穿透性角膜移植术治疗大泡性角膜病变

目的 探讨穿透性角膜移植术治疗大泡性角膜病变的临床疗效。方法 对17例17眼大泡性角膜病变施行穿透性角膜移植术或穿透性角膜移植联合手术。随访观察2～43个月并进行了回顾性分析。结果 角膜植片透明12例,半透明3例,植片混浊2例。其中4例在术后2周～21个月发生角膜免疫排斥反应,经保守治疗后控制。全部患者术后眼部刺激症状消失。除1例术前视力无光感,术后视力无变化外,其余病例术后视力均有不同程度提高。结论 穿透性角膜移植术或穿透性角膜移植联合手术,是解除眼部疼痛刺激症状、提高视力的首选而有效的方法。     

穿透性角膜移植治疗人工晶体植入术后大泡性角膜病变的临床观察

目的探讨穿透性角膜移植术治疗人工晶体植入术后大泡性角膜病变临床疗效。方法对21例（21眼）人工晶体植入术后大泡性角膜病变施行穿透性角膜移植术或穿透角膜移植联合手术，观察术后视力及植片情况。结果随访6～18个月，平均11．6个月，术后临床症状明显缓解或消失，视力较术前均有提高，其中矫正视力0．02以上17例（0．2以上7例）；术后继发性青光眼2例，内皮型排斥反应1例。结论穿透性角膜移植术是治疗人工晶体植入术后大泡性角膜病变的一种理想手术方式，不但缓解症状且能不同程度提高视力。     

穿透性角膜移植治疗人工晶状体植入后大泡性角膜病18例

目的：评价穿透性角膜移植治疗人工晶状体植入后大泡性角膜病的方法和疗效。方法：人工晶状体植入后大泡性角膜病18例行穿透性角膜移植，其中9例单纯行穿透性角膜移植，8例行穿透性角膜移植联合术，1例取出前房植入普通后房型人工晶状体后行穿透性角膜移植，随访时间为4mo～2a。结果：术后随访13例植片透明，3例植片半透明，2例植片混浊。16例矫正视力在0．04～0．6，疼痛症状全部解除。结论：穿透性角膜移植联合术是目前治疗人工晶状体植入后大泡性角膜病较合理而有效的方法。     

穿透性角膜移植治疗人工晶状体植入术后大泡性角膜病变的临床观察

目的 评价穿透性角膜移植术治疗人工晶状体植入术后大泡性角膜病变临床疗效,探讨术中对原人工晶状体的处理。方法 对12例(12只眼)人工晶状体植入术后大泡性角膜病变施行穿透性角膜移植术或穿透性角膜移植术联合手术,观察术后角膜植片及视力变化。结果 随访6～16个月,平均11．2个月,术后临床症状明显缓解或消失,植片保持透明,视力较术前均有提高,其中矫正视力0．02以上11例(0．2以上4例);术后继发性青光眼1例,内皮型排斥反应1例。结论 穿透性角膜移植术是治疗人工晶状体植入术后大泡性角膜病变的一种理想手术方式,不仅能消除刺激症状且能增进视力。术中如何处理人工晶状体应视眼部具体情况。     

穿透性角膜移植术治疗假晶体大泡性角膜病变的临床观察

目的：评价穿透性角膜移植术治疗假晶体大泡性角膜病变的临床疗效，探讨术中对原人工晶体的处理。方法：假晶体大泡性角膜病变１４例（１４只眼）。原人工晶体类型为后房型人工晶体１２例，弹性开放襻前房型人工晶体２例。手术方法为穿透性角膜移植术１２例，穿透性角膜移植联合人工晶体取出术２例。结果：术后临床症状均完全消失，所有植片均透明，矫正视力０．０２以上１２例（０．１以上４例）。随诊３￣２２个月，１３例植片透明     

板层和穿透性联合角膜移植术的临床观察

目的：回顾性研究板层和穿透性联合角膜移植术治疗角膜病的效果。方法：对12例全角膜病变实施板层和部分穿透性联合角膜移植。手术将板层角膜巩膜病变切除，作中央部分穿透的植床，取新鲜尸体眼球，制作相应的角膜植片，植片与植床对应间断缝合。术后跟踪随访。结果：12例角膜植片术后均保持或恢复透明，裸眼视力0．1～0．2者4例，0．2以上者8例。术后免疫排斥反应被控制，没有虹膜前粘连和继发性青光眼并发症出现。结论：板层和部分穿透性联合角膜移植术，对大范围严重的角膜病变有较好的治疗效果，能治愈常规方法难以治愈的患者。     

人工晶状体眼并发大泡性角膜病变及视网膜脱离时应用临时人工角膜进行眼前后节联合手术

目的探讨在人工晶状体眼合并大泡性角膜病变及视网膜脱离病例中应用临时人工角膜行玻璃体切割联合穿透性角膜移植的临床价值。方法对6例(6眼)人工晶状体眼合并大泡性角膜病变及视网膜脱离患者行临时人工角膜下玻璃体切割联合穿透性角膜移植术。结果6例患者术后视网膜均复位良好，5例角膜植片透明，1例患者视力达0．1．2例患者手术中取出人工晶状体。结论该手术是一种安全、有效的治疗手段，对保留人工晶状体眼合并大泡性角膜病变及视网膜脱离患者的眼球及部分视力起到了积极的作用。     

全角膜移植术治疗严重全角膜病变的探讨

目的：评价带环形板层巩膜瓣的全角膜移植术治疗严重全角膜病变的临床疗效。方法：我们对用药无法控制的严重全角膜病变9例进行回顾性研究，其中化脓性角膜溃疡8例，大泡性角膜病变伴全角膜白斑1例。观察术后视力、植片及并发症。结果：随访1－23月，9例视力均有提高，8例植片透明，1例植片半透明。5例术后3－4月出现角膜新生血管。结论：全角膜移植术是治疗严重角膜病变的有效方法，不但能挽救眼球而且能恢复一定的视力。     

治疗性穿透性角膜移植术中偏中央植片的应用

目的：研究治疗性穿透性角膜移植术中偏中央植片的必要性和减少角膜散光改善视功能的方法。方法：记录植孔中心与角膜中心连线延长线上植孔外缘与角膜缘的距离。取供眼相同位置的角膜植片移植，对18例角膜溃疡穿孔偏位者施行偏中央植片的穿透性角膜移植术，平均随访12月，结果：13例移植片透明，10例裸眼视力0．1以上，结论：治疗性穿透性角膜移植术采用偏中央植片定向标记技术效果可靠，可减少角膜散光，改善视功能。     

穿透性角膜移植治疗外伤性角膜病变的临床观察

目的:探讨穿透性角膜移植术治疗外伤性角膜病变的临床疗效。方法:对17例外伤性角膜病变施行穿透性角膜移植术,2例行穿透性角膜移植术联合小梁切除术,观察术后角膜植片及视力变化。结果:随访6~18(平均11.2)mo,术后临床症状明显缓解或消失,植片透明率为84%。视力较术前提高,其中矫正视力0.05以上16例;术后继发性青光眼5例,内皮型排斥反应4例。结论:穿透性角膜移植术是治疗外伤性角膜病变的一种有效的手术方式,其主要并发症为继发性青光眼和角膜移植排斥反应。     

人工晶体植入后大泡性角膜病变的穿透性角膜移植

目的：评价穿透性角膜移植（Penetrating Keratoplasty,PK）治疗人工晶体植入后大光性角膜病变（Bullous Keratopathy,BK）的临床疗效。方法：采用PK治疗人工晶体植入后的BK12例（12眼）,观察术后角膜植片及视力变化。结果：随访8～14个月,平均10.6个月,角膜植片透明10例,半透明2例,术后视力提高8例,视力无改变的3例,视力下降1例。全部病人眼部刺激症状消失。术后继发青光眼3例。结论：PK是治疗人工晶体植入后BK的一种理想的手术方式,术中对人工晶体的处理和防止玻璃体脱出及出血是手术成功的关键。     

人工晶体眼大泡性角膜病变的穿透性角膜移植

目的:研究人工晶体眼大泡性角膜病变行穿透性角膜移植的临床效果和保留或取出原人工晶体的适应证。方法:应用穿透性角膜移植治疗人工晶体植入术后大泡性角膜病变。结果:13例(13眼),术中保留原人工晶体11眼,取出原人工晶体2眼。术后随访平均16个月。随访期间角膜移植片全部透明,术后绝大部分病例视力获得提高,其中视力矫正达到0.2以上有5眼。结论:穿透性角膜移植是治疗人工晶体植入术后大泡性角膜病变有效方法。只要人工晶体位于囊袋内,位置正常,术中应保留原人工晶体,手术安全,术后视力恢复良好。眼科学报1998;14:227～228。     

Pseudophakic bullous keratopathy

We reviewed the records of all patients with pseudophakic bullous keratopathy (271 eyes, 251 patients) seen during a six-month period to determine predisposing factors, associated problems, current management, and visual outcome. Pseudophakic bullous keratopathy was associated most frequently with anterior chamber intraocular lenses in general (155 of 271), and with Leiske style lenses in particular (100 of 271). It was associated with a visual acuity of 20/200 or less in 206 eyes and a visual acuity of counting fingers or less in 129 of the eyes at the initial examination. Penetrating keratoplasties had been performed in 189 of the eyes. After penetrating keratoplasty, 108 of 189 of the eyes had a visual acuity of 20/200 or less (mean follow-up, 15 months). Visual acuity improved with longer follow-up, and among patients with a minimum follow-up of two years, 23 of 36 eyes had a visual acuity of 20/100 or better. Most grafts were clear (145 of 189). Pseudophakic bullous keratopathy was associated with marked visual loss, which was permanent despite clear grafts in 29 of 92 eyes followed-up for one year or longer.     

Long-term outcomes of combined penetrating keratoplasty with iris-sutured intraocular lens implantation

PURPOSE: To evaluate the long-term outcomes of combined penetrating keratoplasty with iris-sutured posterior chamber intraocular lens implantation. PARTICIPANTS: Patients (264 eyes) with aphakic and pseudophakic bullous keratopathy. DESIGN: Retrospective case series. INTERVENTION: Penetrating keratoplasty combined with implantation of an iris-sutured posterior chamber intraocular lens performed by a single surgeon. METHODS: Data were gathered from the institutional database during a period of 10 years (1989-1999) and analyzed using customized software. MAIN OUTCOME MEASURES: Graft survival rate, visual acuity, and intraoperative and postoperative complications. RESULTS: Two-hundred fifty-two consecutive patients (264 eyes) were operated. Graft survival rates were 95% at 1 year, 89% at 2 years, and 81% at 5 years and were comparable to the results of previous corneal transplant studies. Among 180 patients (191 eyes) with a follow-up of at least 2 years (range, 2-11 years; mean, 5 years), the visual acuity at final follow-up visit, compared with preoperative visual acuity was improved in 72% of eyes (mean preoperative visual acuity, 20/250; mean postoperative visual acuity, 20/60). No intraoperative complications were encountered. CONCLUSIONS: Combined penetrating keratoplasty with iris-sutured posterior chamber intraocular lens implantation offers significant vision benefits in this patient group.     

A prospective study on the implantation of anterior chamber intraocular lenses during keratoplasty for pseudophakic and aphakic bullous keratopathy

Between April 1986 and April 1989, the authors conducted a prospective study of the use of open-loop anterior chamber intraocular lenses (AC IOLs) in patients undergoing penetrating keratoplasty for pseudophakic bullous keratopathy or monocular aphakic bullous keratopathy. All patients underwent the same operation--a penetrating keratoplasty combined with insertion of an open-loop AC IOL. Pseudophakic patients had an IOL exchange at the time of surgery. Thirty-six patients have been followed an average of 15 months. Thirty-two (89%) of the grafts are clear. Preoperatively, 100% of eyes had visual acuity less than 20/200. Postoperatively, 11 eyes (31%) have visual acuity better than 20/40 and 23 eyes (64%) have visual acuity better than 20/100. The most common causes for visual acuity less than 20/200 were cystoid macular edema, glaucoma, and immunologic graft failure. Using open-loop AC IOLs in patients with pseudophakic or aphakic bullous keratopathy can give good postoperative results and functional vision.