刺五加注射液对冠心病血瘀症患者血浆内皮素的影响

刺五加与人参、三七均属五加科植物，而人参、三七已在动物试验、临床观察证实具有降低血浆内皮素-1（ET-1）浓度的作用。大量药理实验显示刺五加注射液能够扩张血管、降低血压、抗血小板凝聚、调节血脂、改善血液流变特性和改善微循环，从而改善心肌缺血。目前仅限于动物实验证实刺五加注射液能拮抗ET所致冠状动脉收缩作用。本研究着重从临床角度研究刺五加注射液对冠心病血瘀症患者ET-1的影响，进一步探讨刺五加注射液对冠心病的作用机制。     

刺五加注射液对阿米卡星所致豚鼠耳蜗毛细胞损伤的拮抗作用

目的观察刺五加注射液(ASS)对阿米卡星所致豚鼠耳蜗毛细胞损伤的拮抗作用。方法 40只新生豚鼠随机分为正常对照组、阿米卡星组、刺五加注射液组、刺五加注射液和阿米卡星联合用药组。在耳蜗底回采用内耳微量注射阿米卡星的方式建立豚鼠耳聋模型,连续用药5 d后采用听性脑干反应(ABR)检测各组听阈阈值并对毛细胞结构进行扫描电镜观察。结果实验前ABR测定各组听功能正常;阿米卡星组ABR阈值升高,与正常对照组和刺五加注射液组差异显著,扫描电镜显示阿米卡星组耳蜗毛细胞静纤毛出现融合、散乱、倒伏甚至缺失现象;ASS可显著改善阿米卡星所致听力损伤和毛细胞结构改变。结论 ASS可拮抗阿米卡星所致新生豚鼠耳蜗毛细胞结构损伤造成的听力损害。     

抗感染用抗生素的不良反应及临床分析（附150例报告）

目的了解抗感染用抗生素导致的不良反应（ADR）,加强临床合理使用抗生素。方法调查并分析150例肺部感染患者应用抗生素的ADR资料。结果ADR表现以过敏反应为主,ADR程度以中度为主,主要由头孢菌素所致。结论抗感染用抗生素引起的ADR危害严重,应引起临床重视。     

刺五加注射液临床应用现状

刺五加,明代李时珍在本草纲目中指出:“五加治风湿痿痹,壮筋骨,其功良深”,亦有“宁得一把五加,不用金玉满车”的高度评价。经控药理分析,刺五加含有多种皂甙、多糖和黄酮类化合物,具有多种药理作用和临床用途。近来文献报道了刺五加注射液对多种疾病的治疗作用,现综述如下。1 临床应用1.1 治疗脑血管病郑氏将脑梗塞患者随机分成治疗组60例,对照组50例。治疗组给刺五加40ml加     

丹红注射液对阿霉素大鼠心肌损伤的保护作用

目的探讨丹红注射液(DH)对阿霉素(ADR)所致大鼠心肌损伤的影响及作用机制。方法腹腔注射ADR建立大鼠心肌损伤模型,随机分为对照组、DH组、ADR组、DH+ADR组,各10只。观察大鼠生理状况,比色法测定乳酸脱氢酶(LDH)、肌酸激酶(CK)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)及超氧化物歧化酶(SOD)的活性及丙二醛(MDA)的含量,流式细胞仪检测细胞线粒体膜电位。结果与ADR组相比,DH预处理能显著改善ADR所致的体重下降,降低LDH、CK的活性和MDA的含量,增强SOD、CAT和GSH-Px的活性。线粒体膜电位数据显示,与ADR组相比,DH显著增加心肌细胞线粒体膜电位。结论 DH对ADR所致大鼠心肌损伤具有显著的保护作用,其保护作用与降低心肌氧化应激,提高抗氧化防御和稳定线粒体膜电位有关。     

刺五加注射液局部痛点阻滞治疗颈肌凝结症30例

刺五加注射液局部痛点阻滞治疗颈肌凝结症３０例菏泽地区第三人民医院（２７４０３１）宋凤英，张一中笔者自１９９５年以来用刺五加注射液治疗颈肌凝结症３０例，取得了良好效果。临床资料：颈肌凝结症患者６０例，随机分两组：①治疗组（３０例）：取刺五加注射液４ｍｌ...     

刺五加注射液治疗脑梗死64例的疗效观察

目的为了解刺五加注射液治疗脑梗死的临床疗效。方法64例脑梗死患者随机分为治疗组和对照组。治疗组用刺五加注射液静脉点滴,疗程为15天,对照组用丹参静脉点滴,疗程30天,两组同时控制血压、血糖、血脂。结果治疗组32例中,有效30例,总有效率为93.75%,对照组32例中,有效24例,总有效率为75%。两者疗效差异具有显著性(P<0.05)。结论刺五加注射液治疗脑梗死安全、有效,适合于基层单位使用。     

刺五加注射液治疗冠心病心绞痛57例临床分析

目的观察刺五加注射液治疗冠心病心绞痛的临床疗效。方法对照组52例采用基础治疗，治疗组57例在对照组治疗的基础上加刺五加注射液静脉输注治疗，2周后评定疗效。结果治疗组显效38例，有效14例，无效5例，总有效率91．23％；对照组显效31例．有效9例，无效12例，总有效率76．92％：结论刺五加注射液对治疗冠心病心绞痛具有一定疗效。     

刺五加注射液拮抗内皮素-1的缩血管作用实验研究

目的观察刺五加注射液对内皮收缩猪冠状动脉作用的影响并探讨其作用机制.方法以内皮素在含钙与不含钙K-H液中预收缩离体猪冠状动脉环,观察刺五加累积给药的扩血管效应.结果在含钙与不含钙K-H液中,刺五加均能浓度依赖性地对抗内皮素10 nmol/L的收缩冠状动脉作用,机械去内皮后,刺五加仍能浓度依赖性地对抗内皮素的缩血管作用.结论刺五加对内皮素所致冠状动脉收缩具有拮抗作用,且这种作用为非内皮依赖性的.     

刺五加注射液治疗脑出血临床分析

目的探讨刺五加注射液治疗高血压脑出血的临床疗效。方法60例高血压脑出血患者被随机对等分为对照组(常规疗法+紫外线辐射血液)和治疗组(上述疗法+刺五加注射液静脉滴注的)。结果治疗组显效率96.7%、总有效率100%,明显优于对照组的60.0%、83.3%(P<0.01)。而且治疗组血肿吸收时间比对照组的明显缩短。结论刺五加注射液不仅可用于脑梗死的治疗,也可用于脑出血的治疗,对出血量在30ml以下的病例尤为适宜。     

State of knowledge of helminth fauna of freshwater fishes of Poland

A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status.     

高血压降压治疗目标的再认识

根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10～12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP     

Lack of correlation of degree of villous atrophy with severity of clinical presentation of coeliac disease

BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease.