弹性树脂结合铸造支架可摘义齿修复牙周病患者缺牙的临床评价

目的：探讨弹性树脂与铸造支架联合修复牙周病患者缺牙的临床效果。方法：采用弹性树脂做唇（颊）侧基托及前牙、前磨牙唇（颊）侧固位体,后牙及舌（腭）侧采用铸造支架,设计联合可摘局部义齿,修复28例牙周病缺牙患者,共35件修复体,戴用1年后进行临床评价。结果：弹性树脂结合铸造支架可摘义齿在美观舒适性、固位力、咀嚼功能、食物嵌塞、基牙情况等方面较传统义齿有明显改善。结论：将弹性树脂与铸造支架结合起来修复牙周病缺牙,能很好的解决其美观和功能的问题,是一种较好的修复方法。     

隐形义齿与铸造支架联合修复双端游离缺失的临床探讨

目的：探讨采用隐形义齿与铸造支架联合修复双端游离缺失的临床效果。方法：采用弹性树脂做基托和唇（颊）侧固位体,缺失区和支托采用铸造支架,制作修复件27件,修复双端游离缺失23例。患者戴用1年后进行临床观察。结果：弹性树脂与铸造支架联合义齿的美观舒适感、食物嵌塞、基牙情况等较传统活动义齿均有明显改善。结论：弹性树脂与铸造支架联合义齿修复双端游离缺失是一种解决游离端缺失修复的好方法。     

全冠联合精密附着体修复肯氏一类缺损伴前牙磨损的临床观察

目的：观察金属烤瓷冠联合精密附着体对伴有前牙过度磨损的Kennedy一类牙列缺损修复的临床效果。方法：15例伴有前牙过度磨损的Kennedy—类牙列缺损病例,制作金属烤瓷冠修复前牙磨损,用精密附着体义齿修复后牙游离缺失,对此联合修复体进行2年观察。结果：15例患者均感义齿美观舒适,固位稳定性强,咀嚼功能好,基牙健康。结论：金属烤瓷冠和精密附着体用于伴有前牙磨损的Kennedy一类牙列缺损,修复效果良好。     

铸造支架与隐形义齿联合修复的临床应用

铸造支架修复牙列缺损技术已经多年临床检验，是被广为认可的较成熟的修复技术。隐形义齿又称弹性义齿，是近年发展起来的修复新技术。为择取铸造支架和隐形义齿稳定及美观的优点，将两者联合应用于临床修复牙列缺损15例，观察1～4年，收到了满意的效果。     

弹性树脂卡环铸造部件结合式义齿的临床应用

牙列缺损是口腔修复临床的常见和多发性缺损畸形[1]。在牙列缺损的诸多修复方法中，活动义齿是牙列缺损最常见的方法，但常规可摘局部义齿，存在美观和发音上的不足，许多患者难以接受。弹性树脂卡环铸造部件结合式义齿，是应用弹性树脂材料制作前牙及双尖牙区卡环、基托，而连接杆、支托、磨牙区卡环及小连接体等非弹性部位，采用铸造方法制作的可摘局部义齿。作者从1998年到2000年，对60例患者62件义齿用此方法修复，临床应用证明，能获得满意的修复效果。现介绍如下：1.材料和方法1.1一般资料修复60例患者共62件义齿，男性24例，女性36例…     

弹性附着体义齿修复肯氏Ⅰ、Ⅱ类牙列缺损十年疗效评估

目的：评价弹性附着体义齿修复KennedyⅠ类和Ⅱ类末端游离端牙列缺损的长期临床效果。方法：采用Bredent VKS可变球和窝形附着体对KennedyⅠ、Ⅱ类39例牙列缺损患者进行修复,临床随访10-15年,观察其修复效果。结果：39例患者进行弹性附着体义齿修复设计后自觉义齿美观效果好,异物感小,固位稳定性好,咀嚼效能高。90%的患者远期临床修复效果好。其中1例患者在使用7年后基牙牙根折断,义齿松动,修复失败;少部分分别出现牙龈炎、牙髓炎等症状,经治疗后义齿恢复正常功能。结论：应用弹性附着体义齿修复KennedyⅠ、Ⅱ类牙列缺损有较好的远期疗效,但应按时随诊,及时发现和解决随访过程中出现的问题,以确保附着体义齿修复后的远期疗效。     

FM微铰链式附着体义齿修复KennedyⅡ类牙列缺损的应用研究

目的探讨FM微铰链式附着体义齿修复KennedyⅡ类牙列缺损的临床效果。方法收集KennedyⅡ类牙列缺损且采用FM微铰链式附着体义齿修复的患者27例,随访1～3年,随访内容包括临床和X线片检查,以及患者对义齿的主观评价。结果患者对FM微铰链式附着体义齿的咀嚼功能、固位效果、口腔舒适度、美观和发音功能表示满意;临床和X线片检查未见基牙牙槽骨明显吸收。结论 FM微铰链式附着体义齿固位力持久稳定、美观舒适,短期不会造成基牙牙槽骨明显吸收,是KennedyⅡ类牙列缺损较为理想的修复方式。     

铸造支架式弹性义齿在修复KennedyⅠ、Ⅱ类牙列缺损中的效果观察

目的：通过两种不同的KennedyⅠ、Ⅱ类可摘局部义齿的临床效果观察，为优化义齿没计提供临床依据。方法：对18例末端游离缺失的牙列缺损患者，每人分别制作两种义齿（Ⅰ号义齿：铸造支架＋塑料，Ⅱ号义齿：铸造支架＋弹性义齿材料），进行临床效果观察及患者满意度调查，结果用Fisher确切概率法进行统计分析。结果：美观效果Ⅱ号义齿优于Ⅰ号义齿（P〈0．05）{功能效果Ⅱ号义齿与Ⅰ号义齿相近（P〉0．05）。结论：无金属卡环显露的铸造支架与弹性义齿材料结合的可摘局部义齿设计，是一种值得推广的临床没计。     

MK1精密附着体义齿修复Kennedy П类牙列缺损临床评估

目的：临床研究KennedyП类牙列缺损采用MK1精密附着体义齿进行修复的效果。方法：28例对于原先普通可摘局部义齿不满意的KennedyП类牙列缺损患者，均采用MK1精密附着体义齿进行修复。结果：经过3个月至3年随访，100％的患者表示对该义齿的固位性能、咀嚼效能、舒适程度以及装卸的方便程度感到满意。义齿损坏2例经过简单修理后患者满意。4例保存X线片资料完整者经过3至18个月观察，基牙牙槽骨未见明显吸收。结论：MK1精密附着体义齿修复KennedyП类牙列缺损患者，满意度明显优于普通可摘局部义齿。临床观察还提示，MK1义齿尚不致造成短期基牙牙槽骨损害。     

铸造Twin-Flex卡环修复KennedyⅡ类牙列缺损的临床应用

目的研究整体铸造法制作的Twin-Flex卡环在KennedyⅡ类牙列缺损修复中的使用效果。方法15例KenendyⅡ类牙列缺损患者,应用铸造支架材料整体铸造Twin-Flex卡环进行活动义齿修复,评价义齿的美学效果,固位、支持及稳定性。结果 15例患者,采用整体铸造法制作的Twin-Flex卡环,KennedyⅡ类牙列缺损的末端基牙避免了唇颊侧卡环的暴露,美学效果良好,义齿固位、支持及稳定效果良好。结论整体铸造法制作的Twin-Flex卡环应用于KennedyⅡ类牙列缺损修复,符合游离端设计的基牙及牙槽骨生物力学要求,可取得较好的美学效果及临床应用效果。     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Dysphagia is one of the most important complications encountered in amyotrophic lateral sclerosis (ALS). Our aim was to determine whether oropharyngeal dysphagia impacted the quality of life (QoL) of patients with ALS. Thirty consecutive patients were recruited (31–82 years, 18 men). Swallowing function was evaluated using a standardised videofluoroscopic barium swallow. All the patients completed a specific questionnaire on quality of life in dysphagia (SWAL‐QoL) immediately after the videofluoroscopy. The results of dysphagia outcome severity scale separated 14 patients with oropharyngeal dysphagia and 16 with normal swallowing function. There was no difference in the average age, weight and body mass index of the two groups (dysphagic patients: 68 ± 11 kg versus non‐dysphagic patients: 69 ± 14 kg). Most of the dysphagic patients had a bulbar affection based on their Norris scores which determine the importance of cranial nerves illness (20 ± 8), significantly lower than those of the non‐dysphagic patients (35 ± 5) (P < 0·0001). There was no difference in the neurological peripheral symptoms evaluated by Amyotrophic Lateral Sclerosis Functional Rating Scale scores (dysphagic patients: 26 ± 7 versus non‐dysphagic patients: 27 ± 8) (ns). The swallowing quality of life questionnaire revealed that the dysphagic patients had significant burden (P < 0·001). They were affected by the necessity to applied a food selection (P < 0·01), by the increase in eating duration (P < 0·05) and described a decrease in eating desire (P < 0·05). They complained of fear regarding the risk of dysphagia (P < 0·05). They also described difficulties with oral communication (P < 0·001). All of those complained about dysphagia which impacted directly mental health (P < 0·05) and social life (P < 0·05). In conclusion, oropharyngeal dysphagia is a common symptom accompanying ALS, which alters the patient's QoL, especially social health.     

拔牙位点保存用复合温敏凝胶的构建及体外表征

目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。