氟哌酸治疗淋病临床疗效观察(附45例分析)

本文报告了我科自1988年2月至1989年3月收治淋病患者45例,分别用氟哌酸和青霉素进行对照治疗观察.第一组12例,用青霉素160万u/d分二次肌注.第二组20例,用氟哌酸1200mg/d,每次口服600mg,间隔4小时.第三组13例,用青霉素160万u/d加氟哌酸1200mg/d,其用法同上.全部患者均用1/15000高锰酸钾溶液浸洗患部每天2次.,     

142例女性淋病的治疗

目的 :探讨青霉素G、壮观霉素和氟哌酸治疗淋病的临床疗效。方法 :6 6例用青霉素G 4 80万IU分两侧臀部 1次肌肉注射 ,4 2例用壮观霉素 2 g1次肌肉注射 ,34例用氟哌酸 80 0mg1次口服。结果 :青霉素G、壮观霉素和氟哌酸的治愈率分别为 92 4 % ,95 2 % ,10 0 % ,3种药物差异无显著性 (P >0 0 5 )。结论 :3种药物治疗淋病疗效显著 ,尤其是氟哌酸治疗淋病 ,价格适中 ,使用方便 ,是目前治疗女性淋病的理想药物 ,宜推广使用     

动静脉溶栓、静滴川芎嗪治疗ALDVT疗效观察

目的 :研究动静脉溶栓及静滴川芎嗪氯化钠注射液对急性下肢深静脉血栓形成的疗效。方法 :治疗组用尿激酶 2 0万u 患侧股动脉注射 ,每日 1次共 5天 ,然后 ,尿激酶 2 0万u 静脉注射每日 1次共 5天 ,川芎嗪氯化钠注射液每日静点 1次共 10天 ,青霉素每天 80 0～ 12 0 0万u 共 5～ 7天 ,肝素 5 0 0 0单位 ,每天 2次静点共 7天。对照组 :复方丹参 10支每天静滴 1次共 10天 ,肝素及青霉素同治疗组。结果 :治疗组 2 8例 ,治愈 16例 (5 7% ) ,总有效率为 96 5 % ;对照组 3 0例 ,治愈 8例 ,治愈率 2 6 7% ,总有效率为 70 % ;两组疗效差异非常显著 (P <0 0 1)。结论 :对急性下肢深静脉血栓形成的治疗除抗生素 ,活血化瘀治疗外 ,采用动静脉溶栓及静滴川芎嗪效果尤佳 ,治疗的时间以 2 4h内最好 ,3天以内次之 ,7天以后不宜溶栓治疗     

头孢三嗪与青霉素治疗淋病的疗效观察

1　临床资料85例病人中 ,女 72例 ,男 13例 ( 13例男性为夫妻双方 ) ,年龄 16～ 50岁 ,平均年龄 2 4 .5岁 ,其中从事商业性服务 32例 ,个体客商 2 0例 ,农民、居民 17例 ,机关干部 15例 ,在校学生 1例。诊断与检查 :全部病例均按疾病控制司淋病诊断标准 ,根据病史、临床症状、分泌物检查而确诊。分组及治疗方法 :采用随机分组法对 85例病人分为两组 ,头孢三嗪治疗组为观察组 ,男性 13例 ,女性 30例 ,用法 :每次 1g,肌肉注射 ,每日 2次 ,连用 3天 ;青霉素治疗组为对照组 ,全部为女性 ,4 2例 ,用法 :青霉素 560万 u静滴 ,每日 2次 ,连用 7天。…     

氟哌酸治疗急性淋病57例疗效观察

我们从1988年10月～1989年12月用氟哌酸治疗急性淋病57例,疗效满意,现报告如下。 临床资料 本组67例急性淋病患者均为门诊病人。男33例,女24例,年龄16～46岁,平均23.9岁。57例病人中,氟哌酸治疗前未用其它抗菌素者25例,曾用青霉素或四环素治疗无效者32例。全部病例尿道分泌物及阴道脓性排出物涂片,革兰氏染色,均查到细胞内淋病双球菌。 氟哌酸600mg/日,分3次口服,疗程7天。临床症状全部消失,分泌物涂片未发现淋病双球菌为治愈。临床症状加重或减轻,疗程结束时涂片仍发现淋病双球菌者为无效。 同期用青霉素和四环素治疗细菌学阳性的急性淋病作对照。青霉素组30例,960万单位/日,分2     

氟喹诺酮类药物治疗耐药伤寒的临床及实验室研究

42例经血或骨髓培养证实的耐药伤寒,随机分为5组。对照组静脉滴注氨苄青霉素,每日5～6g,并加用庆大霉素每日16～24万U,疗程14～21天。4组治疗组分别给予氟哌酸0.3～0.4g每日3次,甲氟哌酸0.4g每日2次,氟嗪酸0.3g每日2次,环丙氟哌酸0.4g每日2次治疗,疗程14天。5组的治愈率分别为33.3％、 25％、83.3％、100％和87.5％。30株仿寒杆菌时氟霉素敏感率为10％,氨苄青霉素为20％,氟嗪酸96.7％(MIC_(90)为1μg/ml),氟哌酸、甲氟哌酸及环丙氟哌酸均为100％(MIC_(90)分别为2μg/ml、1μg/ml及0.25μg/ml)。     

清开灵与病毒唑静滴治疗呼吸道感染108例

目的 研究清开灵与病毒唑联用治疗急性呼吸道感染的疗效。方法 161例患随机分为治疗组和对照组治疗组108例用清开灵10～30m1、病毒唑0．6g(儿童10～15mg/kg)分别加入10％葡萄糖或生理盐水250ml静滴,对于白细胞增高,青霉素皮试阴性后给予青霉素800万u(儿童10-20万u／kg)加入生理盐水静滴。结果 治疗组总有效率为93.5％,疗程平均天数为5．3天,对照组总有效率为73．5%,疗程平均天数为71天。结论 清开灵与病毒唑(青霉素)联用治疗呼吸道感染疗效优于单用病毒唑(青霉素)。     

尿激酶治疗突发性耳聋的疗效观察

为观察尿激酶治疗突发性耳聋的临床疗效,对108例(108耳)采用尿激酶治疗,每次10万u静脉滴注,每日一次,辅以葛根素治疗,10天为一疗程,突发性耳聋治疗有效率为86.11%,由此认为,尿激酶治疗突发性耳聋安全可靠,副作用不明显.     

联合治疗重度外阴阴道念珠菌病的临床观察

目的 观察制霉菌素片剂联合酮康唑治疗重度外阴阴道念珠菌病的疗效.方法 对2009年本所门诊就诊的120例重度外阴阴道念珠菌病患者按数字化单盲法随机分为治疗组和对照组,采用制霉菌素片剂100万u每晚阴道给药联合酮康唑片剂200mq每日口服,复方酮康唑软膏(商品名皮康王)每日外用,连用10天为治疗组;单用制霉菌素片剂100万u每晚阴道给药,连用10天为对照组,以后两组病例均在月经前每晚阴道给制霉菌素片剂100万u10天,连用2个月,通过对比治疗后,第15天、30天和3个月随访观察,对重度外阴阴道念珠菌病的症状消除或好转情况进行对比分析.结果 治疗组治疗后第15天,治愈率87.5%,对照组治愈率29.7‰第30天,治疗组治愈率94.6%;对照组治愈率37.5%.第3个月,治疗组治愈率98.2%;对照组治愈率50%,总阳性症状消除或好转情况明显优于对照组.结论 制霉菌素片剂联合酮康唑治疗重度外阴阴道念珠菌病具有较好的疗效.     

立止血加酚妥拉明治疗肺结核大咯血59例报告

目的 :使用立止血加酚妥拉明治疗肺结核大咯血病人 5 9例 ,与常规使用脑垂体后叶素及止血敏、止血芳酸治疗 5 6例进行疗效对比。方法 :对此 5 9例肺结核大咯血病人应用立止血 1KU肌注 ,1KU静推 ,酚妥拉明 2 0mg加 1 0 %葡萄糖注射液 30 0mL静滴 ,每日 1次 ,连用 3d ;对 5 6例使用脑垂体后叶素注射液 1 0 u 肌注 ,1 0 u 加 1 0 %葡萄糖 2 0 0mL静点 ,每日 1次 ,止血敏 4.0止血芳酸 0 .4加 1 0 %葡萄糖 1 0mL静推 ,每日 2次 ,连用 3d。结果 :前者有效率为 88.1 % ( 5 2 /5 9) ,后者有效率为 5 8.9% ( 33/5 6)。结论 :两组比较前者较后者疗效明显提高 ,差异显著 (P <0 .0 5 )。     

Treatment of anorectal gonorrhea infections in men

The charts of 606 men with anorectal gonorrhea infections treated using the current Public Health Service recommendations were reviewed. There were 3.3% failures in the group treated with penicillin--14.4% in those treated with tetracycline hydrochloride, 14.8% in the ampicillin trihydrate group, and none among those treated with spectinomycin hydrochloride. The intramuscular (IM) injection of penicillin G procaine, 4.8 million units, with 1 g of probenicid given orally is the treatment of choice for anorectal gonorrhea. An IM injection of 2 g of spectinomycin hydrochloride was effective but should be reserved for patients allergic to penicillin and for penicillin treatment failures.     

Comparative study of ceftriaxone and spectinomycin for treatment of pharyngeal and anorectal gonorrhea

Of the currently recommended regimens for treatment of uncomplicated gonorrhea, only aqueous penicillin G procaine is effective against infections at all sites. However, procaine penicillin is not effective against penicillinase-producing Neisseria gonorrhoeae and suffers from poor patient acceptability owing to the 10-mL volume of injection and allergic and toxic procaine reactions. Ceftriaxone is a new extended-spectrum cephalosporin with a long serum half-life and is many times more active than penicillin G against both beta-lactamase-positive or -negative strains of N gonorrhoeae. Ceftriaxone was compared as a single, 125-mg, 0.5-mL injection with a single 2-g injection of spectinomycin in difficult to treat pharyngeal gonorrhea in men and women and anorectal gonorrhea of men. Ceftriaxone cured 30/32 (94%) pharyngeal and 52/52 anorectal infections, compared with 6/14 (43%) and 9/9, respectively, for spectinomycin. Both regimens were well tolerated. Ceftriaxone may prove to be a drug of choice for uncomplicated gonorrhea, particularly where homosexual men are treated and/or penicillinase-producing N gonorrhoeae is prevalent.     

Penicillin levels in blood and CSF achieved by treatment of syphilis.

Treponemicidal levels of penicillin in the CSF were not obtained following intramuscular (IM) injections of 600,000 IU of penicillin G procaine along with 2% aluminum monostearate (PAM). Treponemicidal levels of penicillin in the CSF were achieved in 31 patients by probenecid, 500 mg/6 hr by mouth, with penicillin G, 500,000 IU by IM injection, and by probenecid every six hours by mouth and IM injections of penicillin G procaine once a day in two of three patients following injections of 600,000 IU, in four of five following 1.2 million IU, and in three (now all nine) following 2.4 million IU.     

4种抗菌药物对淋球菌体外抗菌活性的研究

本文采用琼脂倍比稀释法检测38株淋球菌对4种抗菌药物的敏感性,并作β-内酰胺酶测定.结果表明,21.1%的菌株对青霉素耐药;7.9%的菌株为PPNG;7.9%的菌株对壮观霉素耐药;而100%的菌株对氟嗪酸、氟哌酸敏感,且MIC_(50)、MIC_(90)值均低.结果显示,应注意淋球菌对青霉素、壮观霉素的耐药性,推荐用氟嗪酸、氟哌酸治疗淋病     

安美汀治疗无合并症淋病40例临床疗效观察

目的：评价安美汀对无合并症淋病的疗效。方法：４０例天合并症淋病患口服安美汀每天３次,每次３７５ｍｇ,连服３日。结果：治愈１００％,全部患服药开始后１～２天内症状消失,未出现明显不良反应。结论：安美汀对治疗无合并症淋病具有疗效好、起效快、副作用少、服用方便等优点。     

Gonococcal drug resistance and treatment of gonorrhoea in Nairobi

The in vitro antibiotic sensitivities of 108 isolates of Neisseria gonorrhoeae from a Nairobi clinic were determined by the agar dilution method. The results indicate that the majority of gonococci were relatively resistant to penicillin (86%) and to tetracycline (85%). By using the relationship between the in vitro antibiotic sensitivity of gonococci and treatment failure of gonorrhea in US patients, we predict that the minimum treatment failure rate for the gonorrhea treatment schemes used in the US would be 5.6% for aqueous procaine penicillin G, 4.8 megaunits intramuscularly together with 1.0 g probenecid by mouth; 6.9% for oral tetracycline HC1, given 500 mg 4 times daily for 5 days; 10.4% for a single oral dose of ampicillin, 3.5 g together with 1.0 g of oral probenecid; and 6.2% for a single dose of spectinomycin, 2.0 g intramuscularly. Gonococcal drug resistance and morbidity will likely continue to increase in Kenya in the absence of a gonorrhea control program.     

Borrelia burgdorferi infection may be the cause of sarcoidosis.

Serum antibody to Borrelia burgdorferi was measured in 33 patients with sarcoidosis which was confirmed clinically and pathologically. The results showed that 81.8% of the patients were positive for anti-B. burgdorferi antibody. In addition, a strain of B. burgdorferi was isolated from a patient's blood. Fifteen patients received ceftriaxone 2g per day or penicillin 12 million U per day. The antibody titers of the patients decreased to nearly normal levels rapidly. Serum angiotensin converting enzyme (SACE) turned to normal range after the treatment. According to the findings mentioned above, we consider that B. burgdorferi infection may be the cause of sarcoidosis and sarcoidosis might be a specific type of Lyme disease.

     

Development of Resistance of Gonococci to Penicillin: An Eight-Year Study

During the last eight years, 5700 strains of Neisseria gonorrhoeae have been isolated and tested for sensitivity to penicillin and sulfadiazine in the Public Health Laboratory (Toronto). At the beginning of the study 63% of the strains tested were sensitive to a concentration of 0.01 unit of penicillin per ml. of diluent. Since then the gonococcus has gradually developed resistance to this antibiotic until 27% of the strains isolated are now resistant to a concentration of 0.3 unit/ml., and 8% are resistant to 1.0 unit/ml. To overcome this degree of resistance it is necessary to give a soluble penicillin preparation intramuscularly in very high dosage (2-8 million units). At the present time there is an urgent need for a satisfactory substitute for penicillin in the treatment of gonorrhea. None has yet been found.     

耳穴放血合咽炎合剂治疗风热型急性咽炎临床观察

目的：观察耳穴放血合咽炎合剂治疗风热型急性咽炎的临床疗效。方法：将60例患者随机分为观察组和对照组各30例。观察组采用针刺（一次性7号针头点刺放血）耳尖,耳垂放血疗法。每天1次。配合喝咽炎合剂煎剂每次30mL,每天喝6～8次。对照组行西药（0.9%氯化钠注射液20mL,硫酸庆大霉素注射液8万U,地塞米松注射液5mg）超声雾化吸入,每天2次,疗程均为5天。结果：观察组疗程结束的愈显率为73.3%,对照组为53.3%。观察组与对照组的愈显率比较差异有显著性意义（P〈0.05）。结论：耳穴放血合咽炎合剂治疗风热型急性咽炎疗效显著,无毒副作用,值得临床推广应用。     

司帕沙星治疗淋病的临床研究

目的 对比观察司帕沙星及大观霉素治疗淋病的效果。方法 选择临床表现及实验室检查确诊为淋病的117例患者,随机分为司帕沙星组及大观霉素组（对照组）,观察临床症状消除情况、淋球菌清除率、非淋菌性尿道炎的伴发比例等。结果 两组治疗结束时淋球菌清除率分别为98.4%、90.9%;在治疗结束时、治疗结束后10天,两组的临床有效率分别为93.5%、89.1%及93.5%、72.7%;两组非淋菌性尿道炎的发病率分别为4.8%、18.2%和4.8%、27.3%。结论 司帕沙星对淋病更有效,且可以同时治疗非淋菌性尿道炎及预防其发生。