Study on Singularity of Chaotic Signal Based on Wavelet Transform

INTRODUCTION The significant information of a signal is often carried by singular characteristics or irregular struc-tures of the signal, for example, the most important information of ECG(electrocardiogram) or EEG isoften presented at the transient points of a signal, such as those points near peaks. The singular charac-teristics of these transient points are more obvious than the smooth parts of signals. Therefore,to studythe singularity of a signal is a meaningful work. Those analysi…     

Can you rely on Treg cells on the rebound?

FoxP3⁺ regulatory T (Treg) cells comprise a highly dynamic population that restrains autoreactivity. Although complete or long‐term depletion of Foxp3⁺CD4⁺ Treg cells in adult mice has been shown to result in chronic inflammation and autoimmune disease, the impact of transient Treg‐cell depletion on self‐reactive responses is poorly defined. A new study published in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: 3621–3631] shows that, although transient depletion of Treg cells in mice is swiftly followed by recovery of Treg‐cell numbers, the “rebounded” population fails to maintain tolerance, culminating in severe autoimmune gastritis. This commentary explores new questions about the quantitative and qualitative aspects of Treg‐cell function in immunological tolerance raised by this study and others.     

Study on Wireless Power Transmission for Gastrointestinal Microsystems Based on Inductive Coupling

INTRODUCTION The interests in capsule endoscope (CE) have increased significantly in recent years. The firstcommercialized CE, M2A can transmit images at the rate of two frames per second[1]. The capsule ispropelled forward passively by gastrointestinal peristalsis waves with digestion. It does not work well forsome diseases, such as constipation, since it can only work continuously for seven hours due to the vol-ume of the batteries integrated in the capsule. A newtype of capsule endo…     

Effects of antisense oligonucleotides on theexpression of macrophage migration inhibitoryfactor on macrophages

It is well known that the infiltration and prolifera tion of macrophages are the main features in manycases of experimental studies and human glomeru lonephritis, and they also play an important role inthe progressive renal injuries in the development ofglonerulonephritis [ 1 4 ]. Macrophage migrationfactor (MIF) is a proinflammatory cytokine thatwas originally described as a product of activatedlymphocytes that inhibited the random migration ofmacrophages in vitro and promoted the acc…     

Study on Endothelial Cell Adhesion and Retention on Tissue Engineered Vascular Grafts

1 IntroductionThe poor adhesion and retention of living endothelial cells (ECs) on the vascular grafts has been remaining as a challenging problem. When implanted into a human body, the performance of a biomaterials on which cells are seeded is greatly af…     

Effect of bombarding energy on ion beam assisted deposited DLC film on UHMWPE

1.IntroductionItiswellknownthatultra-highmolecularweightpolyethylene(~E)isafirstchoicepolarerforuseinfabricationoftotalhipandkneeprostheses.However,overthelastfewyearsithasbecomeincreasinglyapparelltthatveryfewprosthesesimplantedinthebodyweretrulylonglifetime.Muchoftheorthopedicconunuhitynowbelievethatthelong-termfailureoftoealhipandkneeprosthesesisdireCtlyorindireCtlyduetOwear,resultingintheproduCtionofpolyethylene(PE)wearparticlesatinterneebetweentheUHMWPEandmedalcomponentif].Thesepart…     

EM Effects on the Body

15Aug.16 PmAt Room No.713:00一15:00,:30一17:00CO一CHAIRMAN(208) Prof·Jiang Huai,Prof.Yu Jue Prof.FukuiTITLEABSTRACT PAGESThe effeets of 50 Hz magnetie fields on DNA damage H·J .Yang,et al.····················································································……167Influenee of magnetie field of proliferation aetivity ofmarrow eell in rabbits and rats Naozhang He,et al.····…     

Study on Fluid Shear Flow on Osteoblast-like Cells in Their Tensile Loading Experiments

In vitro cell loading experiments are used to investigate stimulation of strain to cellular proliferation. As the flowing conditions of culture fluid in loading systems has been little known, strictly people can not detect the influence of strain to cellular proliferation exactly because shear flow can enhance cell proliferation either. Based on the working principle and cyclic loading parameters, we simplify Navier-Stokes equation to describe the flow of culture fluid on substrates of uniaxial and equi-biaxial fiat tensile loading systems and four point bending system. With approximate solutions, the distributions of velocity field and wall shear flow to cells are gained. Results show: shear flows are zero in the middle (or fixed point or line) of substrate for all systems, and they get larger proportionally to distance from middle and substrate elongate; the shear flow on the substrate of four point bending system is much greater than those of others. This shear flow in four point bending system, confirmed by Owan, I., et al with OPN mRNA increase in their experiment, could cause more influence to osteoblast-like cells than that caused by strain. We estimate the average magnitude of shear stress in Owan‘ s device, the results are consistent with other experimental data about shear flow. In conclusion our study makes it possible to differentiate the influence of strain on cellular proliferation to that of shear flow in loading experiments with the devices mentioned above quantitatively.     

Anatomist on the dissecting table? Dutch anatomical professionals' views on body donation

Anatomical professionals know better than anyone else that donated bodies are a valuable asset to anatomical science and medical education. They highly value voluntary donations, since a dearth of bodies negatively affects their profession. With this in mind, we conducted a survey (n = 54) at the 171st scientific meeting of the Dutch Anatomical Society in 2009 to see to what extent anatomical professionals are willing to donate their own body. The results reveal that none of the survey participants are registered as a whole body donor and that only a quarter of them would consider the possibility of body donation. We argue that the two main constraints preventing Dutch anatomical professionals from donating their own body are their professional and their social environments. In contrast to the absence of registered body donors, half of the anatomical professionals are registered as an organ donor. This figure far exceeds the proportion of registered organ donors among the general Dutch population.     

Studies on Plasma Modification on Polyurethane Surface for the Improvement of Blooa Compatibility

Surface modification of biomedical polyurethane material by means of glowdischarge plasma was investigated in this study. After exposing the material to N. or N./H. plasma for thirty minutes, the hemocompatibilily of the material is significanlly improved according to the in-vitro evaluation presented in the article. The interracial free energy of the surface with water after modification enters the range of one to three dyn/cm after plasma being treated under the optimal technical parameters presented. The haemolytic percentage of the treated polyurethane is less than 5%, indicating that the treated material is a satisfactory candidate for clinical uses.     

Immunotoxicology of cadmium and mercury on B-lymphocytes — I. Effects on lymphocyte function

Heavy metals have been shown to exert immunotoxic effects on humoral immunity. To ascertain the mechanisms by which these immunotoxic effects are exerted, the effects of CdCl₂ and HgCl₂ on the biology of murine B-lymphocytes were studied. It was shown that CdCl₂ aand HgCl₂ inhibited B-cell RNA and DNA synthesis. The IC₅₀ (the concentration required to inhibit a specific B-cell function by 50%) for CdCl₂ was 30 μM for RNA synthesis and DNA synthesis. The IC₅₀ for HgCl₂ was 50 and 120 nM for RNA and DNA synthesis, respectively. Cell cycle analysis revealed that B-cells were arrested throughout the cell cycle with CdCl₂ and HgCl₂. The inhibitory effects exerted by CdCl₂ were rapid, inhibiting RNA synthesis within 2 h of activation. Differentiation to Ig secretion was inhibited by CdCl₂ and HgCl₂ in culture and there appeared to be selective effects on specific Ig isotypes. IgG₃ production was most sensitive to inhibition by CdCl₂ and HgCl₂ followed by IgG₁ and IgG_2b and then IgM and IgG_2a. Changes in the expression of B-cell surface antigens induced by LPS were also influenced by CdCl₂. LPS-induced increases in class II MHC expression was inhibited by CdCl₂, as was the constitutive expression of class I MHC antigen. A summary of the IC₅₀ for CdCl₂ are presented.In summary, both CdCl₂ and HgCl₂ exert early, inhibitory effects on B-cell activation. This is manifested by the inhibition of RNA, DNA and antibody synthesis. However, selective effects on the production of specific Ig isotypes by these metals may influence the ability of B-cells to mount effective immune responses to pathogens.     

The Influence of Interleukin-32γ on Osteoclastogenesis with a Focus on Fusion-Related Genes

We previously reported that interleukin-32 gamma (IL-32γ) has a direct effect on osteoclast differentiation and activation in vitro in the context of receptor activator of NF-κB ligand (RANKL) co-stimulation. However, the stage of osteoclast differentiation at which IL-32γ exerts its effect was not determined. Here, we demonstrated that IL-32γ plays an important role in the fusion of preosteoclasts to yield multinuclear osteoclasts, particularly large osteoclasts. The synergistic effect of IL-32γ on RANKL-induced formation of multinuclear osteoclasts was readily apparent when cells were treated with IL-32γ at the fusion stage. In addition, we demonstrated that IL-32γ induced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and nuclear factor of activated T cells cytoplasmic 1 (NFATc1), and NFATc1 inactivation by cyclosporine treatment attenuated the effect of IL-32γ. These results indicate that IL-32γ is a potential mediator of osteoclast fusion, likely through up-regulation of NFATc1 and DC-STAMP.     

Small molecule—folic acid modification on nanopatterned PDMS and investigation on its surface property

Folic acid (or folate, FA) has attracted considerable attention for cancer therapy. As one small molecule, its receptor (folate receptor, FR) is significantly overexpressed on the surface of many human tumor cells compared with normal cells. In this work, physical and chemical coupled modification method, that is the combination of nanoimprinting technique and graft polymerization, was adopted to modify FA on nanopatterned polydimethylsiloxane (PDMS) surface for possible application in micro-nanofluidic cytology. The surface property of differently treated PDMS was characterized by FTIR, AFM and contact angle measurement. AO/PI double staining, cell counting and MTT method were performed to examine the potential influence of FA modified nanopatterned PDMS on human cervical carcinoma (HeLa) cell behavior. Both FA modification and nanostructure have positive effect on the growth and viability of HeLa cells. It is the first time that the small molecule-folic acid was used to immobilize on the surface of PDMS in order to improve its surface property.     

Research on Superscalar Digital Signal Processor

Under the direction of design space theory,in this paper we discuss the design of a superscalar pipelining using way of multiple issues,and the implement of a superscalar-based RISC DSP architecture. SDSP. Furthermore. in this paper we discuss the validity of instruction preferch,the hranch prediction, the depth of instruction window and other issues that can affect the performance of superscalar DSP.     

Perceptual influences on Fitts’ law

The linear relationship between movement time (MT) and index of difficulty (ID) for Fitts’ type tasks has proven ubiquitous over the last 50+ years. A reciprocal aiming task (IDs 3, 4.5, 6) was used to determine if an enlarged visual display (visual angle 5.1°, 7.4°, or 13.3°) would alter this relationship. With ID = 6, a condition typically associated with discrete action control, the largest visual display (13.3°) allowed the motor system to exploit features of cyclical action control, e.g., shorter dwell times, more harmonic motion, less time decelerating the limb. The large visual display resulted in a quadratic relationship between MT and ID. For the IDs of 3 and 4.5, the visual displays did not alter the underlying control processes. The results are discussed in terms of the preference of the motor system to assemble movements from harmonic basis functions when salient visual information is provided.