原发性颅内内胚窦瘤3例临床病理分析

原发性颅内内胚窦瘤(endodermal sinus tumor,EST)又称卵黄囊瘤,被认为来自多能性原始生殖细胞,主要发生在卵巢、睾丸,少数可见于生殖腺外器官,如后腹膜、纵隔、腮腺、眼睛[1]等,原发于颅内者极为罕见.本文收集我院2000年4月至2007年12月原发性颅内.     

婴儿阴道内胚窦瘤1例

患者．女．8个月。因不规则阴道出血1个月，于2003年4月30日来我院就诊。盆腔CT检查显示：阴道上部、子宫区见6．5cm×3．0cm纵行生长软组织肿物影。密度不均，内见不规则低密度灶．直肠、膀胱受压．膀胱后壁与肿物界限不清。双侧卵巢、肝、胆及双侧。肾均未见异常。胸部X线片未见明显病变。实验室检查，血、尿常规无异常，出凝血时间正常，血清甲胎蛋白（α—FP）13890ug／L，hCG〈10IU／L。于2003年5月10日全身麻醉下阴道分泌物涂片检查，细胞病理学提示葡萄状肉瘤细胞。2003年5月20日阴道脱出3cm×2cm大小组织．质脆，易碎。病理诊断为内胚窦瘤。免疫组化：[第一段]     

原发性纵隔内胚窦瘤：3例报告及文献复习

原发性纵隔内脏窦瘤（Primarymediastinalendo－dermalsinustumor，PMEST）又名卵黄囊瘤（Yolksactumor）是一种罕见的高度恶性的生殖细胞肿瘤。1959年，Teilum[1]首次描述了该肿瘤的一些特征，又称Teilum病。讫今为止，国内文献报道甚少，石主要以个案报告为主。我院1980－1993年间收治了3例，现结合文献复习，对该肿瘤的组织发生、临床表现。诊断及治疗进行讨论。病例资料例1：男性，23岁。胸痛伴呼吸困难半月c查体：左胸部饱满，叩珍呈实音。胸部X线片发现左上纵隔有一边缘清楚的肿块，约9.0×6.5cm。2周后复查胸片，原肿块生长迅速…     

成人睾丸内胚窦瘤综合治疗2例

睾丸内胚窦瘤又称卵黄囊瘤或胚胎性腺瘤,是来源于生殖细胞的非精原细胞瘤,是睾丸肿瘤中罕见的一种病理类型,其恶性程度较高,大多预后不良。我们收治2例,行单纯手术及化疗,现均已存活4年,现报告如下。临床资料病例1:男性,25岁,发现左侧睾丸无痛性肿块半年入院,4岁时有双侧隐睾下降固定手术史。查体:左侧睾丸8.0cm×7.0cm×7.0cm,左侧精索增粗,腹股沟区未及肿大淋巴结。CT提示左睾丸实性占位,CT值为37Hu,中心为水样密度,腹膜后未发现肿大淋巴结;AFP为650ug/L。2002年8月28日作左睾丸肿瘤根治术及腹膜后淋巴结清扫术,病理报告为睾丸内胚窦…     

卵巢内胚窦瘤50例临床病理分析

对５０例卵巢内胚窦瘤的临床及病理资料进行分析，该组病人平均年龄１７．５岁。主要状状为腹部包块，腹痛，腹胀。肿瘤发生在单侧者４０例，双侧者１０例。纯型内胚窦瘤３７例，混合其它生殖细胞肿瘤１３例。病理形态均有疏松网状粘液样结构或形成不规则小囊状结构，可见Ｓ－Ｄ小体及ＰＡＳ阳性滴。     

原发性纵隔内胚窦瘤二例报道

原发性纵隔内胚窦癌甚为罕见，我院收治2例，报道如下。临床资料例1男性，20岁。因持续性脚痛伴胸闷憋气和咳嗽2月，于1983年11月16日入院。体检：一般状况良好，锁骨上淋巴结无肿大，心肺（一），腹部及泌尿生殖系均未见异常。胸部X线平片示：右前上纵隔8cm×7cm×7cm大小球形阴影，边缘整齐。A院诊断：右前上纵隔肿瘤、病人入院后体温38℃左右，给予抗生素及对症治疗，效果不奢。11月24日突感胸闷憋气加重伴有剧烈刺激性干咳。复查胸片发现球形阴影明显增大，并伴有右胸腔积液。右脚穿刺抽出约150ml咖啡色样液、当日即急症手术探查，经右…     

睾丸内胚窦瘤1例报告并文献复习

目的:探讨睾丸内胚窦瘤的生物学行为、临床病理特点、诊断治疗方法及其预后。方法:报告1例睾丸内胚窦瘤的诊断治疗及随访情况,并结合国内外文献进行分析。结果:本例患者肿瘤分期为Ⅰ期,行患侧睾丸肿瘤根治性切除术,术后给予PVB方案化疗3个疗程,效果良好,随访24个月,直至最后一次复查,患者AFP、HCG处于正常水平,相关影像学检查未见复发及远处转移。结论:睾丸内胚窦瘤临床罕见,恶性程度高,总体预后差,其确诊依靠病理,外科手术为主要治疗手段,运用手术加放、化疗的综合治疗措施可显著延长生存期。     

睾丸内胚窦瘤综合治疗一例

病例　患者 ,男 ,2 1岁 ,左侧睾丸进行性肿大一个月 ,不伴红、热、痛 ,阴囊皮肤无变化。患者自幼左侧隐睾 ,12岁时行“睾丸固定术”。于 1996年 4月 2 0日入院 ,查ＡＦＰ阳性 ,临床诊断为左侧睾丸恶性肿瘤 ,于 1996年 4月 2 3日行“左睾丸切除术” ,肿块为 4ｃｍ× 4ｃｍ× 3ｃｍ ,质硬 ,病理报告示 :左睾丸内胚窦瘤。遂又于同年 5月 17日行“后腹膜淋巴结清扫术” ,术后病理示 :左侧后腹膜中下段有淋巴结转移。于 1996年 6月 10日行钴 6 0放疗 ,设腹中前后对穿野 15 0ＣＧｙ× 5次 /ｗ =30Ｇｙ ,盆腔前后对穿野 180ＣＧｙ× 5次 /ｗ =36Ｇ…     

罕见颅内原发性内胚窦瘤（附四例报告）

作者运用光镜、免疫组化及电镜技术研究了4例原发性颅内内胚窦瘤。其组织学具有以下特征:空网状结构、内胚窦样结构、腺样结构、多泡性卵黄囊样结构及透明小滴。免疫组化染色,瘤细胞AFP、CEA和α_1-抗胰蛋白酶阳性。电镜下瘤细胞内外可见高电子密度的圆形物质,瘤细胞内见无定形基底膜样物质。作者还讨论了颅内原发性内胚窦瘤的组织发生。     

Primary endodermal sinus tumor of the cerebellar hemisphere: a case report with review of the literature

Summary Primary intracranial endodermal sinus tumors, which have been regarded as a rare histologic subtype, usually arise in the pineal and suprasellar regions and are often associated with components of other germ cell tumors. We report an extremely rare case of pure primary endodermal sinus tumor found in the cerebellar hemisphere. A 3-year-old boy was admitted to our institution because of gait disturbance, vomiting and deteriorated mental state. MR imaging revealed the presence of a round mass with heterogeneous enhancement in the left cerebellar hemisphere. Radical surgical removal of the tumor was performed, followed by adjuvant chemotherapy, consisting of etoposide, carboplatin and bleomycin. The patient has since attended regular follow-ups, without any neurological deficit or signs of recurrence in the 4 years since diagnosis.     

Case Report of an Endodermal Sinus Vaginal Tumor in an Infant Girl

Case Report An female infant patient, aged 8 months old, suffered from irregular colporrhagia for a period of 1 month after which she was taken to our hospital on 30th April, 2003. A pelvic CT examination     

Ovarian endodermal sinus tumor during pregnancy

We present the rare case of a 31-year-old pregnant woman who underwent resection of a FIGO stage Ia ovarian endodermal sinus tumor at 7 weeks of gestation, and who received no additional treatment, before or after giving birth. She was delivered of a healthy male infant at 40 weeks of gestation, and exhibited no signs of recurrence 28 months after the primary operation. There are 14 previous reports of endodermal sinus tumors during pregnancy. The present case represents the first patient who gave birth to a healthy infant without receiving any additional treatment following surgery, indicating that an early-stage endodermal sinus tumor does not necessarily require adjuvant chemotherapy. Received: August 7, 1998 / Accepted: April 21, 1999     

卵巢内胚窦瘤临床特点与预后相关因素分析

目的分析卵巢内胚窦瘤的临床病理学特点,以及Bc l-2在卵巢内胚窦瘤中的表达,探讨影响该病预后的相关因素。方法回顾性分析辽宁省肿瘤医院1984年1月至2007年12月收治的76例卵巢内胚窦瘤患者的临床病理学资料,分析Bc l-2在卵巢内胚窦瘤中的表达,了解各临床病理因素对预后的影响。结果Ⅰ、Ⅱ、Ⅲ及Ⅳ期卵巢内胚窦瘤患者的5年生存率分别为91.8%、88.9%、39.5%及25.0%。年龄、组织学类型、术前血清中甲胎蛋白值水平、是否保留生育功能的手术方式、术前肿瘤大小并不影响该病的预后。以铂类为基础的化疗方案,化疗疗程数〉3,残余瘤直径≤2 cm和腹水量≤100 mL是影响预后的因素。Bc l-2在不同病理类型间表达差异有统计学意义（P〈0.05）,但Bc l-2并不是影响预后的独立因素。结论临床分期,以铂类为基础的化疗方案,化疗疗程数,残余瘤直径和腹水量是影响预后的因素。     

Primary endodermal sinus (yolk sac) tumor of the anterior mediastinum: a report of a successfully treated eleven-year-old boy.

An asymptomatic 11-year-old Japanese boy with an endodermal sinus (yolk sac) tumor of the anterior mediastinum was successfully treated with cisplatinum-based combination chemotherapy and subsequent surgical excision. The patient is alive and in good health 60 months from diagnosis.     

Solid-pseudopapillary tumor of the pancreas: One case report and literatures review

Introduction
Solid-pseudopapillary tumor （SPT） is a very rare primary neoplasm of the pancreas. Franz first described it in 1959. It is usually seen in young females. In spite of possible histological findings of malignancy, SPPT typically shows a benign clinical course and a low malignant potential. The pathogenesis of these tumors is still controversial. It has been suggested that it might originate from ductal and acinar pancreatic cells, endocrine cells or pluripotential stem cells.     

Endoscopic management in fibrous dysplasia of ethmoid sinus: One case report and literatures review

Introduction
Fibrous dysplasia （FD） is a sporadic real bone structures and marrow are skeletal disorder in which norreplaced by fibro-osseous tissuet. It is classified into three types： monostotic FD, polyostotic FD, and McCune-Albright syndrome. The monostotic is the most common form of FD. The disease primarily affects the long bones of the patients, and may also develop in the craniofacial region. However, FD in the paranasal sinuses is uncommon. The case in this report was diagnosed as FD in the ethmoid sinus which is a rarely seen case.     

Giant condyloma acuminatum (Buschke-Lowenstein tumor) involving a pilonidal sinus: a case report and review of the literature

Giant condyloma acuminatum or Buschke-Lowenstein tumor has been reported to involve many areas about the perineum. The majority of previous documentations have implicated the coronal sulcus, prepuce, and fossa navicularis of the penis as the most likely foci to support growth. Authors have contributed multiple cases of perianal and rectal involvement as well as rare reports of inguinal, bladder, and endocervix-low uterine segment tumors. A case of giant condyloma acuminatum involving a chronic pilonidal sinus overlying the sacrum is described. Wide surgical extirpation was found to be a curative means of management.