共查询到20条相似文献,搜索用时 15 毫秒
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O. A. Lebed'ko T. V. Yatsenko S. S. Timoshin A. Yu. Rubina 《Bulletin of experimental biology and medicine》1997,123(3):232-234
Lipid peroxidation in the lungs and blood are activated while DNA synthesis in the tracheal epithelium and hepatocytes is
inhibited during the first five days of postnatal life in rat pups after severe prenatal hypoxia. Intraperitoneal injection
of the undecapeptide pGlu-Pro-Pro-Glu-Glu-Ser-Lys-Val-Ile-Leu-Phe, a peptide morphogen isolated from the hydra, before hypoxia
normalizes lipid peroxidation in the lungs and blood of the five-day-old pups. A compensatory activation of DNA synthesis
occurs in tracheal epithelium and hepatocytes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 269–272, March, 1997. 相似文献
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E. A. Gan'cheva V. K. Kozlov S. S. Timoshin 《Bulletin of experimental biology and medicine》1997,124(3):929-931
Female rats were exposed to high-altitude hypoxia on days 14–19 of pregnancy. Thirty min before hypoxia the animals were injected
with the hydra peptide morphogen in a dose of 10 μg/kg intraperitoneally. Prenatal exposure to hypoxia suppressed proliferative
processes in thymic cortex and medulla in newborn rats and decreased the lymphocyte count in the female—newborn rat pairs
and the percent of full-term deliveries. Injection of hydra peptide morphogen prevented the development of posthypoxic disorders
in newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 348–350, September, 1997 相似文献
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A. Yu. Khomichuk S. S. Timoshin 《Bulletin of experimental biology and medicine》1990,110(4):1424-1426
Central Research Laboratory, Khabarovsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR D. S. Sarkisov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 10, pp. 425–427, October, 1990. 相似文献
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S. S. Timoshin E. N. Sazonova O. A. Lebed'ko V. V. Kulaeva 《Bulletin of experimental biology and medicine》1998,126(6):1248-1250
The effect of the hydra peptide morphogene, its structural fragment, and antagonist 5N pentapeptide on DNA production in the
myocardium, tongue, gastric and tracheal epithelium was studied in 7-day-old rats. The hydra peptide morphogene stimulated
proliferative activity of the myocardium and epithelium of different organs. 5N fragment did not affect the production of
DNA in the myocardium and suppressed it in the epithelium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 681–683, December, 1998 相似文献
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S. S. Timoshin I. G. Yakovenko G. P. Berezina G. G. Obukhova A. Yu. Rubina N. B. Murzina 《Bulletin of experimental biology and medicine》1997,124(4):965-967
The effect of hydra peptide morphogen on poststress disturbances in albino rats is evaluated. A 4-h immobilization leads to
a rise of corticosterone, activates lipid peroxidation, impairs antioxidant defense system, and induces a marked decrease
in the content of thyrotropic hormone and thyroxine. The relative weight of the thymus significantly decreases 24 h after
immobilization. Moreover, stress inhibits proliferative processes in corneal and pyloric epithelium immediately and 24 h after
immobilization. Hydra peptide morphogen prevents the endocrine shift, normalizes the content of lipoperoxides and α-tocopherol
immediately after stress, weakens poststress proliferation disturbances, induces compensatory stimulation of proliferative
processes in the corneal epithelium 24 h after stress, and normalizes DNA synthesis in the pyloric epithelium, the level of
malonic dialdehyde being elevated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 392–395, October, 1997 相似文献
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Lebed'ko OA Timoshin SS Rubina AY 《Bulletin of experimental biology and medicine》2000,129(6):550-552
Hydra peptide morphogen, its Arg7 analogue, and 6C, 3C, and 5N fragments were injected intraperitoneally in a dose 10−7 mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with3H-thymidine showed that hydra peptide morphogen and its 6C fragment stimulated DNA synthesis in tracheal epitheliocytes, but
inhibited this process in smooth muscle cells. 5N fragment inhibited DNA synthesis in both tissues, while 3C and Arg7 were ineffective.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp. 646–649, June, 2000 相似文献
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S. N. Efuni E. A. Demurov Yu. B. Koloskov V. G. Teplyakov N. K. Khitrov 《Bulletin of experimental biology and medicine》1977,84(1):939-943
Less-marked hypertrophy and signs of myocardial degeneration developed in rabbits exposed for one month to hyperbaric oxygenation (HBO) after the formation of stenosis of the ascending aorta, and the contractile power of the left ventricle was increased more than in animals with stenosis of the aorta kept under ordinary conditions. In rabbits with hypertrophy of the heart developing under conditions of HBO increased powers of adaptation of the myocardium to physical exertion were accompanied by an increase in the functional reserve of the sympathetic control apparatus. HBO evidently favors the development of optimal adaptation of the heart to an increased pressure load.Department of Hyperbaric Oxygenation, All-Union Scientific-Research Institute of Clinical and Experimental Surgery, Moscow. (Presented by Academician B. V. Petrovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 7, pp. 19–22, July, 1977. 相似文献
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E. N. Sazonova O. A. Sazonov O. A. Lebed'ko V. M. Pikalova S. S. Timoshin A. Yu. Rubina 《Bulletin of experimental biology and medicine》2000,130(6):1144-1146
Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied
by3H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 μg/kg stimulated proliferative processes: the index
of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10
μg/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins, are
involved in morphogenesis of the myocardium during the early postnatal ontogeny.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 12, pp. 623–626, December, 2000 相似文献
12.
Newborn rats were born of females exposed to high-altitude hypoxia. Pregnant females were injected i.p. either nonopiate leu-enkephalin
analog or hydra peptide morphogen 10 μg/kg 30 min prior to being placed in a pressure chamber. Prenatal hypoxia causes the
inhibition of the proliferative processes in tracheal epithelium and activation of lipid peroxidation (LPO) in lungs of newborn
rats. The administration of nonopiate leu-enkephalin analog prevents the development of posthypoxic alterations in newborn
rats. The administration of hydra peptide morphogen inhibits the proliferation of tracheal epithelium and lowers the activity
of the antioxidant defense of the lungs in newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
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5, pp. 535–537, May, 1994
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
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L. M. Nepomnyashchikh E. L. Lushnikova M. G. Klinnikova O. P. Molodykh N. V. Ashcheulova 《Bulletin of experimental biology and medicine》1997,124(4):1021-1024
Structural reorganization of the myocardium is observed in CBA mice under conditions of hypogeomagnetic field (reduction by
105 times). Changes in tissue architectonics manifest themselves in a reduced capillary/cardiomyocyte volume ratio against the
background of hemodynamic disturbances. Intracellular disturbances result from impaired regeneration processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 455–459, October, 1997 相似文献
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E. N. Goncharova S. S. Timoshin Zh. D. Bespalova 《Bulletin of experimental biology and medicine》1996,122(3):932-934
The effect of atriopeptide AP-II and its 6-amino-acid acyclic fragment (7–12) AP-H-6-OH on proliferative processes in the
myocardium of 5-day-old albino rats is examined 24 h after a single administration (200 nmol/kg intraperitoneally) by autoradiography
with3H-thymidine and by analysis of mitotic regime. A significant decrease in the amount of DNA-synthesizing cells in the right
atrium, right ventricle, and interventricular septum is recorded after administration of AP-II. Changes in DNA synthesis are
attended by significant changes in the amount of cells in different phases of mitosis, indicating a decrease in the number
of mitotic cells and a metaphasal delay. Administration of AP-H-6-OH causes no significant changes in DNA synthesis in the
myocardium at the early stage of postnatal ontogenesis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 321–324, September, 1996 相似文献
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E. I. Kalenikova V. A. Tishchenko A. Yu. Rubina A. S. Sokolov Yu. A. Blidchenko T. V. Kuznetsova Zh. D. Bespalova 《Bulletin of experimental biology and medicine》1994,118(5):1162-1165
The organ distribution of radioactivity following intravascular bolus injection of3H-Lys-head growth activator in rats was studied. Two minutes after injection the renal level of radioactivity exceeded the
blood level 7-fold; 80% of the total activity was bound with the blood cell membranes. An analysis of chemical derivatives
of the labeled peptide in the plasma by means of reverse-phase high-performance liquid chromatography revealed the presence
of several groups of radioactive metabolites with different hydrophilic properties. High-performance liquid chromatography
of blood extracts obtained from samples taken 0.5, 1, 1.5, 2, 31, and 60 min after injection showed the transformation of
initially hydrophobic head growth activator into more hydrophilic fragments. The3H-Lys-head growth activator-associated radioactivity could be reliably detected in the blood onl during the first two minutes
after injection. The half-period of blood-to-organ distribution of3H-labeled head growth activator lasted less than 30 seconds.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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11, pp. 466–469, November, 1994
Presented by E. I. Chazov, Member of the Russian Academy of Medical Sciences 相似文献
16.
V. Ya. Brodskii 《Bulletin of experimental biology and medicine》1995,119(5):435-440
The mammalian heart is a polyploid organ. Cardiac myocytes undergo polyploidization in the early postnatal ontogeny, and the
degree of their polyploid depends on the conditions of heart growth. The myocardium of healthy persons is characterized by
considerable individual variability of polyploidy. The principal mechanism by which normal and compensatory growth of the
heart occurs in adult mammals is through increases of cytoplasmic mass in postmitotic myocytes. In the normal myocardium,
the protein mass of myocytes does not correspond to the gene dosage, while their protein mass in a hypertrophic myocardium
becomes a multiple of their ploidy. The capacity of polyploid myocytes to grow so as to double their mass constitutes the
reserve of cardiac growth. This reserve, which is laid down in the early ontogeny, materializes in response to functional
overloading of the heart in adult life.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5, pp. 454–459, May, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
17.
T. A. Shustanova N. P. Milyutina T. I. Bondarenko I. I. Mikhaleva 《Bulletin of experimental biology and medicine》1999,128(3):933-935
δ-Sleep-inducing peptide (1 μg/ml) added to erythrocyte suspension from intact rats enhanced quenching of membrane tryptophanyl
fluorescence with pyrene and increased the microviscosity of zones of protein-lipid contacts. Microviscosity and polarity
of membrane lipid phase remained unchanged. Exogenous δ-sleep-inducing peptide increased the negative surface charge of the
erythrocyte membrane. During cold stress, the efficiency of tryptophane fluorescence quenching with pyrene decreased and microviscosity
of protein-lipid contacts decreased, while microviscosity of lipid layer of the erythrocyte membranes did not change; polarity
of deep membrane layers and negative surface charge increased. δ-Sleep-inducing peptide normalized the efficiency tryptophane
fluorescence quenching with pyrene and membrane microviscosity, polarity, and surface charge.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 317–320, September, 1999 相似文献
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M. D. Shmerling A. R. Antonov I. M. Korostyshevskaya A. L. Markel' V. F. Maksimov E. E. Filyushina G. S. Yakobson 《Bulletin of experimental biology and medicine》1996,122(3):887-889
Study of the heart in a new strain of rats with hereditary stress-induced hypertension (NISAG) reveals a complex of structural
and functional changes which are analogous to the manifestations of essential hypertension. These changes are shown to be
adaptive-compensatory in nature and indicative of limited functional reserves of the hypertrophic myocardium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 271–273, September, 1996 相似文献
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V. P. Nuzhnyi M. I. Klibaner A. M. Alaverdyan 《Bulletin of experimental biology and medicine》1977,84(3):1229-1233
The intensity of the changes produced by adrenalin in the myocardium of rats adapted to hypoxia was studied after its administration to the intact animal and perfusion of the isolated heart. The changes were revealed by histochemical reactions for succinate dehydrogenase activity and staining for lipids. After intramuscular injection of a cardiotoxic dose of adrenalin (2.0 mg/kg) into adapted rats no damage to the myocardium was found, whereas perfusion of the isolated heart with adrenalin (20 g/ml) caused the formation of micronecroses of the cardiocytes. However, their volume was statistically significantly smaller than in the isolated heart of intact rats under similar conditions. Differences in the sensitivity of the myocardium in vivo and in vitro indicate that the phenomenon of protection of the myocardium against the harmful effects of adrenalin in rats adapted to hypoxia is manifested at the level of the intact organism. The increase in the resistance of the myocardium itself is probably due to an increase in the power of the metabolic systems during adaptation.Department of Pathological Physiology, Patrice Lumumba Peoples' Friendship University. Department of Geographic Pathology, Research Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 265–268, September, 1977. 相似文献
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A comparative analysis of temporal variations of the heart rate variability after cutting and stimulation of the vagus in
sympathectomized and intact rats showed that changes in heart rate after bilateral vagotomy in sympathectomized rats are opposite
to those in the controls. It is postulated that postganglionic fibers modulate sympathetic influence on intracardiac parasympathetic
neurons.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 21–24, July, 1997 相似文献