经会阴前列腺分层饱和穿刺活检在首次前列腺穿刺活检阴性患者中的价值

目的 探讨经会阴前列腺分层饱和穿刺活检在首次前列腺穿刺活检阴性患者中的应用价值。方法84例因直肠指诊、血清前列腺特异性抗原（PSA）和前列腺MRI检查异常而接受经直肠标准12针穿刺活检且结果为良性的患者,行超声引导下经会阴前列腺分层饱和穿刺活检,计算前列腺癌的检出率。结果84例患者行经会阴前列腺分层饱和穿刺活检,诊断为前列腺癌23例（27.4%）,良性前列腺增生61例（72.6%）,其中合并高级别上皮内瘤变3例,慢性前列腺炎5例。结论经会阴前列腺分层饱和穿刺活检可以提高前列腺癌的检出率,对于初次活检阴性,但直肠指诊、前列腺MRI检查异常并且血清前列腺特异性抗原持续升高的患者,可以考虑应用此穿刺活检方法再次穿刺活检予以明确诊断,避免漏诊和延误治疗。     

超声引导下经直肠前列腺组织活检

近年来，前列腺疾病有逐渐增多的趋势，特别是前列腺癌，彩色多普勒超声引导下经直肠前列腺组织活检术是一种快速有效的诊断技术，它能明显提高前列腺癌的诊断率。自2003年9月-2004年6月对临床怀疑前列腺癌的患者进行彩色多普勒超声引导下经直肠前列腺组织活检。     

直肠超声引导下经会阴前列腺穿刺分析

目的：探讨直肠超声引导下（TRUS）经会阴前列腺穿刺活检术诊断前列腺癌的价值。方法：对491例PSA〉4ng／ml、直肠指检异常或B超发现异常回声的病例行经会阴前列腺标准六点穿刺活检术,同时对可疑回声区随机增加穿刺点,并与病理结果对照分析。结果：穿刺活检证实为前列腺癌190例,阳性率38．70％。结论：TRUS引导下经会阴前列腺穿刺准确率高,并发症少且轻,是诊断前列腺癌的重要方法。     

经直肠前列腺超声造影导向活检对前列腺癌检出率的分析

目的:将经直肠超声(TRUS)引导前列腺穿刺活检方法与经直肠前列腺超声造影(CEUS)联合TRUS引导前列腺靶向穿刺活检方法进行比较,评价采用CEUS联合TRUS引导穿刺活检在前列腺癌(PCa)诊断中的临床应用价值.方法:采用单一的TRUS引导前列腺穿刺活检法,共183例,为普通组.采用CEUS联合TRUS引导前列腺靶向穿刺活检法,共116例,为造影组,将两组穿刺方法PCa阳性率、穿刺针数及并发症进行对比分析和统计学处理.结果:造影组与普通组PCa穿刺阳性率,比较两组间差异无统计学意义(p＞0.05);穿刺阳性针数及穿刺后并发症,比较两组间差异有统计学价值(P＜0.05).结论:经直肠CEUS联合TRUS引导前列腺靶向穿刺活检能在减少穿刺活检针数,减轻患者痛苦的同时,还提高了单针活检的阳性率,减少了并发症的发生,值得临床推广应用.     

达克罗宁联合前列腺神经阻滞麻醉在经直肠前列腺穿刺活检术中应用效果

目的 探讨达克罗宁联合前列腺神经阻滞麻醉在经直肠前列腺穿刺活检术中的应用效果.方法 选取盐城市第三人民医院自2016年1月至2020年3月收治的95例行前列腺穿刺的患者为研究对象.采用随机数字表法将其分为随机分成A组(n=43)与B组(n=52).A组患者采用肛周局部麻醉+利多卡因凝胶直肠表面麻醉,B组患者采用达克罗宁...     

经直肠超声引导下前列腺穿刺活检的临床价值

目的：评价经直肠超声引导下前列腺穿刺活检的临床价值。材料和方法：怀疑前列腺癌并行经直肠超声引导下前列腺穿刺患者２０例。结果：组织学证实前列腺癌（ＰＣＡ）５例、前列腺增生（ＢＰＨ）１２例、前列腺内皮瘤形成（ＰＩＮ）２例和前列腺结核１例。在８例前列腺特异抗原（ＰＳＡ）＞１０μｇ／Ｌ中，ＰＣＡ２例、ＢＰＨ４例、ＰＩＮ２例；在５例ＰＣＡ中，有２例ＰＳＡ＜４μｇ／Ｌ。结论：前列腺穿刺活检是诊断ＰＣＡ的最有效方法之一，有助于前列腺疾病的鉴别诊断。经直肠超声引导下前列腺穿刺活检优于其它前列腺穿刺方法，患者无需麻醉、痛苦小、操作时间短、准确，值得在临床推广应用。     

经直肠超声引导下前列腺穿刺活检的临床应用价值

目的:探讨经直肠超声引导下前列腺穿刺活检的临床价值.材料和方法:146例临床疑似前列腺癌(PCA)患者在经直肠超声引导下对前列腺行"6+X"法穿刺活检.结果:经直肠超声引导下前列腺穿刺活检病理诊断PCA 45例,占30.8%,前列腺增生(BPH) 98例,占67.1%;对PCA诊断的敏感性、特异性、准确性分别为75.6%、80.6%、79.1%.结论:经直肠超声引导下前列腺穿刺活检有助于前列腺疾病的鉴别诊断,具有很高的临床价值.     

免疫组化染色技术在前列腺病变穿刺活检中的应用

目的探讨在前列腺穿刺活检标本组织中应用免疫组化染色技术,对前列腺病变进行诊断和鉴别诊断的意义。方法收集我院前列腺穿刺活检标本53例,对标本进行PAP、PSA及P504s/34βE12/P63鸡尾酒联合标记。结果 53例前列腺穿刺标本中PAP、PSA标记均为阳性,其中P504s标记前列腺癌标本35例阳性,高级别上皮内瘤变2例阳性。其中34βE12/P63在前列腺癌35例阴性,高级别上皮内瘤变中2例呈间断阳性;低级别上皮内瘤变5例阳性,其中1例为间断阳性;前列腺良性结节性增生10例阳性。结论联合检测PAP、PSA及P504s/34βE12/P63,对前列腺病变穿刺活检的鉴别诊断具有重要意义。可显著提高前列腺癌的诊断准确率。     

经直肠超声引导穿刺活检诊断前列腺癌价值分析

目的：探讨经直肠超声引导前列腺穿刺活检（TPB）对前列腺癌（PCa）的诊断价值。方法：选择经常规临床检查拟诊可疑PCa者77例,在直肠超声引导下行TPB,与筛查PC．常用检查方法的活检阳性率进行比较,并对不同PSA值所对应的病理活检阳性率进行分析。结果：经穿刺后送病理检查,共检出Pca25例（32．5％）,良性前列腺增生（BPH）52例（67．5％）;血清PSA异常50例活检阳性率为44．oN,经腹超声（us）阳性36例为27．8％,直肠指检（DRE）阳性32例为21．9％;血清T-PSA〉10μg／L且F-PSA/-PSA〈0．25者13例,活检阳性率为53．8％。结论：经直肠超声引导TPB对PCa的诊断价值较高,但应合理选择适应证。     

经直肠超声引导下前列腺穿刺活检诊断前列腺癌

目的:探讨经直肠彩色多普勒超声引导下前列腺穿刺活检诊断前列腺癌的价值。材料和方法:对36例临床肛门指检、前列腺特异抗原及经直肠超声三项检查之一异常者行经直肠超声检查,并行超声引导下穿刺活检。穿刺部位选择在可疑的前列腺癌结节,再结合6点穿刺法对其它部位进行穿刺。结果:19例前列腺癌,超声发现结节11例,9例位于外腺或内外腺交界处;17例前列腺增生,超声发现结节9例,7例结节位于内腺。结论:对可疑前列腺癌病例行经直肠超声引导下穿刺活检是一种快速有效的诊断技术。     

Temporary Health Impact of Prostate MRI and Transrectal Prostate Biopsy in Active Surveillance Prostate Cancer Patients

PurposeTo assess the temporary health impact of prostate multiparametric MRI (mpMRI) and transrectal prostate biopsy in an active surveillance prostate cancer population.MethodsA two-arm institutional review board–approved HIPAA-compliant prospective observational patient-reported outcomes study was performed from November 2017 to July 2018. Inclusion criteria were men with Gleason 6 prostate cancer in active surveillance undergoing either prostate mpMRI or transrectal prostate biopsy. A survey instrument was constructed using validated metrics in consultation with the local patient- and family-centered care organization. Study subjects were recruited at the time of diagnostic testing and completed the instrument by phone 24 to 72 hours after testing. The primary outcome measure was summary testing-related quality of life (summary utility score), derived from the testing morbidities index (TMI) (scale: 0 = death and 1 = perfect health). TMI is stratified into seven domains, with each domain scored from 1 (no health impact) to 5 (extreme health impact). Testing-related quality-of-life measures in the two cohorts were compared with Mann-Whitney U test.ResultsIn all, 122 subjects were recruited, and 90% (110 of 122 [MRI 55 of 60, biopsy 55 of 62]) successfully completed the survey instrument. The temporary quality-of-life impact of transrectal biopsy was significantly greater than that of prostate mpMRI (0.82, 95% confidence interval [CI] 0.79-0.85, versus 0.95, 95% CI 0.94-0.97; P < .001). The largest mean domain-level difference was for intraprocedural pain (transrectal biopsy 2.6, 95% CI 2.4-2.8, versus mpMRI 1.3, 95% CI 1.1-1.5; P < .001).ConclusionTransrectal prostate biopsy has greater temporary health impact (lower testing-related quality-of-life measure) than prostate mpMRI.     

前列腺穿刺活检联合血清前列腺特异抗原在前列腺癌诊断中的意义

目的探讨经直肠前列腺穿刺活检与血清前列腺特异抗原联合检测在前列腺癌诊断中的价值。方法对61例经直肠指检阳性,和（或）总前列腺特异抗原≥10ug／L,和（或）游离前列腺特异抗原/总前列腺特异抗原〈0．25的可疑前列腺癌患者,在超声引导下经直肠前列腺多点穿刺活检。结果61例中,前列腺活检病理检查诊断为前列腺癌25例（40．98％）,良性前列腺增生36例（59．02％）。其中,游离前列腺特异抗原／总前列腺特异抗原〈0．20的患者中前列腺癌检出8例（8／13,占61．54％）。结论总前列腺特异抗原≥10ug／L,特别是游离前列腺特异抗原／总前列腺特异抗原〈0．20对前列腺癌的诊断比前列腺穿刺活检更为敏感,两者联合检测对临床诊治具有更重要的价值和意义。     

Prospective Analysis on the Relation between Pain and Prostate Volume during Transrectal Prostate Biopsy

Objective

We wanted to assess the relationship between pain and the prostate volume during transrectal ultrasound (TRUS) guided biopsy.

Materials and Methods

Between July and September 2006, 71 patients scheduled for TRUS biopsy of the prostate were considered for inclusion to this study. These patients underwent periprostatic neurovascular bundle block with lidocaine prior to biopsy. Pain was assessed using a Visual Analogue Scale (VAS) during periprostatic neurovascular bundle block (VAS 1), during biopsy (VAS 2), and 20 minutes after biopsy (VAS 3). The mean pain scores were analyzed in the large prostate group (prostate volume > 40 cc) and the small prostate group (prostate volume ≤ 40 cc). P values < 0.05 were considered significant.

Results

The mean prostate volume was 42.2 cc (standard deviation: 8.6). The mean pain scores of VAS 1, 2 and 3 were 4.70 ± 1.61, 3.15 ± 2.44 and 1.05 ± 1.51, respectively. In the large prostate group, the mean pains scores of VAS 1, 2 and 3 were 4.75 ± 1.76, 3.51 ± 2.76 and 1.29 ± 1.70, respectively, whereas in the small prostate group, the means pain scores were 4.66 ± 1.46, 2.77 ± 2.0, and 0.80 ± 1.26, respectively. Although there were no statistical differences of VAS 1, the larger prostate group revealed higher pain scores of VAS 2 and 3 compared with the small prostate group (p < 0.05).

Conclusion

Patients with larger prostate volumes tend to feel more pain during and after TRUS guided prostate biopsy. Our findings suggest that additional analgesic strategies may be necessary when the patients with larger prostate undergo TRUS guided prostate biopsy.     

经直肠超声在前列腺癌近距离放疗中的作用

目的:探讨经直肠超声在前列腺癌近距离放疗中的作用.材料和方法:31例术前穿刺证实前列腺癌病人,在经直肠超声或在经直肠超声及X线透视双重引导下,进行了前列腺癌近距离放疗术.结果:所有病例术后CT均显示种子植入位置良好.结论:经直肠超声在前列腺癌近距离放疗术中有三大功能:第一,能准确计算前列腺体积;第二,能确定耻骨弓与前列腺之间关系;第三:能实时监控同位素放射源的植入.     

Pain during Transrectal Ultrasound-Guided Prostate Biopsy and the Role of Periprostatic Nerve Block: What Radiologists Should Know

Early prostate cancers are best detected with transrectal ultrasound (TRUS)-guided core biopsy of the prostate. Due to increased longevity and improved prostate cancer screening, more men are now subjected to TRUS-guided biopsy. To improve the detection rate of early prostate cancer, the current trend is to increase the number of cores obtained. The significant pain associated with the biopsy procedure is usually neglected in clinical practice. Although it is currently underutilized, the periprostatic nerve block is an effective technique to mitigate pain associated with prostate biopsy. This article reviews contemporary issues pertaining to pain during prostate biopsy and discusses the practical aspects of periprostatic nerve block.