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Patients with stage 3 and stage 4 CKD demonstrate alterations in LV GLS, LVMI, E/e′, LAVI, and LASr but had normal LVEF. Each of these parameters was evaluated using reported normal values as a cutoff (normal indicated as green) in the figure. Left atrial reservoir strain was the strongest predictor of death and MACE and the only echocardiographic parameter that predicted adverse events.
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LA function evaluated on 3DE imaging or speckle-tracking echocardiography, but not LA volume, is an independent predictor of new-onset AF in patients with Chagas disease. The reservoir component of LA function measured on 3DE imaging (total LA emptying fraction < 51.8%) can identify a population at high risk for AF as depicted by the cumulative survival curves.
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