding indicates that ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions.     

死亡相关蛋白激酶基因高甲基化在胃癌形成过程中作用的初步研究

背景：DNA启动子区甲基化可导致肿瘤抑制基因表达沉默，在胃癌的发生、发展中发挥重要作用。目的：观察正常胃黏膜、慢性萎缩性胃炎伴肠化生、异型增生和早期胃癌组织中死亡相关蛋白激酶（DAPK）基因启动子区甲基化状态，探讨其与胃癌发生、发展的关系。方法：以甲基化特异性聚合酶链反应（MSP）检测20例正常胃黏膜、14例慢性萎缩性胃炎伴肠化生、27例异型增生和16例早期胃癌组织中DAPK基因启动子区甲基化状态．并分析其与患者临床病理特征的关系。结果：早期胃癌组织中DAPK基因启动子区甲基化率显著高于正常胃黏膜、慢性萎缩性胃炎伴肠化生和异型增生组织（43.8％对0％、7．1％和11．1％，P〈0．05），而后三者之间DAPK基因启动子区甲基化率无明显差异。DAPK基因启动子区甲基化与患者性别、年龄和病变部位均无关，与幽门螺杆菌（H.pylori）感染和血清癌胚抗原（CEA）水平显著相关（P〈0．05）。结论：DAPK基因启动子区高甲基化是胃癌发生的早期分子事件，在由慢性萎缩性胃炎伴肠化生和异型增生进展至早期胃癌的过程中起重要作用。     

胃癌中幽门螺杆菌感染与原癌基因c—met表达及预后研究

目的　研究幽门螺杆菌(Hp)感染的胃癌(GC)组织中c-met表达及(Hp)感染对胃癌预后的影响。方法　经病理证实,不同病变胃粘膜145例以免疫组化检测c-met基因表达,以W-S法及快速尿素酶试验检测(Hp)感染。结果　在浅表性胃炎(CSG)、萎缩肠化生胃炎(CAG+IM)、异型增生(DYS)、早期GC和进展期GC中,c-met基因表达率分别为25.53%,51.28%,61.54%,66.67%和68.42%,CAG+IM、DYS、GC均显著高于CSG(P＜0.05)。肠型胃癌c-met阳性表达与(Hp)感染密切相关。CAG+IM,DYS和GC组c-met阳性表达(Hp)感染者明显高于阴性组。(Hp)阳性者5年生存期显著短于(Hp)阴性者。结论　(Hp)感染和c-met表达与胃粘膜增殖和恶化有关,前者也与胃癌预后有关。     

幽门螺杆菌感染在胃癌及癌前病变中的研究

目的　研究胃癌及癌前病变与Hp感染的关系 ,以探讨Hp可能的致癌机制。 方法　经内镜和病理明确诊断的胃癌及癌前病变者共 5 48例 ,包括慢性浅表性胃炎 (CSG) 16 3例、慢性萎缩性胃炎 (CAG) 2 0 7例、肠上皮化生 (IM) 71例 ,异型增生(DYS) 4 5例及胃癌 (GC) 6 2例。每例均活检胃窦大小弯、胃角及胃体大小弯共 5块 ,以WS法检测Hp。结果　癌前病变及胃癌Hp感染均较高 ,CAG(4 2 .5 % ) ,IM(76 .1% ) ,DYS(88.9% )和GC(72 .5 % ) ,与CSG(2 3.9% )有显著性差异 (P <0 .0 5或P <0 .0 1)。随着年龄增大 ,CAG、IM、DYS和GC逐步增多 ,而且≥ 5 6岁年龄组IM、DYS和GC显著多于≤ 40岁组 (P <0 .0 5 ) ,但CSG则相反。肠型胃癌和Hp感染密切相关 (P <0 .0 5 ) ,从胃窦小弯和大弯、胃角及胃体小弯和大弯顺序 ,Hp感染随着CSG、CAG、IM、DYS和GC病变而增高 ,Hp感染部位也在上移 ,尤其在胃体小弯及大弯 ,IM、DYS和GC的Hp感染显著高于CSC部位 (P <0 0 5 )。结论　Hp感染是导致从胃炎→胃萎缩→肠化→异型增生→癌变序列发展的危险因子 ,肠型胃癌和Hp感染密切相关 ,胃镜检查应该多部位取活检作病理及Hp检测 ,尤其是高位     

Anti-Helicobacter pylori immunoglobulin G （IgG） and IgA antibody responses and the value of clinical presentations in diagnosis of H.pylori infection in patients with precancerous lesions

AIM: To determine the prevalence of Helicobacter pylori(H. pylon) infection, the serum anti-H, pylori immunoglobulin G (IgG) and IgA antibody responses, and the value of clinical presentations in diagnosis of H. pylori infection in patients with gastric atrophy, intestinal metaplasia and dysplasia.METHODS: H. pylori infection was detected by histology in 209 patients with mild chronic atrophic gastritis (CAG, n=76),severe CAG (n=22), mild intestinal metaplasia (IM, n=22),severe IM (n=58), or dysplasia (DYS, n=31). Serum anti-H. pylori IgG and IgA were double sampled and evaluated by enzyme-linked immunoadsordent assays. 35 clinical presentations were observed and their relationship with H.pylori infection was analyzed by the k-means cluster method.RESULTS: Both IgG and IgA levels in H. pylori positive patients were significantly higher than those negative for H.pylori(P&lt;0.001-0.01). The prevalence of H. pyloriwas highest in severe IM (84.5%), and lowest in mild CAG (51.3%)(P&lt;0.01). They were similar in severe CAG (68.2%), mild IM (72.7%), and DYS (67.7%). In H. pyloripositive patients,the IgG levels in severe CAG were significantly higher than those in mild CAG (P&lt;0.01). In H. pylorinegative patients,both IgG and IgA levels increased remarkably in severe IM,compared to those in mild IM (P&lt;0.01-0.05). H. pyhri infection exhibited no association with patient‘s gender (62.1% inmales; 71.7% in females) and age (r=0.0814, P=0.241).The diagnostic accuracy based on 35 clinical presentations was 65.7%. It could be improved by 5.7% when only the assemblage of digestive symptoms were engaged, or by 8.6% when the pathogenic factors, general status and grossoscopy were combined. The diagnostic accuracy could be decreased when only the general symptoms were engaged, or when the pathogenic factors were accompanied with some common digestive symptoms.CONCLUSION: H. pylori infection is a major risk factor for the process from atrophy, IM to DYS of gastric mucosa.Serum IgG and IgA are good indicators to evaluate this progress with a certain arrearage. Investigation on the effective assemblages of clinical presentations may provide a better understanding in the pathogenesis, diagnosis and treatment for H. pyloriinfection.     

Expression of polycomb protein EZH2 in multi-stage tissues of gastric carcinogenesis

OBJECTIVE: To study the role and significance of the polycomb group (PcG) protein EZH2 (enhancer of zeste homolog 2) in the multi-step process of intestinal-type gastric carcinogenesis. METHODS: Gastric specimens were obtained from 142 patients with gastric disease, including 34 with chronic non-atrophic gastritis (NCAG), 33 chronic atrophic gastritis (CAG) with intestinal metaplasia (IM), 40 CAG with dysplasia (DYS) and 35 with intestinal-type gastric carcinomas (GC), and 32 Helicobacter pylori-negative controls. The EZH2 protein was stained by the immunohistochemical method and was expressed as the intensity and percentage of the total number of epithelial cells. The chronic gastritis and the grading of dysplasia were classified according to Chinese National Consensus on chronic gastritis and the Padova international classification. RESULTS: The EZH2 protein levels in the specimens of normal gastric tissue, NCAG, CAG with IM, DYS and intestinal-type GC were gradually increased (P < 0.05), but statistical significance was not found between the groups of DYS and GC. CONCLUSION: PcG protein EZH2 plays an important role in the multi-step process of intestinal-type gastric carcinogenesis.     

幽门螺杆菌相关胃疾病组织中P53、iNOS的表达

目的通过检测慢性浅表性胃炎、慢性萎缩性胃炎、肠上皮化生、不典型增生、胃癌组织幽门螺杆菌（Hp）和P53、一氧化氮合成酶（iNOS），探讨Hp感染与P53、iNOS表达的关系，以及Hp感染导致胃癌的可能分子机制。方法应用快速尿素酶试验和组织切片革兰氏染色和血清HpCagA抗体检测Hp，用免疫组化SP法检测上述组织的P53、iNOS。结果慢性浅表性胃炎、慢性萎缩性胃炎、肠上皮化生、不典型增生、胃癌组织中Hp检出率分别为45．9％、68．4％、71．4％、75．O％、54．8％，病变各组中P53和iNOS表达阳性率与浅表性胃炎组比较均有显著性差异。除浅表性胃炎组、萎缩性胃炎Hp阳性组的P53表达阳性率外，各病变Hp阳性组的P53和iNOS表达阳性率与各组的Hp感染阳性率呈正相关，各病变组中Hp（＋）组的P53和iNOS表达阳性率显著高于Hp（-）组，均有显著性差异。结论Hp与P53和iNOS阳性表达有一定的相关性。     

慢性萎缩性胃炎内镜与病理诊断的相关性研究

目的　探讨中重度慢性萎缩性胃炎 (CAG)的胃镜下表现与病理结果的关系。方法　对4 9例中重度CAG的胃镜下诊断及表现与病理学结果进行相关性研究。结果　病理诊断中重度CAG33例 ,轻度CAG1 0例 ,正常 6例。肠上皮化生 (IM) 2 7例 ,异型增生 30例。中重度CAG的胃镜诊断与病理结果比较肉眼符合率为 6 7 35 %。其中 2 0例患者胃镜下美蓝染色后 ,诊断符合率为80 %。胃镜下表现与病理结果比较 ,胃黏膜的各种表现对CAG的阳性预测值均达到 80 %以上 ,多种表现同时存在对CAG阳性预测值可达 90 %以上 ,其阳性率之间比较无显著差异。各种胃镜下表现的灵敏度及特异度均在 95 %以上。黏膜变薄等表现对IM及异型增生的阳性预测值均较低在 70 %以下 ,灵敏度及特异度在 30 %以下。黏膜粗糙不平对IM及异型增生诊断的灵敏度分别为 92 85 %和83 33% ,特异度也均在 70 %左右。结论　中重度CAG的胃镜下诊断符合率较低 ,但是通过对胃镜下表现的认识以及染色技术的应用 ,可提高诊断符合率     

Correlations among Helicobacter pylori infection and the expression of cyclooxygenase‐2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia

Background and Aims: To examine the rate of Helicobacter pylori infection and the expression of cyclooxygenase‐2 (COX‐2) and vascular endothelial growth factor (VEGF) in gastric mucosa with intestinal metaplasia or dysplasia, and explore their correlations in precancerous gastric lesions. Methods: A total of 172 patients were included in the study. H. pylori infection was evaluated by hematoxylin–eosin and modified Giemsa staining. The expression of COX‐2 and VEGF proteins was detected by immunohistochemistry. Results: The rates of H. pylori infection in gastric mucosal dysplasia (DYS), intestinal metaplasia in gastric mucosa (IM), chronic atrophic gastritis (CAG) and chronic superficial gastritis (CSG) patients were significant differences (P = 0.001). The average optical density (AOD) values of COX‐2 staining in CSG, CAG, IM and DYS patients were 13.81 ± 5.53, 45.28 ± 21.44, 73.67 ± 26.02 and 91.23 ± 45.11, respectively, with significant differences among CSG, CAG and IM patients (P = 0.037, 0.001 and 0.047 for CSG vs CAG, CSG vs IM and CAG vs IM, respectively). The expression level of VEGF in DYS patients was significantly higher than those in other patients (P = 0.001, 0.001 and 0.001 for DYS vs CSG, DYS vs CAG and DYS vs IM, respectively). The expression levels of COX‐2 in H. pylori‐positive IM, CAG and DYS patients were significantly higher than those in H. pylori‐negative counterparts (P = 0.043, 0.009, 0.001, respectively). Additionally, the expression level of COX‐2 was positively correlated with that of VEGF with the aggravation of gastric mucosal lesions (r = 0.640, P = 0.006). Conclusion: H. pylori infection might be able to induce the expression of COX‐2 in precancerous gastric lesions, which in turn upregulates the expression of VEGF.     

Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry

Background and Aim: To study the low‐molecular‐weight metabolites in blood plasma of patients with the progressive disease, gastric cancer, and to characterize different stages from chronic superficial gastritis (CSG) to chronic atrophic gastritis (CAG), intestinal metaplasia (IM), gastric dysplasia (DYS) and finally gastric cancer (GC). Methods: We applied gas chromatography time‐of‐flight mass spectrometry (GC/TOF‐MS) to determine metabolites levels in plasma obtained from 80 patients including 19 with CSG, 13 with CAG, 10 with IM, 15 with DYS and 22 with GC (nine preoperation and 13 postoperation). Principal component analysis (PCA) and statistics were used to differentiate the stages and to identify the markers of gastric cancer. Results: Totally, 223 peaks were detected in GC/TOF‐MS and 72 compounds were authentically identified. CSG showed distinct difference from the other groups of CAG, IM, DYS and GC, whose plots clustered closely. IM clustered closely to GC, suggesting similar metabolic patterns of them. Fifteen identified metabolites contributed most to the differentiating between CSG and GC, and characterized different stages of GC. Statistics revealed elevated levels of 2‐Hydroxybutyrate, pyroglutamate, glutamate, asparagine, azelaic acid, ornithine, urate, 11‐eicosenoic acid, 1‐monohexadecanoylglycerol and γ‐tocopherol, while downregulation of creatinine, threonate in GC group, indicating that GC patients were obviously involved in oxidative stress, and perturbed metabolism of amino acids and fatty acids. Conclusion: The metabolic phenotype of CSG is significantly different from GC, while that of IM is similar to it. The discriminatory metabolites characterizing progressive stages from CSG to GC might be the potential markers to indicate a risk of GC.     

胃癌及癌前病变组织三叶因子3表达的相关性研究

目的检测三叶因子3（TFF3）在胃癌前病变及胃癌的表达,探讨TFF3的表达与胃癌发生、发展的关系。方法收集慢性浅表性胃炎（CSG）,慢性萎缩性胃炎伴中、重度肠上皮化生（IM）,慢性萎缩性胃炎伴中重度不典型增生（Dys）患者各30例,胃癌（GC）患者40例采用SP免疫组化法检测TFF3蛋白的表达。结果CSG、IM、Dys、GC组织中TFF3表达呈逐渐增强趋势,差异具有统计学意义（P〈0.05）。结论TFF3表达在胃癌发生、发展过程中起一定作用。     

Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions

AIM:To explore the relationship between Cripto-1 (CR-1) and tyrosine phosphorylation STAT3 (p-STAT3) expressions in gastric cancer (GC) and gastric carcinogensis and metastasis.METHODS: The PV9000 immunohistochemical method was used to detect the expression of CR-1 and p-STAT3 in 178 cases of GC, 95 matched normal gastric mucosa, 40 chronic atrophic gastritis (CAG), 48 intestinal meta-plasia (IM) and 25 dysplasia (DYS). RESULTS: The positive rates of CR-1 and p-STAT3 expression were significantly higher in ...     

胃癌中幽门螺杆菌感染与胃粘膜增殖及凋亡研究

目的研究幽门螺杆菌(Hp)感染的胃癌(GC)发展中增殖细胞核抗原(PCNA)表达及细胞凋亡的关系和对胃癌预后意义。方法145例经病理证实,不同胃黏膜病变采用免疫组化检测PCNA基因表达及Warthinstarry法检测Hp感染。采用原位末端标记法(TUNEL)检测细胞凋亡。结果在浅表性胃炎(CSG)、萎缩肠化生胃炎(CAG+IM)、异型增生(DYS)、早期GC和进展期GC中,PCNA基因表达率分别为24.53%,46.28%,60.54%,57.67%和71.42%,CAG+IM、DYS、GC均显著高于CSG(P<0.05)。凋亡指数(AI)分别为(4.55±2.33)%、(6.43±5.60)%、(6.45±5.12)%、(6.55±4.80)%、(8.84±5.63)%,进展期GC显著高于CSG(P<0.05)。胃黏膜凋亡指数与PCNA表达强度有密切相关(P<0.05)。PCNA阳性表达与胃癌组织类型、浆膜浸润和淋巴结转移密切相关,而且BorrmannIV明显高于早期胃癌和BorrmannI,II(P<0.05)。PCNA阳性表达与肠型胃癌Hp感染有关。CAG+IM,DYS和GC组PCNA阳性表达中Hp感染者明显高于阴性者。Hp阳性者5年生存期显著短于Hp阴性者。结论Hp感染和PCNA表达与胃黏膜增殖和恶化有关,且与凋亡有相关性。Hp感染与胃癌预后有关。     

不同胃黏膜病变的细胞增殖变化规律及其意义

目的 研究胃黏膜不同病变时细胞增殖的变化规律及其意义,寻找有效的生物学指标来预测和早期诊断胃癌。方法 采用免疫组织化学SP法检测了30例慢性浅表性胃炎(CSG)、26例慢性萎缩性胃炎(CAG)、40例肠上皮化生(IM)、22例异型增生(DYS)、22例早期胃癌(EGC)和26例进展期胃癌(AGC)的增殖细胞核抗原(PCNA)、表皮生长因子受体(EGFR)、转化生长因子β受体(TGFβR)Ⅰ和TGFβR Ⅱ的表达。所得数据采用秩和检验及Spearman等级相关分析。结果 相应于CSG、CAG、IM、DYS、EGC和AGC不同的胃黏膜病变,PCNA和EGFR的表达递增(P<0.0001),TGFβR Ⅰ(P=0.007)和TGFβR Ⅱ(P<0.0001)的表达递减。PCNA标记指数在DYS时高于CSG、CAG和IM,低于EGC和AGC,其差异有显著性(P<0.0001);EGFR在IM和DYS时比CSG和CAG明显升高,差异有显著性(P<0.0001);TGFβR Ⅰ在EGC和AGC时明显下降,与CSG相比差异有显著性(P=0.007);TGFβRⅡ在AGC时明显下降,与CSG、CAG、IM、DYS及EGC相比差异有显著性(P<0.13001)。EGFR表达与PCNA的表达呈正相关,TGFβR Ⅰ和TGFβR Ⅱ与PCNA分别呈负相关,TGFβR Ⅰ和TGFβRⅡ呈正相关。结论 不同的胃黏膜病变中,DYS是细胞增殖水平发生变化的关键环节;EGFR的升高和TGFβR的下降可能通过对细胞增生水平的调节促进胃癌的发生。     

survivin蛋白在胃癌及癌前病变中的表达和意义

目的探讨survivin蛋白在胃癌及癌前病变中的表达程度和意义。方法收集南方医科大学南方医院消化科及佛山市三水区人民医院消化内镜室诊断并经病理确诊的病例。分为慢性浅表性胃炎组、慢性萎缩性胃炎组、慢性萎缩性胃炎伴轻度不典型增生组、慢性萎缩性胃炎伴中度不典型增生组、胃癌组共5组,每组40例,测定survivin蛋白在各组中的表达程度。结果 survivin表达在慢性浅表性胃炎组平均分值0.075±0.267,阳性率7.5%;在慢性萎缩性胃炎组平均分值0.600±0.744,阳性率45%;在慢性萎缩性胃炎伴轻度不典型增生组平均分值2.075±1.980,阳性率70%;慢性萎缩性胃炎伴中度不典型增生组平均分值4.225±2.402,阳性率95%;在胃癌组平均分值5.750±3.614,阳性率97.5%。survivin表达在胃高分化腺癌中,平均分值2.500±0.707;中分化腺癌平均分值8.750±3.495;低分化腺癌平均分值5.522±3.654;粘液腺癌平均分值3.200±0.837;印戒细胞癌平均分值6.000±0.000。结论 survivin在慢性浅表性胃炎-慢性萎缩性胃炎-不典型增生-胃癌的过程中阳性表达逐渐增高;但其在胃癌中的阳性表达与性别及肿瘤的大小和组织的分化程度无关。     

Epithelial dysplasia in atrophic gastritis. Bioptical follow-up study.

Fifty-nine cases of gastric dysplasia (46 of which were mild, 11 moderate and 2 severe) were studied in relation to their association with atrophic gastritis and intestinal metaplasia. Atrophic gastritis was found in 39 cases (28 of which were mild, 10 moderate and 1 severe). Dysplasia was considered "persistent" when found of the same degree in at least two consecutive check-ups after initial diagnosis (13 cases); it was considered "progressive" if found more severe or evolving as cancer (5 cases) or "regressive" if detected in a lesser degree or no longer detected (13 cases). Sixteen of the 18 persistent or progressive cases of dysplasia were associated with atrophic gastritis, whereas 10 of the 13 cases with regressive dysplasia revealed no concomitant pattern of gastric mucosa atrophy (p less than 0.005). These findings suggest that dysplasia represents a truly pre-neoplastic change particularly when associated with atrophic gastritis and which must therefore be more carefully monitored.     

胃癌幽门螺杆菌感染中c-met基因表达与增殖的关系及其预后

目的 研究c-met基因蛋白及增殖细胞核抗原（PCNA）在幽门螺杆菌（Hp)感染的胃黏膜病变演进中的表达及关系，探讨Hp感染对胃癌预后的意义。方法 采用免疫组织化学法检测145例经病理证实不同胃黏膜病变的c-met和PCNA基因表达，Warthin-Starry法检测Hp感染。结果 在浅表性胃炎（CSG）、萎缩肠化性胃炎、异型增生（DYS）、早期胃癌和进展期胃癌中，c-met和PCNA2种基因在萎缩肠化性胃炎、DYS、胃癌均显著高于CSG（P＜0．05）。对胃黏膜增殖程度与c-met和PCNA阳性表达强度的密切关系分析，表明两者有显著关联（P＜0．01）。c-met和PCNA阳性表达与胃癌组织类型、浆膜浸润和淋巴结转移密切相关，而且Borrmann Ⅳ明显高于早期胃癌（P＜0．05）。c-met－LI和PCNA－LI在胃癌中等级相关表达有极显著的相关性（P＜0．001）。c-met阳性表达与肠型胃癌Hp感染有关。萎缩肠化性胃炎、DYS和胃癌组c-met阳性表达中Hp感染者明显高于阴性者。Hp阳性者5年生存期显著短于Hp阴性者。结论 c-met和PCNA基因表达与胃黏膜增殖和恶化有关，c-met基因可能成为评估胃癌恶化和预后的1项新的重要指标。Hp感染和c-met表达与胃黏膜增殖和恶化有关，Hp感染与胃癌预后有关。