不孕患者子宫内膜息肉的宫腔镜诊治临床分析

目的:探讨不孕患者子宫内膜息肉(EP)发生的相关因素及宫腔镜下EP清除术对助孕效果的影响。方法:接受宫腔镜检查的不孕患者855例,其中EP患者202例(EP组),宫腔正常者653例(对照组)。分析年龄、体质量指数、不孕年限、不孕类型及合并症等与EP发生的相关性;采用宫腔镜术联合药物(三联疗法)治疗,分析术后助孕效果。结果:EP发病率为23.6%,原发不孕、不孕年限>5年者EP发病率增高,EP患者合并子宫内膜异位症、子宫肌瘤、月经稀发几率明显增高(P<0.05);患者接受"三联疗法"治疗后,经助孕后临床妊娠率与对照组比无差异(P>0.05)。结论:宫腔镜手术有助于提高EP检出率,联合药物治疗的"三联疗法"是治疗EP的有效方法。     

IVF-ET失败者行宫腔镜检查的临床价值

目的:探讨IVF-ET失败者行宫腔镜检查的意义及其临床应用价值。方法:选取38例既往有IVF-ET失败史的患者行宫腔镜检查及手术(研究组),与同期常规行宫腔镜检查的不孕患者45例(对照组),就子宫内膜形态的不同表现类型临床结局等方面进行比较。结果:研究组宫腔内膜异常的发生率为84.21%,明显高于对照组的48.89%,其中宫腔粘连、子宫内膜不规则增生以及子宫内膜息肉的发生率均高于对照组(P<0.05)。研究组的32例于宫腔镜术后一年内再次行IVF/ICSI或冷冻胚胎移植术,17例获得临床妊娠。余6例术后至今未行IVF-ET,不避孕未孕。结论:宫腔镜检查、干预有利于改善子宫内膜的形态,提高临床妊娠率,可作为再次IVF前的常规筛查手段。     

宫腔镜手术治疗子宫内膜息肉的临床分析

目的　探讨宫腔镜手术治疗子宫内膜息肉的临床效果。方法　因子宫内膜息肉行各类宫腔镜手术 10 9例 ,其中绝经后子宫内膜息肉 15例、生育期子宫内膜息肉 94例。 10 9例中合并月经紊乱 84例、贫血 34例、痛经 16例、原发不孕 3例、继发不孕 2例。患者年龄 2 6～ 73岁 ,平均 (45± 9)岁 ;随访时间 3～ 2 2个月 ,平均 (12± 5 )个月。月经紊乱者在术前和术后分别填写月经失血图以评估月经血量。结果　 10 9例中 ,单纯息肉切除 35例 ,息肉切除同时浅层内膜切除 9例 ,息肉切除同时内膜切除 6 3例 ,息肉切除同时内膜剥除 2例。 84例月经紊乱者术后闭经 14例、阴道点滴出血 2 6例 ,其余 4 4例月经血量均较术前减少。 34例术前贫血患者 ,术后 1个月血红蛋白即恢复正常。 16例痛经者术后 7例症状消失、7例缓解、2例加重。 5例不孕者术后 4例妊娠。 15例绝经后患者术后无异常出血。结论　有月经改变且无生育要求者 ,息肉切除同时应行子宫内膜电切术 ,可避免息肉复发 ;需保留生育功能的患者 ,可行单纯息肉切除 ,如合并内膜息肉样增生 ,应同时行浅层内膜切除 ;绝经后患者 ,可行单纯息肉切除 ,如合并内膜息肉样增生 ,应同时行子宫内膜剥除。     

宫腔镜手术联合孕激素对多发性子宫内膜息肉术后复发的影响

目的探讨宫腔镜下多发性子宫内膜息肉切除术后应用孕激素预防息肉复发的临床疗效。方法将2012年1月至2013年7月在内蒙古医科大学附属医院行宫腔镜诊治的94例多发性子宫内膜息肉患者分为观察组和对照组各47例,观察组术后予以安宫黄体酮周期性治疗3个月,对照组术后予以随访观察。比较两组患者术后6、12、24个月息肉复发、血红蛋白水平、子宫内膜厚度以及妊娠情况。结果观察组术后子宫内膜息肉的复发率为4.3%,明显低于对照组的17.4%,差异有统计学意义(P0.05);观察组患者术后6、12、24个月的血红蛋白水平均明显高于对照组,而术后6、12、24个月的子宫内膜厚度均低于对照组,差异均有统计学意义(P0.05),两组之间的妊娠率的差异无统计学意义(P0.05)。结论宫腔镜联合孕激素治疗多发性子宫内膜息肉能有效的防止息肉的复发,同时亦能改善其术后血红蛋白水平,降低子宫内膜厚度,改善患者生活质量。     

子宫内膜息肉的手术治疗及术后复发的预防

目的探讨子宫内膜息肉的宫腔镜手术治疗及术后应用孕激素预防复发的效果。方法选择北京大学深圳医院2001年8月至2007年8月行宫腔镜诊治的子宫内膜息肉86例患者,术后分为激素治疗组和观察组,激素治疗组术后给予安宫黄体酮周期性治疗3个月,观察子宫内膜息肉复发及妊娠情况。结果 86例患者中,宫腔镜检查多发性子宫内膜息肉56例,单发性子宫内膜息肉32例;激素治疗组术后2年,复发率为2.3%,观察组复发率为13.9%,两组比较,差异有统计学意义(P0.05)。32例有生育要求的患者中,术后2年23例自然妊娠,妊娠率为71.9%,但激素治疗组妊娠率(70.6%,12/17)和观察组(73.3%,11/15)比较,差异无统计学意义(P0.05)。结论子宫内膜息肉患者行宫腔镜诊断及治疗效果明确,术后应用孕激素治疗可能有助于预防子宫内膜息肉的复发。     

2003例不孕症患者宫腔镜检查结果分析

目的:探讨宫腔镜检查在不孕症诊治中的应用价值。方法:回顾性分析实施宫腔镜检查的不孕症患者的病例资料。结果:12 003例患者中,原发不孕762例(38.0%),继发不孕1 241例(62.0%)。2宫腔镜检查显示有宫腔内病变者757例(37.8%),其中原发不孕274例,继发不孕483例,原发不孕和继发不孕组宫腔病变的发生率无统计学差异(P0.05)。3宫腔内病变分别为:子宫内膜息肉(EP)、子宫内膜增殖症、宫腔粘连(IUA)、子宫内膜结核、子宫畸形、子宫内膜炎、黏膜下肌瘤、子宫内膜癌和宫腔异物9类,原发不孕症中EP、内膜结核、子宫内膜增殖症的发病率均高于继发不孕症组(P0.05)。继发不孕症中宫腔粘连的发生率明显高于原发不孕症组(P0.01)。42 003例患者中有体外受精-胚胎移植(IVF-ET)失败病史的182例,其中宫腔内有病变93例(51.1%),显著高于无IVF-ET失败病史者的宫腔内病变率(37.8%)(P0.01)。结论:不孕症患者的宫腔内病变发生率接近40%,EP是原发不孕症患者最常见的宫腔内病变类型;IUA是继发不孕症患者最常见的宫腔内病变类型。对不孕症患者尤其是有过IVF-ET失败病史的患者,进行宫腔镜检查是非常必要的。     

子宫内膜息肉的临床特征及息肉摘除术后对妊娠影响的相关因素分析

目的:探讨子宫内膜息肉(EPs)的临床特征,以及息肉摘除后对妊娠的影响及相关因素。方法:收集2014年5月至2015年5月于中山大学附属第一医院行宫腔镜手术或宫腹腔镜手术并最终病理确诊为EPs的患者464例,将其中单纯EPs合并不孕的123例患者做研究组。收集同期行相应手术的正常宫腔患者219例做为对照组。结果:464例EPs患者中,合并不孕占55.60%,合并月经异常占35.6%,合并子宫内膜异位症(EMs)占11.2%,合并子宫肌瘤者占8.4%。EPs摘除术后,研究组中30~35岁和≥35岁患者的临床妊娠率显著高于对照组(69.23%vs 49.30%,P=0.027;65.52%vs 40.54%,P=0.044),而两组中30岁患者的临床妊娠率比较,差异无统计学意义(64.29%vs 65.77%,P=0.864)。结论:EPs患者常合并不孕、月经异常、EMs或子宫肌瘤。EPs治疗后可改善年龄≥30岁患者的妊娠结局,既往有息肉史,年龄≥35岁或不孕年限≥10年是影响术后成功妊娠的因素。     

宫腔镜切除术治疗子宫内膜息肉的效果及影响术后自然妊娠状态的因素分析

目的：探讨宫腔镜切除子宫内膜息肉（endometrial polyp,EP）的疗效及影响术后自然妊娠状态的因素。方法：选取2013年2月-2014年11月在天津市咸水沽医院妇产科宫腔镜电切治疗的60例EP合并不孕患者为研究对象。术后3、6、18个月随访患者的阴道不规则出血、EP复发率、自然妊娠率,并分析影响患者术后自然妊娠的因素。结果：术后阴道不规则出血发生率为3.33%,EP复发率为1.67%。术后3个月累积自然妊娠率为28.33%,术后6个月累积自然妊娠率为50%,术后18个月累积自然妊娠率为65.00%。单因素分析结果显示,不同年龄EP患者宫腔镜术后自然妊娠率差异有统计学意义（P＜0.01）;不同不孕年限、不孕类型及息肉大小的EP患者宫腔镜术后自然妊娠率比较差异无统计学意义（P＞0.05）。多因素分析显示,年龄＞30岁是EP患者宫腔镜切除术后自然妊娠率的影响因素（OR=11.00,95%CI：4.108~29.454,P=0.000）;原发性不孕、不孕年限＞3年、息肉＞1 cm或多发则不是EP患者术后自然妊娠率的影响因素（P＞0.05）。结论：对于EP合并不孕的患者,宫腔镜治疗具有良好的治疗效果,且患者年龄越小术后自然妊娠的成功率越高。     

宫腔镜下不同手术方式治疗子宫内膜息肉的临床疗效观察

目的探讨宫腔镜下不同手术方式治疗子宫内膜息肉的疗效。方法对不同年龄和不同生育要求的子宫内膜息肉患者327例,分别行子宫内膜息肉切除+子宫内膜汽化电切术(A组,53例);子宫内膜息肉切除+子宫内膜电切术(B组,175例);子宫内膜息肉切除+息肉旁浅层内膜切除术(C组,54例,要求保留生育功能者);子宫内膜息肉切除+子宫内膜电凝术(D组,45例,绝经后患者)。结果手术时间:A组(15·1±0·8)s,B组(19·7±0·7)s,C组(20·9±0·7)s,D组(22·1±0·8)s,A组平均手术时间与其他3组比较,差异有统计学意义(P<0·01);术后子宫内膜息肉复发率:A、D组为0,B组为1·7%(3/175),C组为7·4%(4/54),C组术后复发率与其他3组分别比较,差异均有统计学意义(P<0·05);C组术后无闭经者,但术后息肉复发率高于其他3组,C组中有14例术后5~23个月妊娠。结论宫腔镜下不同手术方式治疗子宫内膜息肉的临床疗效无明显差异,但子宫内膜息肉切除+息肉旁浅层内膜切除术后复发率高;应根据患者年龄、生育要求等选择适宜的宫腔镜下手术方式。     

左炔诺孕酮宫内缓释系统预防子宫内膜息肉复发的疗效分析

目的探讨宫腔镜下子宫内膜息肉电切术后应用左炔诺孕酮宫内缓释系统(LNG-IUS)预防子宫内膜息肉复发的疗效。方法将2009年8月-2011年8月郑州大学第一附属医院因子宫内膜息肉行宫腔镜下子宫内膜息肉电切术的60例患者,采用完全随机化分组法分为研究组(30例,术后放置LNG-IUS)和对照组(30例,术后未行特殊处理)。随访比较两组患者术后6、12、24个月子宫内膜息肉复发、血红蛋白水平和子宫内膜厚度。结果研究组患者治疗后24个月血红蛋白水平[(120.15±9.51)]g/L显著增加(P0.05);术后6、12、24个月子宫内膜厚度[(0.57±0.14)mm、(0.79±0.21)mm、(0.93±0.22)mm]均低于治疗前[(1.46±0.56)mm](P0.05);术后24个月子宫内膜息肉的复发率(6.90%,2/29)与对照组(39.29%,11/28)比较,差异有统计学意义(P0.05)。所有患者术后均无严重并发症发生,术后24个月随访,研究组2例(6.90%,2/29)患者有阴道淋漓出血。结论左炔诺孕酮宫内缓释系统能有效预防子宫内膜息肉复发,值得在临床推广。     

Pregnancy rates after hysteroscopic polypectomy depending on the size or number of the polyps

Objective To assess the reproductive benefits of hysteroscopic polypectomy in previous infertile women depending on the size or number of the polyps. Design and methods In this retrospective study, from February 2000 to September 2005, totally 83 selected women were included with: a) diagnoses of primary or secondary infertility, endometrial polyp/polyps and abnormal uterine bleeding. Endometrial polyps were diagnosed by transvaginal ultrasound followed by diagnostic hysteroscopy, to confirm diagnosis, and hysteroscopic polypectomy. All 83 subjects who consisted the study group, met inclusion criteria: age under 35 years, at least 12 months of infertility, from 3 to 8 months menstrual disorders (intermenstrual bleeding or spotting, menometrorrhagia or menorrhagia) and from 3 to 18 months of follow-up with attempts to conceive after hysteroscopic polypectomy. The endometrial polyp/polyps appeared to be the only reason to explain their infertility after infertility workup of the couples. There was a comparison of fertility rates after hysteroscopic polypectomy between patients having endometrial polyp ≤ 1 cm and patients with bigger or multiple polyps. Results Of the 83 subjects, all were found to have endometrial polyps in diagnostic hysteroscopy, confirmed at histologic examination after hysteroscopic polypectomy. Among patients of the study group, there were no significant differences in age, type or length of infertility, or follow-up period after the procedure. The mean size of the endometrial polyps was 1.9 ± 1.4.cm. Thirty-one patients had endometrial polyp ≤ 1 cm and 52 patients had bigger or multiple endometrial polyps. Following polypectomy, menstrual pattern was normalized in 91.6% of patients. Spontaneous pregnancy and delivery at term rates, in the total population of the study, increased after the procedure and were 61.4% and 54.2% respectively. There was no statistical difference in fertility rates between patients having polyps ≤ 1 cm and patients having >1 cm polyps or multiple polyps. Spontaneous abortion rate in the first trimester of pregnancy was 6% of the total number of patients and there was no statistical difference between patients with small or bigger/multiple polyps. Type of infertility did not affect fertility rates after hysteroscopic polypectomy. Complication rate after hysteroscopic polypectomy was as low as 2.4%, while recurrence rate of the procedure reached 4.9% of patients. Conclusion Hysteroscopic polypectomy of endometrial polyps appeared to improve fertility and increase pregnancy rates in previous infertile women with no other reason to explain their infertility, irrespective of the size or number of the polyps. Type of infertility of patients seems not to affect fertility rates after hysteroscopic polypectomy. Menstrual pattern was normalized in the majority of patients after hysteroscopic polypectomy. In addition, hysteroscopic polypectomy is a safe procedure with low complication rate.     

Pregnancy rates after hysteroscopic polypectomy and myomectomy in infertile women.

OBJECTIVE: To compare reproductive benefits of hysteroscopic myomectomy and polypectomy for infertility to outcomes in infertile couples with normal hysteroscopic findings. METHODS: Women with diagnoses of infertility who had hysteroscopic evaluations by a single surgeon between 1975 and 1996 were sent a routine follow-up questionnaire regarding their reproductive histories. All 92 subjects who were located responded to the questionnaire, and 78 met inclusion criteria: age under 45 years, at least 12 months of infertility, and at least 18 months of follow-up with attempts to conceive, including in vitro fertilization in women with bilateral tubal occlusion. RESULTS: Of the 78 subjects, 36 had myomectomies, 23 had polypectomies, and 19 had normal cavities. Among the three groups, there were no significant differences in age, type of infertility, length of infertility, or follow-up after the procedure. Polypectomy subjects had significantly higher pregnancy and live birth rates than women with normal cavities. Women who had myomectomies larger than 2 cm had significantly higher pregnancy and live birth rates, achieving statistical significance at a myoma size of 3 cm or greater for live births. Spontaneous abortion rates among first pregnancies after myomectomy, polypectomy, or normal study were similar: 31.5%, 27.7%, and 37.5%, respectively. CONCLUSION: Both hysteroscopic polypectomy and hysteroscopic myomectomy appeared to enhance fertility compared with infertile women with normal cavities. Despite concern that hysteroscopic resection of a large myoma might ablate a large surface area of the endometrial cavity, the reproductive benefit appears greater than the risk.     

Pregnancy rates following hysteroscopic polypectomy,myomectomy, and a normal cavity in infertile patients

Objective: To assess the reproductive benefits of hysteroscopic myomectomy and polypectomy for infertility when compared to infertile couples with a normal cavity at hysteroscopy.Material and Methods: All patients with a diagnosis of infertility who underwent hysteroscopic evaluation by a single surgeon between 1975 and 1996 were sent a questionnaire as routine follow-up regarding their reproductive history. All 100 subjects who were located responded to the questionnaire, and 78 subjects met the inclusion criteria; age <45 years, 12 months of infertility, and 18 months of follow-up with attempts to conceive including in vitro fertilization in patients with bilateral tubal occlusion.Results: Of the 78 subjects, 36 had undergone a myomectomy, 23 a polypectomy, and 19 had a normal cavity. Among the three groups there was no significant difference in their ages, types of infertility, length of infertility, or follow-up after the procedure. Using the Cox proportional hazard model, and adjusting for age, polypectomy patients had a significantly higher pregnancy rate (RR 3.89, P < .01) and a higher live birth rate (RR 2.42, P = .06) than patients with a normal cavity. Patients who had undergone a myomectomy also had a higher pregnancy rate (RR 2.02, P = .11) and live birth rate, but this did not achieve statistical significance. Pregnancy following a hysteroscopic myomectomy was associated with a larger fibroid resection (3.15 cm vs 2.5 cm P = .05). The spontaneous abortion rate following the myomectomy, polypectomy, or a normal study was equivalent, 28.1%, 23.1%, and 29.2%, respectively.Conclusions: Both hysteroscopic polypectomy and hysteroscopic myomectomy appear to enhance fertility when compared to infertile patients with a normal cavity. Despite concern that hysteroscopic resection of a large myoma may ablate a large surface area of the endometrial cavity, patients with larger myomas were more likely to conceive following resection.     

子宫内膜非典型息肉样腺肌瘤24例临床分析

目的：探讨子宫内膜非典型息肉样腺肌瘤（atypical polypoid adenomyoma,APA）患者的诊治方法。方法：回顾性分析2006年1月-2015年6月首都医科大学附属复兴医院收治的24例APA患者的临床特点、诊治情况及预后,总结经验指导治疗。17例（70.8%）患者临床表现为阴道异常出血,1例（4.2%）阴道排液,3例（12.5%）超声提示宫腔占位,3例（12.5%）原发性不孕。24例患者均行宫腔镜手术,术后病理确诊。结果：24例均经病理明确诊断。宫腔镜检查和阴道彩色超声检查子宫内膜息肉及子宫黏膜下肌瘤的检出率分别为61.1%、68.4%和11.1%、15.8%,差异均无统计学意义（P＞0.05）。手术时间5～40 min,平均为（23.7±8.6）min,术中出血5～20 mL,平均为（6.5±2.9）mL。术后随访1～10年,失访4例。3例患者宫腔镜子宫内膜息肉电切术后行全子宫切除术,术后随访无异常。1例3个月后复查仍为APA,再次宫腔镜手术,术后肌注促性腺激素释放激素激动剂（GnRHa）,复查病理正常后宫腔放置左炔诺孕酮宫内缓释系统,至今随访2年无异常。1例术后8年因子宫内膜上皮内瘤变行子宫切除术,余15例至今随访无异常;2例不孕患者术后妊娠并足月分娩。结论：宫腔镜电切术作为APA的一种有效的治疗方式,具有定位准确、手术创伤小、复发率低的优点,但因有病变复发及恶变可能,术后仍应密切随访。 【关键词】     

A randomised controlled trial comparing outpatient versus daycase endometrial polypectomy

OBJECTIVE: To evaluate outpatient versus daycase endometrial polypectomy by comparing success rate, complications, patient tolerance, pain score, analgesia requirement and recovery. DESIGN: A randomised controlled trial. SETTING: A large UK Teaching hospital. POPULATION: Forty consecutive women diagnosed with an endometrial polyp at outpatient hysteroscopy were randomly assigned in equal proportions to outpatient or daycase polyp removal. METHODS: The outpatient cohort underwent endometrial polypectomy either using grasping forceps or a bipolar electrode (Versapoint; Gynecare Inc., Menlo Park, CA, USA) introduced down the operating channel of a rigid hysteroscope (Versascope; Gynecare Inc.). The daycase cohort underwent traditional endometrial polyp resection using a hysteroscopic, monopolar, electrosurgical resecting loop, performed under general anaesthetic. MAIN OUTCOME MEASURES: The main outcome measures were as follows: success rates and intra or postoperative complications, time away from home, analgesia requirements, pain scores on the day of and one day after endometrial polypectomy, return to work and preoperative fitness and preference for the location of a future endometrial polypectomy. RESULTS: The majority of women from both cohorts were premenopausal (62.5%), parous (85%) and in paid employment (62.5%). One woman allocated to outpatient polypectomy had cervical stenosis and dilatation was unsuccessful in the outpatient setting. There were no other intra or postoperative complications in either arm of the study. The mean intraoperative visual analogue style (0-100 mm) pain score during outpatient polypectomy was 23.7 mm (1-62). A proportion of women (20%) described no intraoperative discomfort; however, the majority (75%) described mild or moderate intraoperative discomfort. More women in the outpatient cohort (58%) described themselves as pain free for the remainder of the day than in the daycase cohort (28%) (P= 0.09). The day after the procedure, all women from the outpatient group described slight or no discomfort compared with only 41% of women from the daycase group (P= 0.02). All women undergoing outpatient polypectomy had a significantly shorter mean time away from home (3.24 [1.5-5] hours) than women undergoing daycase polypectomy (7.42 [6-10.5] hours), P < 0.0005. Similarly, women from the outpatient cohort had a significantly faster mean return to preoperative fitness (1 [0-4] day versus 3.2 [1-13] days; P= 0.001) and required less postoperative analgesia than the daycase cohort. Ninety-five percent of women from the outpatient cohort and 82% of women from the daycase cohort stated they would prefer to undergo an endometrial polypectomy in the outpatient setting should they require a further polyp removal. CONCLUSION: Endometrial polypectomy can be successfully performed in the outpatient setting with minimal intraoperative discomfort, a significantly shorter time away from home and faster recovery and is preferred by women when compared with daycase polypectomy. Resources need to be made rapidly available to undertake larger scale research and develop this service across the UK.     

A randomized prospective study of the use of endometrial ablation for prevention of recurrent endometrial polyps in breast cancer patients receiving tamoxifen

Objective: To assess the roles of endometrial ablation in prevention of recurrence of tamoxifen-associated endometrial polyps in breast cancer patients.Design: A randomized prospective study of tamoxifen-treated patients who underwent hysteroscopic removal of endometrial polyps with or without simultaneous resection of the endometrium.Materials and Methods: Twenty consecutive women (aged 43–61 years) undergoing hysteroscopic removal of tamoxifen-associated endometrial polyps were randomized via a computer-generated random table to undergo or not to undergo concomitant endometrial ablation. All patients had undergone endometrial sampling prior to the procedure. The patients were followed for at least 18 months (range 18–24 months). The follow-up included transvaginal ultrasonography every 6 months and hysteroscopy when endometrial irregularity was noted. The main outcome variable was recurrence of endometrial polyps while the occurrence of uterine bleeding was noted.Results: In the 10 study group women, who underwent endometrial ablation, only 1 patient had a 1 × 1 cm endometrial polyp diagnosed and removed during the follow-up period. Seven of the study women remained amenorrheic, and 3 experienced spotting a few days every month. In the control group, a recurrent endometrial polyp, necessitating hysteroscopic removal, was diagnosed postoperatively in 6 women (two-tailed Fisher’s Exact test; P < .06).Conclusion: Recurrence of endometrial polyps, one of the most common problems in breast cancer patients receiving long-term treatment with tamoxifen, can be significantly reduced by performing endometrial ablation at the time of hysteroscopic removal of the polyp. The possible risk of occult endometrial cancer is yet to be determined.     

The effect of hysteroscopic polypectomy on the concentrations of endometrial implantation factors in uterine flushings

Endometrial polyps have been associated with infertility and early pregnancy loss. The aim of this study was to investigate the effect of hysteroscopic polypectomy on the concentrations of endometrial implantation factors in uterine flushings. Pre-menopausal women with a certain diagnosis of endometrial polyp on contrast-enhanced transvaginal ultrasound scan were recruited into this prospective study. In all women, paired samples of uterine flushings were obtained on the same day of the menstrual cycle prior to and post hysteroscopic polypectomy. Enzyme-linked immunoassays were performed to analyse glycodelin, interleukin-6 (IL-6), interleukin-10 (IL-10), tumour necrosis factor α (TNFα) and osteopontin, whilst immunoradiometric assay was used to analyse insulin-like growth factor binding protein-1 (IGFBP-1). Concentrations of IGFBP-1, TNFα and osteopontin in uterine flushings were significantly lower in the mid-secretory phase prior to polypectomy in comparison to the measurements obtained after complete surgical removal of the polyp (P < 0.05). There were no differences in the concentrations of glycodelin, IL-6 and IL-10 in paired samples prior to and post-polypectomy. The presence of endometrial polyps is associated with decreased mid-secretory concentrations of IGFBP-1, TNFα and osteopontin, which are reversed following surgical polypectomy.