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结核性脑膜炎(tuberculous meningitis,TBM)是肺外结核中最严重的临床表现类型,具有较高的病死率及致残率,故早期、快速诊断及鉴别诊断TBM对疾病的治疗和预后至关重要。笔者通过综述近年来脑脊液(cerebrospinal fluid,CSF)检测在TBM早期诊断及与化脓性脑膜炎、病毒性脑膜炎(viral meningitis,VM)和新型隐球菌性脑膜炎(cryptococcul neoformans meningitis,CNM)的鉴别诊断方法,旨在为TBM的早期诊断与鉴别诊断提供一定的诊疗思路。 相似文献
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王兆星 《肾脏病与透析肾移植杂志》2011,20(3):275-279
随着造影剂在临床的广泛使用,造影剂肾病(CIN)已成为院内获得性急性肾损伤(AKI)的常见病因。早期诊断CIN可指导及时有效地治疗进而改善患者预后。有可能早期诊断CIN的生物标志物包括胱抑素C、中性粒细胞明胶酶相关载脂蛋白、白细胞介素18、肾损伤分子1、肝脏型脂肪酸结合蛋白等。本文对近年来临床工作和基础研究中被人们所关注的各种CIN早期诊断生物标志物做一综述,通过横向对比,进一步探讨适合用于CIN早期诊断的生物标志物。 相似文献
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结核性脑膜炎(tuberculous meningitis,TBM)是最常见的肺外结核之一,约占全部结核病患者的1%;但死亡率可达26.8%,死亡多发生在患病最初的6个月,早期诊断及治疗是改善TBM预后的重要因素。临床上对TBM的诊断是通过临床表现、脑脊液检测、头颅影像学检查及是否并发颅外结核等综合分析后作出的。脑脊液检测是诊断TBM的重要指标,通过检测脑脊液中的结核分枝杆菌及其特异性的标志物,可以为TBM的诊断提供重要帮助。 相似文献
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结核性脑膜炎的诊断标准及其验证 总被引:1,自引:0,他引:1
结核性脑膜炎(TBM)是慢性脑膜炎的最常见类型,发病率与死亡率很高。唯一可靠的诊断方法是证实脑脊液(CSF)中存在结核杆菌,但费时,且检出率低。早期诊断和治疗对预后至关重要。为明确而易于表达诊断,作者利用临床特征、CSF检查、CT发现以及神经系统以外的结核证据等条件设计了一套诊断标准,并以76例病人为对象,经PCR检查,细菌分离,病理学检查,H·R·Z正规化疗并随访3个月,观察症状改善情况等,检验该标准的可靠性。 相似文献
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肺间质病变(ILD)是类风湿关节炎(RA)最常见的关节外表现,死亡率和发病率较高.目前,RA-ILD的诊断基于患者临床表现和影像学检查,但缺乏有效的生物标志物.本文对近年来RA-ILD生物标志物的研究进行综述,寻找与RA-ILD早期诊断,预后评估以及致病机制相关的基因和自身抗体,为临床上诊断RA-ILD提供新思路. 相似文献
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Rafi A Naghily B 《The Southeast Asian journal of tropical medicine and public health》2003,34(2):357-360
The early diagnosis of tuberculous meningitis (TBM) is very important. In this study, the efficiency of the polymerase chain reaction (PCR), one of the most reliable and sensitive DNA-based assays, was compared with conventional methods (acid-fast microscopy and culture) for the detection of M. tuberculosis in cerebrospinal fluid(CSF) specimens from patients suspected of TBM. Of the 29 CSF specimens from highly-probable TBM patients (based on clinical features), 25 were positive by PCR (86.2%), whereas only one of 29 was acid-fast microscopy (AFM) positive (3.4%), and 5 out of 29 were culture-positive (17.2%). No positive results were found by AFM, culture or PCR in the non-tuberculous control group. The results of this study indicate that the application of PCR should be extremely useful in the diagnosis of TBM. 相似文献
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目的通过比较结核性脑膜炎和急性细菌性脑膜炎患者的临床特征和实验室指标,探索结核性脑膜炎的早期诊断方法。方法对2005年1月—2014年5月住院确诊的173例结核性脑膜炎和87例急性细菌性脑膜炎患者的临床特征和实验室指标进行回顾性分析,采用logistic回归分析筛选与诊断相关的影响因素,并采用ROC曲线求诊断界值,建立结核性脑膜炎早期诊断模型。结果结核性脑膜炎早期诊断的相关因素包括:头痛时间≥6 d、外周血WBC计数〈14×109/L、脑脊液(cerebrospinal fluid,CSF)WBC计数〈600×106/L、CSF中性粒细胞比例〈0.75。用这4个指标建立的结核性脑膜炎早期诊断模型对应的ROC曲线下面积为0.999(95%CI:0.998-1.000),具有较高的诊断价值。通过回代法进行验证,模型的误判率为1.15%,低于Thwaites模型的误判率(8.85%)。结论本研究建立的结核性脑膜炎诊断模型具有较高的诊断价值,诊断符合率较高,值得进一步进行临床验证与应用。 相似文献
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Jennifer Ho Ben J. Marais Gwendolyn L. Gilbert Anna P. Ralph 《Tropical medicine & international health : TM & IH》2013,18(6):783-793
Tuberculous meningitis (TBM) comprises a significant proportion of TB cases globally and causes substantial morbidity and mortality, especially in children and HIV‐infected patients. It is a challenging condition to diagnose due to its non‐specific clinical presentation and the limited sensitivity of existing laboratory techniques. Smear microscopy and culture are the most widely available diagnostic tools yet are negative in a significant proportion of TBM cases. Simplified and more affordable nucleic acid amplification tests (NAATs) are increasing in use in resource‐limited settings but have not been optimised for cerebrospinal fluid (CSF) samples. Novel diagnostic methods such as CSF interferon‐gamma release assays and various biomarkers have been developed but require further evaluation to establish their utility as diagnostic tools. There is an urgent need for further research into optimal diagnostic strategies to decrease the morbidity and mortality as a result of delayed or missed diagnosis of TBM. In this review, we discuss current and novel diagnostic tests in TBM and areas where future research should be prioritised. 相似文献
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�Ƽ��������������Ф�����������䪬 《中国实用内科杂志》2014,34(5):492-494
??Abstract??Objective To investigate the applicability of Hristea diagnostic scoring in differentiated diagnosis between viral meningitis (VM) and tuberculous meningitis (TBM).Methods The study was performed retrospectively in resident patients with TBM (n=87) or VM (n=76) in our hospital.The prediction of TBM was determined by Hristea diagnostic scoring using parameters such as duration of symptoms before admission??neurological stages??cerebrospinal fluid (CSF)/blood glucose ratio and CSF protein concentrations.The diagnostic value of the scoring was assessed by calculating the area under the receiver operating characteristic (ROC) curves.Results The Hristea scores of all parameters were significantly different between TBM and VM patients.The sensitivity??specificity??positive predictive value and negative predictive value of Hristea scoring for TBM were 89.7%??86.8%??88.6% and 88.0%??respectively.The area under the ROC curve value for the diagnostic scoring was 0.92.Conclusion Hristea diagnostic scoring is helpful in early diagnosis and differential diagnosis of TBM and VM??and the usefulness of the scoring should be validated in larger series. 相似文献
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P Chedore F B Jamieson 《The international journal of tuberculosis and lung disease》2002,6(10):913-919
OBJECTIVE: A 5-year retrospective study of the performance of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test (MTD) for detecting Mycobacterium tuberculosis complex in cerebrospinal fluid (CSF). Patient data from culture-confirmed cases of tuberculous meningitis (TBM) were also analysed. RESULTS: In total, 311 CSF specimens were tested by the MTD, of which 17 were positive. When compared with culture (gold standard), the sensitivity and specificity of the MTD test were 93.8% and 99.3%, respectively. The positive and negative predictive values for TBM were 88.2%, and 99.7%. Clinical and epidemiological information was requested for all culture-positive TBM patients. These data were used to assess the mortality rate (55.6%) and to determine common factors that could be applied as selection criteria for the appropriate testing of CSF by MTD. CONCLUSION: The study found the MTD test to be a rapid, sensitive and specific test for TBM. A history of immigration from an area endemic for tuberculosis (TB), a history of TB, symptoms of neurological deficits and the results of CSF analyses could be used to appropriately select CSF for MTD testing in order to provide a critical early diagnosis of TBM. 相似文献
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Z Y Hu 《中华结核和呼吸杂志》1990,13(5):299-301, 320
Specific antibody for IgM in cerebrospinal fluid (CSF) of 45 patients with tuberculous meningitis (TBM), 33 patients with non-TBM and 51 control patients was determined by enzyme-linked immunosorbent assay, and compared with specific antibody for IgG. The sensitivity and specificity was 71.1% and 98.8% for IgM antibody, and 88.9% and 96.4% for IgG antibody respectively, but the positive rate of IgM antibody at early stage of TBM was higher than that of IgG antibody. There was a highly significant positive correlation between positive rates of the two types of antibody and contents of protein in CSF. The sensitivity and specificity was 97.8% and 98.8% respectively in detecting both the IgM and IgG antibodies in CSF simultaneously, which can be used as a supplementary method for the diagnosis of TBM. 相似文献
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目的 评价3种快速检测技术在早期结核性脑膜炎诊断中的应用价值。方法 采用离心涂片抗酸染色法、改良抗酸染色法、GeneXpert MTB/RIF技术(简称“GeneXpert技术”)对2016年8月至2018年6月河北省胸科医院和石家庄市第五医院收治的根据临床表现、影像学及实验室检查等临床确诊的45例结核性脑膜炎、42例非结核性脑膜炎患者的脑脊液标本进行分枝杆菌检测,并对结果进行分析。采用SPSS 19.0软件进行统计学分析,率的比较采用χ 2检验、校正χ 2检验,以P<0.05为差异有统计学意义。结果 以临床诊断为标准,45例结核性脑膜炎患者脑脊液分别应用离心涂片抗酸染色法、改良抗酸染色法、GeneXpert技术检测分枝杆菌的敏感度分别为4.44%(2/45)、88.89%(40/45)、35.56%(16/45);依次两两比较,差异均有统计学意义(χ 2值分别为64.46、13.16、27.23,P值均=0.000)。42例非结核性脑膜炎患者的脑脊液用离心涂片抗酸染色法、改良抗酸染色法、GeneXpert技术检测分枝杆菌均为阴性。3种检测技术检测分枝杆菌的特异度均为100.00%。结论 改良抗酸染色法较离心涂片法及GeneXpert技术检测分枝杆菌阳性率高,具有较好的确诊结核性脑膜炎的价值。 相似文献
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The Prognostic Factors of Adult Tuberculous Meningitis 总被引:3,自引:0,他引:3
Background: Our aim was to analyze the prognostic factors and therapeutic outcomes of adult tuberculous meningitis (TBM).
Patients and Methods: Clinical data of 36 patients with adult TBM were retrospectively identified at our institution over a period of 5 years.
Results: 36 adult TBM patients, 23 males and 13 females, aged 16–83 years, were included in this study. The 36 patients were also
divided into three groups (stages I, II and III) according to the severity of TBM on admission. Therapeutic outcomes at 3
months were determined using a modified Barthel Index (BI). For the purpose of statistical analysis, the patients were divided
into two groups: good outcome (BI ≥ 12) and poor outcome (BI < 12). Positive cerebrospinal fluid (CSF) culture was found in
47% (17/36) of patients and isoniazid-resistant strains were found in 18% (3/17) of culture-proven TBM. We statistically compared
clinical manifestations, CSF features and therapeutic results of the two patient groups. Significant prognostic factors included
severity of TBM at the time of admission, the presence of headache, fever, hydrocephalus, high CSF protein concentration and
high CSF lactate concentration. In stepwise logistic regression analysis, only the presence of hydrocephalus and severity
of TBM on admission were strongly associated with therapeutic failure even after adjusting for other potentially confounding
factors.
Conclusion: In Taiwan, TBM is an important public health issue and the emergence of resistant strains of this disease in recent years
presents a therapeutic challenge. Because delay in diagnosis is directly related to poor outcome, early diagnosis and early
treatment are essential for survival.
Received: July 17, 2000 · Revision accepted: July 16, 2001 相似文献