延续性护理对青年高血压脑出血患者治疗依从性及预后的影响

目的探讨延续性护理对青年高血压脑出血患者治疗依从性及预后的影响。方法 选取2016 年1 月～2019 年6 月在本院进行高血压脑出血手术治疗的102 例青年患者为研究对象,随机设为研究组与对照组。对照组进行常规干预,研究组在常规干预的基础上进行延续性护理干预。比较两组的总遵医率、临床护理效果、并发症发生情况及生活质量评分。结果 研究组总遵医率高于对照组（P＜0.05）;研究组干预后的神经功能评分低于对照组,而巴氏指数评分高于对照组（P＜0.05）;研究组并发症总发生率少于对照组（P＜0.05）;研究组干预后各项生活质量评分均高于对照组（P＜0.05）。结论 对青年高血压脑出血患者采用延续性护理干预,能够促使其治疗依从性得到显著提高,预后情况得到明显改善,利于临床应用及推广。     

门诊妇科阴道炎护理健康教育干预效果观察分析

目的：观察并分析在门诊妇科阴道炎患者的护理工作中实行健康教育干预的效果。方法：从该院2013年02月至2015年06月门诊收治的妇科阴道炎患者中随机选取100例,按照自愿原则将其平均分为干预组和对照组各50例。对照组采用常规门诊护理干预路径,干预组在其基础上实施强化健康教育,持续干预2周,随访6个月,将两组患者6个月内阴道炎复发率、健康行为依从性等指标作比较。结果：随访6个月内,干预组（4.0％）阴道炎复发率要明显地低于对照组（20.0％,P ＜0.05）;干预组（94.0％）的健康行为依从率要显著地高于对照组（74.0％,P ＜0.05）。结论：对门诊阴道炎患者实施强化健康教育,有利于提高患者对疾病的认知水平,改善其健康行为依从性,降低阴道炎的复发率,值得借鉴和尝试。     

健康教育干预对慢性胃炎患者的护理效果研究

目的：探析慢性胃炎患者运用健康教育干预的临床效果。方法：选择该院2015年2月至2016年2月期间收治的140例慢性胃炎患者为研究对象，随机分为两组，其中给予对照组常规护理，而观察组则运用健康教育干预，对比两组护理效果。结果：与对照组相比，观察组的疾病知识知晓率较高，组间对比差异明显（P＜0.05）；同时，随访6个月，两组的复发率对比有差异（P＜0.05）。结论：临床上给予慢性胃炎患者健康教育干预，可以提高患者的治疗依从性，从而降低复发率。     

护理干预对慢性心力衰竭心理状态及预后的影响

目的：分析慢性心力衰竭（心衰）患者予以护理干预对心理状态及预后的影响。方法：将100例慢性心衰患者均分为2组，各50例，对照组实施常规护理，研究组予以系统的护理干预。两组皆予以≥半年随访，观察记录护理前后抑郁自评量表（SDS）与抑郁状态问卷（DSI）评分情况，以及随访半年复发率，并对比分析。结果：两组护理 SDS 评分与 DSI 评分皆有一定改善（P ＜0.01），研究组改善更佳（P ＜0.01）；研究组随访半年复发率明显低于对照组（P ＜0.01）。结论：慢性心衰患者予以系统的护理干预处理，可改善心理状态，并降低复发，值得借鉴。     

对小儿肺炎患者进行健康教育的效果观察

目的：探讨分析对小儿肺炎患者进行健康教育的临床效果。方法：选取2011年12月～2013年12月间我院收治的肺炎患儿100例作为研究对象,采用随机数字表法将其分为对照组（50例）和健康教育组（50例）,为对照组患儿进行常规护理,为健康教育组患儿在进行常规护理的基础上进行健康教育,观察对比两组患儿病情的复发率、对治疗及护理的依从性,并将对比的结果及两组患儿的临床资料进行回顾性的分析。结果：健康教育组患儿的病情复发率（10%）明显低于对照组患儿（33.3%）,差异显著（P＜0.05）,具有统计学意义。健康教育组患儿对治疗及护理的依从性得分（主要包括体育锻炼评分、饮食调理评分及预防措施评分）均明显优于对照组患儿,差异显著（P＜0.05）,具有统计学意义。结论：对小儿肺炎患者进行健康教育的临床效果显著,值得在临床上推广应用。     

护理干预对慢性阻塞性肺疾病患者治疗依从性与复发的影响

目的 探讨护理干预对慢性阻塞性肺疾病患者治疗依从性与复发的影响。方法 选择60例COPD患者,随机分为干预组和对照组各30例。对照组实施对症治疗及常规护理,干预组实施系统护理干预,着重侧重心理护理、氧疗、用药饮食指导及健康教育,比较两组的治疗依从性、两组患者的平均住院时间、护理满意度及随访半年后两组患者的复发率。结果 干预组患者的依从率达96.7%,显著高于对照组的73.3%,差异有统计学意义（P〈0.05）。干预组患者的平均住院时间明显短于对照组,干预组患者的护理满意度评分明显高于对照组,差异有统计学意义（P〈0.05）。随访半年,干预组复发1例,对照组复发6例,两组复发率比较,差异有统计学意义（P〈0.05）。结论 对慢性阻塞性肺疾病患者治疗期间实施系统的护理干预,有利于提高患者的依从性,降低复发率,促进患者疾病的康复。     

全程健康教育模式在糖尿病护理干预中的效果观察

目的：探讨全程健康教育模式在糖尿病护理干预中的应用效果.方法：将120例我院住院治疗的糖尿病患者随机分为干预组和对照组各60例,同一治疗程序下,对照组行传统健康教育,干预组行全程健康教育.结果：实施全程健康教育模式6个月后,干预组患者空腹血糖水平较健康教育前及同期对照组血糖水平均明显降低,血糖控制达标率（61.7％）明显高于对照组（41.7％）,比较均有统计学差异（P＜0.05）;随访半年后干预组患者糖尿病知识知晓、治疗依从性测评得分均明显高于对照组（P＜0.05）;干预组低血糖事件发生率在出院后6个月时较对照组明显降低（P＜0.05）.结论：糖尿病全程健康教育模式效果明显,可作为制度化、常规化的护理措施临床推广应用.     

健康教育护理路径对单纯腰椎压缩性骨折患者腰背功能恢复的效果观察

目的 探讨健康教育护理路径对单纯腰椎压缩性骨折患者腰背功能恢复的效果.方法 将2013年1月～2014年1月期间我院收治的82例单纯腰椎压缩性骨折患者随机分为研究组与对照组各41例.对照组患者应用常规护理,研究组在此基础上应用健康教育护理路径干预.结果 ①研究组护理的总满意率为100.00％,明显高于对照组的82.93％ （P＜0.05）.②研究组健康知识掌握的优良率为95.12％,对照组为70.73％ （P＜0.05）.③治疗前两组患者疼痛评分、Frankel评分比较无统计学差异（P＞0.05）;治疗后两组患者疼痛评分显著降低,Frankel评分显著升高（P＜0.05）,研究组上述评分显著优于对照组（P＜0.05）.结论 针对单纯腰椎压缩性骨折患者应用健康教育护理路径,效果显著,可以有效改善患者的腰背功能,加快恢复速度,适于临床推广.     

情境体验式健康教育在肝癌患者护理中的效果观察

目的 探讨肝癌患者护理中采用情境体验式健康教育的临床疗效。方法 选取2017 年9 月～2018 年9 月于我院就诊的肝癌患者74 例，以“双盲法”为原则进行分组，分别是常规组（n=37）和研究组（n=37），常规组应用常规护理，研究组采用情境体验式健康教育，比较两组护理干预后的心理状态、生活质量、健康教育认知水平、依从性情况。结果 干预前两组心理状态指标SAS、SDS 评分均处于同一水平，干预后两组上述指标评分均明显降低，且研究组SAS、SDS 评分降低程度比常规组更显著（P＜0.05）；与常规组相比，研究组生活质量各指标身体功能、角色功能、情绪功能、社会功能、总体生活质量评分更高（P＜0.05）；研究组健康教育知识掌握程度明显比常规组更好（P＜0.05）；研究组、常规组患者依从率分别为91.89%、70.27%，研究组明显更好（P＜0.05）。结论 肝癌患者护理中采用情境体验式健康教育，可有效改善患者的不良心理情绪，增强认知水平，进而提高生活质量，值得临床广泛推广。     

基于“医院-家庭”健康信息满足护理对多囊卵巢综合征取卵移植术患者妊娠结局的影响

目的：分析基于“医院-家庭”健康信息满足护理对多囊卵巢综合征取卵移植术患者妊娠结局的护理效果及价值。方法：选取2019 年1月至2020 年1月舟山市妇女儿童医院多囊卵巢综合征取卵移植术患者80例,按照随机数表法分为研究组（n =40 例）与对照组（n =40例）,研究组患者给予基于“医院-家庭”健康教育信息满足护理,对照组患者给予常规护理,比较2组患者护理前后状态-特质焦虑量表（STAI）评分、相关疾病认知水平、受精率、流产率及妊娠率。结果：2组患者护理后STAI评分均有所改善,研究组患者与对照组相比明显降低（P ＜0.05）;研究组患者护理干预后对促排卵、取卵术、多囊卵巢综合征、并发症等相关知识了解水平与对照组相比明显提高（P ＜0.05）;研究组患者经护理干预后妊娠率明显高于对照组（P ＜0.05）。结论：基于“医院-家庭”健康信息满足护理能有效提高取卵移植术后患者疾病认识水平,减少患者负面情绪,有效提高妊娠率。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.