以吡柔吡星为主的化疗方案治疗非何杰金淋巴瘤60例临床观察

非何杰金淋巴瘤（NHL）为血液系统常见的恶性肿瘤。2000年至2005年我院以环磷酰胺、吡柔吡星、长春新碱和强的松组成CTOP方案治疗NHL患者60例,取得了令人满意的疗效,现报道如下。     

何杰金氏病化疗进展

近代化疗始于何杰金氏病，随着联合化疗的进展，尤其近30年有效联合化疗方案的改进与增多，在中晚期患者采用化疗的治愈率已超过50％。自1946年Goodman等报道用氮芥治疗何杰金氏病起开始了何杰金氏病的单一药物化疗。相继许多学者观察到很多比疗药物单位应用可取得一定的疗效，有效率在20％～70％，而完全缓解率只有10～20％，为了提高疗效与根治何杰金氏病，1965年Lacher与Durant首先报道应用长春花破与苯丁酸氮齐治疗复发的晚期何杰金氏病，同年Devita报道用氮芥，长春新碱、氢甲喋呤、强的松治疗何杰金病，自此开始了何杰金病的联合化…     

现代药剂学研究新进展

近年来，现代药剂学发展迅速，新型制剂技术具有广阔的发展前景。本文就国内外缓控释给药系统、透皮给药系统、靶向给药系统、智能型给药系统、大分子给药系统的最新研究进展进行了综述。     

原发性气管非何杰金淋巴瘤一例并文献复习

通过报道一例原发于气管的非何杰金淋巴瘤病例并复习文献，探讨该病的临床特点、诊断、治疗，以提高对其的认识。气管非何杰金淋巴瘤患者常表现有呼吸困难、喘息、咳嗽，常被误诊为哮喘；多数除有气道受累外还伴发胸内其他病变；原发性气管非何杰金淋巴瘤以低分化组织细胞学更常见，很多患者显示出黏膜相关的淋巴组织学特点，可采用手术、化疗、放疗单独或联合治疗。局限发生在气管和支气管的非何杰金淋巴瘤很罕见，在气道阻塞性疾病的鉴别诊断中应考虑到非何杰金淋巴瘤，气管镜是诊断的重要手段。     

小儿皮肤非何杰金淋巴瘤4例报告

小儿皮肤非何杰金淋巴瘤４例报告郭承吉姜凝（第一临床学院儿科，沈阳１１０００１）关键词非何杰金淋巴瘤；诊断；治疗小儿皮肤非何杰金淋巴瘤非常少见，我院从１９８９年～１９９５年遇到４例，报告如下。１临床资料例１男，６岁。面部及四肢皮肤出现瘀斑样皮疹１０个月...     

儿童腹腔的非何杰金淋巴瘤

儿童腹腔的非何杰金淋巴瘤徐伟珏，等。中华小儿外科杂志１９９６；１７（３）：１４１为了解儿童原发于腹腔的非何杰金淋巴瘤早期诊断及正确治疗，分析５例不同阶段的儿童原发于腹腔的非何杰金淋巴瘤。１例为急腹症，早期行剖腹探查并作肿块完全切除，加化疗，预后较好。...     

COMP方案治疗39例非何杰金淋巴瘤白血病

本文采用COMP方案(环磷酰胺,长春新碱、6-巯基嘌呤、强的松)治疗非何杰金淋巴瘤白血病(NHLL)44例,其中可评价的病例39例。本组39例中获客观疗效者18例,总有效率为46.2%。经临床验证绝大多数患者化疗的副作用为轻、中度,因此患者可耐受COMP方案。     

非何杰金淋巴瘤骨髓CD44表达及其临床意义

目的：探讨CD44分子与非何杰金淋巴瘤恶性程度和临床分期的关系。方法：应用骨髓单个核细胞进行免疫组化（SABC）的方法，检测非何杰金淋巴瘤骨髓CD44阳性率。结果：非何杰金淋巴瘤骨髓CD44阳性率为80％，实验组与对照组阳性率有显著性差异（P＜0．01），实验组单个核细胞CD44阳性率随病程分期增加阳性率逐渐增高（P＜0．01），随恶性程度增加阳性率增加（P＜0．05）。结论：非何杰金淋巴瘤病人骨髓单个核细胞CD44表达增高，且CD44的增高与病程和恶性程度有关。预测非何杰金淋巴瘤患者的病程和恶性程度。     

舌非何杰金淋巴瘤误诊嗜酸性淋巴肉芽肿1例

非何杰金淋巴瘤是恶性淋巴瘤的一种，早期发生在舌根部的非何杰金淋巴瘤症状不明显，常常出现误诊。1998-03我科经治1例现报告如下。     

新型给药系统及其在中药现代化中的应用

本论述了近年来国际上新型给药系统——缓控释给药系统、靶向给药系统、透皮给药系统、黏附给药系统、无针粉末喷射给药系统、自乳化药物传递系统等的特点及其在中药制剂中的应用，并扼要介绍了一些国际上应用前景良好的最新给药系统——药物涂层支架、基因治疗载体系统、生物芯片、分子马达、纳米陷阱等，以期为中药剂型改革与中药现代化研究提供参考。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.