非创伤性修复治疗技术在儿童乳牙龋齿治疗中的应用

目的探讨非创伤性修复治疗技术在儿童乳牙龋齿治疗中的应用。方法选取2017年2月～2018年2月在本院收治的60例乳牙龋齿疾病患儿作为本次研究对象,随机分为对照组(n=30)与观察组(n=30);对照组患儿行传统修复治疗,观察组则采用非创伤性修复治疗;对比观察两组患儿比较两组治疗效果与患儿治疗过程中的配合情况。结果对照组患儿治疗过程中配合率为56.67%,观察组为93.33%,观察组配合率显著高于对照组(P0.05);对照组治疗总有效率为78.00%,观察组为98.08%,观察组治疗总有效率高于对照组,差异显著(P0.05)。结论非创伤性修复治疗技术在儿童乳牙龋齿治疗中具有更高临床疗效,可显著提高患儿治疗配合率,具有更高临床应用价值。     

非创伤性修复治疗技术在儿童乳牙龋齿的治疗

目的研究非创伤性修复治疗技术在儿童乳牙龋齿治疗中的临床应用。方法将40例儿童乳牙龋齿患儿随机分成对照组和研究组,各20例,对照组采取传统的修复治疗技术,研究组采用非创伤性修复治疗技术,观察两组患儿临床治疗中的配合情况及修复效果。结果研究组的配合率为60.0%,明显高于对照组的10.0%;对照组的总有效率为70.2%,明显低于研究组的97.9%,差异有统计学意义(P0.05)。结论非创伤性修复治疗技术能够提高患儿的临床配合率,且治疗效果显著,值得临床应用及推广。     

综合护理干预在乳牙牙髓病及根尖周病中的作用

目的分析综合护理干预在乳牙牙髓病及根尖周病中的作用。方法回顾性分析我院在2018年3～9月期间收治的208例乳牙牙髓病及根尖周病患儿,按护理方法不同分为对照组(n=104)及观察组(n=104),分别进行常规护理、综合护理干预;比较两组患儿护理效果。结果观察组护理后疼痛程度、牙科焦虑畏惧感均低于对照组,差异有统计学意义(P0.05);观察组治疗依从性优良率为96.15%,明显高于对照组的75.00%,差异有统计学意义(χ2=17.178,P=0.000)。观察组护理满意度评分为(95.81±3.15)分,对照组护理满意度评分为(82.41±5.28)分,差异有统计学意义(t=22.226,P=0.000)。结论对乳牙牙髓病及根尖周病患儿采取综合护理干预,可提高患儿治疗依从性,临床价值较高,值得推广。     

冠修复及根管治疗同步治疗139例隐裂牙牙髓病患者的临床疗效观察

目的 探讨冠修复及根管治疗同步治疗隐裂牙牙髓病患者的临床疗效。方法 选择我院2018年1月～2019年1月收治的278例隐裂牙牙髓病患者随机分为观察组(n=139)和对照组(n=139)。对照组采用先根管后冠修复治疗,观察组采用冠修复及根管同步治疗。观察比较两组的临床疗效,牙龈指数、出血指数、咀嚼效率、咬合力、松动度等牙功能指标及VAS评分。结果 观察组显效94例(67.62%)、有效40例(28.78%)、无效5例(3.60%),整体临床疗效优于对照组(Z=-7.140,P=0.000);观察组临床总有效率为96.40%,明显高于对照组77.70%(χ2=21.571,P=0.000);观察组牙龈指数(0.43±0.07)分,出血指数(0.29±0.04)分,显著低于对照组(t=-28.005,P=0.000;t=-39.873,P=0.000);咀嚼效率(0.93±0.11),咬合力(64.41±6.59)kg,松动度(0.89±0.09)分,显著高于对照组(t=22.537,P=0.000;t=18.515,P=0.000;t=39.293,P=0.000);治疗后,两组VAS评分下降(P0.05),且观察组VAS评分(2.74±0.33)分显著低于对照组(4.81±0.52)分(t=-39.627,P=0.000)。结论 冠修复及根管治疗同步治疗隐裂牙牙髓病临床疗效显著,可有效改善患者牙龈指数、出血指数等牙龈状况,增加患牙咬合力,恢复咀嚼功能,减轻疼痛程度,值得推广应用。     

49例老年髋部骨折患者的手术治疗及预后评估研究

目的探讨老年髋部骨折患者的手术治疗效果及预后情况。方法选择我院2017年3月～2018年9月收治的98例患者随机分为观察组(n=49)和对照组(n=49)。对照组患者给予常规保守牵引治疗,观察组给予手术治疗。观察比较两组临床疗效、髋关节功能Harris评分及术后并发症发生情况。结果观察组优良率为89.80%高于对照组的79.59%,但差异无统计学意义(χ2=1.968,P=0.161);两组疗效整体比较,差异有统计学意义(Z=-6.928,P=0.000)。治疗后,两组Harris评分与治疗前比较均显著升高,差异有统计学意义(t=-18.663,P=0.000; t=-15.682,P=0.000);且治疗后观察组Harris评分(88.47±15.84)分显著高于对照组(81.36±12.56)分,差异有统计学意义(t=2.462,P=0.016)。观察组术后并发症发生率4.08%显著低于对照组的16.33%,差异有统计学意义(χ2=4.009,P=0.045)。结论手术治疗老年髋部骨折临床疗效显著,可有效改善患者髋关节功能,减少并发症,提高患者生活自理能力及生活质量,值得推广应用。     

盐酸利托君与硫酸镁联合治疗146例早产胎膜早破的临床效果

目的探讨盐酸利托君与硫酸镁联合治疗早产胎膜早破患者的临床疗效。方法本文选择我院2017年3月～2018年3月收治的291例患者,随机分为观察组(n=146)和对照组(n=145)。对照组采用硫酸镁治疗,观察组在对照组的基础上联合盐酸利托君治疗。比较两组临床疗效、宫缩抑制时间、延长妊娠时间及妊娠方式。结果观察组总有效率为91.78%,高于对照组84.83%,但两组差异无统计学意义(χ~2=3.409,P=0.065);两组整体疗效比较,观察组优于对照组(Z=-8.248,P=0.000)。观察组宫缩抑制时间与对照组比较显著降低,而延长妊娠时间显著延长,差异有统计学意义(t=-12.481,P=0.000;t=4.285,P=0.000)。治疗后,两组SF-36评分与治疗前比较均显著升高,差异有统计学意义(t=9.119,P=0.000;t=7.653,P=0.000)。且治疗后观察组SF-36评分为(83.52±21.28)分,显著高于对照组的(78.33±17.67)分,差异有统计学意义(t=2.264,P=0.024)。观察组的自然分娩比例与对照组比较显著升高,而剖宫产比例显著降低,差异有统计学意义(χ~2=12.398,P=0.000)。结论盐酸利托君与硫酸镁联合治疗PPROM临床疗效显著,可有效缩短宫缩抑制时间,延长患者孕周,降低剖宫产率,改善生活质量及妊娠结局,安全性高,值得推广应用。     

自体血清治疗角膜深层异物剔除的术后疗效观察

目的探究自体血清对角膜深层异物剔除术后角膜恢复的影响。方法选取2018年5月～2019年4月本院门诊收治的80例角膜深层异物患者进行研究,随机分为对照组(n=40)和观察组(n=40),对照组给予广谱抗生素常规治疗,观察组给予自体血清和广谱抗生素联合治疗,比较两组临床疗效、治疗后角膜水肿情况、荧光素染色情况和不良反应发生率。结果治疗后观察组患者的临床疗效总有效率(85.00%)明显高于对照组(65.00%),差异有统计学意义(χ~2=4.267,P=0.039);治疗后观察组角膜水肿情况优于对照组,差异有统计学意义(Z=2.315,P=0.021);治疗后观察组荧光素染色评分显著低于对照组,差异有统计学意义(t=9.817,P=0.000);观察组总不良反应发生率(5.00%)与对照组(5.00%)比较,差异无统计学意义(χ~2=0.000,P=1.000)。结论自体血清可促进角膜上皮修复,对角膜深层异物剔除术后恢复疗效显著,且安全无副作用,在临床上有较高的应用价值。     

非创伤性修复技术治疗老年龋齿的临床疗效

目的 探讨非创伤性修复技术治疗老年龋齿的临床疗效.方法 回顾性分析2008年1月到2009年12月收治的96例老年龋齿患者的临床资料.根据随机样的原则分为2组,治疗组49例,采用非创伤性修复技术治疗.对照组47例,采用常规方法.于治疗后半年、1年随访患者观察疗效.结果 6个月、12个月治疗组成功率97.96%,91.84%,对照组成功率82.98%,74.47%,同期相比,治疗组均明先高于对照组,差异显著,有统计学意义（P〈0.05）.结论 非创伤性修复技术对老年龋齿的疗效显著,值得临床推广.     

雷贝拉唑治疗十二指肠炎的疗效和安全性分析

目的探讨雷贝拉唑治疗十二指肠炎的疗效和安全性。方法选择2016年7月‐2017年7月该科收治的150例十二指肠炎患者,采用随机数字表法分为两组,观察组75例采用雷贝拉唑治疗,对照组75例采用奥美拉唑治疗。治疗4周后对比两组临床疗效、临床症状评分及不良反应发生率。结果观察组总有效率为96.00%,对照组为85.33%,两组差异具有统计学意义(χ~2=6.297,P=0.000);观察组临床症状总分为(4.08±0.68)分,低于对照组的(4.58±0.73)分,组间差异具有统计学意义(t=2.614,P=0.017);观察组不良反应发生率为2.67%,对照组为4.00%,两组差异无统计学意义(χ~2=1.313,P=0.106)。结论雷贝拉唑治疗十二指肠炎临床疗效显著,可有效缓解临床症状,且安全性高、不良反应少,值得临床推广应用。     

无创伤性修复技术在乳牙龋齿治疗中的应用价值

目的探讨无创伤性修复技术在乳牙龋齿治疗中的应用价值。方法选取许昌市公疗医院接收的64例(176颗)乳磨牙龋齿患儿作为研究对象,以治疗方式的不同将其分为观察组和对照组,每组32例(88颗),对照组患儿采用高速涡轮钻修复,观察组患儿则采用无创伤修复技术进行治疗,比较两组患儿的临床疗效。结果观察组治疗总有效率为93.2%,对照组治疗总有效率为85.2%,差异有统计学意义(P<0.05),且观察组患儿术中配合率明显高于对照组(P<0.05)。结论采用无创伤性修复技术治疗乳牙龋齿可取得较好的修复效果,有较高的应用价值,值得临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.