Nodular Necrotizing-Scleritis Associated with Epstein-Barr Virus Infection: A Case Report

ABSTRACT

Purpose

To report a case of necrotizing scleritis associated with Epstein-Barr virus (EBV) infection.     

Epidemiologic Characteristics of Work-related Eye Injuries and Risk Factors Associated with Severe Eye Injuries: A Registry-based Multicentre Study

ABSTRACT

Purpose

Work-related eye injuries have been reported with a variety of epidemiologic and clinical characteristics. We aimed to identify epidemiologic characteristics of work-related eye injuries and risk factors associated with severe injury in a large metropolitan city.     

Intraretinal Cystoid Spaces in Regression of Punctate Inner Choroidopathy Lesions

ABSTRACT

Purpose

To describe and evaluate the intraretinal cystoid spaces (ICSs) in the eyes of punctate inner choroidopathy (PIC) patients.     

Retinal and Choroidal Changes of Vitreoretinal Lymphoma from Active to Remission Phase after Intravitreal Rituximab

ABSTRACT

Purpose

To identify main qualitative and quantitative changes by spectral-domain optical coherence tomography (SD-OCT) in eyes with vitreoretinal lymphoma (VRL) shifting form active to remission phase, after intravitreal rituximab (IVR).     

Progressive sector retinitis pigmentosa due to c.440G>T mutation in SAG in an Australian family

ABSTRACT

Background

Heterozygous c.440 G > T mutation in the S-antigen visual arrestin (SAG) gene has been described as a cause of autosomal dominant retinitis pigmentosa (adRP) in a series of patients of Hispanic origin. This study presents the early and late clinical features and disease progression rates in an Australian family with SAG adRP.     

Successful Treatment of Necrotizing Retinitis with Epstein–Barr Virus-Positive Ocular Fluid by Intravitreal Methotrexate Injection

ABSTRACT

Purpose

To present a case of necrotizing retinitis with Epstein–Barr virus (EBV)-positive ocular fluid in a patient with sudden unilateral vision loss, which was successfully treated with intravitreal methotrexate (MTX) injections.     

Optimizing optical coherence tomography and histopathology correlation in retinal imaging

Objective

To develop a methodology to correlate optical coherence tomography (OCT) images and histopathological sections from the same eye. Part 1: To determine the best fixative for optimal OCT and histopathological analysis in post-mortem eyes. Part 2: A protocol is proposed to correlate histopathological features and OCT scans from the same post-mortem eyes.

Variable expressivity in patients with autosomal recessive retinitis pigmentosa associated with the gene CNGB1

ABSTRACT

Purpose

In a cohort of eight families (11 patients) with autosomal recessive retinitis pigmentosa (arRP), we clinically characterized disease associated with mutations in CNGB1.     

Comparison of fovea-sparing and non-internal limiting membrane peeling for retinoschisis with foveal detachment in highly myopic eyes

PurposeTo compare the visual and anatomical outcomes of two different treatment strategies (non-internal limiting membrane (ILM) peeling and fovea-sparing ILM peeling) for retinoschisis with foveal detachment (FD) in highly myopic eyes.DesignA retrospective cohort study.MethodsNinety-five eyes from 92 highly myopic patients with retinoschisis with FD were divided into two groups, including 44 eyes from 43 patients who received 23-gauge, 3-port vitrectomy without ILM peeling (group A) and 51 eyes from 49 patients who received vitrectomy with fovea-sparing ILM peeling (group B). All eyes also underwent cataract surgery.ResultsThere were no significant differences between the two groups in terms of sex, age, diopters, axial length (AL), or central foveal thickness (CFT) before surgery (P > 0.05). One month after surgery, foveoschisis and FD were resolved in 74.47% of the eyes in group B and in only 12.50% of those in group A. Six months after surgery, foveoschisis and FD were resolved in 96.08% of the eyes in group B and in only 72.73% of those in group A (P < 0.05). There were no significant differences between the two groups in terms of BCVA 6 months after surgery. The postoperative complication was macular holes, which were found in seven eyes (15.90%) in group A and in one eye (1.96%) in group B (P < 0.05).ConclusionHighly myopic eyes with FD that underwent fovea-sparing ILM peeling appeared to obtain a better anatomical outcome than those that did not undergo non-ILM peeling. The two procedures obtained similar results in terms of visual function.Subject terms: Retinal diseases, Vision disorders

Myopic foveoschisis with foveal detachment had been treated by vitrectomy without ILM peeling as well as foveal sparing ILM peeling in an attempt to reduce the occurrence of postoperative complications. We performed this retrospective study to assess which is the best method for improving anatomical and functional outcomes, and to reduce the incidence of postoperative macular holes.

Myopic retinopathy is one of the most common causes of irreversible visual impairment and blindness due to the high incidence rate of high myopia [1]. Myopic foveoschisis (MF), a common finding in the macula of highly myopic eyes [2], is one of the major causes of poor vision in eyes with pathologic myopia. Based on optical coherence tomography (OCT) images of the macular region, MF can be divided into three stages: isolated retinoschisis, retinoschisis with foveal detachment (FD), and retinoschisis with a macular hole (MH) [3]. Patients with isolated retinoschisis may have stable vision for a long time. However, when retinoschisis progresses to FD or FD progresses to MH, the patient’s visual acuity drops sharply, and MH retinal detachment may easily develop [4]. Thus, stage II (retinoschisis with FD) is the best time to start surgical treatment.At present, the mainstream treatment for retinoschisis with FD is vitrectomy. Studies have shown that vitrectomy could result in good anatomical and visual outcomes in highly myopic eyes [5–15]. However, how to address the ILM remains controversial. Some studies proposed vitrectomy without ILM peeling and showed that the prevalence of postoperative MH was much lower than that in ILM peeling cases, but the recovery rate may not be satisfactory [12, 16]. In contrast, people who promote ILM peeling believe that it can increase the recovery rate but that postoperative MH may occur (8–18%) [17, 18] and result in poor postoperative VA. Recently, some researchers have proposed a fovea-sparing ILM technique to reduce the risk of iatrogenic MH formation [19–24]. Could fovea-sparing ILM peeling increase the anatomic resolution and reduce the incidence of postoperative MHs in FD patients at the same time? Comparing non-ILM peeling with fovea-sparing ILM peeling, which procedure is better? For these purposes, we designed this study. This study analyzed 95 eyes from 92 patients with MS and FD treated with PPV without ILM peeling or with ILM peeling that avoided the foveal area to determine which procedure is better for treating this disease.     

Neurorretinopatía autoinmune secundaria a infección por el virus del Zika

Case report

A 40-year-old woman diagnosed with Zika virus infection 6 months before she arrived at this hospital. She referred to a progressive and painless vision loss, of 2 weeks onset after the infection diagnosis. She was treated with topical steroids. Previous visual acuity was recovered, but she still refers to reduced visual field and nyctalopia. Ophthalmologic examination revealed severe retinal sequels, compatible with autoimmune retinopathy. Based on the clinical features and the temporal relationship with Zika virus infection, non-para-neoplastic autoimmune retinopathy was diagnosed and managed with steroids and infliximab.

Enucleation and evisceration: an analysis of indications,histopathological findings,and surgical trends over 23 years at a tertiary care hospital in western Canada

Objective

To report indications for eye removal, histopathological diagnosis, and surgical trends in enucleation versus evisceration over a 23-year period.

Diabetes Mellitus–Associated Uveitis: Clinical Features in a Chilean Series

ABSTRACT

Purpose

To describe clinical features of patients with diabetes mellitus-associated uveitis (DMAU).     

A novel mutation in the aspartate beta-hydroxylase (ASPH) gene is associated with a rare form of Traboulsi syndrome

ABSTRACT

Background

Traboulsi syndrome is a rare autosomal recessive genetic disorder. The present study aimed to identify the pathogenic variants in the ASPH gene responsible for a rare and unique presentation of Traboulsi syndrome associated with cardiac disorder.     

Intravitreal Bevacizumab for Inflammatory Neovascularization of the Lens after Traumatic Open Globe Injury

ABSTRACT

Purpose

To describe a case of inflammatory neovascularization of the lens after open globe injury.     

Sub-Tenon Sustained Controllable Delivery of Dexamethasone for Treating Severe Acute Experimental Uveitis

ABSTRACT

Purpose

To evaluate the efficacy of dexamethasone (DXM) through sub-tenon sustained controllable drug delivery system (SSCDDS) for treating severe acute experimental uveitis.     

Ocular Manifestations of Sickle Cell Disease: Signs,Symptoms and Complications

ABSTRACT

Background

Sickle cell disease is an inherited hematological disorder that can affect any organ in the body including the eyes (1–6). Previous studies on ocular manifestations of sickle cell disease generally included samples of less than 100 patients. In this study, we aim to assess the frequency of different ocular signs, symptoms and complications among sickle cell disease patients.     

Presenting Features,Treatment and Clinical Outcomes of Cytomegalovirus Retinitis: Non-HIV Patients Vs HIV Patients

ABSTRACT

Purpose

To compare clinical features, complications, and outcomes of CMV retinitis in non-HIV immunocompromised patients with HIV infected patients.     

Associations of Social Determinants of Health and Self-Reported Visual Difficulty: Analysis of the 2016 National Health Interview Survey

ABSTRACT

Purpose

To determine the association of selected social determinants of health (SDH) assessed by the National Health Interview Survey (NHIS) among adults with visual difficulty.     

Endophthalmitis following Suture Removal – Clinical Outcomes and Microbiological Profile

Aims: To review the clinical pro?le and report the microbiology and treatment outcomes of endophthalmitis following suture removal.

Methods: In this multi-center, retrospective interventional case series, 11 eyes of 11 patients who developed endophthalmitis following suture removal from January 2006 to December 2017 were reviewed.

Results: Nine of the 11 patients developed a culture-proven, acute onset endophthalmitis [5.3 ± 3.1 days (range 2–10 days)]. Mean age was 15.8 ± 21.2 years (median 7; range, 1–66 years). Presenting visual acuity was extremely low ranging from light perception (PL) to counting fingers close to face (CFCF) at the time of diagnosis of endophthalmitis. Out of the 11 patients, 8 belonged to the pediatric age group; four out of those eight had loose sutures secondary to cataract surgery, two patients had loose sutures secondary to penetrating keratoplasty and 1 case each had loose sutures secondary to corneal tear repair and secondary IOL implantation, respectively. Streptococcus pneumoniae was the most common organism and was identified in seven cases and was susceptible to vancomycin in all these cases. Other bacterial isolates were Haemophilus influenzae and Achromobacter denitrificans. Three out of the 11 eyes had visual outcome of 20/200 or better. Six eyes were phthisical and one eye was eviscerated. Mean follow-up was 26.3 ± 31.2 weeks (range 2–92 weeks). Visual outcomes ranged from 20/40 to no light perception at the last follow-up.

Conclusions: Endophthalmitis following suture removal though rare, is observed most commonly in the pediatric population and has an acute and a fulminant course. Streptococcus pneumoniae was the most commonly isolated microorganism. Visual acuity outcomes were poor despite prompt recognition of endophthalmitis and appropriate antibiotic therapy.