肺部髓外浆细胞瘤1例报道

1病例资料患者,男,58岁,因髓外浆细胞瘤术后20 d余于2010年11月16日入院。入院前5月余出现胸闷、气促,伴四肢乏力,入院2月余出现胸痛,外院CT示:右上肺占位,考虑右上肺周围型肺癌可能性大,伴肺门及纵隔淋巴结肿大。2010年10月9日收住我院胸外科,复查胸部CT示:右肺上叶及中叶胸膜下占位性病变,并肺门及纵隔多发淋巴结肿大,右侧胸腔积液,2010年10月20日行胸腔镜右胸探查术,胸膜活检     

14例髓外浆细胞瘤患者的临床特征分析及治疗

  目的   探讨伴髓外浆细胞瘤（extramedullary plasmacytoma,EMP）的多发性骨髓瘤（multiple myeloma,MM）患者的临床特点,治疗选择及预后。   方法   对14例确诊的伴髓外浆细胞瘤的多发性骨髓瘤进行回顾性分析。   结果   14例患者男女比为1:l,中位年龄56.9岁。9例患者初诊时即出现EMP,5例在治疗过程中发生。治疗选择包括化疗,手术,放疗或自体移植。6例患者单发EMP,8例多发EMP（multiextramedullary plasmacytomas,MEP）;单发患者中5例部分或接近完全缓解,1例病情进展;多发患者中5例死亡,1例病情进展,2例部分缓解。   结论   MM伴有MEP者对常规化疗反应差,预后不良,需要探讨新的治疗策略。      

髓外浆细胞瘤七例临床分析

髓外浆细胞瘤临床极少见。自1965年Schrid-de报告首例以来,国外文献已陆续见有报道。而国内文献所报道的病例尚不多,迄今为止,在公开发表的文献中仅见50例左右。我院自1965年7月以来收治7例,均经活检或手术后病理证实,现报道如下。临床资料年龄及性别本组男3例,女4例。年龄最小者30岁,最大60岁,平均49.7岁。肿瘤部位本组6例发生于头颈部,其中鼻腔2例,鼻咽2例,眶下1例,颌下1例。1例     

腹壁髓外浆细胞瘤1例报告

浆细胞肿瘤是单克隆性浆细胞异常增殖性疾病。按照WHO分类,浆细胞肿瘤被分为浆细胞骨髓瘤〔多发性骨髓瘤(MM)〕、骨孤立性浆细胞瘤(solitary plasmacytomaofbone,SPB)和髓外浆细胞瘤(extramerdullary plasmacytoma,EMP)。EMP占全部浆细胞肿瘤的5%～10%。其中约80%的EMP发生于上呼吸道,胃肠道约占10%,发生于腹部皮下的EMP报道较少。本研究将确诊的1例EMP病例报道如下。     

髓外浆细胞瘤与骨单发性浆细胞瘤17例

1977年1月至1988年1月治疗12例髓外装细胞瘤(EMP),5例骨单发性浆细胞瘤(SPB)。单纯放疗10例,手术加放疗5例,手术加化疗2例。照射剂量41～70Gy.60％的SPB在治疗后平均22.3个月发展为多发性骨髓瘤,EMP无发生。16.7％的EMP疗后局部复发,25％的EMP和20％的SPB有区域淋巴结转移。全组3年生存率13/16(81％),EMP与SPB生存率无差异。     

髓外浆细胞瘤2例报告

髓外浆细胞瘤(extramedullary plasmacytoma,EMP)在临床上极少见,现将我院2005年收治的2例髓外浆细胞瘤报告如下。1资料例1,女性,68岁,因“鼻出血1年,鼻塞半年”入院。患者2004年5月无诱因出现鼻出血,量多,色鲜红,可自止。近半年来感鼻阻,流清涕,在当地医院诊为“鼻息肉”,未治疗。2005年7月29日因鼻阻加重,在当地医院行“鼻息肉摘除术”,术后病检“(右鼻腔)髓外浆细胞瘤(中度恶性)”。免疫组化:LCA( ),CD45RO(部分 ),CD3(-),CD20(-),CKAE3(-),HMB45(-),CD56( )。遂于2005年9月5日入我院行术后放疗,设鼻前品字野,DT40Gy/(20F·4…     

髓外浆细胞瘤的诊断和治疗

目的 探讨髓外浆细胞瘤（EMP）的诊断和治疗。方法 4例髓外浆细胞瘤的临床资料。结果 1例疗后失访。2例分别随访74月和56月，无局部复发、远处转移，无进展证据。1例治疗后6个月复发，18个月时死于多发性骨髓瘤（MM）。结论 EMP的诊断确立必须有组织学结果，并经系统检查除外MM；放疗和手术是EMP的主要治疗手段。     

髓外浆细胞瘤和骨的孤立性浆细胞瘤9例

在浆细胞瘤中，多发性骨髓瘤（mm）常见，而髓外浆细胞瘤（EMP）及骨的孤立性浆细胞瘤（SPB）则罕见。1985—1995年间，作者治疗髓外浆细胞瘤7例，骨的孤立性浆细胞瘤2例。单纯放疗4例，手术加放疗5例。全组3年生存率6／8（7％）。1例SPB在治疗后2年发展为mm，而无1例EMP发生。EMP及SPB治疗后，预后较好。对于预测发展为mm的指标，尚需进一步研究。     

Renal Extramedullary Plasmacytoma——One Case Report

T Extramedullary plasmacytoma (EMP) is rare in multiple myeloma, especially kidneys are involved. We report one case, including diagnosis and treatment. The purpose of this paper is to provide an attention on the extramedullary plasmacytoma disease, reducing the misdiagnose with this disease.     

Extramedullary Plasmacytoma of the Mediastinum

A case of extramedullary plasmacytoma originating from the uppermediastinum is described. Its pathologic, cytologic and immunohistopathologicfindings were distinctive. The neoplastic cells had dense bodiesin the cytoplasm. Neither M-protein in the serum nor Bence Jonesprotein in the urine was detected. However, cellular IgG, havinga lamda-type light chain was shown, by immunohistochemical stainingfollowing trypsin digestion, to be present in the tissue sections.     

髓外浆细胞瘤8例临床分析及文献复习

[目的]探讨髓外浆细胞瘤（EMP）的临床特点与治疗方法。[方法]回顾性分析8例EMP的临床资料,并复习相关文献。[结果]EMP好发于头颈部,男性多见,预后相对较好,较易转化为多发性骨髓瘤。[结论]EMP是罕见的低度恶性肿瘤,确诊依靠病理并排除多发性骨髓瘤等,局部治疗是其主要的治疗手段,化疗对于肿瘤分化较差及复发患者有一定的作用。     

Plasmacytoma of the Nasolacrimal Duct Simulating Dacryocystitis: An Uncommon Presentation for Extramedullary Relapse of Multiple Myeloma

The most common site for localized forms of plasma cell neoplasms (extramedullary plasmacytoma; EMP) is the upper respiratory tract, including the oropharynx, nasal cavities, sinuses and larynx. A 50-year-old woman with a history of myeloma in complete remission after autologous stem cell transplantation complained of two weeks of epiphora of the left eye with subsequent diplopia, bloody nasal discharge and progressive swelling around the nasolacrimal sac. A solitary mass in the left sinonasal area, extending to the nasolacrimal duct (NLD) was detected on MRI, whose histopathological examination was consistent with plasmacytoma. Further clinical investigation ruled out multiple myeloma (MM). The patient underwent debulking surgery and adjuvant chemotherapy followed by local radiotherapy in an attempt to achieve complete response. Despite being a rare entity, EMP of the NLD should be considered in the differential diagnosis of epiphora and dacryocystitis. To our knowledge, this is the first case of a plasmacytoma of the NLD presenting as isolated extramedullary relapse of MM. The follow-up in EMPs should include appropriate imaging studies, a systemic workup to rule out MM.Key words: Dacryocystitis, Multiple myeloma, Nasolacrimal duct, Plasmacytoma     

巨大食管息肉一例报告

目的食管息肉是一种少见的疾病。我们报道一例巨大食管息肉病例,该病人有吞咽困难和呕血的症状。我们完善各项检查后,肯定肿块是食管平滑肌瘤。在胸部探查中,我们发现为食管息肉并予以切除。术后病理报告食管巨大纤维血管息肉伴粘液变。外科医师应该意识到这种少见疾病的存在。     

巨大食管息肉一例报告

目的食管息肉是一种少见的疾病。我们报道一例巨大食管息肉病例，该病人有吞咽困难和呕血的症状。我们完善各项检查后，肯定肿块是食管平滑肌瘤。在胸部探查中，我们发现为食管息肉并予以切除。术后病理报告食管巨大纤维血管息肉伴粘液变。外科医师应该意识到这种少见疾病的存在。     

巨大食管息肉一例报告(英文)

目的食管息肉是一种少见的疾病。我们报道一例巨大食管息肉病例,该病人有吞咽困难和呕血的症状。我们完善各项检查后,肯定肿块是食管平滑肌瘤。在胸部探查中,我们发现为食管息肉并予以切除。术后病理报告食管巨大纤维血管息肉伴粘液变。外科医师应该意识到这种少见疾病的存在。     

Extramedullary Plasmacytoma of the Paranasal Sinuses: Combining Surgery with External Radiotherapy

Extramedullary plasmacytomas (EMP) are rare neoplasms characterized by the proliferation of a single B-lymphoid cell clone, arising primarily in the head and neck region. The purpose of this study is to report our experience in the management of EMPs arising in the paranasal sinuses. We retrospectively reviewed clinical records of 7 patients (4 men and 3 women), admitted between 1995 and 2010 for EMPs of the paranasal sinuses—5 within the ethmoid and 2 in the maxillary sinus. Treatment consisted in endoscopic resection followed by external RT. The mean follow-up period is 50 months (range 9–67 months). Local recurrences developed in 2 out of 7 cases. Both recurrences occurred in maxillary EMPs and they underwent salvage treatment—combination of RT and surgery. At the time of analyzing these data 5 patients (70 %) were alive and two (30 %) have died of their disease. A single patient, presenting local relapse at 6 months, died due to the disease at 9 months. One patient progressed to multiple myeloma. Larger controlled clinical trials are necessary to establish an optimal treatment of choice that implies an individualized management of these patients.