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1.
BackgroundBuyang-Huanwu-Tang (Boyang-Hwano-Tang, BHT) is a widely used traditional Chinese herbal medicine for treating ischemic stroke in South Korea and China. Its efficacy in vascular dementia has been reported. There has been no comprehensive systematic review of BHT for vascular dementia.MethodsWe searched 15 electronic databases from inception to November 25, 2021. We included only randomised controlled clinical trials. Studies that used BHT alone or with Western medicine were included. Two independent reviewers conducted the screening, data extraction, and the Cochrane risk of bias and quality of evidence assessment. A meta-analysis was performed.ResultsA total of 18 eligible trials with 1254 participants were included. Of these, 15 were included in the meta-analysis. The pooled results suggested that BHT alone (mean difference [MD] 1.31; 95% confidence interval [CI] −2.94 to 5.56; P = 0.55) was similar to Western medicine alone in terms of the Mini-Mental State Examination(MMSE). Additive BHT therapy showed a significant improvement in the MMSE (MD 1.42; 95% CI 0.28 to 2.56; P = 0.01), Hasegawa Dementia Scale score (MD 3.91; 95% CI 2.87 to 4.94; P < 0.001) and total effective rate (risk ratio 1.35; 95% CI 1.20 to 1.52; P < 0.001). The overall risk of bias was unclear or high. The quality of evidence was very low to moderate. Only four studies reported minor or no adverse events.ConclusionsThe results support the clinical use of BHT for the improvement of cognitive function in patients with vascular dementia. The methodological quality of the included studies was relatively poor. Therefore, further rigorously designed trials are required. 相似文献
2.
《Taiwanese journal of obstetrics & gynecology》2021,60(5):874-877
ObjectiveCystic hygroma often ameliorates or disappears with pregnancy progression. Fetuses/neonates with amelioration, when without chromosomal or major structural abnormality, generally show a favorable outcome at birth. The present study was aimed to clarify the short/long-term outcomes of fetuses/neonates with the amelioration of cystic hygroma during pregnancy.Material and methodsThis was a retrospective observational study. We focused on fetuses with cystic hygroma managed in our institute between January 2006 and June 2019. The infants were followed by pediatricians (neonatologist, pediatric cardiologist, and pediatric neurologist) and pediatric outcomes were retrieved from the medical records up to 3 years old.ResultsOne hundred and seven fetuses with cystic hygroma were included. Of the 107, cystic hygromas ameliorated in 31 fetuses (31/107: 29%). Of the 31, there were 26 livebirths. Half (n = 13) of the 26 fetuses had a good outcome, whereas the remaining half (n = 13) had abnormalities. Various abnormalities were detected in their infancies. A nuchal thickness (diameter of hygroma) of ≥5 mm was significantly correlated with abnormalities (P = 0.047).ConclusionPhysicians should pay attention to fetuses/neonates with ameliorated cystic hygroma. Of those, special attention should be paid to fetuses/neonates with a nuchal thickness at diagnosis ≥5 mm. 相似文献
3.
ObjectiveTo test the efficacy of Gua Sha therapy in patients with chronic low back pain.Methods50 patients with chronic low back pain (78% female, 49.7 ± 10.0 years) were randomized to two Gua Sha treatments (n = 25) or waitlist control (n = 25). Primary outcome was current pain intensity (100-mm visual analog scale); secondary outcome measures included function (Oswestry Disability Index), pain on movement (Pain on Movement Questionnaire), perceived change in health status, pressure pain threshold, mechanical detection threshold, and vibration detection threshold.ResultsAfter treatment, patients in the Gua Sha group reported lower pain intensity (p < 0.001) and better overall health status (p = 0.002) compared to the waitlist group. No further group differences were found. No serious adverse events occurred.ConclusionsGua Sha appears to be an acceptable, safe, and effective treatment for patients with chronic low back pain. Further rigorous studies are needed to confirm and extend these results. 相似文献
4.
《Journal of pediatric and adolescent gynecology》2022,35(6):647-652
Study ObjectiveTo examine the clinical characteristics and prevalence of congenital bleeding disorders (CBDs), with emphasis on congenital factor VII (FVII) deficiency and other rare bleeding disorders, in adolescent and young adult females referred to a hemophilia treatment center (HTC) for evaluation and management of heavy menstrual bleeding (HMB) and iron deficiency anemia (IDA)DesignIn this single-center retrospective study, we reviewed the clinical characteristics and prevalence of CBDs in postmenarchal females, younger than 22 years of age, referred to an HTC from 2015 to 2021 for evaluation of HMB with or without IDA.ResultsOne hundred females, with a mean age of 15 years (range 9-20 years), met initial study criteria, and 95 were included in the final analysis. Forty-five (47%) females were ultimately diagnosed with a CBD. The most prevalent diagnoses were FVII deficiency and type 1 von Willebrand disease (VWD) (42.3%, n = 19 each). Forty-two percent of patients with FVII deficiency had a low-for-age FVII activity level, 21.1% were only positive for the FVII R353Q variant associated with borderline FVII levels, whereas 36.8% had both a low-for-age FVII activity level and a positive R353Q variant. Eighty percent of patients with a CBD were found to have relatives with abnormal bleeding symptoms.ConclusionCongenital FVII deficiency is prevalent among female adolescents experiencing HMB with or without IDA. In addition to VWD, evaluation for this specific factor deficiency should be considered as part of the initial CBD workup. Presence of abnormal bleeding history in the family could also help to predict presence of a CBD. 相似文献
5.
IntroductionStroke is the leading cause of non-traumatic disability in adults, with balance and gait disturbances representing the main limitations of body functions. Dance therapy (DT) has shown positive effects in older adults and in patients with neurological pathologies. This systematic review aims to examine the feasibility, acceptability and effects of DT in stroke rehabilitation, specifically on functional gains of gait and balance.MethodsA systematic search was carried out for articles published in the MEDLINE, PEDro, Web of Science, Scopus and CINHAL in February 2021 and updated in April 2021. Results: Eight studies were included (2 clinical cases, 5 case series and 1 randomized controlled trial), 7 of them in patients with chronic stroke and only 1 in subacute stroke phase. The most widely used dance modality was tango and ballet, with sessions ranging from 30 to 110 min. DT seems to show positive effects on post-stroke body functions and activities such as gait and balance. Reported dropout rates are inconsistent, no adverse effects were reported, and participant satisfaction was high.ConclusionGiven the heterogeneity and uneven quality of the included studies, strong conclusions cannot be put forward on the effectiveness of DT in post-stroke body function and activities. Nevertheless, DT seems to be safe and acceptable therapy for patients, and no adverse effects have been reported. More studies with a high level of evidence and feasibility are needed to determine the patient profile, the characteristics of the intervention, the participation rate and the role of the rehabilitation professional most likely to generate optimal benefit. 相似文献
6.
Kuntharee Traisrisilp Supatra Sirichotiyakul Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Phudit Jatavan Sirinart Sirilert Theera Tongsong 《Taiwanese journal of obstetrics & gynecology》2021,60(4):706-710
ObjectiveTo evaluate the performance of first trimester sonomarkers in the detection of fetal Down syndrome among Thai pregnant women.Materials and methodsPregnant women at 11–13+6 weeks’ gestation underwent ultrasound examination for assessment of nuchal translucency (NT), nasal bone (NB), tricuspid regurgitation (TR), and abnormal ductus venosus (aDV) Doppler waveforms. The women were followed up for final outcomes. Fetal abnormalities other than trisomy 21 were excluded. The performances of each sonomarker and their combinations in predicting fetal Down syndrome were calculated.ResultsA total of 7820 pregnant women meeting the inclusion criteria were available for analysis, including 20 cases with fetal Down syndrome and 7800 unaffected cases. Of the four sonomarkers, NT, as a single sonomarker, had the highest detection rate (55.0% at a false positive rate of about 5%), whereas the remaining single sonomarkers had low detection rate (15–20%). The combination of all sonomarkers had the highest detection rate of 70% but the false positive rate was as high as 10.8%. The combination of NT and NB had a detection rate of 60% with an acceptable false positive rate of 6.9%, whereas the other combinations yielded relatively high false positive rates.ConclusionThe first trimester genetic sonogram in screening for Down syndrome among Asian women is acceptably effective and may be offered to some selected groups of the population. NT is the best sonomarker with a detection rate of 55% at 5% false positive rate and its combination with NB can improve performance with minimal increase in false positive rate. 相似文献
7.
BackgroundThe best physiotherapeutic approach in shoulder pathology that generates prolonged immobilization is still uncertain. Kinesitherapy remains the most widely used option. Myofascial therapy is a therapeutic approach in which the aim is to release fascial tension and regain mobility although its efficacy in shoulder pathology has not been sufficiently studied. This Prospective, single-blind randomized controlled trial in a university hospital setting aimed to compare the efficacy of myofascial therapy and kinesitherapy in improving function in shoulder pathology with prolonged immobilization.MethodsPatients were randomly assigned to a control group or to the intervention group.Both groups completed a therapeutic exercise program. Main Outcome Measures: The QuickDash questionnaire was the primary outcome, Pain Visual Analog Scale and the Range Of Motion of the shoulder were the secondary outcomes. The outcomes were evaluated at baseline (T0), at 4 (T2), 8 (T2), and 12 weeks (T3)Results44 participants were included. In the analysis of evolution over time, a significant improvement in functionality and range of motion measurements was observed in both groups (p < 0.05), although at 12 weeks only Myofasical Group achieved a clinically and statistically significant reduction in pain. Comparative analysis at 12 weeks revealed no statistically significant differences between the two therapies in the variables explored.ConclusionsBoth, myofascial therapy and kinesitherapy can improve function, mobility, and pain in patients with painful shoulder associated with prolonged immobilization, with no significant differences between therapies, although in the medium term only myofascial therapy achieves a clinically and statistically significant improvement in pain.Trial registrationTrial registration: ClinicalTrials.gov NCT04944446. 相似文献
8.
《Journal d'obstetrique et gynecologie du Canada》2023,45(8):587-606.e8
ObjectiveThis guideline reviews the evidence-based management of normal and complicated monochorionic twin pregnancies.Target PopulationWomen with monochorionic twin or higher order multiple pregnancies.Benefits, Harms, and CostsImplementation of these recommendations should improve the management of both complicated and uncomplicated monochorionic (and higher order multiple) twin pregnancies. They will help users monitor monochorionic twin pregnancies appropriately and identify and manage monochorionic twin complications optimally in a timely manner, thereby reducing perinatal morbidity and mortality.These recommendations entail more frequent ultrasound monitoring of monochorionic twins compared to dichorionic twins.EvidencePublished literature was retrieved through searches of PubMed and the Cochrane Library using appropriate MeSH headings (Twins, Monozygotic; Ultrasonography, Prenatal; Placenta; Fetofetal Transfusion; Fetal Death; Fetal Growth Retardation). Results were restricted to systematic reviews, randomized controlled clinical trials, and observational studies. There were no date limits, but results were limited to English or French language materials.Validation MethodsThe content and recommendations were drafted and agreed upon by the principal authors. The Board of the SOGC approved the final draft for publication. The authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and conditional [weak] recommendations).Intended AudienceMaternal-fetal medicine specialists, obstetricians, radiologists, sonographers, family physicians, nurses, midwives, residents, and other health care providers who care for women with monochorionic twin or higher order multiple pregnancies.Tweetable AbstractCanadian (SOGC) guidelines for the diagnosis, ultrasound surveillance and management of monochorionic twin pregnancy complications, including TTTS, TAPS, sFGR (sIUGR), acardiac (TRAP), monoamniotic twins and intrauterine death of one MC twin.SUMMARY STATEMENTS
- 1.Morbidity and mortality in twin pregnancies are most commonly related to: (1) chorionicity, (2) prematurity, (3) fetal growth restriction, and (4) congenital anomalies (high).
- 2.Virtually all monochorionic placentas have vascular anastomoses between the two placental cord insertions (high).
- 3.Besides prematurity and growth discordance, the vast majority of twin complications arise in monochorionic twin pregnancies (high).
- 4.Twin–twin transfusion syndrome affects approximately 10%–15% of monochorionic twin pregnancies (high).
- 5.The diagnosis of twin–twin transfusion syndrome is based on ultrasound findings of significant discordance in both amniotic fluid volume and bladder size (high). Cardiac dysfunction in the recipient twin or growth discordance often co-exist, but are not essential criteria for the diagnosis (high).
- 6.Fetoscopic laser ablation of the placental vascular anastomoses is the best treatment for twin-twin transfusion syndrome presenting before 28-30 weeks gestation, rather than amnioreduction or septostomy (high).
- 7.The Solomon laser technique decreases the risk of twin–twin transfusion syndrome recurrence and twin anaemia-polycythaemia sequence (high).
- 8.Twin anaemia-polycythaemia sequence occurs spontaneously in 4%–5% of monochorionic twin pregnancies (moderate). It typically develops later in pregnancy than twin–twin transfusion syndrome (usually >24–26 weeks gestation) (moderate). Twin anaemia-polycythaemia sequence may co-exist with twin–twin transfusion syndrome and has been reported in up to 13% of cases of TTTS in which the fetoscopic laser ablation procedure was incomplete (high).
- 9.Ultrasound features of twin anaemia-polycythaemia sequence are increasingly discordant middle cerebral artery peak systolic velocities, suggestive of anaemia in one fetus and polycythaemia in the other, often without significant amniotic fluid discordance (high). Other signs may include differential placental echogenicities and a “starry sky” liver in the recipient twin (moderate).
- 10.Selective fetal growth restriction in monochorionic twin pregnancies has been defined as an estimated fetal weight (EFW) of one twin below the 3rd percentile, or at least 2 of the following four variables: (1) EFW <10th percentile, (2) abdominal circumference <10th percentile, (3) EFW discordance ≥25%, or (4) umbilical artery pulsatility index of the smaller twin >95th percentile (high).
- 11.In monochorionic twins, estimated fetal weight discordance >25% and abnormal umbilical artery Doppler waveforms are independent risk factors for an adverse perinatal outcome. (high).
- 12.The ultrasonographic features of twin reversed arterial sequence are an amorphous, usually edematous, acardiac twin, which is retrogradely perfused via a placental artery-to-artery anastomosis by its healthy “pump” co-twin (high).
- 13.A large acardiac twin (e.g., an acardiac:“pump” twin abdominal circumference ratio ≥50%) may put its “pump” co-twin at risk of high-output cardiac failure (high). The overall risk of intrauterine death of the “pump” twin is approximately 30% before 18 weeks gestation (high).
- 14.If one of a monochorionic twin pair dies, the surviving co-twin may be at risk of neurological morbidity and intrauterine death (high). Imaging may not detect changes in the co-twin’s brain for several weeks after the death of its sibling (moderate).
- 15.Ultrasound features of monoamniotic twins include the absence of a dividing amniotic membrane, a single placenta, close proximity of placental cord roots, concordant sex and, commonly, cord entanglement (high).
- 16.Only 2%–4% of monoamniotic twins will develop twin–twin transfusion syndrome (high).
- 17.Structural anomalies, particularly cardiac, are more common in monochorionic twins than in dichorionic twins or singletons (high).
- 18.Conjoined twins are extremely rare and the organs/structures that are shared will determine the potential for surgical intervention and survival (high).
- 1.In spontaneously conceived pregnancies, we recommend using the larger of the two crown–rump lengths to estimate gestational age (conditional, moderate).
- 2.Viability, gestational age, chorionicity and amnionicity should be assessed between 110 and 136 weeks gestation in all multiple pregnancies (strong, high).
- 3.If chorionicity cannot be confidently established sonographically, pregnancies should be monitored as if they were monochorionic (conditional, moderate).
- 4.Twins should be labelled on antenatal ultrasound according to their lateral (right/left) or vertical (top/bottom) orientation, rather than their proximity to the cervix, and, ideally, that labelling should be maintained across all subsequent ultrasound examinations (strong, moderate).
- 5.A detailed anatomy scan should be performed at approximately 18–20 weeks gestation for all monochorionic twins (strong, high). Where the expertise is available, an early anatomy ultrasound can be performed at 12–14 weeks gestation (conditional, moderate).
- 6.In all twin pregnancies, cervical length should be assessed, either transabdominally or transvaginally, at the time of the anatomical ultrasound scan and, ideally, once more at around 23–24 weeks gestation (strong, moderate).
- 7.All monochorionic pregnancies should undergo ultrasound surveillance every 2 weeks from 16 weeks gestation until delivery to detect twin–twin transfusion syndrome, twin anaemia-polycythaemia sequence and selective fetal growth restriction (strong, high).
- 8.Ultrasound assessment of all monochorionic twins from 16 weeks onwards should include measurement of growth (fetal biometry), fetal bladder filling, and the single deepest pocket of amniotic fluid on both sides of the membrane, as well as umbilical and middle cerebral artery peak systolic velocity Doppler studies for each fetus (strong, high).
- 9.Monochorionic twins without complications should be delivered between 36 and 37 weeks gestation. Unless there are other obstetric contraindications, vaginal delivery is appropriate (strong, high).
- 10.If twin–twin transfusion syndrome or significant selective fetal growth restriction is suspected, the ductus venosus should be assessed (strong, high). Cardiac structure and function should be assessed in the recipient twin whenever twin–twin transfusion syndrome is suspected (strong, high).
- 11.For cases of twin–twin transfusion syndrome, urgent consultation with or referral to one of the fetal therapy laser centres in Canada is recommended, as fetoscopic laser ablation of placental vascular anastomoses is the best therapy for twin–twin transfusion syndrome (strong, high).
- 12.Ultrasonography should be performed weekly for 4 weeks after fetoscopic placental laser and then every 2 weeks following clinical resolution, with ongoing antenatal care shared or co-ordinated with the regional maternal–fetal medicine centre (strong, high). Assessment should include amniotic fluid volume in both sacs, bladder sizes, Doppler waveforms (middle cerebral artery peak systolic velocity, umbilical artery pulsatility index and ductus venosus), and intra-cranial anatomies, as well as measurement of cervical length and documentation of any chorio-amnion separation (strong, high).
- 13.Fetal intracranial anatomy should be carefully re-evaluated after an interval of at least 4 weeks following a laser procedure (strong, moderate).
- 14.Whenever monochorionic twin complications are encountered, including twin anaemia-polycythaemia sequence, selective fetal growth restriction, twin reversed arterial perfusion sequence, monoamnioticity, discordance for an anomaly, or a single intrauterine death, referral to, or at least consultation with, the regional maternal–fetal medicine program or fetal therapy centre is recommended (strong, high), so that all management options can be explored. The optimal management of twin anaemia-polycythaemia sequence has yet to be determined. (conditional, moderate).
- 15.When selective fetal growth restriction is suspected, fetal surveillance should be intensified and the pregnancy managed by referral to, or at very least with input from, a regional maternal–fetal medicine centre with expertise in this condition (strong, moderate).
- 16.In selective fetal growth restriction, timing of delivery should take into account gestational age, evidence of haemodynamic compromise as assessed by umbilical and middle cerebral artery and ductus venosus Doppler studies, and biophysical wellbeing (strong, moderate).
- 17.Whenever the death of one monochorionic twin is diagnosed early in pregnancy, colour Doppler ultrasonography should be used to exclude twin reversed arterial perfusion sequence, by confirming the absence of blood flow in the suspected demised twin (strong, high).
- 18.In twin reversed arterial perfusion sequence, especially with a large acardiac twin, occlusion of the circulation to the acardiac twin, either by laser, radio frequency ablation of the intra-fetal vessels or bipolar cautery should be considered (conditional, moderate).
- 19.After the spontaneous death of one monochorionic twin, surveillance for fetal anaemia by middle cerebral artery peak systolic velocity measurement should be instituted rapidly, as anaemia correlates with the risk of a hypotensive neurological injury (strong, high). The surviving twin may benefit from intrauterine transfusion (conditional, moderate). Fetal neurosonography and, ideally, MRI should be used to identify any potential cerebral injury; however, ultrasonographic evidence of injury may take 3-4 weeks to develop after the death of the co-twin (strong, high).
- 20.Care should be taken not to misdiagnose monochorionic-diamniotic pregnancies as monoamniotic, when one twin has anhydramnios (e.g., the donor in twin–twin transfusion syndrome) (conditional, moderate).
- 21.Monoamniotic twins are at high risk of cardiac abnormalities and should undergo a detailed anatomical ultrasound with particular emphasis on fetal cardiac evaluation (strong, high).
- 22.Monoamniotic twins should be monitored closely from viability onwards (either as out-patients or in-patients) and should undergo an elective caesarean delivery at approximately 33 weeks gestation (conditional, moderate).
- 23.Aneuploidy screening can be offered in monochorionic pregnancies as either combined prenatal serum screening (i.e., first-trimester screening or integrated prenatal screening, as available provincially) or cell-free fetal DNA analysis of maternal blood (conditional, moderate).
- 24.Invasive prenatal testing (chorionic villus sampling or amniocentesis) should be offered in the presence of a structural anomaly or abnormal genetic screening (strong, high). Amniocentesis from both sacs should be considered for discordant anomalies because of the rare possibility of heterokaryotypic anomalies in monochorionic twins (strong, high).
- 25.If indicated for discordance for an anomaly, selective termination of pregnancy in monochorionic twins must always be performed by a vascular occlusion method and never by intravascular fetal injection (strong, high).
9.
《台湾医志》2022,121(12):2556-2565
BackgroundThe actual relative dose intensity (RDI) of the attenuated R-CCOP regimen (rituximab, cytoxan, pegylated liposomal doxorubicin [PLD], vincristine, and prednisone) has not been fully investigated in Chinese geriatric patients with diffuse large B-cell lymphoma (DLBCL). In particular, the optimum dose for PLD remains unclear.MethodsWe retrospectively collected clinical data from patients with untreated DLBCL aged 65–80 years subsequently treated with the R-CCOP. The restricted cubic spline model (RCS) was used to test the non-linear relationship between the predictors and outcomes.ResultsEighty-four patients were enrolled, with a median age of 73.5 years. More than half of the patients (54.8%) received at least 6 cycles. The median dose per cycle of cytoxan and PLD were 605.5 and 19.9 mg/m2. The 5-year progression-free survival (PFS), overall survival rate, and disease-specific survival rates were 38.7%, 44.8%, and 57.2%, respectively. The RDI of PLD (PLD-RDI, <70% vs ≥ 70%) was only significant in the univariate analysis (P = 0.002) but not in the multivariate analysis. The RCS model showed a decreasing trend of hazards with an increasing PLD dose per cycle after adjustment. No significant difference was observed between the low- and high-risk groups with PLD-RDI ≥ 70% (P = 0.548). However, patients in the high-risk group had unfavorable PFS with PLD-RDI < 70% (P = 0.006).ConclusionThe optimal dose of PLD for elderly patients with DLBCL in China remains to be determined. Evaluating the tolerance and identifying risk categories are critical for clinical decision-making in this population. 相似文献
10.
《Taiwanese journal of obstetrics & gynecology》2022,61(5):858-862
ObjectiveTo assess the technical feasibility of laparoscopic tubocornual anastomosis (TCA) at restoring tubal patency in patients with proximal tubal occlusions.Materials and methodsA retrospective analysis of fourteen females with identified proximal tubal occlusions seeking to restore their tubal patency in a university-affiliated tertiary hospital between 2011 and 2018. Tubal patency within one year after the surgery was evaluated.ResultsThe patients had a mean age of 34.0 ± 3.6 years old, median parity of 1 child, and mean BMI of 23.0 ± 5.2 kg/m2. Of the fourteen patients, two (14.3%) received bilateral TCA, eight (57.1%) received only unilateral TCA, and four (28.6%) received TCA on one side and tubal anastomosis on the other. The operative time was 126.4 ± 37.9min for unilateral procedure and 201.0 ± 1.4 min for bilateral anastomoses. Postoperative hysterosalpingogram (HSG) demonstrated a patency rate of 64.2% at the TCA sites. Two ectopic pregnancies were reported thereafter.ConclusionThis preliminary series demonstrates that laparoscopic TCA is technically feasible and provides promising results for patients with proximal tubal occlusions hoping to restore their tubal function in order to conceive naturally. A larger prospective series is mandatory to establish its significance and application in clinical practices. Notably, infertile patients without surgically correctable factors are not suitable for this procedure. 相似文献
11.
BackgroundTotal knee arthroplasty (TKA) is one of the most popular surgeries in the orthopedic field. One of the reasons for a failed TKA is pain and difficulty to return to normal function. A pain control method that is becoming more and more popular is the use of virtual reality (VR). We aimed to examine VR intervention in the immediate post-operative physiotherapy following TKA.MethodsThis prospective randomized-controlled study recruited a total of 55 patients undergoing primary TKA in a single institute, operated by three surgeons. They were assigned either study group or control group. Both groups were treated with conventional physiotherapy and CPM equipment (Continuous passive motion device), the study group received additional VR modality. Both groups completed a series of questionnaires prior and after the intervention: State-Trait Anxiety Inventory (STAI) questionnaire (used to diagnose anxiety), Visual analog scale (VAS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) (knee function score).ResultsThe average age was 70 years-old with equal distribution of male and female. Both groups showed a decrease in pain and anxiety following the intervention (p value < 0.05) but there was no difference between the groups (p value > 0.05 for all parameters). The was no difference in the WOMAC scores in the six-month post-operative examination between groups (p-value = 0.653).ConclusionsVirtual reality intervention in the immediate post-operative period following total knee arthroplasty decrease pain and anxiety but did not influence the pain, anxiety, and long-term function results more than conventional physiotherapy. 相似文献
12.
Background and purposeChemotherapy-induced phlebitis (CIP) is one of the most important and common complications in patients with cancer. Currently, the use of complementary methods to prevent or alleviate phlebitis symptoms has attracted great attention. In this study, we aimed to assess the effects of topical sesame oil in reducing the pain severity of CIP.Materials and methodsThis randomized clinical trial was conducted on 60 patients with colorectal cancer afflicted with CIP. Patients received, twice a day for seven consecutive days, a 5-min massage solely (as the control group) or with 10 drops of sesame oil (as the experimental group) within the 10 cm radius of the affected site. The pain severity was evaluated by the visual analog scale on the first, third, fifth, and seventh days of the intervention.ResultsMean changes of the pain severity compared to the baseline were significant on the third (P = 0.009), fifth (P < 0.001), and seventh (P < 0.001) days of the intervention in favor of the experimental group. Also, a significant reduction in the pain severity both in the experimental and control groups was observed during the seven days (F = 720.66, Ptime < 0.001); however, the decrease was more significant in the experimental group (F = 21.46, Pgroup < 0.001).ConclusionApplication of massage with sesame oil as a complementary method is effective in reducing the pain severity of patients with CIP. 相似文献
13.
Background and purposeThis study aimed to determine the effect of Binaural Beats(BB)on feeling of pain, and patient comfort during colonoscopy without sedation.Materials and methodsIt is a randomized, controlled, double-blind procedural study of 115 patients that underwent colonoscopy without sedation. The patients were randomly assigned into the experimental group (n = 42) and the control group (n = 48) that were given BB starting 5 min before and continuing until the end of the colonoscopy procedure without any intervention other than routine nursing care. Measures of the state of anxiety (VAS-Anxiety scale) administered before the procedure, and measures of feeling of pain (Visual Analogue scale VAS-pain), Satisfactory and Willingness to repeat the procedure as Likert scales were also collected soon after the colonoscopy procedure.ResultsFeeling of pain was lower and scores of the level of comfort were higher in the experimental group when compared to the control group (p < 0.05).ConclusionsBB is an effective and safe method for reducing pain and improving patient comfort in cases undergoing colonoscopy without sedation. Since BB method is a non-pharmacological, non-invasive, inexpensive and simple method without any side effects, it may be used to reduce the feeling of pain and discomfort for non-sedated patients undergoing colonoscopy. 相似文献
14.
《Journal d'obstetrique et gynecologie du Canada》2023,45(6):417-429.e1
ObjectiveTo describe the current evidence-based diagnosis and management of adenomyosis.Target PopulationAll patients with a uterus of reproductive age.OptionsDiagnostic options include transvaginal sonography and magnetic resonance imaging. Treatment options should be tailored to symptoms (heavy menstrual bleeding, pain, and/or infertility) and include medical options (non-steroidal anti-inflammatory drugs, tranexamic acid, combined oral contraceptives, levonorgestrel intrauterine system, dienogest, other progestins, gonadotropin-releasing analogues), interventional options (uterine artery embolization), and surgical options (endometrial ablation, excision of adenomyosis, hysterectomy).OutcomesOutcomes of interest include reduction in heavy menstrual bleeding, reduction in pelvic pain (dysmenorrhea, dyspareunia, chronic pelvic pain), and improvement in reproductive outcomes (fertility, miscarriage, adverse pregnancy outcomes).Benefits, Harms, and CostsThis guideline will benefit patients with gynaecological complaints that may be caused by adenomyosis, especially those patients who wish to preserve their fertility, by presenting diagnostic methods and management options. It will also benefit practitioners by improving their knowledge of various options.EvidenceDatabases searched were MEDLINE Reviews, MEDLINE ALL, Cochrane, PubMed, EMBASE. The initial search was completed in 2021 and updated with relevant articles in 2022. Search terms included adenomyosis, adenomyoses, endometritis (used/indexed as adenomyosis before 2012), (endometrium AND myometrium) uterine adenomyosis/es, symptom/s/matic adenomyosis] AND [diagnosis, symptoms, treatment, guideline, outcome, management, imaging, sonography, pathogenesis, fertility, infertility, therapy, histology, ultrasound, review, meta-analysis, evaluation]. Articles included randomized controlled trials, meta-analyses, systematic reviews, observational studies, and case reports. Articles in all languages were searched and reviewed.Validation MethodsThe authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Table A1 for definitions and Table A2 for interpretations of strong and conditional [weak] recommendations).Intended AudienceObstetrician-gynaecologists, radiologists, family physicians, emergency physicians, midwives, registered nurses, nurse practitioners, medical students, residents, and fellows.Tweetable AbstractAdenomyosis is common in reproductive-aged women. There are diagnostic and management options that preserve fertility available.SUMMARY STATEMENTS
- 1.Providers should be aware that adenomyosis has been associated with heavy menstrual bleeding, pelvic pain, infertility, miscarriage, and adverse pregnancy outcomes (moderate).
- 1.Transvaginal sonography should be the first-line modality for imaging of suspected adenomyosis in patients presenting with heavy menstrual bleeding, pelvic pain, infertility, miscarriage, and adverse pregnancy outcomes (strong, high).
- 2.Transvaginal sonography in patients presenting with symptoms suggestive of adenomyosis should be assessed by radiologists for the following: presence of features typical of adenomyosis, location, focal or diffuse disease, cystic or non-cystic disease, uterine layer involvement, extent of disease, and the size of the largest lesion or affected area (strong, high).
- 3.Magnetic resonance imaging should be considered by clinicians if there is inconclusive sonographic evaluation of adenomyosis or suspicion of significant concomitant pelvic pathology (conditional, moderate).
- 4.Oral contraceptives, levonorgestrel-releasing intrauterine system, and dienogest should be used as first-line medical options for pain and heavy menstrual bleeding from adenomyosis (strong, moderate).
- 5.Gonadotropin-releasing hormone (GnRH) agonists can be considered as a second-line agent for management of pain and heavy menstrual bleeding from adenomyosis; add-back hormones should be initiated if GnRH agonists are used longer than 6 months (strong, low).
- 6.Uterine artery embolization is an effective treatment option for heavy bleeding and pain associated with adenomyosis; it can be offered to patients who have completed child-bearing and would like to preserve their uterus (strong, moderate).
- 7.Minimally invasive thermal ablation procedures, such as high-intensity focused ultrasound, radiofrequency ablation, and percutaneous microwave ablation, might be used for the treatment of symptomatic adenomyosis in the future, but more data are needed before they are used outside of a research context (conditional, low).
- 8.Adenomyomectomy is an effective treatment option for symptomatic adenomyosis (strong, moderate).
- 9.Adenomyomectomy can be a challenging surgical procedure, with the potential for significant perioperative morbidity, and should be performed by an experienced surgeon (strong, low).
- 10.Focal adenomyosis may be amenable to surgical excision using minimally invasive routes (laparoscopy, robotic); however, diffuse adenomyosis is best approached using an open technique (conditional, low).
- 11.Given the substantial risk of intraoperative hemorrhage, anemia (hemoglobin <120 g/L) should be corrected before adenomyomectomy (strong, low).
- 12.Patients undergoing adenomyomectomy should be counselled about the uncertain impact of these procedures on fertility and pregnancy. They should be specifically informed about the increased risk of uterine rupture during pregnancy, and the need for pre-labour cesarean delivery (strong, low).
- 13.Total hysterectomy is an effective treatment option for symptomatic adenomyosis and can be offered to women who have completed child-bearing after appropriate counselling regarding risks, benefits, and alternative treatments (strong, low).
- 14.Patients with dysmenorrhea undergoing surgical management of adenomyosis should be counselled to have concurrent excision of any coexisting endometriosis during surgery, for more complete relief of their symptoms (strong, low).
- 15.The impact of adenomyosis on pregnancy outcomes in patients undergoing fertility treatments is uncertain (conditional, low).
- 16.For patients with adenomyosis undergoing in vitro fertilization, gonadotropin-releasing hormone agonist downregulation for a period of 2 to 4 months may be considered before transferring fresh or frozen embryos (weak, low).
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《Journal d'obstetrique et gynecologie du Canada》2023,45(9):665-677.e3
ObjectiveTo summarize the current evidence and to make recommendations for antenatal fetal health surveillance (FHS) to detect perinatal risk factors and potential fetal decompensation in the antenatal period and to allow for timely intervention to prevent perinatal morbidity and/or mortality.Target populationPregnant individuals with or without maternal, fetal, or pregnancy-associated perinatal risk factors for antenatal fetal decompensation.OptionsTo use basic and/or advanced antenatal testing modalities, based on risk factors for potential fetal decompensation.OutcomesEarly identification of potential fetal decompensation allows for interventions that may support fetal adaptation to maintain well-being or expedite delivery.Benefits, harms, and costsAntenatal FHS in pregnant individuals with identified perinatal risk factors may reduce the chance of adverse outcomes. Given the high false-positive rate, FHS may increase unnecessary interventions, which may result in harm, including parental anxiety, premature or operative birth, and increased use of health care resources. Optimization of surveillance protocols based on evidence-informed practice may improve perinatal outcomes and reduce harm.EvidenceMedline, PubMed, Embase, and the Cochrane Library were searched from inception to January 2022, using medical subject headings (MeSH) and key words related to pregnancy, fetal monitoring, fetal movement, stillbirth, pregnancy complications, and fetal sonography. This document represents an abstraction of the evidence rather than a methodological review.Validation methodsThe authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and weak recommendations).Intended audienceAll health care team members who provide care for or education to obstetrical patients, including maternal fetal medicine specialists, obstetricians, family physicians, midwives, nurses, nurse practitioners, and radiologists.SUMMARY STATEMENTS
- 1.Accurate and ongoing early identification of risk factors for potential fetal decompensation allows care providers to develop an individualized care plan to optimize fetal well-being (moderate).
- 2.The nonstress test (NST) may be used in conjunction with a review of the total clinical picture to assess fetal well-being. An NST should be used only in the presence of a clear indication or finding associated with increased risk of fetal hypoxemia (moderate).
- 3.Sonography can evaluate amniotic fluid, estimated fetal weight, biophysical profile/modified biophysical profile, and Doppler blood flows to provide information regarding fetal well-being in pregnancies at risk of fetal morbidity (moderate).
- 4.Interprofessional team communication and documentation should be clear, using accepted and defined terminology (high).
- 1.Care providers should review and document perinatal risk factors (prior pregnancy, fetal, maternal, familial) at the initial visit and update factors throughout pregnancy (strong, moderate).
- 2.Pregnant individuals should be advised of local resources and/or the need for transfer of care based on pregnancy risk factors (strong, moderate).
- 3.Regular prenatal visits should include assessment and documentation of the presence of fetal heart tones, uterine size, pregnancy concerns or risk factors, the plan of care, and the discussion with the pregnant individual (strong, moderate).
- 4.All pregnant individuals should be advised to regularly monitor fetal movements starting at 26 weeks gestation (conditional, low).
- 5.If a reduction of fetal movements is identified, regardless of the technique used to assess fetal movements, pregnant individuals should be advised to present to their care provider or local obstetrical unit immediately for further evaluation (strong, low).
- 6.The nonstress test (NST) should be administered and interpreted by appropriately trained health professionals (strong, high).
- 7.A ≥2 cm × 1 cm pocket of fluid by transabdominal sonography should be used as the criterion for the amniotic fluid component of the biophysical profile (strong, moderate).
- 8.To ensure patient safety, care providers should develop clear protocols locally to communicate and document changes in fetal status identified during antenatal fetal surveillance and escalation of care (strong, moderate).
- 9.Care providers should use non-routine antenatal fetal health surveillance modalities, such as an NST, biophysical profile, or fetal Doppler sonography, only in the presence of a clear indication or finding associated with increased risk of fetal hypoxemia (strong, moderate).
16.
《Taiwanese journal of obstetrics & gynecology》2020,59(5):748-753
ObjectiveOperative hysteroscopy intravascular absorption (OHIA) syndrome refers to fluid overload complications from operative hysteroscopies. Despite guidelines for safe operative hysteroscopies, instances of OHIA syndrome have been reported.Case reportWe reported three cases of OHIA syndrome. A 48-year-old female patient presented net irrigation fluid of 11,900 mL and developed severe metabolic acidosis, conscious disturbance, acute pulmonary edema, and unexpected intensive care unit admission. A 49-year-old female patient presented net irrigation fluid of 4500 mL and developed desaturation and acute pulmonary edema. A 45-year-old female patient presented net irrigation fluid of 2400 mL and developed hyponatremia, increased hilum lung marking, and prolonged postanesthesia care unit observation.ConclusionFor safety, clinicians should use isotonic electrolyte–containing distension media and bipolar electrosurgical instruments in operative hysteroscopies, and fluid status should be monitored closely, particularly at net and total irrigation amounts >3000 and > 8000 mL, respectively. Intrauterine pressure should also be minimized to reduce intravascular and intraperitoneal absorption. 相似文献
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《Journal d'obstetrique et gynecologie du Canada》2023,45(2):150-159.e1
ObjectiveThe purpose of this technical update is to establish the state of the science regarding emerging and novel electronic health (eHealth) and mobile health (mHealth) solutions for urinary incontinence among women.Target populationWomen over 18 years with urinary incontinence.OptionsWebsites and mobile health applications are useful in the conservative care of urinary incontinence. Relevant care providers should be familiar with such tools, particularly those that use motivational principles for behaviour change, which can be used as adjunct tools for urinary incontinence care. Telemedicine is an effect mode to provide services for the conservative care of urinary incontinence.OutcomesUse of eHealth and mHealth solutions has potentially significant health outcomes for patients, providers, and global health systems. Broader use of telemedicine, in and of itself, could improve care access and reduce costs incurred by patients and the health care system.Benefits, Harms, and CostsEvidence for the efficacy of eHealth and mHealth technologies and applications for urinary incontinence ranges from weak to strong. However, the research landscape for many of these novel solutions is developing rapidly. Furthermore, these options have minimal or no harm and confer an established cost benefit and care access benefit.EvidenceThe Cochrane Library, Medline, EMBASE, CENTRAL databases (from January 2014 to April 2019) were searched to find articles related to conservative care of urinary incontinence in women (over 18 years) and studies on eHealth and mHealth interventions for urinary incontinence. Articles were appraised, and the collective evidence was graded.Validation methodsThe authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online Appendix A (Tables A1 for definitions and A2 for interpretations of strong and conditional [weak] recommendations).Intended audienceRelevant primary care providers and medical specialists, including physicians, nurses, midwives, and pelvic health physiotherapists.SUMMARY STATEMENTS
- 1.Electronic and mobile health interventions for urinary incontinence are growing, both in their availability in the health care market and in the science to support their use (moderate).
- 2.Electronic health interventions offered in conjunction with pelvic floor muscle training, either self-directed or directed by a health care provider (physiotherapist), may provide a marginal benefit in symptom improvement for stress urinary incontinence among women (low).
- 3.Application- and web-based programming for urinary incontinence should include traditional components of self-management programs, including motivational strategies to support behavioural interventions (high).
- 4.Bladder diaries are the most studied electronic health tool for overactive bladder and urge urinary incontinence. The acceptability and feasibility of these mobile health solutions has been established (low).
- 5.There is limited research on how electronic health interventions improve urge urinary incontinence and overactive bladder (low).
- 6.Telehealth can be an effective platform for patient education and counselling on conservative and surgical management of uncomplicated stress urinary incontinence (high).
- 1.Mobile health solutions, such as applications that incorporate evidence-based, motivational, behavioural intervention principles, should be recommended to women with stress urinary incontinence if tailored in-person care is not available or accessible (strong, high).
- 2.There is currently insufficient evidence to recommend the routine use of electronic health interventions that include a physical device to improve stress urinary incontinence symptoms (conditional, very low).
- 3.Electronic health interventions may be recommended to complement stress urinary incontinence treatment, but providers should familiarize themselves with the specific interventions recommended, since they vary significantly in terms of composition, cost, and benefit (conditional, very low).
- 4.Health care providers remain the key knowledge translators and advisors on overactive bladder and urge urinary incontinence; they should not assume that patients will get the information they need from a website (strong, moderate).
- 5.Health care providers may recommend web-based self-management programs that incorporate evidence-based motivational behavioural intervention principles if tailored in-person care is not available or accessible to patients (strong, low).
- 6.Application-based bladder diaries may be used as an alternative to traditional bladder diaries as a self-monitoring tool (conditional, low).
- 7.Follow-up visits for uncomplicated stress urinary incontinence may be considered in women who are comfortable with this platform (strong, low).
- 8.Although there is insufficient evidence to recommend virtual or telehealth consultation for routine pessary care instructions, these platforms can be considered on a case-by-case basis depending on the patient’s comfort with pessary self-care (conditional, very low).
- 9.Surgical counselling for stress urinary incontinence via telehealth or virtual platforms may be considered for women who are comfortable with shared decision-making on these platforms (strong, moderate).
- 10.Post-operative virtual visits may be offered as an alternative to in-person visits after uncomplicated surgery for stress urinary incontinence (strong, moderate).
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BackgroundMindfulness interventions can improve psychological distress and quality of life (QoL) in cancer survivors. Few mindfulness programs for cancer recovery exist in Southeastern U.S. The primary objective of this study was to assess the feasibility of a modified mindfulness-based stress reduction (MBSR) program for breast cancer patients in Birmingham, Alabama. The secondary objective was to explore potential program effects on mindfulness skills and QoL.MethodsThis study was a prospective, quasi-experimental feasibility study conducted over 10 months at a university hospital. Feasibility was achieved if 80% of eligible patients screened enrolled in the study and 70% of enrolled patients attended all 8 program sessions. Effectiveness was estimated by changes in mindfulness and QoL indicators measured with validated scales administered at 3 time points and assessed with a non-parametric Friedman test. Sessions included meditation, yoga, and an attention practice called body scan. There were 3 groups of 2–5 patients.ResultsThe sample totaled 12 patients. Forty-four percent (12/27) of eligible patients enrolled in the study, and two out of 12 enrolled patients completed 8 program sessions, resulting in 16.7% (2/12) retention. However, more than half (66.7%) of participants completed at least 7 sessions. Between baseline and 8-week follow-up, patients demonstrated statistically significant improvements in distress, general wellbeing, and fatigue-related QoL.ConclusionsFeasibility objectives were not achieved. However, a majority of participants (66.7%) completed 7 of 8 program sessions. Program effects were promising for distress, fatigue, and wellbeing. Results warrant further research on MBSR-like programs for breast cancer patients in Alabama. 相似文献