共查询到19条相似文献,搜索用时 78 毫秒
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目的:探讨长期住院精神分裂症患者的心电图QTc间期延长检出率及影响因素。方法:纳入2020年6月在武汉市精神卫生中心住院的精神分裂症患者中符合要求长期住院的患者,收集临床资料,以QTc间期>440 ms为延长的标准,将患者分为QTc延长组和正常组,比较两组的基本特征和实验室指标,分析QTc间期延长的影响因素。结果:共纳入患者111例,22例患者QTc间期延长,QTc间期延长检出率19.82%;QTc间期延长组和正常组在性别、年龄、体质量指数(BMI)、空腹血糖(FPG)、血钾(K)方面差异具有统计学意义(P均<0.05);多因素Logistic回归分析发现性别、年龄、FPG、K为长期住院精神分裂症患者QTc间期延长的独立影响因素。结论:长期住院精神分裂症患者心电图QTc间期延长检出率较高,性别、年龄、FPG、K是其独立影响因素,临床上应予以重视,防止发生猝死。 相似文献
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目的 调查抗精神病药致首发精神疾病QTc间期延长的影响因素.方法 对服用稳定剂量抗精神病药治疗1月的309例首发精神疾病患者进行回顾性调查,收集人口学资料、空腹血糖、血压、血脂等生化指标、心电图资料,以QTc≥440ms作为QTc间期延长的标准,分析QTc间期延长的状况及其相关因素.结果 QTc间期延长的发生率为10.6%.药物治疗组QTc间期均值大于基线期,差异有统计学意义(P<0.05);药物联合电休克治疗组以及药物联合脑电治疗组QTc间期与基线期相比,差异无统计学意义(P>0.05).单一抗精神病药治疗组QTc间期与基线期差异无统计学意义(P>0.05);而抗精神病药联用以及抗精神病药联用抗抑郁药/心境稳定剂组QTc间期均值大于基线期,差异有统计学意义(P<0.05).抗精神病药等效氯丙嗪剂量<1000mg/d组别QTc间期与基线期相比差异有统计学意义(P<0.05).抗精神病药剂量与QTc间期没有相关性.女性是QTc间期延长的风险因素(OR=3.26,95%CI=1.050~10.094),其他因素未进入回归方程.结论 首发精神疾病患者抗精神病药治疗期间QTc间期延长存在性别差异,女性发生QTc间期延长的风险是男性的3.26倍.药物联用延长的QTc间期并未达到异常值.抗精神病药剂量与QTc间期没有相关性.除了性别因素外,其他指标不是QTc间期延长的风险因素. 相似文献
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目的 调查精神分裂症患者心电图QTc间期延长及相关影响因素。方法 对服用稳定剂量抗精神病药的522例住院精神分裂症患者进行横断面调查,收集人口学资料,测定空腹血糖等生化指标,并进行心电图检查,以QTc≥440ms作为QTc间期延长标准,分析QTc间期延长状况及其相关因素。结果 QTc间期延长发生率12.8%,女性(22.7%)高于男性(7.8%),差异有统计学意义(P〈0.01),心电图窦性心动过速和传导阻滞患者QTc间期延长风险分别是心电图正常患者的2.6和3.1倍(P〈0.05)。结论 抗精神病药治疗期间QTc间期延长发生率存在性别差异,女性QTc间期延长的风险可能更高。 相似文献
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抗精神病药物与QT间期延长和尖端扭转型室速 总被引:4,自引:0,他引:4
QT间期是心室除极和复极在心电图上的表现,根据专家调查,认为最有可能延长QT间药的药物依次为抗心律失常药、抗精神病药;在高危患者有可能为抗感染药、抗精神病药及抗抑郁药。QT间期延长可引起一种称为“尖端扭转型室速(Torsade Pointes,TdP)”的潜在致命性心律失常,故而QT间期延长对药物选择具有重要的临床意义。 相似文献
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目的 探讨抗精神病药(APD)引起患者体重增加及其相关因素。方法 对67例首次住院单用APD治疗的精神分裂症患者进行住院及出院后4个月的随访评估。结果 各时点体重增加与GI评分无相关性,体重增加在出院时与BPRS、SAPS减分值有相关性,而随访期与SANS减分值有相关意义。逐步回归分析显示,在α=0.05水平上,进入回归方程的因素依次为:APD品种,最大服药剂量与服药时间的积、阴性症状,病前1年最佳功能水平。结论 APD治疗中的体重增加,是与疗效无关的药物副作用及其形成受药物、精神症状及综合社会心理因素等方面的影响,而饮食与活动的中介作用不应低估。控制体重增加有重要的医学社会意义。 相似文献
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目的评估利培酮、喹硫平、奥氮平、齐拉西酮4种非经典抗精神病药对精神分裂症患者心电图校正QT间期(corrected QT interval,QTc)的影响。方法 97例精神分裂症患者随机分为利培酮组(n=25)、喹硫平组(n=23)、奥氮平组(n=28)、齐拉西酮组(n=21),口服4种药物中的单一药物治疗。治疗前连续3次心电图检查,血药浓度达稳态后(1次常规服药前30分钟、估计Tmax、Tmax后60分钟)再连续3次心电图检查,测量QT间期,以Bazett’s公式校正为QTc。计算治疗前后QTc均值并进行比较。结果与治疗前相比,治疗后4组QTc都有延长,利培酮组[(382.4±16.3)ms vs.(378.6±13.9)ms]、奥氮平组[(379.2±15.6)ms vs.(376.7±15.13)ms]、喹硫平组[(382.8±16.9)ms vs.(377.5±14.3)ms]、齐拉西酮组[(402.4±33.8)ms vs.(377.1±14.6)ms],与治疗前比较差异有统计学意义(P<0.05)。治疗后QTc各组之间比较差异有统计学意义(P<0.05),齐拉西酮组延长最明显,其中1例女性患者QTc达534 ms。结论 4种非经典抗精神病药均不同程度延长精神分裂症患者QTc。 相似文献
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Agelink MW 《The American journal of psychiatry》2002,159(6):1062-3; author reply 1064
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Correll CU Frederickson AM Figen V Ginn-Scott EJ Pantaleon Moya RA Kane JM Manu P 《European archives of psychiatry and clinical neuroscience》2009,259(1):23-27
Objective Treatment with atypical antipsychotics may prolong the rate-corrected Q–T interval (QTc) on electrocardiogram and increase
the risk of dangerous ventricular arrhythmias. Polytherapy with atypical antipsychotics is becoming common, but the effect
of this practice on the QTc has not been explored in detail.
Methods Among 364 adults treated with atypical antipsychotics randomly selected from consecutive admissions to a single hospital,
electrocardiograms with measurable Q–T intervals in at least six leads were available for 38 of 49 patients receiving polytherapy
with two atypical antipsychotics. Daily chlorpromazine equivalent, QTc duration and QTc dispersion were assessed in this group
and in 73 closely matched patients receiving atypical antipsychotic monotherapy.
Results The daily chlorpromazine equivalent of atypical antipsychotics was significantly greater in the polytherapy group (525.2 vs.
244.7 mg, P = 0.0003). Polytherapy and monotherapy patients were similar with regard to QTc duration, QTc dispersion and proportion of
patients with gender-adjusted QTc prolongation (7.9% vs. 9.6%). The QTc duration had only a modest correlation with the total
antipsychotic dose (P = 0.064). The presence of hypokalemia (3.0–3.5 mEq/l) was not associated with longer QTc intervals.
Conclusions The common practice of polytherapy with two atypical antipsychotics does not seem to lead to significant QTc prolongation
compared to monotherapy.
Grant Support: The Zucker Hillside Hospital Advanced Center for Intervention and Services Research for the Study of Schizophrenia
(MH074543-01) from the National Institute of Mental Health, Bethesda, Maryland. 相似文献
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Robert Brashear H Spivey JM 《The Journal of clinical psychiatry》2007,68(1):169; author reply 169-169; author reply 170
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Benjamin A Furst Katherine M Champion Joseph M Pierre Donna A Wirshing William C Wirshing 《Neuropsychopharmacology》2002,51(3):264-265
BACKGROUND: QTc interval prolongation can occur as a result of treatment with both conventional and novel antipsychotic medications and is of clinical concern because of its association with the potentially fatal ventricular arrhythmia, torsade de pointes. METHODS: One case is described in which a patient with schizophrenia, who was being treated for dyslipidemia, developed a prolonged QTc interval while taking quetiapine and lovastatin. RESULTS: QTc returned to baseline when the lovastatin dose was reduced. CONCLUSIONS: QTc prolongation associated with antipsychotic medication occurs in a dose-dependent manner. We therefore hypothesize that the addition of lovastatin caused an increase in plasma quetiapine levels through competitive inhibition of the cytochrome P(450) (CYP) isoenzyme 3A4. Our case highlights the potential for a drug interaction between quetiapine and lovastatin leading to QTc prolongation during the management of dysipidemia in patients with schizophrenia. 相似文献
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