共查询到20条相似文献,搜索用时 437 毫秒
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Martínez-Gómez LE Cruz M Martínez-Nava GA Madrid-Marina V Parra E García-Mena J Espinoza-Rojo M Estrada-Velasco BI Piza-Roman LF Aguilera P Burguete-García AI 《Annals of human genetics》2011,75(5):612-620
Type 2 diabetes (T2D) is a chronic degenerative disease that involves the participation of several genetic and environmental factors. The objective of the study was to determine the association of the IRS1 (rs1801278), CAPN10 (rs3792267), TCF7L2 (rs7903146 and rs12255372), and PPARG (rs1801282) gene polymorphisms with T2D, in two different Mexican populations. We conducted a case-control replication study in the state of Guerrero and in Mexico City, with 400 subjects from Guerrero and 1065 from Mexico City. Data were analyzed by logistic regression, adjusting by ancestry, age, gender, and BMI, to determine the association with T2D. Heterozygosity for the Gly972Arg variant of the IRS1 gene showed the strongest association for T2D in both analyzed samples (OR = 2.43, 95% CI 1.12-5.26 and 2.64, 95% CI 1.37-5.10, respectively). In addition, an association of two SNPs of the TCF7L2 gene with T2D was observed in both cities: rs7903146, (for Guerrero OR = 1.98 CI95% 1.02-3.89 and for Mexico OR = 1.94 CI95% 1.31-2.88) and rs12255372 (OR = 1.79 CI95% 1.08-2.97, OR = 1.78 CI95% 1.17-2.71 respectively). We suggest that our results provide strong evidence that variation in the IRS1 and TCF7L2 genes confers susceptibility to T2D in our studied populations. 相似文献
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Parra EJ Cameron E Simmonds L Valladares A McKeigue P Shriver M Wacher N Kumate J Kittles R Cruz M 《Clinical genetics》2007,71(4):359-366
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Dennis O Mook-Kanamori Sandra WK de Kort Cornelia M van Duijn Andre G Uitterlinden Albert Hofman Henri?tte A Moll Eric AP Steegers Anita CS Hokken-Koelega Vincent WV Jaddoe 《BMC medical genetics》2009,10(1):67
Background
An inverse association between birth weight and the risk of developing type 2 diabetes (T2D) in adulthood has been reported. This association may be explained by common genetic variants related to insulin secretion and resistance, since insulin is the most important growth factor in fetal life. The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy. 相似文献10.
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Vipin Gupta Rajesh Khadgawat Hon Keung Tony NG Satish Kumar Ajay Aggarwal Vadlamudi Raghavendra Rao M. P. Sachdeva 《Annals of human genetics》2010,74(4):361-368
The aim of this study was to validate the single nucleotide polymorphisms (SNPs) of four candidate genes (TCF7L2, HHEX, KCNJ11, and ADIPOQ) related to type 2 diabetes (T2D) in an endogamous population of north India; the Aggarwal population, having 18‐clans. This endogamous population model was heavily supported by recent land mark work and we also verified the homogeneity of this population by clan‐based stratification analysis. Two SNPs (rs4506565; rs7903146) in TCF7L2 were found to be significant (p‐value = 0.00191; p‐value = 0.00179, respectively), and odds ratios of 2.1 (dominant‐model) and 2.0 (recessive‐model) respectively, were obtained for this population. The TTT haplotype in the TCF7L2 gene was significantly associated with T2D. Waist‐Hip ratio (WHR), systolic blood pressure (SBP), and age were significant covariates for increasing risk of T2D. Single‐SNP, combined‐SNPs and haplotype analysis provides clear evidence that the causal mutation is near to or within the significant haplotype (TTT) of the TCF7L2 gene. In spite of a culturally‐learned sedentary lifestyle and fat‐enriched dietary habits, WHR rather than body‐mass‐index emerged as a robust predictor of risk for T2D in this population. 相似文献
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Osama Alsmadi Khalid Al-Rubeaan Gamal Mohamed Fadi Alkayal Haya Al-Saud Nouran Abu Al-Saud Nasser Al-Daghri Shahinaz Mohammad Brian F Meyer 《BMC medical genetics》2008,9(1):72
Background
The rs7903146 and rs12255372 variants of TCF7L2 have been strongly associated with type 2 diabetes (T2D) risk in most populations studied to date. Meta-analysis of 27 different studies has resulted in a global OR of 1.46 [1.42–1.51] (rs7903146 variant). Thus far, despite a high incidence of T2D, the role of this variant in Arabs has not been established. 相似文献16.
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Mayans S Lackovic K Lindgren P Ruikka K Agren A Eliasson M Holmberg D 《European journal of human genetics : EJHG》2007,15(3):342-346
A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D. 相似文献
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Andreas Holstein Michael Hahn Antje Körner Michael Stumvoll Peter Kovacs 《BMC medical genetics》2011,12(1):30
Background
Variants in the TCF7L2 have been shown to be associated with an increased risk for type 2 diabetes (T2D). Since the association with diabetes could be explained by effects on insulin secretion, we investigated whether patients with diabetes risk alleles at rs7903146 might have an altered hypoglycaemic response to sulfonylureas (SUs). 相似文献19.
Stéphane Cauchi David Meyre Hélène Choquet Samia Deghmoun Emmanuelle Durand Stefan Gaget Cécile Lecoeur Philippe Froguel Claire Levy-Marchal 《BMC medical genetics》2007,8(1):37
Background
In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 相似文献20.
Association of TCF7L2 Polymorphism with Diabetic Nephropathy in the South Indian Population
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Dhanasekaran Bodhini Manickam Chidambaram Samuel Liju Visvanathan G. Prakash Vijay Gayathri Coimbatore S. Shanthirani Unnikrishnan Ranjith Ranjit M. Anjana Viswanathan Mohan Venkatesan Radha 《Annals of human genetics》2015,79(5):373-379