针灸分期治疗贝尔氏面瘫的临床效果分析

目的分析针灸分期治疗贝尔氏面瘫的临床疗效。方法选取2014年6月至2015年8月于我院接受治疗的贝尔氏面瘫患者90例,随机分为观察组45例和对照组45例。将观察组患者按发病和就诊时间分为三组进行分期治疗,给予对照组患者行常规针灸治疗。分析、比较两组的临床治疗效果。结果通过针灸治疗,观察组患者总有效率为97.78%,对照组患者总有效率为93.33%,观察组显著高于对照组,比较差异均具有统计学意义(P0.05)。结论针灸治疗贝尔氏面瘫具有较好的效果,采用分期治疗可取得更加理想的效果。     

针灸治疗颅脑外伤疗效分析

目的观察通窍活血汤加针灸治疗创伤性颅脑外伤疗效。方法选取78例颅脑外伤入院患者,随机分为治疗组和对照组,对照组给予常规对症治疗,治疗组在此基础上给予通窍活血汤加针灸治疗,观察两组疗效。结果两组在治疗后GCS评分均升高,但治疗组升高幅度明显高于对照组（P〈0.01）;治疗组治愈7例,显效19例,总有效率为66.67%;对照组治愈4例,显效16例,总有效率为51.28%;治疗组疗效明显优于对照组（P〈0.01）。结论使用通窍活血汤加针灸治疗创伤性颅脑外伤能够加速颅脑神经恢复,提高患者的生活质量,值得临床推广。     

针灸分期治疗贝尔氏面瘫效果观察

目的:观察并探讨利用针灸分期治疗贝尔氏面瘫的临床效果。方法:选取2014年10月至2015年10月我院针灸科收治的贝尔氏面瘫患者100例,随机分成观察组和对照组两组,每组50例,观察组采用针灸分期治疗治疗,对照组常规针灸治疗,观察两组治疗效果并进行判定。结果:100例患者均通过各组治疗方法连续治疗1个月,观察组有29例显效,20例有效,总有效率98%;对照组有18例显效,13例有效,总有效率62%。两组疗效差异明显,并且P0.05,有统计学意义。结论:相比传统针灸治疗而言,针灸分期治疗对于患者贝尔氏面瘫的恢复促进作用更好,显效有效率更高,是值得临床推广的一种治疗贝尔氏面瘫的针灸方法。     

中西医结合治疗贝尔麻痹56例临床分析

目的：观察以针灸为主中西医结合治疗贝尔麻痹临床效果。方法将56例贝尔麻痹患者随机分成两组，治疗组第1周给予激素治疗，第2周开始给予针刺治疗；对照组只给予1周针刺治疗。结果治疗组疗效明显优于对照组（P ﹤0.05）。结论以针灸为主配合激素、中药的中西医结合治疗贝尔麻痹效果明显优于单纯针灸治疗。     

针刺配合通窍活血汤治疗30例神经性耳鸣临床观察

[背景]观察针刺配合通窍活血汤治疗神经性耳鸣的临床疗效.[病例报告]选择神经性耳鸣患者60例,按照随机数字表法分为对照组和治疗组,每组各30例.对照组给予针刺治疗,治疗组给予针刺配合通窍活血汤治疗,30d后观察两组疗效.对照组总有效率为76.6%,治疗组为85.4%,两组间差异有统计学意义(χ2=8.834,P<0.05).[讨论]针刺配合通窍活血汤治疗神经性耳鸣临床疗效较好.     

活血通窍汤治疗抗精神病药物所致的高催乳激素血症的临床研究

目的探讨活血通窍汤治疗抗精神病药物所致的高催乳激素血症(Hp)的临床疗效。方法将2010年8月至2015年2月收治的104例抗精神病药物所致Hp患者,根据入院顺序平分为治疗组与对照组,各52例。对照组给予阿立哌唑联合溴隐亭治疗,治疗组在对照组治疗的基础上给予活血通窍汤。两组治疗疗程均为4周。观察两组患者治疗后临床疗效及内分泌激素[血清催乳素(PRL)]、精神症状[阳性和阴性症状量表(PANSS)评分]、不良反应情况。结果治疗后治疗组与对照组的有效率分别为98.1%和88.5%,治疗组明显高于对照组(P0.05)。治疗组与对照组治疗后的PRL含量及PANSS评分均明显低于治疗前(P0.05),同时治疗后治疗组的PRL、PANSS评分明显低于对照组(P0.05),组间对比差异明显(P0.05)。两组治疗期间治疗组便秘、失眠、头晕、嗜睡等不良反应发生情况明显少于对照组(P0.05)。结论活血通窍汤治疗抗精神病药物所致的Hp能缓解精神症状,有效抑制PRL的表达,减少不良反应的发生,从而有利于总体疗效的提高。     

针灸配合通窍活血汤治疗脑外伤后头痛疗效观察

目的观察针灸配合通窍活血汤加味治疗颅脑外伤后头痛的临床疗效。方法 126例确诊为头部外伤的患者,随机分为两组,在常规治疗基础上,治疗组（72例）应用针灸配合通窍活血汤加味治疗;对照组（54例）应用颅痛定、益脑灵治疗,两组患者治疗15d后观察疗效。结果治疗组中头痛缓解,有效率明显高于对照组（P〈0.05）、平均治愈时间明显短于对照组（P〈0.01）。结论在常规治疗基础上运用针灸配合通窍活血汤加味可明显提高颅脑外伤后头痛的疗效,缩短疗程。     

从络论治急性脑梗死的疗效观察

目的观察从络病病因辨证加减通窍活血汤早期干预急性脑梗死患者的临床疗效。方法将80例患者随机分为对照组40例和中医组40例,对照组予以常规西医+康复治疗,中医组在对照组基础上依据络病病因辨证加减通窍活血汤治疗,连续治疗2周,观察2组患者的临床疗效、神经功能缺损评分(NFDS)变化情况。结果两组患者治疗后神经功能缺损评分均较治疗前显著改善,且中医组改善程度较对照组显著(P0.05);中医组治疗有效率90%,明显高于对照组80%(P0.05)。结论依据络病理论辨证加减通窍活血汤治疗急性脑梗死能明显提高疗效。     

针灸治疗贝尔氏面瘫132例时效性研究

目的探讨针灸治疗贝尔氏面瘫不同病理阶段的临床疗效。方法选取2012年3月~2015年4月来本院门诊并收治入院的贝尔氏面瘫患者132例,根据发病时间长短分为发展期组51例,静止期组44例及恢复期组37例,均予以中医针灸治疗4个疗程,比较三组临床疗效及治疗前后面神经改善情况。结果发展期组临床有效率为92.1%,明显高于静止期组的63.6%及恢复期组的62.1%,差异有统计学意义(P均0.05)。三组治疗后的Sunnybrook评分均较治疗前得以不同程度提高,其中发展期组Sunnybrook量表评分为(55.2±13.7)分,明显高于静止期组(43.8±3.5)分、恢复期组(36.5±3.9)分,t值分别为16.214、17.704,P均0.05。结论对贝尔氏面瘫发展期时予以针灸治疗可取得满意的临床疗效,建议临床治疗时把握此段治疗时机。     

祛风解毒活络汤治疗周围性面瘫急性期疗效观察

目的:探讨祛风解毒活络汤治疗治疗周围性面瘫急性期的临床疗效。方法:将70例周围性面瘫急性期患者分为观察组和对照组,每组35例。观察组针灸治疗同时服用祛风解毒活络汤,对照组单用针灸治疗,对比两种的临床疗效。结果:观察组总有效率为91.43%,对照组总有效率为82.86%,两组比较差异有统计学意义(P0.05)观察组面神经功能恢复优于对照组。结论:祛风解毒活络汤可明显缓解周围性面瘫急性期患者的病症。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.