共查询到20条相似文献，搜索用时 31 毫秒
1.
Sophie Vieujean Caroline Coibion Laurence Seidel Edouard Louis 《Scandinavian journal of gastroenterology》2020,55(9):1041-1048
Abstract
Objectives
To compare dynamic contrast-enhanced (DCE)-MRI parameters in affected and unaffected segments of CD patients with those of a control group, and to assess the correlation between DCE-MRI parameters and clinical index of activity (HBI) as well as biomarkers (CRP and faecal calprotectin). 相似文献2.
Eman M. El-Serougy Nahla N. Eesa Hatem M. El-Azizi Hayat A. Badawi 《The Egyptian Rheumatologist》2019,41(1)
Background
Evaluation of remission in Rheumatoid Arthritis (RA) largely relies on composite scores based on clinical and laboratory assessments however, patients can fulfill clinical remission criteria as defined by composite scores, yet still have evidence of synovitis detectable on imaging.Aim of the work
To evaluate hand and wrist joints in patients with RA in clinical remission using power Doppler (PD) ultrasonography and to study the association between ultrasonographic findings and composite index scores.Patients and methods
This study was conducted on 50 RA patients in clinical remission. Ten matched healthy subjects were included as control. The modified health assessment questionnaire (MHAQ) was assessed in the patients; disease activity was calculated using a composite index score including disease activity score (DAS28) and clinical disease activity index (CDAI). Ultrasonographic assessment of the hand and wrist joints was performed.Results
The mean age of the patients was 50.9?±?9.2?years, disease duration was 10.6?±?5.5?years and were 38 females and 12 males. The mean DAS28 was 2.3?±?0.3. On ultrasonographic examination, 14 (28%) patients had normal synovium, while 18 (36%) showed synovial hypertrophy without evidence of inflammation and 18 (36%) had PD signals. DAS28 was higher in patients with PD signals (2.36?±?0.3) compared to those without synovitis (2.3?±?0.28). There was a significant correlation between PD activity and CDAI (p?=?0.005), MHAQ (p?=?0.002) and disease duration (p?=?0.023).Conclusion
Power Doppler ultrasound can detect residual inflammation in RA patients in clinical remission and its scores were signficantly associated with the clinical disease activity index and functional status. 相似文献3.
Abbed K.M. Hameed Tamer O. El-Said Hamdia Y. Askar Basma A. ElKady 《The Egyptian Rheumatologist》2019,41(2)
Background
Numerous tools to assess activity of rheumatoid arthritis (RA) are available to use. For any marker to be a more appropriate indicator of disease activity, it should be more authentic to the patho-physiologic basis of the disease.Aim of the work
To determine the performance of serum adenosine deaminase (sADA) in measuring disease activity in RA.Patients and Methods
100 RA patients and 100 matched controls were included in the study. The disease activity score (DAS28) with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed. sADA level was determined by spectrophotometry. The sADA level was integrated in the DAS28 formulae and the corresponding values were determined.Results
The mean age of the RA patients was 61.8?±?9.7?years, 68% were females and they had a disease duration of 12.5?±?3.7?years. The mean DAS28-ESR was 4.2?±?1.3 and DAS28-CRP 3.5?±?1.1. The mean sADA was significantly higher in the patients (33.6?±?11.6?U/L) compared to the control (25.1?±?9.9?U/L) (p?<?0.001). The sADA level and DAS28-sADA did not differ according to the gender, methotrexate use, rheumatoid factor or anti-citrullinated protein autoantibodies positivity. The mean DAS28-sADA significantly increased in higher activity categories (p?<?0.001). sADA significantly correlated with the disease activity parameters. DAS28-sADA significantly correlated with DAS28-ESR (r?=?0.57, p?<?0.001) and DAS28-CRP (r?=?0.604, p?<?0.001). DAS28-sADA showed a sensitivity of 0.9 and specificity 0.69 for detection of disease activity measured with DAS28-ESR and was 0.88 and 0.65 when measured with DAS28-CRP.Conclusion
Integration of sADA in the DAS28 index can be a useful marker that reflects RA activity. 相似文献4.
Marta Freitas Sofia Xavier Rui Magalhães Joana Magalhães Carla Marinho José Cotter 《Scandinavian journal of gastroenterology》2020,55(9):1079-1086
Abstract
Background
The liver-renal-risk (LIRER) score was developed to predict adverse outcomes in cirrhotic patients with Model for End-stage Liver Disease (MELD)<18, helping the allocation to liver transplantation in this population. We aimed to assess its prognostic performance compared to other prognostic scores in first admission for hepatic cirrhosis decompensation. 相似文献5.
Naglaa S. Ghazy Rasha A. Abdel Noor Maaly M. Mabrouk Wael F. Mohammed 《The Egyptian Rheumatologist》2019,41(2)
Background
End stage renal disease can decrease lupus activity especially after renal replacement therapy, so assessment of activity after starting hemodialysis (HD) is essential to avoid immunosuppressive complications and prevent flares.Aim of the work
To assess lupus activity in patients on regular HD and determine the differences in activity and number of lupus flares between patients who were maintained on steroids and immunosuppressives and those not.Patients and methods
Thirty-five systemic lupus erythematosus (SLE) patients on regular HD. were recruited from 14 hemodialysis centers in five cities in Gharbia Governorate, Egypt. The patient?s files were reviewed and SLE disease activity index (SLEDAI) was measured.Results
The mean age of patients was 30.7?±?9.2?years and were 29 females and 6 males with a median disease duration of 6?years and SLEDAI of 3. 57.1% of the cases did not record lupus flare after dialysis while 42.9% were active; 11 (31.4%) of them had 1 flare, 3 (8.6%) had 2 flares and 1 (2.9%) had 3 flares. and according to the SLEDAI grading, 77.2% had no flare, 11.4% had mild flare and 11.4% moderate; none had a severe flare. There was no significant difference between those maintained on steroids or immunosuppressives and patients who stopped treatment after HD as regard number of flares and disease activity grading.Conclusions
Lupus activity is not uncommon after starting hemodialysis but giving a prolonged immunosuppressive therapies is not necessary in all cases and should be given cautiously to avoid their side effects. 相似文献6.
Abdulrahman Alduraywish Mostafa Ragheb Nageh Louis Khaled Aldossari Rania Kishk 《Scandinavian journal of gastroenterology》2020,55(8):963-969
Abstract
Objectives
Haemodialysis (HD) patients are at risk for blood-borne infections as occult HCV infection, which justifies comprehensive studies. We aimed to determine the prevalence and risk factors of occult HCV infection (OCI) among HD patients. 相似文献7.
Mohamed Naseem Sameh Samir Ibtsam Khairat Ibrahim Lamiaa Khedr Abeer Abd Elmonem Shahba 《Journal of the Saudi Heart Association》2019,31(1):41-49
Objectives
Disease activity has been considered as independent cardiovascular risk factor in rheumatoid arthritis (RA) patients. We aimed to evaluate the effect of RA disease activity on left ventricular (LV) and right ventricular (RV) functions by speckle tracking echocardiography (STE).Methods
120 patients with RA without evidence of cardiovascular disease and 40 healthy control subjects were included. Disease activity was evaluated according to Simplified Disease Activity Index (SDAI) score and Disease Activity Score 28 (DAS28). LV and RV functions were assessed using conventional echocardiography and global longitudinal strain (GLS) technique measured by STE.Results
81 patients had active disease while 39 patients were in remission. The LV and RV GLS value for active RA patients was reduced compared to RA patients in remission and control group (p?=?<0.001). There was a significant correlation between RA disease activity scores level and LV GLS value, increasing levels of disease activity was associated with worse LV GLS (r?=??0.802, p value?=?<0.001) and r?=??0.824, p value?=?<0.001) for SDAI and DAS28 scores respectively. Also, there were significant correlations between RA disease activity scores level and RV GLS value as the disease activity level increases the RV GLS value become worse (r?=??0.682, p value?=?<0.001) and r?=??0.731, p value?=?<0.001) for SDAI and DAS28 scores respectively Receiver operating characteristic (ROC) curve analysis showed that SDAI score and DAS28 were predictive for reduced LV GLS with a cut off value of >7 and >2.8 respectively with sensitivity of 77.6%, specificity of 85.0% and area under ROC curve?=?90.4 for SDAI score and with sensitivity of 89.7%, specificity of 71.7% and area under ROC curve?=?89.4 for DAS28 score. Also, SDAI score and DAS28 were predictive for reduced RV GLS with a cut off value of >11 and >3 respectively with sensitivity of 73.1%, specificity of 93.5% and area under ROC curve?=?91.6 for SDAI score and with sensitivity of 84.6%, specificity of 80.4% and area under ROC curve?=?90.8 for DAS28 score.Conclusion
Disease activity in patients with rheumatoid arthritis is associated with lower left and right ventricular function. Disease activity scores can predict subclinical left and right ventricular dysfunction. 相似文献8.
Jonathan R. White Said Din Richard J. M. Ingram Stephen Foley Mohammad Aftab Alam Richard Robinson 《Scandinavian journal of gastroenterology》2020,55(8):907-916
Abstract
Purpose
Clinical trials have demonstrated efficacy of vedolizumab in ulcerative colitis (UC) and Crohn’s disease (CD). Further real-world data is needed to inform clinical practice. The primary outcome was to assess corticosteroid-free and clinical remission after vedolizumab initiation. Secondary outcomes included effect on disease activity scores, biochemical markers, concomitant drug use, endoscopic remission, surgical intervention, hospital admissions and adverse events. 相似文献9.
Ahmad Hassan Ali Jennifer Damman Shamita B. Shah Yinka Davies Melissa Hurwitz Mariam Stephen 《Scandinavian journal of gastroenterology》2020,55(8):941-950
Abstract
Background
Oral vancomycin (OV) in primary sclerosing cholangitis (PSC) has been evaluated as a potential therapeutic agent. We report the long-term biochemical course and outcomes of patients with PSC treated with OV. 相似文献10.
Luca Maccioni Bei Gao Sophie Leclercq Boris Pirlot Yves Horsmans Philippe De Timary 《Gut microbes》2020,12(1)
ABSTRACT
Background
Animal data suggest a role of the gut-liver axis in progression of alcoholic liver disease (ALD), but human data are scarce especially for early disease stages. 相似文献11.
Alexandra Voce Kristen G. Anderson 《The American journal of drug and alcohol abuse》2020,46(3):348-356
ABSTRACT
Background
Alcohol use during adolescence has been predicted by motives to drink or abstain, as well as parental attitudes to youth drinking. As peers can provide access and opportunities to drink, permissiveness of peers’ parents toward alcohol is also of importance. 相似文献12.
Maria Kulecka Barbara Fraczek Michal Mikula Natalia Zeber-Lubecka Jakub Karczmarski Agnieszka Paziewska 《Gut microbes》2020,11(5):1374-1384
ABSTRACT
Background
Little data are available on the subject of gut microbiota composition in endurance athletes as well as connections between diet and specific bacteria abundance. However, most studies suggest that athletes’ microbiota undergoes major alterations, which may contribute to increased physical performance. Therefore, we decided to investigate differences in gut microbiota between healthy controls and endurance athletes. 相似文献13.
Emmanuel Stamatakis Joanne Gale Adrian Bauman Ulf Ekelund Mark Hamer Ding Ding 《Journal of the American College of Cardiology》2019,73(16):2062-2072
Background
It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting.Objectives
The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with physical activity, standing, and sleep.Methods
A longitudinal analysis of the 45 and Up Study calculated the multivariable-adjusted hazard ratios (HRs) of sitting for each sitting-MVPA combination group and within MVPA strata. Isotemporal substitution modeling estimated the per-hour HR effects of replacing sitting.Results
A total of 8,689 deaths (1,644 due to CVD) occurred among 149,077 participants over an 8.9-year (median) follow-up. There was a statistically significant interaction between sitting and MVPA only for all-cause mortality. Sitting time was associated with both mortality outcomes in a nearly dose-response manner in the least active groups reporting <150 MVPA min/week. For example, among those reporting no MVPA, the all-cause mortality HR comparing the most sedentary (>8 h/day) to the least sedentary (<4 h/day) groups was 1.52 (95% confidence interval: 1.13 to 2.03). There was inconsistent and weak evidence for elevated CVD and all-cause mortality risks with more sitting among those meeting the lower (150 to 299 MVPA min/week) or upper (≥300 MVPA min/week) limits of the MVPA recommendation. Replacing sitting with walking and MVPA showed stronger associations among high sitters (>6 sitting h/day) where, for example, the per-hour CVD mortality HR for sitting replaced with vigorous activity was 0.36 (95% confidence interval: 0.17 to 0.74).Conclusions
Sitting is associated with all-cause and CVD mortality risk among the least physically active adults; moderate-to-vigorous physical activity doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. 相似文献14.
Katrine Kauczynska Romstad Trond Espen Detlie Taran Søberg Petr Ricanek Marte Eide Jahnsen Frode Lerang 《Scandinavian journal of gastroenterology》2020,55(10):1139-1145
Abstract
Objectives
Acute upper gastrointestinal bleeding is a well-recognized complication of peptic ulcers and erosions. The aim of this study was to assess the incidence rate and identify risk factors for this complication in southeastern Norway. 相似文献15.
Aim of the work
This study aimed to assess long-term articular damage and function in rheumatoid arthritis (RA) patients in relation to the type of treatment. Early disease modifying anti-rheumatic drug (DMARD) therapy has not been evaluated in this study.Patients and methods
One hundred and fifty RA patients (141 females and 9 males) with disease duration more than five years and disease activity score-28 (DAS-28) <3.2 were included in this study. Sixty patients received disease modifying anti-rheumatic drugs (DMARDs) (group A), 60 received DMARDs and corticosteroids (CS) (group B), and 30 patients received CS only (group C). The functional outcome was assessed using the Modified Health Assessment Questionnaire (MHAQ). The articular damage was measured by using Rheumatoid Arthritis Articular Damage (RAAD) Score. The van der Heijde modification of the Sharp erosion score was used to define the plain X-ray of both hands and feet.Results
The mean age of the patients was 49.3?±?11.5?years, and disease duration was 12?±?7.9?years. There was a significant difference between the RAAD, visual analogue scale and MHAQ scores among the three groups (p?=?0.001), with higher score in group C followed by B. By using Multiple regression analysis to examine the relationship between RAAD score and other independent variables there was a significant association of the RAAD score with higher X-ray score (p?<?0.001) and with patients taking steroids only (p?=?0.001).Conclusion
Although, use of corticosteroids may help to control the disease activity, but it increases the risk of overall joint damage. 相似文献16.
Chang Seok Bang Hae Min Jeong Woon Geon Shin Jae Ho Choi Jae Seung Soh 《Gut microbes》2020,11(5):1314-1323
ABSTRACT
Aim
To compare the efficacy and safety between modified quadruple- and bismuth-containing quadruple therapy as first-line eradication regimen for Helicobacter pylori infection. 相似文献17.
Haitao Shang Tao Bai Yuhua Chen Chao Huang Shengyan Zhang Pengcheng Yang 《Scandinavian journal of gastroenterology》2020,55(9):1049-1056
Abstract
Background and aims
Diarrhea was not uncommon in patients with coronavirus disease 2019 (COVID-19), but the significance remains undetermined. 相似文献18.
Sawitri Assanangkornchai Darika Saingam Walailuk Jitpiboon Alan F. Geater 《The American journal of drug and alcohol abuse》2020,46(3):325-332
ABSTRACT
Background
Underage drinking contributes to numerous health and social problems among adolescents. The Alcoholic Beverage Control Act, issued in Thailand in 2008, contains several clauses aiming at preventing underage and novice drinking, such as raising the minimum legal purchasing age from 18 to 20, banning alcohol sale and consumption in places frequented by youth, and banning alcohol advertisements. 相似文献19.
Rakhi Krishna Jina Raj Drishya Dev Sruthy C. Prasad Sudheer O. V. 《Scandinavian journal of gastroenterology》2020,55(7):860-864
Abstract
Background
Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure 相似文献20.
Christopher Cappelli James Russell Pike Georgia Christodoulou Nathaniel R. Riggs Christopher M. Warren Mary Ann Pentz 《The American journal of drug and alcohol abuse》2020,46(3):316-324
ABSTRACT