颞侧眼轮匝肌蒂皮瓣修复眼睑缺损

目的：探讨以眼轮匝肌为蒂的颞区皮瓣修复眼睑缺损的临床应用。方法：在颞侧设计眼轮匝肌为蒂的皮瓣,将皮瓣向内推进或旋转1800修复睑缺损区。结果：7例眼睑缺损修复均取得了满意的效果,未出现并发症。结论：眼轮匝肌蒂颞区皮瓣修复眼睑缺损比局部或皮下蒂组织瓣易于移转,修复后外形满意且供区隐蔽,是修复眼睑缺损的良好选择。     

眼轮匝肌蒂颞区皮瓣修复眼睑缺损

目的:探讨以眼轮匝肌为蒂的颞区皮瓣修复眼睑缺损的临床应用.方法:根据对耳颠部颞浅动脉系统与额部及眼眶区周围血管系统之间的交通吻合情况的解剖学研究结果,应用以眼轮匝肌为蒂的颞区皮瓣修复眼睑缺损12例.结果:12例眼睑缺损修复均取得了满意的效果,未出现并发症.结论:眼轮匝肌蒂颞区皮瓣修复眼睑缺损比局部或皮下蒂组织瓣易于移转,修复后外形满意且供区隐蔽,是修复眼睑缺损的良好选择.     

眼轮匝肌蒂颞区皮瓣修复中面部软组织缺损

目的：探讨应用眼轮匝肌蒂颞区皮瓣修复中面部小面积软组织缺损（包括眼睑、鼻部及邻近颜面部缺损）的方法及效果。方法：2004年～2010年应用眼轮匝肌蒂颞区皮瓣修复中面部缺损25例,其中鼻尖鼻翼缺损4例,鼻背缺损3例,下睑缺损9例,上睑缺损5例,邻近颜面部缺损4例。结果：1例转移至鼻尖部的皮瓣远端出现坏死,经换药后创面愈合,其余皮瓣完全存合;随访4个月～5年,受区功能形态恢复满意,供区瘢痕不明显,无面神经额支损伤,无眼睑闭合不全,无下睑退缩、外翻等并发症发生。结论：眼轮匝肌蒂颞区皮瓣厚薄适宜,蒂较长,转移灵活,供区隐蔽,是修复中面部小面积缺损的一种较为理想的皮瓣。     

眼轮匝肌蒂颞颧区扩张皮瓣修复眶下区皮肤缺损

目的 探讨以外眦眼轮匝肌为蒂的颞颧区扩张皮瓣修复眶下区皮肤缺损的方法,并对该方法进行评价. 方法 对16例眶下区皮肤缺损患者,采用外眦眼轮匝肌为蒂的颞颧区扩张皮瓣进行修复.手术共分两期,一期手术在颞颧区埋置扩张器,二期手术设计以外眦眼轮匝肌为蒂的颞颧区扩张皮瓣,转移修复眶下区皮肤缺损. 结果 转移的颞颧区扩张皮瓣成活良好,11例患者获3个月至3年随访,颞颧区扩张皮瓣转移后未发生挛缩,切口瘢痕不明显,皮肤颜色、质地与眶周皮肤一致. 结论 以外眦眼轮匝肌为蒂的颞颧区扩张皮瓣能够修复较大面积眶下区皮肤缺损,设计灵活,皮瓣转移后对面部外形影响小.     

眼轮匝肌蒂颞区皮瓣的临床应用

颞区是面部缺损修复的理想皮瓣供区。已有多位作者报告应用眼轮匝肌蒂颞区皮瓣修复眼睑缺损、鼻缺损以及面颊部缺损取得满意的修复效果[1 4] 。我们对本院 1995年 1月～ 2 0 0 1年 5月期间应用眼轮匝肌蒂颞区皮瓣的 6 2例患者进行了回顾性研究 ,并提出两种新的临床应用方法。1 临床资料 :我院应用此技术修复面部软组织缺损 6 2例 ,缺损部位包括上睑、下睑、鼻尖、鼻背、鼻翼、面颧部等 ,造成缺损的原因有外伤、烧伤、肿瘤、感染和先天性因素 ,手术效果令人满意。眼轮匝肌呈扁平状 ,该肌及其之上的皮肤血供丰富 ,它的一部分可用作皮瓣的蒂部 …     

眼轮匝肌蒂颞部皮瓣修复颜面部软组织缺损

目的探讨用眼轮匝肌蒂颞部岛状皮瓣修复颜面部、鼻部及下睑小面积软组织缺损的方法及效果.方法1994年～1999年设计以眼轮匝肌为蒂,以同侧颞区无毛发区为供区,皮瓣最大范围3cm×5cm.皮瓣带蒂岛状移位至颜面部创面,共修复下睑外翻、鼻部、面部瘢痕及色素痣切除后的组织缺损12例.结果术后12例皮瓣完全成活,随访2年,疗效良好.皮瓣宽在3cm以下时供区均可直接缝合,术后较少遗留瘢痕及继发畸形.结论眼轮匝肌是一个多元血管供血的肌肉,以其眶部肌肉为蒂的同侧颞部无毛区岛状小皮瓣是修复颜面部小面积软组织缺损的一个可行方法.但颜面部组织缺损面积较大时,供区缝合困难,应慎用.     

应用眼轮匝肌蒂颞部岛状皮瓣矫正睑外翻

目的探讨应用眼轮匝肌蒂颞部岛状皮瓣修复睑外翻的方法及效果。方法设计以眼轮匝肌为蒂的颞区皮瓣,将皮瓣旋转180°移位至眼睑部瘢痕松解后的创面,修复瘢痕性睑外翻。结果术后12例患者,皮瓣完全成活,随访6个月,睑外翻无复发,供区瘢痕不明显。结论眼轮匝肌蒂颞部岛状皮瓣血供可靠,修复睑外翻可取得功能与外观双重修复的满意结果。     

应用眼轮匝肌蒂颞部岛状皮瓣矫正睑外翻

目的探讨应用眼轮匝肌蒂颞部岛状皮瓣修复睑外翻的方法及效果.方法设计以眼轮匝肌为蒂的颞区皮瓣,将皮瓣旋转180°移位至眼睑部瘢痕松解后的创面,修复瘢痕性睑外翻.结果术后12例患者,皮瓣完全成活,随访6个月,睑外翻无复发,供区瘢痕不明显.结论眼轮匝肌蒂颞部岛状皮瓣血供可靠,修复睑外翻可取得功能与外观双重修复的满意结果.     

眼轮匝肌蒂颞区皮瓣修复面部缺损

目的面部缺损在临床上较为常见，因局部皮瓣或皮下蒂皮瓣是由皮下直接供血，皮瓣修复的区域受到限制。为此，进行了以面部表情肌为供血来源的皮瓣探讨。方法通过对眼轮匝肌的血管及面神经颞支的解剖研究，扩大了以眼轮匝肌为蒂的颞区皮瓣的应用范围。结果１８例面部软组织缺损修复均取得了满意的效果。结论眼轮匝肌颞区皮瓣比局部或皮下蒂组织瓣易于移转，且供区隐散蔽。     

眼轮匝肌蒂颞区皮瓣修复面部缺损

目的 面部缺损在临床上较为常见，因局部皮瓣或皮下蒂皮瓣是由皮下直接供血，皮瓣修复的区域受到限制。为此，进行了以面部表情肌为供血来源的皮瓣探讨。方法 通过对眼轮匝肌的血管及面神经颞支的解剖研究，扩大了以眼轮匝肌为蒂的颞区皮瓣的应用范围。结果１８例面部软组织缺损修复均取得了满意的效果。结论 眼轮匝肌颞区皮瓣比局部或皮下蒂组织瓣易于移转，且供区隐散蔽。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.     

Systemic analgesia adapted to the children's condition

A concept of balanced analgesia using nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol (acetaminophen), opioids, and corticosteroids can also be used in patients with pre-existing illnesses. NSAIDs are the most effective treatment for acute pain of moderate intensity in children; however, these drugs should be avoided in patients at increased risk for serious side effects, e.g. patients with renal impairment, bleeding tendency, or extreme prematurity. NSAIDs can be given with minimal risks to the younger child with mild to moderate asthma, and, in these patients, the use of steroids can be encouraged; in addition to their antiemetic and analgesic action, a beneficial effect on asthma symptoms can be expected. In the non-intubated child with cerebral trauma, exaggerated sedation caused by opioids and increased bleeding tendency caused by NSAIDs must be avoided. In neonates and small infants, the oral administration of sucrose or glucose is helpful to minimize pain reaction during short uncomfortable interventions.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.