氨苯砜单一疗法治疗持久性隆起性红斑一例并文献复习

报道1例氨苯砜单一疗法治疗持久性隆起性红斑并对既往报道文献进行复习。患者,女,80岁。双手掌、臀部、双下肢及足底红褐色斑片半年。组织病理检查：表皮角化过度、角化不全,棘层轻度增厚,真皮浅中层血管壁纤维蛋白样变性,血管周围轻度嗜中性粒细胞,少许淋巴细胞浸润,局部胶原纤维嗜碱性变。诊断：持久性隆起性红斑。口服氨苯砜100 mg,日1次,3个月后随访,皮损明显好转。     

持久性隆起性红斑1例

临床资料患者,女,79岁。主因臀部、四肢伸侧、手足紫红色斑块2年,于2007年8月4日就诊我科。患者2年前无明显诱因臀部出现甲盖至钱币大小紫红     

持久性隆起性红斑1例

患者男,73岁。臀部、四肢伸侧、手足等处反复发生对称性持久性紫红色斑片、结节、斑块7月,部分皮损表面出现溃疡,皮损处偶感微痒。组织病理示白细胞碎裂性血管炎。诊断:持久性隆起性红斑。     

持久性隆起性红斑一例

患者男,52岁,臀部、四肢反复红斑、丘疹、血疱伴痛1年.患者1年前无明显诱因四肢关节伸侧先后出现片状红斑、丘疹、结节,中央出现血疱、坏死、结痂,伴痛,皮疹持久不消退,部分融合扩大,且伴肘膝、掌指、踝关节疼痛,但无晨僵、关节畸形及活动障碍,无发热、肌肉酸痛.曾服用中药等治疗(具体不详),皮疹未消退.近半年臀部、手足也出现类似皮疹,关节疼痛较前加剧,指关节肿胀、压痛明显,活动受限,遂至我院住院治疗.既往体健.     

持久性隆起红斑1例

患者女，40岁，因掌指关节、膝关节伸侧结节。斑块3年，于2003年5月来我院就诊。患者3年前左手掌指关节受伤后出现红斑，肿胀，1个月后双手掌指关节，膝关节伸侧出现红斑，皮损逐渐增多，变硬、隆起形成结节，由淡红色逐渐变为紫红色和棕红色，平素无自觉症状，遇冷时皮损处略感疼痛。曾在外院肌内注射药物（具体药名不详）治疗，3周后大部分损消退，停药10余天后皮损复发，家族中无类似疾病患者。     

持久性隆起性红斑1例

患者女,49岁,全身皮疹反复20余年。体格检查:双肘膝关节伸侧、双手背、踝关节可见散在、多个暗红色斑块,蚕豆至鸽蛋大小,表面光滑,质硬,四肢散在大量红色结节、斑块。皮肤组织病理:表皮大致正常,真皮浅中层大量的中性粒细胞浸润,多数小血管管壁增厚,纤维蛋白样变性,血管壁及其周围可见中性粒细胞和核尘。诊断:持久性隆起性红斑。治疗:予氨苯砜每日1片口服,疗效显著。     

持久性隆起性红斑1例

<正>1临床资料患者女,51岁。因双侧手掌、肘部、膝部和足跟部紫红色隆起的结节、斑块,逐渐增大,病程约12年,于2014年7月来我科就诊。患者于12年前无明显诱因偶然发现上述肢体部位多处出现皮疹。双侧手掌、肘部、膝部和足跟部早期仅为小的红斑、丘疹,     

持久性隆起性红斑1例

患者女,38岁。因四肢紫红色结节、斑块伴微痒半个月,于2005年1月30日就诊。患者半个月前开始于双足踝部起暗红色斑疹,以后部分皮损扩大融合成斑块。新发斑疹为鲜红色,以后则为紫红色或带有黄色,斑疹逐渐累及四肢。     

持久性隆起性红斑并发溃疡1例

持久性隆起性红斑是一种白细胞碎裂性血管炎,临床上不常见,诊断主要依靠临床表现、组织病理及免疫组织病理的结果.笔者诊治1 例伴有溃疡的持久性隆起性红斑患者,经治疗后溃疡已愈合,皮损基本消退,现报告如下.     

结节性持久性隆起性红斑1例

持久性隆起性红斑(erythema elevatum diutinum,简称EED)是一种慢性纤维化性白细胞碎裂性血管炎,其典型皮损为四肢关节伸侧的紫红色斑块,而表现为大结节者则很少见[1],现将我科诊治的1例报告如下.1 病历摘要患者女,70岁.因全身起多发性皮肤结节伴疼痛3年,于2010年5月27日来我科门诊就诊.3年前,无明显诱因患者双足后跟出现结节,伴轻微疼痛,在当地医院行手术切除,组织病理检查未明确诊断.此后,右足趾端伸侧、左手掌指关节、指间关节伸侧、双肘关节伸侧、右耳和臀部陆续出现类似结节伴疼痛,受压部位的皮损表面有破溃.在当地医院行数次病理检查均未明确诊断.患者既往体健,否认有关节痛、结核病等病史,无皮肤及内脏肿瘤病史.家族中无类似疾病患者.     

甲氨蝶呤治疗持久性隆起性红斑1例

患者女,37岁,因四肢斑块伴胀痛半年,加重2周于2020年1月来我所就诊。半年前患者无明显诱因四肢出现红斑,渐增多变大,伴疼痛。于外院行病理检查,示右小腿皮损真皮乳头水肿不明显,真皮全层及皮下脂肪血管丛周围见大量中性粒细胞、淋巴细胞浸润,可见核尘,血管纤维样改变不明显……     

A case of erythema elevatum diutinum associated with B-cell lymphoma: a rare distribution involving palms, soles and nails

We report a case of erythema elevatum diutinum (EED) in association with malignant B-cell lymphoma. A 62-year-old man developed EED with an unusual distribution involving the palms, soles and nails. Treatment with dapsone was effective for his skin and nails until he developed generalized lymphadenopathy which turned out to be malignant lymphoma. Many haematological diseases, e.g. IgA paraproteinaemia and myeloma, have been reported in association with EED, but not malignant lymphoma. Even though it may just be a coincidence, we would like to add malignant lymphoma as one of the diseases associated with EED because the activity of EED and malignant lymphoma fluctuated in parallel.     

持久性隆起性红斑伴再生障碍性贫血一例并文献复习

持久性隆起性红斑(erythema elevatum diutinum, EED)是一种罕见的皮肤白细胞破碎性血管炎,其病因不明确,认为与感染、血液系统疾病、自身免疫性疾病感染的循环免疫复合物在血管壁沉积有关,因此除单纯的皮肤表现外,既往报道39.4%的EED伴发HIV、病毒性肝炎、链球菌感染、副蛋白血症、骨髓增生异常综合征、系统性红斑狼疮和类风湿性关节炎等疾病。现报道我院诊治的持久性隆起性红斑伴再生障碍性贫血一例,并通过文献检索,分析伴发其他系统性疾病的EED的临床特征,初步探讨EED与血液系统疾病及恶性肿瘤的关联性。     

Erythema elevatum diutinum and HIV infection: a report of five cases

Erythema elevatum diutinum (EED) is emerging as a specific HIV-associated dermatosis, 11 cases having so far been reported in the medical literature and five patients with the disease having been seen by us during the last 4 years. As the disease is poorly known, it is easily confused with Kaposi's sarcoma or bacillary angiomatosis, but the histopathological features are diagnostic. EED is considered to be an immune complex-mediated vasculitis. A streptococcal infection seemed to be the trigger factor in four of our patients. Partial control of the cutaneous lesions was achieved by the use of antibiotics.     

A case of erythema elevatum diutinum associated with peripheral ulcerative keratitis

A young woman with recurrent painful lesions on the dorsal aspects of her hands associated with arthralgia presented with pain and redness of both eyes. After extensive investigations, a diagnosis of erythema elevatum diutinum accompanied by peripheral ulcerative keratitis was made. The patient was treated with dapsone 50 mg, t.i.d., and responded well.     

Late‐stage nodular erythema elevatum diutinum mimicking sclerotic fibroma

Erythema elevatum diutinum (EED) is a rare, cutaneous vasculitis of uncertain origin. EED can present clinically as chronic bilateral, symmetrical, periarticular papules, plaques and nodules. We report here an unusual case of EED presenting as multiple, densely fibrosing nodules on the feet of a 60‐year‐old human immunodeficiency virus positive woman. The initial evaluation of the patient was complicated by the strong histologic resemblance of multiple lesions to sclerotic fibroma, a cutaneous manifestation of Cowden disease. Our case highlights the important features that distinguish these 2 pathologic entities.