CT导向下经皮针刺活检前纵隔肿瘤

目的　探讨经皮针刺活检前纵隔肿瘤的影响穿刺准确性的因素。资料与方法　回顾性分析 80例前纵隔肿瘤CT导向下经皮针刺活检术。结果　 (1)病理学明确诊断 6 7例 ,不能确定诊断 13例 ;(2 )细针抽吸、切割针活检穿刺敏感性分别为 75 %、90 .5 % ;(3) 16例小病灶穿刺敏感性为 6 8.8% ,6 4例大病灶穿刺敏感性为 87.5 % ;(4)胸腺类肿瘤、淋巴结转移性癌活检准确性均为 92 % ,淋巴瘤活检准确性仅为 6 5 % ,与前两组比较有统计学意义(P <0 .0 5 ) ;(5 )穿刺并发症发生率为 7.5 %。结论　切割针活检阳性率高于细针活检 ,活检阳性率大病灶高于小病灶 ,胸腺类肿瘤、淋巴结转移性癌活检阳性率显著高于淋巴瘤 ;CT导向下经皮针刺活检术是前纵隔肿瘤安全、有价值的诊断方法。     

CT透视引导下胸部小病灶穿刺活检的临床价值

目的探讨CT引导胸部小病灶穿刺活检技术及诊断价值。方法 50例胸部小病灶(<3 cm)在CT引导下采用自动切割式活检针穿刺活检。结果50例胸部肿块穿刺活检病灶取材成功100%。胸部肿块穿刺活检的诊断准确率96%(48/50),对恶性病变诊断准确率97.5%(39/40),良性病变为90%(9/10)。并发气胸2例,少量出血1例。结论 C T引导下穿刺活检是安全、有效的诊断手段,对于胸部病变诊断的准确率高,CT引导下胸部小病灶穿刺活检对胸部病变的诊断和治疗具有重要意义。     

CT引导下经皮肺穿刺活检并发症的相关因素分析

目的:分析引起CT引导下经皮肺穿刺活检并发症发生的相关因素.方法:选取2003年10月～2005年9月CT引导下肺穿刺活检的病例284例,分析穿刺并发症的发生与性别、年龄、病灶大小、深度、病灶周围有无肺气肿、穿刺次数、穿刺针粗细等的关系,并进行统计分析.结果:共发生气胸26例,出血(包括肺内出血和针道出血)48例.并发症的发生与病灶大小、深度、病灶周围有无肺气肿、穿刺次数、穿刺针粗细及年龄有关(P＜0.05).结论:CT引导下经皮肺穿刺活检常见并发症有气胸和出血.病灶大小、深度、病灶周围肺气肿、穿刺次数、穿刺针粗细以及年龄是肺穿刺活检并发症的相关因素.     

X线导向经皮胸部穿刺针吸活检(附401例报告)

目的：评价Ｘ线导向经皮穿刺针吸活检术对胸部病变的诊断价值。方法：对４０１例胸部肿块或结节进行了４５１人次Ｘ线导向经皮穿刺针吸活检术。结果：穿刺针吸标本细胞学或细菌学检查阳性３５６例（８８．８％），阴性４５例（１１．２％）。经手术病理、随访或治疗等证实，真正阳性３５６例，真正阴性４例，诊断正确率为８９．８％，假阴性４１例，误诊率为１０．２％。穿刺活检术后发生气胸４１例（１０．２％），少量咯血３３例（８．２％），无大出血或大量咯血者，亦无死亡病例。结论：Ｘ线导向经皮穿刺针吸活检对胸部肿块或结节是一种简单实用且比较安全的获取诊断资料的检查方法。     

Variables affecting the risk of pneumothorax and intrapulmonal hemorrhage in CT-guided transthoracic biopsy

The influence of various variables on the rate of pneumothorax and intrapulmonal hemorrhage associated with computed tomography (CT)-guided transthoracic needle biopsy of the lung were evaluated retrospectively. One hundred and thirty-three patients underwent CT guided biopsy of a pulmonary lesion. Two patients were biopsied twice. Variables analyzed were lesion size, lesion location, number of pleural needle passes, lesion margin, length of intrapulmonal biopsy path and puncture time. Eighteen-gauge (18G) cutting needles (Trucut, Somatex, Teltow, Germany) were used for biopsy. Pneumothorax occurred in 23 of 135 biopsies (17%). Chest tube placement was required in three out of 23 cases of pneumothorax (2% of all biopsies). Pneumothorax rate was significantly higher when the lesions were located in the lung parenchyma compared with locations at the pleura or chest wall (P < 0.05), but all pneumothorax cases which required chest tube treatment occurred in lesions located less than 2 cm from the pleura. Longer puncture time led to an increase in pneumothorax rate (P < 0.05). Thirty-seven (27%) out of 135 biopsies showed perifocal hemorrhage. Intrapulmonal biopsy paths longer than 4 cm showed significantly higher numbers of perifocal hemorrhage and pneumothorax (P < 0.05). Significantly more hemorrhage occurred when the pleura was penetrated twice during the puncture (P < 0.05). Lesion size <4 cm is strongly correlated with higher occurrence of perifocal hemorrhage (P < 0.05). Lesion margination showed no significant effect on complication rate. CT-guided biopsy of smaller lesions correlates with a higher bleeding rate. Puncture time should be minimized to reduce pneumothorax rate. Passing the pleura twice significantly increases the risk of hemorrhage. Intrapulmonal biopsy paths longer than 4 cm showed significantly higher numbers of perifocal hemorrhage as well as pneumothorax.     

Ultrasonically guided percutaneous needle aspiration biopsies (author's transl)]

Ultrasonically guided percutaneous fine needle aspiration biopsies were carried out in 179 patients with sonographically proven space occupying lesions of the liver, pancreas and kidneys as well as the retroperitoneal space. The fine needle aspiration biopsies were done using a B-scan-aspiration-biopsy transducer with a special needle having an outer diameter of 0,4--0,6 mm. Liver metastases were proven cytologically in 57/70 patients (81%), pancreatic carcinomas in 20/31 patients (64%), kidney tumours in 15/20 patients (75%), retroperitoneal lymph node metastases and primary malignant lymphomas in 20/32 patients (62%). The ultrasonically guided fine needle aspiration biopsy is simple, practically without pain, risk or complications for the patient, and is an economically feasible examination method.     

Percutaneous needle biopsy of soft tissue tumors guided by ultrasound and computed tomography

Ultrasound and computed tomography (CT) guided percutaneous needle biopsy of soft tissue lesions was performed in 39 patients. A correct diagnosis was obtained in 35 of 42 biopsies, with an overall accuracy rate of 83%. No false-positive diagnoses were obtained, and no complications related to the procedure were encountered. The value of this technique in the management of selected patients with soft tissue masses is detailed.     

Sonographically-Guided 14-Gauge Core Needle Biopsy for Papillary Lesions of the Breast

Objective

We wanted to assess the need for surgical excising papillary lesions of the breast that were diagnosed upon sonographically guided 14-gauge core needle biopsy.

Materials and Methods

Sixty-nine women (age range: 25-74 years, mean age: 51.7 years) with 69 papillary lesions (4.9%) were diagnosed and followed after performing sonographically guided 14-gauge core needle biopsies. Surgical excision was performed for 44 (64%) of 69 papillary lesions, and 25 lesions were followed with imaging studies (range: 6-46 months, mean: 17.9 months). The histologic findings upon core biopsy were compared with the surgical, imaging and follow-up findings.

Results

Core needle biopsies of 69 lesions yielded tissue that was classified as benign for 43 lesions, atypical for 18 lesions and malignant for eight lesions. Of the 43 lesions that yielded benign papilloma upon core needle biopsy, one had intraductal papillary carcinoma found upon surgery. An immediate surgical biopsy was recommended for this lesion because of the imaging-histologic discordance. No additional carcinoma was found during the imaging follow-up. Surgical excision was performed for 17 atypical papillary lesions, and this revealed intraductal (n = 6) or invasive (n = 2) papillary carcinoma in 8 (47%) lesions. Of the seven intraductal papillary carcinomas, surgery revealed invasive papillary carcinoma in one (14%).

Conclusion

Our results suggest that papillary lesions of the breast that are diagnosed as benign upon sonographically guided 14-gauge core needle biopsy can be followed when the results are concordant with the imaging findings.     

Pancreatic needle biopsy guided by ultrasound or CT

24 patients suspected to have a pancreatic expansive lesion underwent a biopsy with Chiba needle: 15 biopsies were guided by US and 9 by CT. Such series regards lesions having a diameter between 2.5 and 5.5 cm with average values of 4 cm. The results showed high specificity (100%) and satisfactory accuracy (66.6%); complications never set in. The authors prove the clinical utility of this procedure instead of the laparotomy and stress the importance of a strict collaboration between radiologist and cytologist in order to achieve the best results.     

Fine-needle percutaneous biopsy of renal masses with helical CT guidance

PURPOSE: To evaluate the feasibility, accuracy, and clinical role of fine-needle percutaneous biopsy of renal masses, with helical computed tomographic (CT) guidance. MATERIALS AND METHODS: In 63 patients (mean age, 62 years), 73 biopsies were performed. The median tumor size was 4.0 cm. Tumor biopsy was performed with an 18-gauge needle by using helical CT guidance in an outpatient setting. Two to four cores per tumor were obtained. RESULTS: Biopsy material was insufficient for analysis in 15 (21%) procedures. The median tumor size of failed or successful biopsies was 3.0 or 4.8 cm, respectively (P =.03). A benign lesion was found at eight biopsies. Two samples were suspicious for renal cell carcinoma (RCC). RCC was found in 38 biopsy samples. The remainder were transitional cell carcinoma, metastasis, lymphoma, or sarcoma. Twenty-six patients underwent nephrectomy. The accuracies of biopsy for histopathologic and Fuhrman nuclear grade evaluation were 89% and 78%, respectively. For tumors of 3.0 cm or smaller or larger than 3.0 cm, 37% (11 of 30) or 9% (four of 43) had failure of biopsy, respectively (P =.006). No substantial morbidity occurred. CONCLUSION: Fine-needle biopsy with helical CT guidance is accurate for the histopathologic evaluation of renal masses without morbidity. Indications are renal lesions that do not have the typical radiologic features of RCC, Bosniak category III or IV cystic lesions, and locally advanced or metastatic RCC.     

CT引导下经皮肺穿刺活检的临床应用与结果分析

目的总结CT引导下经皮肺穿刺活检术的临床应用。方法采用GE—Hispeed螺旋CT机，各种型号病理穿刺针及切割针对36例胸部占位性病变，实施CT引导下经皮穿刺活检术。结果病灶直径1．5cm～10cm大小，平均3．5cm。穿刺成功35例，活检阳性率100％，并发症有气胸3例，咯血1例，术后经抗炎及止血处理，气胸很快吸收，咯血停止。结论CT引导下经皮肺穿刺活检术成功率高，并发症少而轻，对胸部占位性病的定性诊断具有重要的临床意义。     

Predictive value of benign percutaneous adrenal biopsies in oncology patients

PURPOSE: Percutaneous CT guided biopsy is accepted as a safe procedure for the diagnosis of indeterminate adrenal masses in oncologic patients. The purpose of this study was to evaluate the accuracy of a 'negative for tumour' adrenal biopsy in the oncologic patient population by assessing subsequent outcome including clinical course, size and imaging characteristics of the adrenal lesions on follow-up imaging studies and pathological findings at re-biopsy or following adrenal mass resection. MATERIALS AND METHODS: Retrospective analysis of 225 oncological patients (FM, 128;87; age range 33-87 years, mean age 66 years) who had undergone CT guided biopsies of an adrenal mass over a 5-year period was performed. Those patients with a report consistent with 'negative for malignancy' were evaluated by reviewing the medical records for patient demographics, primary malignancy, histology of adrenal tumour, subsequent surgical interventions, repeat adrenal biopsy under image guidance, by open surgery or at autopsy, subsequent abdominal imaging in which the adrenal gland was imaged, and long-term outcome including hospital admissions, or death. RESULTS: Of the 225 CT-guided adrenal biopsies performed, 41 (18%) were negative for neoplasm. The primary neoplasm in these 41 patients included lung cancer (n=32), breast (n=5), renal cell carcinoma (n=2), bladder (n=1), and prostate (n=1). The size of the adrenal lesions ranged from 2.8-5 cm. Of the 41 biopsies, which were negative for tumour; 10 were identified as adenomas and the rest showed benign adrenal cortical cells or hyperplasia on cytopathology and histopathology. Repeat biopsies were obtained in 13/41 (31%) patients; whereas 2/41 (5%) had their adrenal gland analyzed on post mortem examination. None of these 15 repeat evaluations yielded tumour. CONCLUSION: In oncological patients, pathological analysis of tissue samples obtained by CT-guided percutaneous biopsy, suggesting benign aetiology, is reliable and predicts a benign course on long-term follow-up. A negative or benign pathology result for a CT guided percutaneous adrenal biopsy can be regarded as a true negative evaluation in oncological patients with no necessity to repeat the biopsy.     

CT引导下寰枢椎病变经皮穿刺活检

目的 全面系统地探讨寰枢椎病变CT引导下穿刺活检的入路选择,评价其安全性及临床应用价值。材料与方法 25例寰枢椎病变行CT引导下经皮穿刺活检。穿刺部位包括C1及C2椎体的各个部位。根据病变的部位不同,设计相应的进针路径,穿刺取材。结果 25例中,24例获得明确病理诊断,穿刺活检准确率96％。其中12例手术治疗,穿刺病理与手术病理符合率100％。无并发症发生。结论 寰枢椎病变解剖关系复杂,毗邻脊髓及重要的大血管,选择适宜的穿刺路径尤为关键。寰枢椎病变不同的穿刺路径,只要避开大血管及脊髓,操作是比较安全的。为临床确定治疗方案提供了必要的病理依据。     

透视引导经皮细针穿刺活检肺癌假阴性的相关因素分析

目的探讨肺癌病灶经皮细针穿刺抽吸活检假阴性结果产生的相关因素和避免方法。资料与方法回顾性研究60例在电视透视下(有1例加用CT引导)行经皮针吸肺活检的病例．追踪肺穿刺细胞学结果与手术病理或临床随访结果。分类记录假阴性病灶的操作人员、病理结果、术中发现和病灶CT特征。结果发现假阴性14例(20．3％)。恶性病灶直径3～5cm,深度≥4cm,有坏死或继发感染．则易致穿刺假阴性。结论经皮细针穿刺抽吸活检肺内病灶时一定要仔细分析病灶特征并熟练掌握相应的穿刺技巧．尽量避免发生假阴性。     

B超定位肝穿刺活检的临床应用

目的对慢性肝炎患者进行B型超声检查,并在B超定位下肝穿刺活检作组织病理学诊断,以明确肝脏的炎症活动分级与肝纤维化程度分期。方法对84例慢性肝炎患者进行超声检查,采取B超定位,组织切割针获取标本,送病理组织学检查。结果84例超声诊断轻度肝损伤53例,中度肝损伤18例,可疑肝硬化8例,肝硬化5例。组织病理学诊断:轻度慢性肝炎39例,中度慢性肝炎26例,早期肝硬化12例,肝硬化7例。结论通过超声定位肝穿刺活检作组织病理学诊断,可了解慢性肝炎的病理分级分期,从而指导临床治疗。     

MR fluoroscopy-guided transthoracic fine-needle aspiration biopsy: feasibility

The purpose of this study was to evaluate the feasibility of using an open-configuration magnetic resonance (MR) imaging system with MR fluoroscopic guidance to perform percutaneous transthoracic fine-needle aspiration biopsy in patients with lung masses. Percutaneous transthoracic aspiration biopsies were performed with MR fluoroscopic guidance in 14 patients. The masses were 2-7 cm in diameter (mean, 4.1 cm). The needle was positioned by using a free-hand technique with MR fluoroscopic guidance. The needle tip reached the target lesion, and biopsy was performed. Analysis of the biopsy specimens facilitated a specific diagnosis in all patients. Pneumothorax was noted in two patients (14%) with chronic obstructive pulmonary disease. Study results showed that the described MR fluoroscopy-guided transthoracic biopsy technique can be used safely and successfully for lung masses. MR fluoroscopy can be used to reach the target lesion easily and accurately.     

Percutaneous abdominal and pelvic interventional procedures using CT fluoroscopy guidance.

OBJECTIVE: The purpose of our study was to assess the use of low-milliamperage CT fluoroscopy guidance for percutaneous abdominopelvic biopsy and therapeutic procedures. MATERIALS AND METHODS: We reviewed the clinical records and relevant imaging studies of 97 patients who underwent 119 percutaneous CT fluoroscopy-guided abdominal or pelvic procedures: fluid collection aspiration or drainage catheter insertion (n = 59), biopsy (n = 49), hepatocellular carcinoma ethanol ablation (n = 6), chemoneurolysis (n = 4), and brachytherapy catheter insertion (n = 1). These procedures were guided using a helical CT scanner providing real-time fluoroscopy reconstruction at six frames per second. A control panel and video monitor beside the gantry allowed direct operator control during all interventional procedures. RESULTS: One hundred twelve (94.1%) procedures were successfully performed using either a stand-off needle holder and continuous real-time CT fluoroscopy guidance or incremental manual insertion and intermittent CT fluoroscopy to confirm position. Image quality using low milliamperage was adequate for needle or drainage tube placement in all but two low-contrast liver lesions. Two hematomas were accessed but yielded no fluid on aspiration; one drainage procedure was abandoned after the patient developed endotoxic shock. Imaging of ethanol distribution during injection facilitated tumor ablation and neurolytic procedures. CT fluoroscopy allowed rapid assessment of needle, guidewire, dilator, and catheter placement, especially in nonaxial planes. Average CT fluoroscopy time for biopsy and therapeutic procedures was 133 sec (range, 35-336 sec) and 186 sec (range, 20-660 sec), respectively. CONCLUSION: CT fluoroscopy is a practical clinical tool that facilitates effective performance of percutaneous abdominal and pelvic interventional procedures.     

CT fluoroscopy guided transpleural cutting needle biopsy of small (≤2.5 cm) subpleural pulmonary nodules

Purpose

Small subpleural pulmonary lesions are difficult to biopsy. While the direct, short needle path has been reported to have a lower rate of pneumothorax, the indirect path provides a higher diagnostic yield. Therefore, we tried to optimize the needle pathway and minimize the iatrogenic pneumothorax risk by evaluating a CT fluoroscopy guided direct approach to biopsy subpleural lesions.

Material and methods

Between 01/2005 and 01/2007, CT fluoroscopy guided core biopsies were performed in 24 patients. Using our technique, the tip of the guide needle remains outside the visceral pleura (17 G coaxial guide needle, 18 G Biopsy-gun, 15 or 22 mm needle path). The position of the lesion relative to the needle tip can be optimized using CT fluoroscopy by adjusting the breathing position of the patient. The Biopty gun is fired with the needle tip still outside the pleural space. Cytological smears are analyzed by a cytopathologist on-site, and biopsies are repeated as indicated with the coaxial needle still outside the pleura.

Results

Median nodule size was 1.6 cm (0.7-2.3 cm). A definitive diagnosis was obtained in 22 patients by histology and/or cytology. In one patient, only necrotic material could be obtained. In another patient, the intervention had to be aborted as the dyspnoic patient could not follow breathing instructions. An asymptomatic pneumothorax was present in seven patients; chest tube placement was not required.

Conclusion

The presented biopsy approach has a high diagnostic yield and is especially advantageous for biopsies of small subpleural lesions in the lower lobes.     

Sonographically guided percutaneous biopsy of gastrointestinal tract lesions

OBJECTIVE. Our objective was to evaluate the role and safety of sonographically guided percutaneous biopsy in the diagnosis of digestive tract lesions when the lesions are not suitable to biopsy by endoscopy and safely reachable by sonography. MATERIALS AND METHODS. We performed 42 biopsies in 41 patients (age range, 14-81 years; mean age, 57.5 years). We performed biopsies with real-time sonographic guidance using graded compression, with a 3.5-5-MHz microconvex transducer. In 39 biopsies, core specimens were obtained with an 18-gauge automatic needle gun; fine-needle aspiration biopsy was obtained in 28 patients with a 22-gauge needle and in the other four patients with a 21-gauge needle. In the remaining three patients, a coaxial technique with 20- and 22-gauge needles for cytology was used. RESULTS. In 40 (95.2%) of 42 core biopsies performed, a specific diagnosis was obtained. A positive diagnosis was obtained in 16 (45.7%) of 35 fine-needle aspirations. The lesions were located from the pharynx to the sigmoid colon. Twenty-eight patients had malignant lesions, and 13 had benign lesions. Only one serious complication, bile peritonitis, was observed. CONCLUSION. Percutaneous biopsy with sonographic guidance can be used safely and efficiently to diagnose digestive tract lesions that can be visualized on sonography and are not accessible endoscopically.     

CT引导纤维支气管镜对小支气管源性癌的活检价值

目的：探讨CT引导纤维支气管镜(纤支镜)对小支气管源性癌的活检价值。方法：33例CT引导纤支镜活检结果与手术病理对照并与纤支镜盲检及CT引导经皮肺穿刺活检比较。结果：单纯1～3级大支气管内病变，可采用纤支镜直视活检；小支气管内病变以CT引导纤支镜活检更为可靠、准确和并发症少；细支气管及肺泡病变则以CT引导经皮肺穿刺活检成功率高。结论：对发生于小支气管内的较小病灶，CT引导纤支镜活检，可以采集到更全面的病理标本，并通过镜检 刷检 多点活检技术的综合应用，能进一步提高活检的准确性。