宝石能谱CT低剂量对比剂肺动脉成像

目的探讨利用能谱CT低剂量对比剂肺动脉成像诊断肺动脉栓塞及肺梗死的价值。方法对我院2014年1~4月间怀疑肺动脉栓塞的30例患者,行能谱CT低剂量对比剂肺动脉成像,可获得常规CT肺血管造影图像、单能量图像及碘基物质图像,观察肺动脉内有无栓子,记录栓子数、栓子部位以及栓塞程度,分析碘基物质图的影像学表现,记录肺内灌注减低区的位置及数目。结果明确诊断肺动脉栓塞的患者12例,共检出36处肺动脉及其分支栓子,左、右肺动脉主干8处,肺叶动脉16处,肺段动脉12处,共测得肺内灌注减低区16处。结论能谱CT低剂量对比剂肺动脉成像不但能够降低对比剂用量,最大限度减少对比剂的不良反应的发生,而且利用最佳单能量图和碘基物质图及定量测量等工具,能够更准确、安全的诊断肺动脉栓塞及肺梗死。     

螺旋CT肺动脉造影对肺栓塞的诊断

目的：评价螺旋CT及其肺动脉造影诊断肺动脉栓塞（PE）的价值。方法：回顾性分析12例PE患,均行螺旋CT容积扫描,并在工作站进行图像后处理,获得肺动脉多平面重建图像及三维立体图像。结果：对12例196支肺动脉分支进行分析,受累率为46.4%;栓子发生在主肺动脉、左右肺动脉干及叶段肺动脉。多平面重建图像上表现为充盈对比剂血管内有充盈缺损区,或其远侧方无对比剂充填区。肺动脉成像示,主干血管内可见充盈缺损影,或呈截断状影;叶栓塞或段栓塞亦呈突然“截断状”,其远侧方肺动脉分支不显影或呈纤维状。结论：螺旋CT肺动脉造影不仅可以获得轴位图像,而且可以获得立体图像,可多轴向旋转观察PE部位,是诊断叶或段以上PE可靠而直观的检查方法。     

128MSCT应用三低技术结合iDose~4在肺动脉成像的研究

目的探讨128MSCT应用三低技术结合iDose~4在肺动脉成像的可行性。方法对体质量指数正常疑似肺动脉栓塞60例患者行CT肺动脉血管成像(CTPA)检查,随机分两组,各30例,其中常规剂量组(A组)采用120kV、200mAs,370mgI/ml对比剂60ml,重建图像采用滤波反投影(FBP)技术;实验组(B组)采用80kVp、80mAs,300mgI/ml对比剂35ml,重建图像分别采用iDose~4(B1组)及FBP技术(B2组);记录各组的CT容积剂量指数(CTDIvol)、剂量长度乘积(DLP)、有效剂量(ED)、背景噪声(BN)、肺动脉强化CT平均值(SIvessel)、肺动脉噪声比(SNR)和对比信噪比(CNR)。各组结果采用ANOVA单因素方差分析,组内两两比较采用LSD法,主观图像质量评分比较采用秩和检验。结果 A及B1组图像均满足诊断要求,且两组图像噪声、SNR、CNR、图像总体质量比较差异,无统计学意义(P 0. 05)。B组较A组的ED值、对比剂总碘量分别下降了76. 2%及52. 7%。结论 128MSCT应用三低技术结合iDose~4行肺动脉CTPA检查是可行和有效的,同时降低了患者的辐射剂量及对比剂量的碘摄入量,具有较高的临床应用价值。     

不同碘浓度对比剂在MSCT腹部血管成像的临床应用研究

目的探讨不同碘浓度对比剂对MSCT腹部血管成像质量的影响。方法 150例腹部CT血管成像受检者随机分成3组(每组50例),采用不同碘浓度的对比剂:300mgI/ml、320mgI/ml和370mgI/ml行MSCT扫描,根据原始图像和后处理重建图像,主要观察三组病例腹主动脉及其分支血管的显示程度,从而对图像质量进行评判。分别测量腹腔干水平、肾动脉水平、髂动脉分叉水平处腹主动脉CT值。结果 3组不同平面腹主动脉内对比剂浓度均维持在较高的水平,差异无统计学意义。3组不同碘浓度对比剂显示腹主动脉、腹腔干、肝总动脉、肾动脉及分支能力的差异无统计学意义(P>0.05)。结论在相同注射速率条件下多层螺旋CT腹部血管成像使用低浓度对比剂可以获得满意的CTA图像,同时减轻了对比剂不良反应。     

宝石CT低剂量对比剂能谱成像联合CTPA在肺栓塞诊断中的应用

目的探讨能谱CT低对比剂用量肺碘基图成像联合CTPA技术,在肺动脉栓塞诊断中的应用价值。方法回顾性分析37例肺栓塞患者,所有患者都经临床确诊且行能谱CT低剂量对比剂肺动脉成像,对上述37例患者分别由2名高级职称的影像诊断医师进行图像分析,采用CT肺动脉造影(CTPA)、能谱成像和CTPA+能谱的方法,分别记录观察到的栓子数量、发生部位。分别获取栓塞区与对照区的碘基值及CT值,通过配对t检验观察低灌注区与正常区之间碘含量及CT值间的差异。结果 37例肺栓塞患者,CTPA法、能谱成像和CTPA+能谱分别检出栓子208个、235个、246个,肺叶及以上动脉栓子34个、34个、34个,肺段动脉栓子90个、97个、103个,肺亚段及以下动脉栓子84个、104个、109个。CTPA+能谱分析在检测肺段和亚段及以下栓子方面有明显优势(P0.01),栓塞区与对照区的碘基值分别为4.46±4.85,21.62±4.40,二者有显著差异(P0.01),CT值分别为-817.52±81.21,-805.89±78.16,二者无明显差异(P=0.289)。结论 CTPA+能谱方法在检测肺动脉栓子方面有明显优势,肺栓塞区域的碘基值较CT值更能反映肺部血流灌注情况,CTPA+能谱方法将成为肺栓塞早期诊断的可靠检查方法。     

双源CT肺动脉成像在肺动脉栓塞诊断中的应用价值

目的:探讨双源CT肺动脉成像对肺动脉栓塞(PE)的诊断价值.方法:对58例临床拟诊为PE的患者行双源CT肺动脉成像,总结PE的直接、间接征象及分型,并比较MPR、MIP、VR和CTVE对肺动脉栓子的显示效果.结果:直接征象:58例中45例诊断为PE,共发现栓子 658支(中心型170支,偏心型208支,附壁型74支,完...     

肺动脉栓塞病变螺旋CT诊断价值

肺动脉栓塞(pulmonary embolism,PE)早发现、早治疗是影响患者预后的关键,随着MSCT在心、肺大血管方面的成像技术越来越成熟,明显提高了肺小血管和血管内栓子的显示率[1～3].本文回顾性分析了我院2010年1月～2012年1月确诊的18例肺动脉栓塞治疗前后的临床资料,以其评价CT肺血管成像(MSCT pulmonary angiogram,MSCTPA)在肺动脉栓塞治疗前后中的临床价值.     

低浓度低剂量对比剂宝石能谱CT肺动脉成像的初步研究

目的:探讨应用低浓度、低剂量对比剂宝石能谱CT肺动脉成像的可行性.方法:60例临床拟诊为肺动脉栓塞(PE)的患者随机分成两组,每组30例,行CT肺动脉血管成像(CTPA)检查.A组为常规组,使用浓度为370 mg I/mL的对比剂碘帕醇,用量为60 mL,扫描管电压为120 kVp.B组为能谱组,使用浓度为300 mg I/mL的对比剂碘帕醇,用量为20 mL,扫描方式为能谱模式(GSI).比较常规组和能谱最佳单能量组肺动脉CT值、图像背景噪声、信噪比(SNR)、对比噪声比(CNR)、CT剂量指数(CTDIvol)、剂量长度乘积(DLP)、有效辐射剂量(ED)及图像质量主观评分的差异.结果:B组肺动脉最佳单能量图像能量水平集中在63～68 keV.能谱组(7.5g)较常规组(24.0g)所用的碘总量明显下降,两组差异有统计学意义(P＜0.05).能谱最佳单能量组图像质量与常规组CTPA相比,两者肺动脉CT值、图像噪声、SNR、CNR、DLP、ED以及主观评分之间差异均无统计学意义(P＞0.05).结论:宝石能谱CT低浓度、低剂量对比剂CTPA检查,在降低人体碘摄入量的同时,能达到与常规120 kVp结合高浓度、常规剂量对比剂相当的图像质量,且辐射剂量未增加.     

预注射双点监测法行肺动静脉CT血管成像的可行性研究

目的:评价预注射双点监测法行多层螺旋CT肺动脉成像(CTPA)和肺静脉成像(CTPV)的成像技术及图片质量。方法:应用MSCT对30例疑似肺动脉栓塞患者行CTPA及CTPV检查。对比剂剂量为20ml(370mg I/ml),所有患者均采用预实验时间-密度曲线法,监测平面定于支气管隆突水平。CTPA及CTPV的兴趣区(ROI)分别选在肺动脉主干及相应层面肺静脉内,分别获得肺动脉及肺静脉时间-密度曲线,以对比剂注射开始到增强峰值的时间为延迟时间。采用盲法对CTPA及CTPV图像中同级别肺动静脉CT值进行测量并进行统计学分析。结果:30例患者均同时获得肺动脉及肺静脉的时间-密度曲线。肺动脉对比剂达峰值时间为(10.2±1.8)s,肺静脉对比剂达峰值时间为(14.7±2.3)s。所有图像均能清晰显示肺动静脉1～4级血管。CTPA及CTPV图像中1～4级动静脉血管CT值差异均具有统计学意义(P<0.05)。结论:预注射双点监测法可同时完成CTPA及CTPV肺动静脉各级分支成像,并且达到临床诊断要求。     

急性肺动脉栓塞CTA检查技术和图像后处理方法的探讨

目的 通过研究16层螺旋CT血管造影的检查技术和图像后处理方法,以期提高基层医院对急性肺动脉栓塞(PE)的诊断准确率.方法 收集临床高度怀疑急性PE患者30例,随机分为两组各15例,采用相同检查流程,在不同扫描条件下进行CT肺动脉血管成像,原始图像在ADW4.3图像工作站中采用MPR、MIP及VR方法进行后处理.观察不同扫描条件和不同后处理技术对PE诊断正确率的影响.结果 ①对比剂浓度300mgI/ml、350或370mgI/ml均可,剂量80～90ml为宜,注射速率3～3.5ml/s即可;②延迟扫描时间17～20s,肺动脉及分支对比剂充盈良好;③吸氧及呼吸训练有助于减少伪影;④扫描范围从肺底至肺尖,足先进,对减少膈肌运动引起的呼吸伪影有好处;⑤肺叶及以上动脉内栓子在MPR、MIP和VR显示率相仿,但MPR有助于显示肺段及以下动脉内栓子.结论 16层螺旋CT采用合适的扫描技术和图像后处理方法,能有效提高PE患者的诊断正确率,在基层医院具有推广价值.     

CO2-enhanced CT imaging for the detection of pulmonary emboli: feasibility study in a porcine model

RATIONALE AND OBJECTIVES: The authors investigated the feasibility of using computed tomography (CT) with CO2 gas as a negative contrast agent for detecting pulmonary emboli in a porcine model. MATERIALS AND METHODS: Seven pigs with or without pulmonary emboli underwent thoracic imaging with multi-detector row spiral CT. To identify optimal injection and scanning protocols, the first four pigs were scanned repeatedly in the supine and prone positions with different scan delays (10, 15, and 20 seconds) and different volumes of CO2 (60, 120, 180, and 240 mL), which were hand infused (each infusion took 10-15 seconds). The last five pigs with emboli were scanned with iodinated contrast medium and then rescanned with 120 or 180 mL of CO2. The CO2 volumes and scan delays were qualitatively assessed. The supine and prone CT scans and the number and location of thrombi depicted in the CO2- and contrast material-enhanced CT scans were compared. RESULTS: Because the pulmonary artery in pigs is in the posterior anatomy, the prone position was more effective than the supine position with CO2 enhancement. An infusion of 120 mL of CO2 was sufficient to enhance the entire pulmonary artery, and scanning timed to coincide with the completion of infusion was the most effective. Both the CO2- and contrast-enhanced CT scans demonstrated all thrombi. Thrombi were more apparent on the CO2-enhanced CT scans than on the contrast-enhanced scans because of the high contrast interface between soft tissue and gas. However, two of the seven pigs with thrombi experienced abrupt cardiac arrest after CO2-enhanced scanning and could not be resuscitated. The cause of these events was not determined in the current study. CONCLUSION: The CT depiction of pulmonary emboli is feasible with CO2 gas as a negative contrast agent and may even be superior to that with iodinated contrast media. Further studies are required to evaluate the safety of this method and to develop an improved delivery of CO2 gas for this application.     

Multislice computed tomography perfusion imaging for visualization of acute pulmonary embolism: animal experience

The purpose of our animal study was to evaluate a new computed tomography (CT) subtraction technique for visualization of perfusion defects within the lung parenchyma in subsegmental pulmonary embolism (PE). Seven healthy pigs were entered into a prospective trial. Acute PE was artificially induced by fresh clot material prior to the CT scans. Within a single breath-hold, whole thorax CT scans were performed with a 16-slice multidetector-row CT scanner (SOMATOM Sensation 16; Siemens, Forchheim, Germany) before and after intravenous application of 80 ml of contrast medium with a flow rate of 4 ml/s, followed by a saline chaser. The scan parameters were 120 kV and 100 mAs_eff, using a thin collimation of 16×0.75 mm and a table speed/rotation of 15–18 mm (pitch, 1.25–1.5; rotation time, 0.5 s). Axial source images were reconstructed with an effective slice thickness of 1 mm (overlap, 30%). A new automatic subtraction technique was used. After 3D segmentation of the lungs in the plain and contrast-enhanced series, threshold-based extraction of major airways and vascular structures in the contrast images was performed. This segmentation was repeated in the plain CT images segmenting the same number of vessels and airways as in the contrast images. Both scans were registered onto each other using nonrigid registration. After registration both image sets were filtered in a nonlinear fashion excluding segmented airways and vessels. After subtracting the plain CT data from the contrast data the resulting enhancement images were color-encoded and overlaid onto the contrast-enhanced CT angiography (CTA) images. This color-encoded combined display of parenchymal enhancement of the lungs was evaluated interactively on a workstation (Leonardo, Siemens) in axial, coronal and sagittal plane orientations. Axial contrast-enhanced CTA images were rated first, followed by an analysis of the combination images. Finally, CTA images were reread focusing on areas with perfusion deficits indicating PE on the color-coded enhancement display. Subtraction was feasible for all seven studies. In one animal, opacification of the pulmonary arteries was suboptimal owing to heart insufficiency. In the remaining six pigs, a total of 37 perfusion defects were clearly assessable downstream of occluded subsegmental arteries, showing lower or missing enhancement compared with normally perfused lung parenchyma. Indeterminate findings from CTA showed typical PE perfusion defects in four out of six cases on CT subtraction. Additionally, 22 peripheral triangular-shaped enhancement defects were delineated. Nine of these findings were reclassified as definitely being caused by PE on second reading of the CTA data sets. Our initial results have shown that this new subtraction technique for perfusion imaging of PE is feasible, using routine contrast delivery. Dedicated examination protocols are mandatory for adequate opacification of the pulmonary arteries and for optimization of data sets for subsequent subtraction. Perfusion imaging allows a comprehensive assessment of morphology and function, providing more accurate information on acute PE.This paper contains data on behalf of the Amersham Health Research Fellowship Grant, ECR 2003.     

多层螺旋CT在肺动脉栓塞诊断中的应用价值

目的 研究多层螺旋CT在肺动脉栓塞诊断中的临床应用，着重研究亚段肺动脉栓塞的诊断价值。方法 共34例，下肢深静脉血栓16例，近期大手术史11例，肺癌1例，不明原因6例。34例均使用GE Light Speed Plus多层螺旋CT(MSCT)行平扫及造影增强扫描，1次采集4层图像。结果 分析34例共1824支肺动脉分支，其中507支肺动脉分支显示了栓塞，占27．8％。在680支肺段动脉中，246支显示了栓塞，占36．2％；而亚段肺动脉1041支中，141支显示了栓塞，占13．5％。平扫肺动脉栓塞的间接征象为肺纹理稀少19例，肺动脉高压2例，胸水16例，胸膜下梗死灶共41个，梗死灶多发11例，单发12例，双肺6例。1例慢性栓塞栓子钙化，极为少见。造影增强后肺动脉栓塞的直接征象为不同程度的肺动脉分支充盈缺损。充盈缺损有4种表现形式：中心型57支，偏心型160支，附壁血栓131支，完全阻塞型159支。结论 多层螺旋CT肺动脉造影是诊断肺动脉栓塞的快速、有效、无创伤的诊断方法，尤其对亚段肺动脉栓塞是一种先进的方法，可以代替肺动脉造影，可与电子束CT媲美，可能成为诊断肺动脉栓塞的首选方法。     

螺旋CT血管成像技术在肺动脉栓塞诊断中的应用

目的探讨螺旋CT肺动脉血管成像(sp iral CT pu lmonary angiography,SCTPA)技术对肺动脉栓塞(pu lmonary embolism,PE)的诊断价值。方法收集SCTPA检查并证实为PE的患者25例,采用单/多排螺旋CT扫描机行肺动脉增强检查并行多平面重建(MPR)、最大强度投影(M IP)和表面遮盖显示(SSD)重建。结果本组25例PE共行29次SCTPA检查,中央型PE 23例(92%),周围型PE 2例(8%)。主肺动脉、左及右肺动脉、叶间肺动脉、叶肺动脉、舌支肺动脉的显示率均达100%,对段肺动脉的显示率达97.77%,对亚段肺动脉的显示率也达68.00%。PE受累血管主要集中在叶、段肺动脉,受累率在46.58%~75.00%之间。结论SCTPA技术为临床及早发现并明确诊断PE的可靠检查手段之一。     

多层螺旋CT对外伤性脾破裂的诊断准确性

目的评价多层螺旋CT对外伤性脾破裂的诊断准确性。方法 55例由临床与手术证实的外伤性脾破裂患者均经多层螺旋CT(MSCT)平扫,其中20例又经对比增强CT扫描。对所有患者的CT表现进行了回顾性分析。结果在55例中,起初CT平扫正确诊断50例(90.9%)外伤性脾破裂。增强扫描的20例全部(100%)得到正确诊断。在CT平扫像上,外伤性脾破裂主要表现为脾脏肿大、形态不规则、密度不均匀、边缘模糊及弧形高密度影,而CT增强扫描显示了脾脏内或表面不规则撕裂口、脾内未强化血肿及假性动脉瘤形成。49例(89.1%)患者伴发腹腔积液。早期或轻微脾破裂时,腹腔积液主要见于左侧结肠旁沟及道格拉斯窝。38例(69.1%)患者合并其他脏器或组织损伤。结论多层螺旋CT在外伤性脾破裂的诊断中,具有安全、快速、准确率高等优势。在患者病情许可的条件下,对比增强扫描可提高诊断准确率及合并症的检出率,并能正确分型,为临床选择治疗方案提供可靠依据。     

MR Diagnosis of a Pulmonary Embolism: Comparison of P792 and Gd-DOTA for First-Pass Perfusion MRI and Contrast-Enhanced 3D MRA in a Rabbit Model

Objective

To compare P792 (gadomelitol, a rapid clearance blood pool MR contrast agent) with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), a standard extracellular agent, for their suitability to diagnose a pulmonary embolism (PE) during a first-pass perfusion MRI and 3D contrast-enhanced (CE) MR angiography (MRA).

Materials and Methods

A perfusion MRI or CE-MRA was performed in a rabbit PE model following the intravenous injection of a single dose of contrast agent. The time course of the pulmonary vascular and parenchymal enhancement was assessed by measuring the signal in the aorta, pulmonary artery, and lung parenchyma as a function of time to determine whether there is a significant difference between the techniques. CE-MRA studies were evaluated by their ability to depict the pulmonary vasculature and following defects between 3 seconds and 15 minutes after a triple dose intravenous injection of the contrast agents.

Results

The P792 and Gd-DOTA were equivalent in their ability to demonstrate PE as perfusion defects on first pass imaging. The signal from P792 was significantly higher in vasculature than that from Gd-DOTA between the first and the tenth minutes after injection. The results suggest that a CE-MRA PE could be reliably diagnosed up to 15 minutes after injection.

Conclusion

P792 is superior to Gd-DOTA for the MR diagnosis of PE.     

Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent: diagnostic performance and confidence

PURPOSE: To assess whether characterization of solid focal liver lesions could be improved by using ultrasonographic (US) contrast-specific modes after sulfur hexafluoride-filled microbubble contrast agent injection, as compared with lesion characterization achieved with preliminary baseline US. MATERIALS AND METHODS: Four hundred fifty-two solid focal hepatic lesions that were considered indeterminate at baseline gray-scale and color Doppler US were examined after microbubble contrast agent injection performed by using low-acoustic-power contrast-specific modes during the arterial (10-40 seconds after injection), portal venous (50-90 seconds after injection), and late (100-300 seconds after injection) phases. Two readers independently and retrospectively reviewed baseline and contrast material-enhanced US scans and classified each depicted lesion as malignant or benign according to standard diagnostic criteria. Sensitivity, specificity, accuracy, and positive and negative predictive values and areas under the receiver operating characteristic curve (Az) were calculated by considering histologic analysis (317 patients) or contrast-enhanced helical computed tomography followed by serial US 3-6 months apart (135 patients) as the reference standards. RESULTS: Different contrast enhancement patterns were observed according to lesion characteristics. During the late phase, benign lesions were predominantly hyper- or isoechoic relative to the adjacent liver parenchyma, whereas malignant lesions were predominantly hypoechoic. Review of the contrast-enhanced US scans after baseline image review yielded significantly improved diagnostic performance (P <.05). Overall diagnostic accuracy was 49% before versus 85% after review of the contrast-enhanced scan for reader 1 and 51% before versus 88% after review of the contrast-enhanced scan for reader 2. Diagnostic confidence-that is, the Az-was 0.820 before versus 0.968 after review of the contrast-enhanced scan for reader 1 and 0.831 before versus 0.978 after review of the contrast-enhanced scan for reader 2. CONCLUSION: The use of contrast-specific modes with a sulfur hexafluoride contrast agent led to improved characterization of solid focal liver lesions.     

肺动脉闭锁伴室间隔缺损的多层螺旋CT诊断

目的:回顾性分析肺动脉闭锁伴室间隔缺损(PAVSD)的多层螺旋CT(MSCT)表现。方法:分析5例肺动脉闭锁伴室间隔缺损患者的MSCT图像。4例行平扫及双期扫描,另1例行单期扫描。结合薄层图像、多平面重组、薄层最大密度投影以及容积再现法进行观察。结果:MSCT显示肺动脉瓣闭锁2例,肺动脉干中断、无中央共汇者3例。5例均见室间隔缺损。2例见明显的支气管动脉扩张;2例见直接主动脉肺动脉侧支;2例见间接主动脉肺动脉侧支。1例合并右心室发育不良及三尖瓣狭窄,1例合并房间隔缺损;3例合并右位主动脉弓,2例合并主动脉后左无名静脉。1例有手术史者可见上腔静脉与右肺动脉吻合,与右心房无交通。结论:MSCT可清楚地显示PAVSD的主要表现。     

Ytterbium-DTPA. A potential intravascular contrast agent

Ytterbium-DTPA was evaluated as a potential intravascular contrast agent. Ytterbium-DTPA was synthesized from ytterbium oxide and diethylene triamine penta-acetic acid (DTPA). CT scans of increasing concentrations of ytterbium and iodine showed that at 125 kVp, ytterbium was denser than an equal concentration of iodine. The LD50 of intravenous ytterbium-DTPA was 10 mM/kg (1.73 g ytterbium/kg) in rats. In enhanced CT scans and pulmonary angiography in dogs, ytterbium was visibly denser than iodine, and CT Hounsfield units showed greater enhancement of the aorta and inferior vena cava with ytterbium. The animals showed no sign of acute or delayed toxicity. Ytterbium-DTPA deserves further evaluation as a contrast agent for high kVp techniques.     

肝硬化患者肺微循环多层螺旋CT灌注研究

目的:采用MSCT灌注成像技术研究肝硬化患者肺部微循环灌注参数的变化。材料和方法:对20例正常对照组、24例代偿期肝硬化组和19例失代偿期肝硬化组行16层螺旋CT肺部同层动态增强扫描后,在工作站上使用perfusion3软件包对扫描数据进行处理,得出感兴趣区的时间-密度曲线(time-density curve,TDC)和各灌注参数值,包括血流量(blood flow,BF)、血容量(blood volume,BV)、对比剂平均通过时间(mean transit time,MTT)和表面渗透积乘积(permeability surface area product,PS)。采用SPSS11.5软件包对上述数据进行统计学分析。结果:BF、BV值在各组的总体均数差别有统计学意义(P<0.01)。失代偿期肝硬化组的BF、BV值较正常对照组和代偿期肝硬化组都明显增加,组间差别有统计学意义(P<0.01)。代偿期肝硬化组的BF、BV值与正常对照组比较,组间差别无统计学意义(P>0.05)。MTT值各组的总体均数间差别有统计学意义(0.05>P>0.01)。失代偿期肝硬化组的MTT值较正常对照组和代偿期肝硬化组减少,组间差别有统计学意义(0.05>P>0.01)。PS值各组间差别无统计学意义(P>0.05)。结论:MSCT肺部微循环灌注成像技术可反映肝硬化患者病情程度。