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甲下恶性黑色素瘤误诊为甲沟炎1例 总被引:1,自引:1,他引:0
杨文勇 《中国麻风皮肤病杂志》2004,20(2):99-99
患者,女,50岁。1年前无明显诱因右手食指甲下正中出现一条黑线,不久从甲端开始开裂,逐渐向下延伸,并伴感染,反复出血、流脓。一直以甲沟炎治疗无效,裂口创面迅速增大,出现溃烂,变黑色,经久不愈。于1999年3月1日到我院取活组织病理检查,镜下:瘤细胞呈上皮样、异型性明显、体积较大、多边形、轮廓清楚、胞浆丰富、淡染,可见黑色素颗粒,核大,圆形或不规则形,可见病理性核分裂相,核仁明显增大。瘤细胞排列成巢状、条索状、腺泡状或 相似文献
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Merkel细胞癌是一种罕见的、具有高度侵袭性的皮肤神经内分泌癌,好发于老年人的日光暴露部位,尤其是头颈部(41%~50%),其次是四肢(32%~38%)。Merkel细胞癌可与鳞状细胞癌、鲍温病、基底细胞癌等皮肤肿瘤合并发生。我们报道一例发生在非光暴露部位的Merkel细胞癌合并原位鳞状细胞癌,并对相关文献进行复习。 相似文献
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患者男,73岁,右足拇趾趾甲病变10年,近1年甲床反复感染,脓性分泌物,创面不能愈合。皮损组织病理示:皮肤溃疡性病变,可见肉芽组织及鳞状上皮增生,部分鳞状上皮细胞巢团边缘不规则、基底膜不清,于间质内呈浸润性生长,巢团内细胞极向紊乱,细胞异型。免疫组化结果:p53弥漫强阳性,呈突变型表达,S100(-),HMB-45(-),诊断:鳞状细胞癌。 相似文献
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临床资料患者,男,34岁。以"龟头肿物4个月,局部溃疡伴疼痛10天",于2014年2月就诊我科。患者于4个月前龟头起红斑,伸面出现一个豆大隆起性皮肤损害,无自觉症状,肿物逐渐增大,曾外用药(不详)未见好转,于10天来龟头出现破溃,破溃处逐渐扩大形成深在性溃疡伴疼痛。 相似文献
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患者,女,46岁。全身角化性丘疹30年余,头皮破溃1年余。皮肤科情况:躯干四肢褐色斑块,部分中央萎缩;枕部可见18 cm×9 cm溃疡。枕部皮损组织病理检查示条索状异型肿瘤细胞;免疫组化示鳞癌。上肢皮损组织病理检查:多个角化不全柱。诊断:泛发性汗孔角化症合并枕部巨大鳞癌。给予放疗,效果可。 相似文献
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报告1例泛发性扁平苔藓并发巨大鳞状细胞癌。患者男,20岁。因全身暗红色斑块10年,面部肿块5个月就诊。腹部皮损组织病理活检显示,符合扁平苔藓病理改变,面部肿块经病理诊断为中分化鳞状细胞癌。 相似文献
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Dalle S Depape L Phan A Balme B Ronger-Savle S Thomas L 《The British journal of dermatology》2007,156(5):871-874
BACKGROUND: Subungual squamous cell carcinoma (SCC) is rare. Its diagnosis is often missed or delayed because the clinical presentation is often atypical and can mimic other conditions such as verruca vulgaris, onychomycosis, trauma-induced nail dystrophy or exostosis. OBJECTIVES: To define the different clinical presentations and the main pathological features and to evaluate the most appropriate surgical management of subungual SCC. METHODS: A retrospective review of all the cases of subungual SCC seen in our institution over a 5-year period. RESULTS: Thirty-five cases were selected. The spectrum of the clinical features encountered was extremely large including leuconychia, subungual hyperkeratosis, trachonychia, subungual tumoral syndrome, longitudinal erythronychia and melanonychia. Most cases (31 of 35) were invasive. Relapse rate after surgical treatment was low after wide surgical excision (5%) of the nail apparatus or amputation of the digit. However, limited surgical excision led to more frequent relapses (56%). CONCLUSIONS: Nail apparatus SCC is often misdiagnosed. Most cases are invasive at the time of diagnosis. Wide surgical excision bears a lower risk of relapse. Micrographic surgery should be considered for a better control in cases treated with limited surgical excision. 相似文献
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