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沈二霞 《分子诊断与治疗杂志》2012,4(1):46-49
T细胞是免疫系统启动特异性免疫应答以抵御外界病原体入侵的核心力量之一,其免疫功能的发挥依赖于不同环境下的不同分化条件及功能状态。自1986年Mossman和Coffman首次报道了Th1与Th2细胞亚群以来,人们先后又发现了Th17、Th22以及Treg细胞亚群。过去人们一直认为IL-9属于Th2类细胞因子,可作用于多种炎症细胞和组织细胞,在对抗寄生虫感染和诱导变态反应性疾病中发挥着重要的作用。近年研究发现,机体内可能存在着一群新型的CD4+Th细胞亚群,具有分泌IL-9和IL-10的能力,有学者称之为"Th9"细胞。Th9细胞亚群在变态反应性疾病中所起的作用还不十分清楚,本文将对这一细胞亚群在慢性变态反应性疾病中发挥的作用作一阐述。 相似文献
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黑色素瘤(melanoma)是恶性度最高的皮肤恶性肿瘤,手术切除是其主要治疗方式,部分患者需要联合使用免疫治疗,但免疫治疗存在明显的毒副作用。多项研究表明Th9细胞及其分泌的白介素-9(interleukin 9,IL-9)具有直接与间接(激活机体免疫应答)的抗黑色素瘤效应。此外,Th9细胞/IL-9可能作为免疫治疗的疗效预测指标。Th9/IL-9可能是黑色素瘤患者治疗及疗效判断的潜在靶点。 相似文献
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目的:探讨辅助性T细胞9(Th9)比例及其细胞因子白介素9(IL-9)在慢性淋巴细胞白血病(CLL)患者外周血中的表达水平及临床意义。方法:选取2021年6月至2022年6月于新疆医科大学第一附属医院就诊的43例初诊CLL患者作为病例组,采用Binet分期系统将病例组分为Binet A组(13例)、Binet B组(20例)和Binet C组(10例),同期在本院体检的20例健康志愿者作为对照组。流式细胞术检测外周血Th9细胞比例,Western blot检测Th9特异性转录因子PU. 1和IRF4的表达水平,ELISA检测血清细胞因子IL-9的表达水平。比较各组Th9细胞比例、PU. 1、IRF4和IL-9的表达差异;结合患者临床资料分析Th9比例、IL-9与CLL临床病理指标的相关性。结果:CLL组Th9细胞比例、PU. 1、IRF4和IL-9的表达均明显高于对照组(P<0.05);组内比较,CLL患者Binet B和C组的Th9细胞比例和IL-9的表达均高于Binet A组(P<0.05),Th9细胞比例在Binet B组与C组间差异无统计学意义(P> 0.05... 相似文献
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目的探讨T淋巴细胞(Th22、Th9)与银屑病免疫病理机制的关系。方法选取银屑病患者50例为研究对象,健康者50例为对照组,比较银屑病患者Th22、Th9细胞及效应因子与正常人的差异,探讨白细胞介素(IL-22、IL-9)的数量与疾病严重程度的相关性。结果银屑病组Th9细胞百分比和IL-22、IL-9含量均显著高于对照组(P<0.05)。银屑病PASI评分值与IL-22、IL-9的表达水平呈显著正相关。结论 Th22、Th9细胞及其效应因子参与银屑病的免疫病理机制,IL-22、IL-9与银屑病的严重程度具有显著正相关性,对银屑病治疗提供理依据。 相似文献
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Th17细胞在炎性疾病中的作用 总被引:2,自引:2,他引:0
Th17细胞是新近发现的一种CD4^+T细胞亚群,其主要产生的效应因子是IL-17。过去研究认为,Th1型的干扰素-γ和IL-12在组织炎性损伤中发挥重要作用。随着对Th17细胞的深入研究,发现其在介导慢性炎性反应和自身免疫性疾病发病机制中是关键的致病因素。本文简要对Th17细胞在炎性疾病中的促炎作用作一综述。 相似文献
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异基因造血干细胞移植是有望治愈血液系统疾病、部分先天性疾病和自身免疫性疾病等的方法,但移植物抗宿主病(graft—versus—hostdisease,GVHD)是异基因造血干细胞移植后的重要并发症,并引发受者死亡,直接影响移植效果。众多免疫细胞和炎症因子参与了GVHD的发生,近年来发现的一类新的CD4+IL-17+T细胞(Th17细胞),IL-17和Th17细胞成为了感染免疫、自身免疫性疾病、肿瘤免疫和GVHD研究领域的热点。本文就IL-17和Th17细胞在GVHD免疫调控中的作用作一综述。 相似文献
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特发性血小板减少性紫癜患者血浆白细胞介素18及其有关细胞因子 总被引:5,自引:0,他引:5
白介素18是新的细胞因子,能诱导产生γ-干扰素,增强自然杀伤细胞及辅助性Th1细胞的活性,与Th1细胞分化及细胞毒效应有关。特发性血小板减少性紫癜(ITP)是自身免疫性出血性疾病,其发病与Th细胞之间的失衡有关。为了进一步探讨免疫调控细胞因子在ITP发病中的作用及其临床意义,采用ELISA双夹心法,检测了32例ITP患和18名正常人血浆中Th细胞相关细胞因子IL-18、TNF-α和sC5b-9的水平变化。检测发现:ITP患血浆IL-18、TNF-α及sC5b9水平增高,且血浆IL-18升高与TNF-α和sC5b-9呈正相关。结论:血浆IL-18、TNF-α、sC5b-9等细胞因子水平异常增高与ITP患的Th1/Th2失衡相关,在ITP患的免疫紊乱中起一定的作用,动态观察有利于临床治疗。 相似文献
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H. Oppenheim-Gluckman G. Marioni J. Chambry M.T. Aeschbacher C. Graindorge 《Annales de Réadaptation et de Médecine Physique》2005,48(9):623-661
OBJECTIVE: To explore the impact of brain injury of a parent on adolescent behavioural and emotional symptoms and personal experience. PATIENTS AND SETTING: Eleven adolescents from 13 to 18 years old with a brain-injured parent with cognitive impairment. MAIN OUTCOME MEASURES: Multiple case report. Assessment of anxiety and depression on the R-CMAS scale and the BDI. Qualitative analysis of a semi-structured interview and of the family drawing. RESULTS: Pathological scores on the R-CMAS scale involved 36% of the cases and the BDI, 45%. Impulsivity involved 36% of cases, difficulties in learning at school 73%, and somatic symptoms 45%. Feeling of loneliness involved 64% of cases and difficulty for the adolescent to speak about feelings in the family 82%. The symbolic position of the brain-injured parent was maintained in all cases. In 45% of cases, the parent was unable to recognize the adolescent, and in 55%, some characteristics of the adolescent were linked to the illness of the parent. A feeling of insecurity pervaded all cases. The family drawing revealed abnormalities in the bodily representation of the family members, especially a lack of hands or a representation of amputated hands in 91% of the cases and unsteadiness of the family members, also represented as ghosts in 82% of cases. CONCLUSION: Living with a brain-injured parent increases depression disorders, a feeling of loneliness and insecurity in adolescents. The inability for the adolescent to recognize parent's personality and the identification with caracteristics of the parent due to the illness is worrying. Abnormalities in the bodily representation of the family members and their unsteadiness are characteristic signs. 相似文献
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JY Salle M Castellarin CL Labrousse M Munoz S Guinvarc'h P Dudognon 《Annales de Réadaptation et de Médecine Physique》1995,38(8)
The authors have evaluated the efficiency of loco-regional injections of buflomedil in the shoulderhand syndrome in hemiplegic patients by using a clinical score and the measure of transcutaneous pression of oxygen (TcPO2) at wrist. The study was carried out in 15 patients who were given three injections of 100 mg on D1, D3, D5, five weeks post stroke. They were evaluated on D12 and D26 and their conditions were compared with five hemiplegic untreated patients. The study confirms the clinical efficiency of the treatment as regards pain and vasomotor disorders in algodystrophy. TcPO2 data confirms the clinical improvement in vasomotor disorders. Indeed TcPO2 initial decrease reflecting the local hypoxia notably improves thanks to treatment without returning to normal. 相似文献
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胚胎时期淋巴细胞的发生位点一直存在争议。为明确能自主产生淋系的解剖部位,本研究选取小鼠8.5天胚胎的卵黄囊(胚外)和脏壁层(胚内体系)作为实验对象,此时血液循环尚未建立。用集落形成实验检测脏壁层和卵黄囊的造血集落,用OP9共培养检测脏壁层和卵黄囊的B淋巴细胞,用三步法检测脏壁层和卵黄囊的T细胞生成。结果表明:在标准的集落形成实验中,两者均能产生典型的造血集落,但其类型有差异。通过OP9共培养发现:脏壁层可产生B淋巴细胞,它们表达B220、CD19和IgM。采用三步法在OP9-DL1上诱导脏壁层至第16天,可产生CD44-/CD25+幼稚T细胞前体以及CD4+/CD8-单阳性T细胞。然而,上述共培养体系均不能诱导卵黄囊产生B和T淋巴细胞。结论:与卵黄囊相比,脏壁层具有较强的体外淋系分化潜能。今后,应用新的模式动物有望获得更可靠的体内证据,以解答淋系起源这一关键科学问题。 相似文献
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《Molecular therapy》2023,31(4):1177-1187
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目的 分析山东地区汉族人群TLR-9基因rs187084、rs352139等位点的多态性,探讨其与系统性红斑狼疮的相关性.方法 采用PCR-RFLP等方法对92例系统性红斑狼疮患者和88例健康对照者TLR-9 基因rs187084、rs352139的多态性进行分析,计算基因型和等位基因频率结果:SLE患者TLR-9基因rs187084CC、CT、TT基因型频率分别是0.185、0.413和0.402,rs352139AA、AG、GG基因型频率分别是0.228、0.533和0.239,与对照组间差异没有统计学意义(χ2=2.99,P〉0.05,χ2=4.54,P〉0.05).结论 TLR-9基因可能在SLE发病中起一定作用. 相似文献
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目的:观察Rab9与NPC1蛋白在小胶质细胞内的定位及其与溶酶体、高尔基体和晚期内体的关系.方法:以小鼠小胶质细胞系BV-2为对象,采用特异性识别Rab9、NPC1的抗体和溶酶体、高尔基体、晚期内体的特异性表面标记进行荧光免疫细胞化学染色,在激光共聚焦显微镜下观察.结果:Rab9和NPC1共定位于小胶质细胞胞浆内,Rab9表达于溶酶体、高尔基体和晚期内体.结论:Rab9对NPC1蛋白的正常功能可能有重要影响. 相似文献
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Wade D. Schwendemann MD Stephen A. Contag MD Joseph R. Wax MD Richard C. Miller MD William J. Polzin MD Patrick P. Koty PhD William J. Watson MD 《Journal of ultrasound in medicine》2009,28(1):39-42
Objective. The purpose of this study was to identify the most common prenatal sonographic findings in fetuses with complete trisomy 9. Methods. A retrospective review of all cases of trisomy 9 at 5 participating institutions over a 15‐year interval was conducted. Indications for referral and sonographic findings in each case were reviewed to identify characteristic fetal structural anomalies. Results. Six cases of trisomy 9 are presented. Most patients were referred for abnormal sonographic findings on screening examinations (66%) or advanced maternal age (33%). Fetal heart defects and central nervous system malformations were the most frequent sonographic anomalies seen. Conclusions. Sonographic findings in trisomy 9 are similar to those found in other autosomal trisomies. Because trisomy 9 is uniformly lethal and is not included as part of the standard prenatal aneuploidy screening by fluorescence in situ hybridization analysis, clinicians should be cautious in counseling patients with structurally abnormal fetuses until the full karyotype is available. 相似文献
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