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1.
Objective
To determine and compare the prevalence and pattern of agenesis of third molar and mandibular second premolar in paediatric orthodontic patients of age group 9–15 for sexual dimorphism.Methods
The digital orthopantograph was obtained from the archive record of patients of age group 9–15 year. Radiographs of 301 patients were evaluated after taking exclusion criteria into account and were assessed for the presence/absence of third molars and mandibular second premolar. Tooth development evaluation followed the method of Demirjian et al., based on eight stages of tooth formation. The agenesis of third molar in maxilla and mandible between age groups and gender was compared using Chi-squared test.Results
The rate of agenesis of third molars was observed 36.8% in the present study. Twenty-four (24.3%) percentage of the study population showed agenesis of all the four third molars. The agenesis of third molars was found to be higher among males than females (p > 0.05). Prevalence of agenesis of mandibular second premolar was 4.7–5%.Conclusions
Agenesis of third molars was more commonly seen in the maxilla, having male predilection. Maxillary right third molar was the most commonly missing tooth irrespective of gender. 相似文献2.
Kalyana Chakravarthy Pentapati Preetinanda Mishra Mehrshad Damania Siddharth Narayanan Garima Sachdeva Geetanshu Bhalla 《Saudi Dental Journal》2017,29(2):74-77
Objective
Reliability of intra-oral camera using teledentistry in screening of oral diseases.Methodology
A trained and calibrated examiner used intra-oral camera to capture videos of oral cavity along with clinical examination to evaluate caries, plaque, calculus, tooth wear and fluorosis, stains in children.Results
The mean DT and DMFT were significantly higher with use of intra-oral camera than with clinical examination (p = 0.001 and 0.001) respectively. A positive strong significant correlation was seen between intra-oral camera and clinical examination with respect to DT, MT, FT and DMFT (r = 0.721, p < 0.001; r = 0.908, p < 0.001; r = 0.869, p < 0.001; r = 0.876, p < 0.001) respectively. Reliability of intra-oral camera when compared with clinical examination varied from substantial to almost perfect agreement various oral conditions. Disclosed immature plaque was not clear while mature plaque was clearly demonstrated.Conclusion/recommendations
Intra-oral camera was shown to be a reliable tool to identify common oral diseases. Further studies involving applications like sealant retention, pre-malignant lesions, recurrent apthae, gingival recession and dental malocclusion and effectiveness in regular screening are needed. 相似文献3.
Objectives
To reveal mothers’ beliefs about signs and symptoms associated with teething and their treatment practices.Population and methods
A cross-sectional study done in Mansoura District on 457 mothers and their children with one or more erupted teeth. Mothers were interviewed during vaccination session at 25 chosen health facilities. Mothers were asked whether they agree or disagree about 24 signs and symptoms claimed to be associated with teething.Results
Only 1.8% reported no symptoms at the time of teething. Majority had correct knowledge related to bite fingers/objects (70.5%) and drooling (60.0%). Inaccurate knowledge was reported as gum rubbing (42.0%), gum swelling (47.0%), diarrhea (51.0%), fever (83.2%) and weight loss (46.0%). Only 16.8% of mothers have good knowledge about teething problems. Logistic regression analysis revealed that the independent predictors of good knowledge are higher education (AOR = 3.7), urban residence (AOR = 2.5) and having a first-born child (AOR = 5.5). Only 13.4% of mothers did not give any treatment for teething problems. Antipyretics and antibiotics were the most frequently given treatments (71.3%, and 24.3%; respectively).Conclusions
The majorities of mothers had low knowledge about teething problems and gave unnecessary treatments. 相似文献4.
Thamer Alkhadra 《Saudi Dental Journal》2017,29(4):140-143
Objective
To evaluate if there is any difference in alveolar bone surface area in patients with high vertical facial dimension (long face), average vertical facial dimension (average face), and low vertical facial dimension (square short face).Materials and methods
Forty-five patients who had cone beam computed tomography (CBCT) as part of their orthodontic records were chosen according to their facial vertical dimension. Each group consisted of fifteen patients. Mandibular alveolar bone volume was calculated using Dolphin 3D Imaging software as the total surface area of the symphysis at the level of lower right canine to lower left canine and total surface areas for each patient was considered as total bone volume. Comparison was performed between groups using t-test.Results
Long face type patients showed higher bone volume (total surface area 3220 ± 368 mm2), average face patients have average bone volume (total surface area 2059 ± 620 mm2) while square short face patients have the lowest total bone volume (total surface area 1877 ± 112 mm2). There was a significant difference between long face and square short face groups (P < 0.005) however, there was no significant difference between long face and average face groups.Conclusions
Patients with long face type have higher mandibular alveolar bone volume compared to short facial type patients. 相似文献5.
Purpose
Investigate and compare fracture resistance of four commercially available esthetic crowns.Methods
Sixty-four anterior crowns were used: NuSmile Primary crowns (NuSmile, Houston, Tex. USA) (16); Preveneered Cheng Crowns, (Orthodontic Technologies Inc., Houston, TX) (16); NuSmile ZR (NuSmile, Houston, Tex. USA); and Cheng Crowns zirconia (Orthodontic Technologies Inc., Houston, TX). Crowns were mounted and cemented on a negative replica and placed under servo hydraulic mechanical universal testing machine. Force was applied at 90° with crosshead speed of 1 mm/min until they fractured. Maximum breaking loads were recorded. Data was then analyzed using software that measured the fracture resistance of the crowns. One-way Analysis of Variance (ANOVA) was used to find the differences between the groups and Scheffe post hoc test was used for intergroup comparisons. The level of significance was set as p ≤ 0.05.Results
Mean maximum loads were as follows: NuSmile ZR crowns (937.36 + 131.68 N), Cheng Zirconia Crowns (751.43 + 102.103 N), NuSmile Primary crowns (482.37 + 76.92), and Preveneered Cheng Crowns (415.57 + 12.28). Zirconia crowns the had highest fracture resistance compared to preveneered crowns (p < 0.05). No significant difference between NuSmile ZR Zirconia and Cheng Crowns zirconia nor between NuSmile primary Preveenered and Preveneered Cheng Crowns.Conclusion
Zirconia crowns showed the highest fracture resistance with NuSmile zirconia crowns to being able to resist fracture even under intense pressure of load compared to Cheng Crowns zirconia. 相似文献6.
Objective
To determine oral health comprehension among parents of cerebral palsy (CP) children.Methods
A self-administered questionnaire was utilized to obtain the required information. The study was conducted in two main centers for disabled children in Riyadh, Saudi Arabia.Results
Parents of all 157 CP children registered in the two centers completed the questionnaire. Mothers mostly (86.6%) completed the questionnaire. Majority (98.7%) of the parents knew the importance of dental health for general health. More than two-third (70%) of the parents thought that teeth should be brushed thrice daily or after each meal. About three in every ten (29.9%) parents were not aware of the beneficial effect of fluoride in preventing dental caries; and very few (9.6%) were aware of water as a source of fluoride. Almost all (98.7%) the parents knew that sugary foods caused dental caries. Three-fourth (75.8%) of the parents were not aware of the possible harmful effects of bottled juices on teeth. There were no significant (p > 0.05) associations between the parental age/gender with any of the dependent variables.Conclusion
Parents of CP children generally showed satisfactory oral health comprehension. However, they need further oral health education in several areas. 相似文献7.
Tarun Walia Salem Abu Fanas Madiha Akbar Jamal Eddin Mohamad Adnan 《Saudi Dental Journal》2017,29(3):117-122
Objective
To assess fluoride concentration in drinking water which include tap water of 4 emirates - Abu Dhabi, Dubai, Sharjah and Ajman plus bottled water, commonly available soft drinks & juices in United Arab Emirates.Methods
Five different samples of tap water collected from each of the four emirates of UAE: Ajman, Sharjah, Abu Dhabi and Dubai; twenty-two brands of bottled water and fifteen brands of popular cold beverages, purchased from different supermarkets in U.A.E were tested using ion selective electrode method and the fluoride concentration was determined.Results
The mean fluoride content of tap water samples was 0.14 mg F/L with a range of 0.04–0.3 mg F/L; with Ajman tap water samples showing the highest mean fluoride content of 0.3 mg F/L. The mean fluoride content for both bottled drinking water and beverages was 0.07 mg F/L with a range of 0.02–0.50 mg F/L and 0.04–0.1 mg F/L respectively. Majority (68.2%) of the bottled water are produced locally within U.A.E while a few (31.8%) are imported.Conclusions
The tap water, bottled water and beverages available in U.A.E show varying concentrations of fluoride, however none showed the optimal level necessary to prevent dental caries. Dental professionals in U.A.E should be aware of the fluoride concentrations before prescribing fluoride supplements to children. 相似文献8.
Objective
The purpose of this study was to evaluate the antibacterial activity of ethanol and hexane extracts of Salvadora persica against common oral pathogens.Materials and methods
Well diffusion, Minimum Inhibition Concentration (MIC), Minimum Bactericidal Concentration (MBC), and Broth microdilution tests were used to determine the optimum antimicrobial concentrations of S. persica extracts against Streptococcus mutans (S. mutans), Streptococcus sanguis (S. sanguis), and Streptococcus salivarius (S. salivarius) over 1, 3, 6, 12, and 24 h. Chlorhexidine (CHX) 0.2% was used as a positive control.Results
The findings showed that the microbial activity of both extracts was concentration-dependent. Ethanol extract of S. persica at 25, 50, and 100 mg/ml had more growth inhibitory effect against all isolates compared to hexane extract. In addition, ethanol extract at 8 mg/ml (MBC value) was able to eradicate the growth of all isolates. S. sanguis and S. salivarius were very sensitive to hexane extract and required 4 mg/ml (MBC value) for their eradication while S. mutans was the most resistant (MBC = 8 mg/ml).The statistical findings of CFU counts showed no significant difference (p = 1.000) in antibacterial effectiveness between the two extracts against all isolates. A significant decline overtime in CFU counts was noted, except at 12 h and 24 h where no significant difference (p = 0.793) was observed and was comparable to CHX.Conclusion
Ethanol and hexane extracts of S. persica were found to exhibit maximum antimicrobial activity against S. mutans, S. sanguis and S. salivarius at high concentrations. 相似文献9.
Aim
The aim of this study was to evaluate clinically and radiographically, extraction socket healing using autologous platelet rich fibrin (PRF).Materials and methods
Twenty-four subjects needing single tooth simple extractions were selected. Twenty-four extraction sockets were divided into test group (PRF, n = 12) and control group (blood clot, n = 12). PRF was prepared with blood drawn from individuals after extraction using standard technique. PRF was placed in test group sockets followed by pressure application and figure 8 sutures. Sockets in control group were allowed to heal in the presence of blood clot and received a figure 8 suture. Ridge width was assessed using cast analysis with the help of acrylic stent and a pair of calipers. Radiographic analysis of socket surface area was performed using computer graphic software program. The clinical follow up assessments were performed at 1, 4 and 8 weeks. Collected data was assessed using ANOVA and multiple comparisons test.Results
Subjects were aged between 25 and 50 (mean 37.8) years, including 15 females. The mean horizontal ridge width for sockets in the test group were 11.70 ± 2.37 mm, 11.33 ± 2.30 mm and 10.97 ± 2.33 mm at 1, 4 and 8 weeks respectively. Ridge width proportions were significantly higher among test group as compared to control group between baseline to 4 and 8 weeks respectively. The mean radiographic bone fill (RBF) percentage in the test group, was 74.05 ± 1.66%, 81.54 ± 3.33% and 88.81 ± 1.53% at 1, 4 and 8 weeks respectively. The mean RBF was significantly higher in the test group than control group at all time intervals.Conclusion
The study outcomes demonstrate that the use of PRF accelerate socket wound healing after tooth extraction as noticed by increased bone fill and reduced alveolar bone width resorption using clinical and radiographic methods. 相似文献10.
11.
A. Sumathi Felicita 《Saudi Dental Journal》2017,29(4):185-193
Aim
To align a dilacerated maxillary central incisor and partially impacted canine with unilateral extraction in a young patient with skeletal deep bite.Materials and methods
A 14 year old male patient reported to the hospital with skeletal deep bite (basal plane angle-17°), severe horizontal pattern of growth (Go-Gn to Sn -22°), upright maxillary incisors (U1 to NA -26°) and retroclined lower incisors (L1 to NB -11°). The maxillary left central incisor was dilacerated, and the maxillary left canine was partially impacted. Unilateral extraction of the left maxillary premolar and left mandibular central incisor was done. A canine disimpaction spring was used to align the impacted canine. An anterior bite plane was given to open the bite.Results
Superimposition of lateral cephalogram (T1, T2) revealed bite opening, normal overjet and overbite. There was backward rotation of the mandible and increase in lower anterior facial height. There was no evidence of root resorption or loss of vitality in the dilacerated tooth. Clinically the canine was well aligned in the arch.Conclusion
Orthodontic management of a dilacerated incisor can be done without root resorption or loss of vitality. The partially impacted canine was well aligned in the arch. Unilateral extraction can produce good treatment results. 相似文献12.
Nawaf Labban Hanan Al-Otaibi Abdulaziz Alayed Khaled Alshankiti Mohammad A. Al-Enizy 《Saudi Dental Journal》2017,29(3):102-110
Aim
The aim of the study was to evaluate the influence of gender and skin color on the preference of different teeth shades in general population.Materials and methods
Two standardized frontal smile photographs of male and female subjects were manipulated using photoshop to represent 4 skin colors [(type II, III, IV, and V) (Fitzpatrick scale)]. The teeth shades under each skin color were digitally manipulated to represent one of 6 teeth shades (BL1, BL2, BL3, BL4, B1 and A1). A questionnaire assessed demographic characteristics (age, nationality, gender, education level, occupation, and income) along with the satisfaction of their smiles. Male and female set of pictures with combination of skin colors and teeth shades were presented and participants were asked to select the most esthetically pleasing teeth shade with regard to gender and skin color. Cross-tabulations and chi-squared tests were used to perform the statistical analyses (α = 0.05).Results
Three hundred and thirty-six (60.4% male; 39.6% female) individuals participated in the study. The difference in the preferred teeth shades was significant among the male and female photographs across all skin colors (p < 0.05). Lighter teeth shades were preferred among female subjects compared to male subjects with the same skin color. In addition, lighter teeth shades were preferred among subjects with a lighter skin color and vice versa (p < 0.05).Conclusion
Gender and skin color influences the perception of teeth shades among general population. Therefore, lighter tooth shades (BL1, BL2) for lighter skin color and comparatively darker tooth shades (BL4, B1, A1) for darker skin individuals should be prescribed as these are perceived as natural among Saudi population. 相似文献13.
Erica Roitero Federico Lasserre Marc Anglada Frank Mücklich Emilio Jiménez-Piqué 《Dental materials》2017,33(1):e28-e38
Objective
The aim of this work is to generate micrometric linear patterns with different topography on dental grade zirconia by means of UV laser interference and to assess the quality of the produced surface, both in term of the geometry produced and of the surface damage induced in the material.Methods
The third harmonic of a Q-switched Nd:YAG laser (355 nm, pulse duration of 10 ns and repetition rate of 1 Hz) was employed to pattern the surface of 3Y-TZP with micrometric-spaced lines. The resulting topography was characterized with White Light Interferometry and Scanning electron microscopy: pattern depth (H), amplitude roughness parameters (Sa, filtered-Sa), Fourier spatial analysis and collateral damages were related to laser fluence and number of pulses employed.Results
With our experimental setup, line-patterning of zirconia surfaces can be achieved with periodicities comprised within 5 and 15 μm. Tuning laser parameters allows varying independently pattern depth, overall roughness and surface finish. Increasing both fluence and number of pulses allows producing deeper patterns (maximum achievable depth of 1 μm). However, increasing the number of pulses has a detrimental effect on the quality of the produced lines. Surface damage (intergranular cracking, open porosity and nano-droplets formation) can be generated, depending on laser parameters.Significance
This work provides a parametric analysis of surface patterning by laser interference on 3Y-TZP. Best conditions in terms of quality of the produced pattern and minimum material damage are obtained for low number of pulses with high laser fluence. With the employed method we can produce zirconia materials with controlled topography that are expected to enhance biological response and mechanical performance of dental components. 相似文献14.
Hassan Suliman Halawany Abdullah Salman Binassfour Waleed Khalid AlHassan Rami Ayed Alhejaily Nassr Al Maflehi Vimal Jacob Nimmi Biju Abraham 《Saudi Dental Journal》2017,29(1):15-23
Objective
The purpose of this study was to investigate evolving trends in dental post graduate specialty preferences and career aspirations among final year dental students in Saudi Arabia.Materials and methods
A cross sectional survey using a self-administered questionnaire was conducted among final year dental students from seventeen universities in Saudi Arabia. The questionnaire enquired about socio-demographic details and the ranking of three of their best preferences among the list of specialties/general dentistry and career options. They were also enquired about their opinion regarding the total time required to become a dentist and their intention to go for further studies abroad. The questionnaire assessed factors influencing their choices using a 5 point Likert scale ranging from extremely important to not important. Binary logistic regression to examine the combined effect of several independent variables on the likelihood of choosing a dental specialization/general dentistry and career option were analyzed.Results
The overall response rate was 64.6%. Restorative and Aesthetic Dentistry was the most preferred specialty (n = 98; 17.7%) followed by Endodontics (n = 78; 14.1%); Prosthodontics (n = 65; 11.7%) and Orthodontics (n = 63; 11.4%). The two most preferred careers were ‘Civilian dentist in public sector’ followed by ‘Academic services dentist’. Overall, students reported that the influence of family members in the dental profession, preference for private practice and specific interest in patient population as the most important factors in choosing a specialty/general dentistry. Intellectual content of the specialty was ranked the least important. On the other hand, the most important factors for choosing a career were variety of non-clinical duties, access to child care facilities and research opportunities.Conclusion
The results of this study show the top preferred specialties and career choices which can be a baseline for establishing national policies and for the improvement of graduate programs. There seems to be a need to promote mentoring activities and provide guidance and encouragement to pre-doctoral dental students in selecting the most appropriate specialty within their capability domain. 相似文献15.
Gadeer Elea Mukatash-Nimri Marwan A. Al-Nimri Omar G. Al-Jadeed Zaid R. Al-Zobe Khuzama K. Aburumman Nader A. Masarwa 《Saudi Dental Journal》2017,29(1):24-28
Aim
To find out the prevalence of “true” burning mouth syndrome and study the association between patients’ spontaneous complaints of burning mouth and systemic conditions in a group of middle age and elderly “denture wearers” patients in Jordan.Methods
A group of 129 patients (112 female and 17 male) of “complete denture wearers” subjects aged 40 years and over attended prosthetic clinic at King Hussein Medical Hospital complaining from oral burning, with no oral lesion possibly responsible for the burning sensations were selected. Assessment of oral and general status was done based on questioners, detailed history taking, medical records and extra and intraoral examination. The existed complete dentures retention, stability, jaw relationship and the free way space were evaluated. The current blood test and instrumental protocol for examination of patients with burning mouth complains were performed for each patient. Then those studied patients with burning mouth sensations including “true” burning mouth syndrome have been compared to the controls with regard to the presence of local problem, undermined local, systemic or psychological disease.Results
The diagnosis of “true” burning mouth syndrome was established in (2.3%) of the studied population two females and one male. In most patients (58%) more than one site was affected. Significant positive associations were found between local factors (i.e., wearing complete dentures with unsatisfactory retention or jaw relationship, dry mouth or candidasis) and patients suffering from burning mouth sensation. The results also show that some systemic or psychological disorders were significantly more present among patients with burning mouth symptoms when compared to the control group (p < 0.05).Conclusion
Spontaneous symptoms of burning mouth without mucosal signs should be considered as a manifestation of undermind pathology and/or distress, and the multi-factorial causes of burning mouth syndrome and sensation need to be referred to the suitable specialist for better treatment results. 相似文献16.
H. Schweikl M. Godula C. Petzel C. Bolay K.A. Hiller W. Buchalla 《Dental materials》2017,33(1):110-118
Objective
Resin monomers such as 2-hydroxyethyl methacrylate (HEMA) induce apoptosis because of the excess formation of reactive oxygen species (ROS). The portion of ROS including superoxide anions, hydrogen peroxide or hydroxyl radicals in monomer-induced apoptosis is unknown. Here, the effectiveness of superoxide anions or hydroxyl radicals was analyzed using tempol or sodium formate as radical scavengers.Methods
RAW264.7 mouse macrophages were exposed to HEMA (0–6–8 mM) in the presence of tempol (0–0.05–0.5–5.0 mM) or sodium formate (0–1–5–10 mM). The formation of ROS using DCFH2-DA or dihydrorhodamine 123 (DHR123) as fluorescent dyes and the induction of apoptosis was determined by flow cytometry after 1 h or 24 h exposure periods. Expression of enzymes related to ROS metabolism was detected by Western blotting.Results
DCF fluorescence significantly increased after short exposure (1 h) while DHR123 fluorescence was enhanced after a long exposure period (24 h) in cells treated with HEMA. Although no influence was detected on the formation of ROS, tempol or sodium formate protected cells from HEMA-induced apoptosis. The number of cells in late apoptosis or necrosis induced with 6 or 8 mM HEMA was reduced in the presence of tempol or low concentrations of sodium formate. HEMA-induced expression of catalase, indicating oxidative stress, decreased in the presence of tempol.Significance
Superoxide anions and hydroxyl radicals contribute to HEMA-induced apoptosis. The current findings support the development of strategies based on the pharmacological inhibition of enzymes producing superoxide anions finally converted to hydroxyl radicals to compensate for potential adverse tissue reactions associated with dental composites. 相似文献17.
Huda Tulbah Eman AlHamdan Amal AlQahtani Asma AlShahrani Mona AlShaye 《Saudi Dental Journal》2017,29(3):111-116
The fabrication of a clinically acceptable dental prosthesis requires proper communication between the dentist and the dental technician. Prosthodontic educators have been concerned with this interaction and communication. Fixed prosthodontics laboratories revealed that the technicians are often dissatisfied with the information provided in work authorizations.
Objective
To evaluate the quality of communication between dentists and laboratory technicians via work authorizations for fixed prosthodontics in both governmental and private dental laboratories in Riyadh area from the technician’s perspective.Methods
A sample of 66 dental laboratories, including all government dental laboratories and a selected number of randomly chosen private dental laboratories from each district of Riyadh (40%), participated in the survey.A questionnaire was developed to include questions related to the following areas of work authorization: clarity and accuracy of instructions, patient information, type of prosthesis, choice of materials, design and shade of the prosthesis and type of porcelain glaze. The questionnaire was answered in a face-to-face interview by technicians who were qualified in fixed prosthetic work. Data were analyzed through parametric tests (T-test and one-way ANOVA) to identify significant values (P < 0.05).Results
This survey showed a lack of communication between dentists and dental laboratories regarding the following: marginal design, pontic design, staining diagram, type of porcelain and glaze needed for the prosthesis. Significant differences were observed between the government and private dental laboratories. There was a greater lack of communication between the dentists and government laboratory technicians in Riyadh.There was no statistically significant difference between private laboratories of different areas in Riyadh city (P < 0.05).Conclusion
The quality of communication between dentists and dental technicians in Riyadh can sometimes be inadequate, and governmental laboratories have a lower level of communication. 相似文献18.
Lena Rothmund Franz-Xaver Reichl Reinhard Hickel Panorea Styllou Marianthi Styllou Kai Kehe Yang Yang Christof Högg 《Dental materials》2017,33(1):54-62
Objective
An increment layering technique in a thickness of 2 mm or less has been the standard to sufficiently convert (co)monomers. Bulk fill resin composites were developed to accelerate the restoration process by enabling up to 4 mm thick increments to be cured in a single step. The aim of the present study is to investigate the effect of layer thickness on the elution of components from bulk fill composites.Methods
The composites ELS Bulk fill, SDR Bulk fill and Venus Bulkfill were polymerized according to the instruction of the manufacturers. For each composite three groups with four samples each (n = 4) were prepared: (1) samples with a layer thickness of 2 mm; (2) samples with a layer thickness of 4 mm and (3) samples with a layer thickness of 6 mm. The samples were eluted in methanol and water for 24 h and 7 d. The eluates were analyzed by gas chromatography/mass spectrometry (GC/MS).Results
A total of 11 different elutable substances have been identified from the investigated composites. Following methacrylates showed an increase of elution at a higher layer thickness: TEGDMA (SDR Bulk fill, Venus Bulk fill), EGDMA (Venus Bulk fill). There was no significant difference in the elution of HEMA regarding the layer thickness. The highest concentration of TEGDMA was 146 μg/mL for SDR Bulk fill at a layer thickness of 6 mm after 7 d in water. The highest HEMA concentration measured at 108 μg/mL was detected in the methanol eluate of Venus Bulk fill after 7 d with a layer thickness of 6 mm.Significance
A layer thickness of 4 mm or more can lead to an increased elution of some bulk fill components, compared to the elution at a layer thickness of 2 mm. 相似文献19.
Jung-Hwan Lee Hae-Hyoung Lee Hae-Won Kim Je-Wook Yu Kyoung-Nam Kim Kwang-Mahn Kim 《Dental materials》2017,33(1):e1-e12
Objective
The study assessed the cytotoxicity and immunomodulatory/anti-inflammatory effect of extract from zinc oxide–eugenol (ZOE)-based dental materials during setting using immortalized human dental pulp stem cells (IHDPSCs) and mouse bone marrow monocytes (IMBMMs), and identified the responsible extract component.Methods
In accord with the ISO 10993-12, we extracted a mixture of ZOE cement and sealer after a specified time. The extract was analyzed by two types of mass spectrometry (ICP-MS and GC–MS). Cell viability was evaluated with extract and serial concentrations of ZnCl2, ZnSO4, and eugenol liquid by WST assay. The immunomodulatory/anti-inflammatory effect of a ZOE component was determined by RT-PCR to detect the downregulatory effect of inflammatory mRNA expression after lipopolysaccharide (LPS)-induced inflammation.Results
Zn2+ and eugenol (2–20 ppm) were detected in the ZOE cement and sealer extracts. During the early stage of setting, significant cytotoxicity was observed in IHDPSCs and IMBMMs (p < 0.05). The half maximal effective concentration of Zn2+ was 5–8 ppm, whereas that of eugenol could not be detected within 80 ppm. After extract treatment, the expression of inflammatory mRNA was significantly lower in inflamed IHDPSCs, but not inflamed IMBMMs, than in the LPS control (p < 0.05). However, eugenol, not Zn2+, at 5–20 ppm downregulated inflammatory mRNA expression in the inflamed IMBMMs with and without the exchange of LPS-pretreated medium.Significance
ZOE was highly cytotoxic, especially during setting, to both cells due to Zn2+ while the immunomodulatory/anti-inflammatory effect of ZOE was induced by eugenol. 相似文献20.
Michael Wendler Renan Belli Anselm Petschelt Daniel Mevec Walter Harrer Tanja Lube Robert Danzer Ulrich Lohbauer 《Dental materials》2017,33(1):99-109