环境因素引起皮肤衰老

人体皮肤直接与外环境接触，受环境因素影响最为显著，尤其是身体暴露部位，如面部、颈部、上臂等。据目前所知，对皮肤有不良作用的环境因素主要有日光中紫外线、红外线，香烟的烟雾，空气污染等，它们均可加速皮肤的衰老过程。     

7个坏习惯加速皮肤衰老

美国《健康》杂志最新载文,刊：出多位专家总结出的导致皮肤衰老加速的7个坏习惯及相关建议。1．出门不涂防晒霜纽约市皮肤科专家尼尔-萨迪克博士表示,日晒是导致皮肤衰老的主要原因。即使在阴天、雨天或雪天,也会接触到紫外线。此外,紫外线还会穿过玻璃,伤害人体皮肤。所以即使在室内也要加强保护。     

吸烟对皮肤衰老的影响及其作用机制

现代社会人们越来越注重外在形象,尤其是年轻人更希望永葆青春。因而,有关预防或延缓皮肤衰老的研究备受关注。皮肤衰老的迟早、程度受到许多相互作用因素的影响,概括起来可分为自然因素和人为因素两方面,前包括年龄的增长及遗传因素等,这些作用是因人而异,不可避免的。后的作用却是可以预防的,如日光暴露,阳光中紫外线对皮肤时损害己得到广泛研究;     

景天类植物延缓皮肤衰老的实验研究

为了研究景天类植物提取物对延缓皮肤衰老作用 ,采用自身配对设计 ,在 6和 15月龄豚鼠背部皮肤涂抹 0 5 %的景天类植物提取物共 30天。通过组织学观察及生化方法检测丙二醛 (MDA)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)及真皮胶原含量。结果表明 ,涂抹景天类植物提取物的皮肤真皮成纤维细胞明显增多且活跃。皮肤组织SOD及GSH Px活性增高 ,真皮酸溶性胶原中羟脯氨酸含量增加 ,脂质过氧化产物MDA含量减少。提示景天类植物提取物具有良好的延缓皮肤衰老的作用。     

放缓皮肤衰老的脚步

人过中年，无论如何掩饰，脸上的皱纹都会泄露年龄的秘密。不仅如此，干燥、暗淡无光、松弛、色斑等皮肤问题也纷至沓来。对此，读者朋友有许多疑问，山东省济南市中心医院皮肤科主任王丽华如是回答——     

延缓皮肤衰老有良策

随着年龄的增长,皮肤衰老是自然规律。但是如果你能加强养生保健,就能延缓皮肤衰老的进程。     

香烟与皮肤皱纹

你知道吸烟能引起皮肤皱纹吗甲你知道什么是烟容吗？在中华医学会和法国欧莱雅公司的资助下，河南省人民医院皮肤科钱革博士与中国医学科学院皮肤病研究所王千秋教授合作，对吸烟对皮肤衰老和皱纹的影响进行了系统研究，再次确认吸烟是促进皮肤衰老、加重皮肤皱纹的主要影响因素。     

维生素能否延缓皮肤衰老

皮肤是人体最大的器官,担负着保护、感觉、调节体温、分泌和排泄、吸收、代谢等多方面作用。随着年龄的增长,皮肤也会像人体其他器官一样逐渐老化,功能减弱     

紫外线对皮肤影响的流行病学研究

波长１００～４００ｎｍ的电磁辐射称为紫外辐射或紫外线（ＵｌｔｒａｖｉｏｌｅｔＲａｄｉａｔｉｏｎ,ＵＶＲ）。根据紫外线的物理和生物学特性,将其分为长波紫外线（ＵＶＡ）波长４００～３２０ｎｍ,中波紫外线（ＵＶＢ）波长３２０～２８０ｎｍ和短波紫外线（ＵＶＣ...     

晨起用丝瓜汁擦脸可延缓皮肤衰老

丝瓜不但是美味菜肴，更是一种天然的美容佳品。据日本《每日新闻》报道，日本崎玉县有位名叫平林英子的女作家，虽然已年过八旬，但面容依然红润光滑。其秘密就是每天早上用丝瓜汁擦脸，几十年从不间断。     

Lifestyle Factors and Visible Skin Aging in a Population of Japanese Elders

Background

The number of studies that use objective and quantitative methods to evaluate facial skin aging in elderly people is extremely limited, especially in Japan. Therefore, in this cross-sectional study we attempted to characterize the condition of facial skin (hyperpigmentation, pores, texture, and wrinkling) in Japanese adults aged 65 years or older by using objective and quantitative imaging methods. In addition, we aimed to identify lifestyle factors significantly associated with these visible signs of aging.

Methods

The study subjects were 802 community-dwelling Japanese men and women aged at least 65 years and living in the town of Kurabuchi (Takasaki City, Gunma Prefecture, Japan), a mountain community with a population of approximately 4800. The facial skin condition of subjects was assessed quantitatively using a standardized facial imaging system and subsequent computer image analysis. Lifestyle information was collected using a structured questionnaire. The association between skin condition and lifestyle factors was examined using multivariable regression analysis.

Results

Among women, the mean values for facial texture, hyperpigmentation, and pores were generally lower than those among age-matched men. There was no significant difference between sexes in the severity of facial wrinkling. Older age was associated with worse skin condition among women only. After adjusting for age, smoking status and topical sun protection were significantly associated with skin condition among both men and women.

Conclusions

Our study revealed significant differences between sexes in the severity of hyperpigmentation, texture, and pores, but not wrinkling. Smoking status and topical sun protection were significantly associated with signs of visible skin aging in this study population.Key words: skin aging, quantitative method, Japan, older adults, lifestyle     

帕金森病与环境因素

帕金森病(Pakinson’s disease，PD)是发生于中老年的神经系统常见的变性疾病，以静止性震颤、肌强直、运动迟缓为临床特征，病理表现为选择性黑质多巴胺能神经元变性，及残余多巴胺能神经元出现嗜酸性包涵体Lewy小体。在老年性疾病中，帕金森病患病率仅次于Alzhei病，且随着中国老龄化加深，患病率有上升趋势，因此帕金森病正受到越来越多的关注。     

Effects of Eggshell Membrane on Keratinocyte Differentiation and Skin Aging In Vitro and In Vivo

Skin aging is one of the hallmarks of the aging process that causes physiological and morphological changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a beneficial effect on maintaining skin health and improving the skin aging process in vitro using neonatal normal human epidermal keratinocytes (NHEK-Neo) and in vivo using interleukin-10 knockout (IL-10 KO) mice. In NHEK-Neo cells, 1 mg/mL of enzymatically hydrolyzed ESM (eESM) upregulated the expression of keratinocyte differentiation markers, including keratin 1, filaggrin and involucrin, and changed the keratinocyte morphology. In IL-10 KO mice, oral supplementation of 8% powdered-ESM (pESM) upregulated the expression of growth factors, including transforming growth factor β1, platelet-derived growth factor-β and connective tissue growth factor, and suppressed skin thinning. Furthermore, voltage-gated calcium channel, transient receptor potential cation channel subfamily V members were upregulated by eESM treatment in NHEK-Neo cells and pESM supplementation in IL-10 KO mice. Collectively, these data suggest that ESM has an important role in improving skin health and aging, possibly via upregulating calcium signaling.